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March 20, 20141©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
Advances	
  in	
  Op-cal	
  Design	
  
	
  
OSA,	
  Northern	
  California	
  Sec9on	
  
March	
  20,	
  2014	
  
Giacomo	
  Vacca,	
  Ph.D.1,	
  Hannu	
  Leh9mäki2,	
  Tapio	
  Karras3,	
  Sean	
  Murphy4	
  
1Kine9c	
  River	
  Corp.,	
  2Plan	
  energy	
  Ltd.,	
  3Design	
  Parametrics	
  Inc.,	
  4SKMurphy	
  Inc.	
  
March 20, 20142©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
March 20, 20143©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
March 20, 20144©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
March 20, 20145©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
Semrock’s	
  SearchLight™	
  
March 20, 20146©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
Example:	
  Flow	
  Cytometry	
  
© 2011 Life Tech
light	
  source(s)	
  
flow	
  cell	
  
forward-­‐sca[er	
  
detector(s)	
  
fluorescence	
  
detector(s)	
  
side-­‐sca[er	
  
detector(s)	
  
spectral	
  
filters	
  
March 20, 20147©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
March 20, 20148©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
New	
  Design	
  Tools:	
  
LiveIdeas	
  and	
  BeamWise	
  
March 20, 20149©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
LiveIdeas™:	
  Op9mize	
  Design	
  
March 20, 201410©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
BeamWise™	
  	
  
Automa9ng	
  Biophotonics	
  
System	
  Design	
  
•  	
  Beam-­‐anchored	
  tool	
  
•  	
  Builds	
  3D	
  CAD	
  model	
  using:	
  	
  
–  simulator	
  results	
  
–  func9onal	
  layout	
  
–  optomechanical	
  component	
  data	
  
•  	
  Creates	
  2D	
  drawings	
  &	
  parts	
  lists	
  for	
  manufacturing	
  
•  	
  Supports	
  explora9on	
  of	
  design	
  op9ons	
  
	
  with	
  efficient	
  change	
  management	
  
March 20, 201411©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
BeamWise™:	
  Automated	
  3D	
  Model	
  	
  
&	
  Document	
  Crea9on	
  
March 20, 201412©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
Step-­‐by-­‐Step	
  Walkthrough	
  
March 20, 201413©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
March 20, 201414©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
Network(
Path(ID
NetList(
Vector
From To Magnitude
Mag.(
Units
Direction
Dir.(
Units
B1 v01 SO01 MI01 50.00++++++++++++ mm 270 degrees
B1 v02 MI01 LE01 50.00++++++++++++ mm 180 degrees
B1 v03 LE01 LE02 50.00++++++++++++ mm 180 degrees
B1 v04 LE02 LE03 150.00++++++++++ mm 180 degrees
B1 v05 LE03 MI02 50.00++++++++++++ mm 180 degrees
B1 v06 MI02 LE04 75.00++++++++++++ mm 90 degrees
B1 v07 LE04 LE05 50.00++++++++++++ mm 90 degrees
B1 v08 LE05 FC01 75.00++++++++++++ mm 90 degrees
B1 v09 FC01 LE06 50.00++++++++++++ mm 90 degrees
B1 v10 LE06 PD01 50.00++++++++++++ mm 90 degrees
(B2,+B3) v11 FC01 MO01 38.00++++++++++++ mm 0 degrees
(B2,+B3) v12 MO01 LE07 65.00++++++++++++ mm 0 degrees
(B2,+B3) v13 LE07 BS01 70.00++++++++++++ mm 0 degrees
B2 v14 BS01 FI01 25.00++++++++++++ mm 0 degrees
B2 v15 FI01 FI02 35.00++++++++++++ mm 0 degrees
B2 v16 FI02 PD02 25.00++++++++++++ mm 0 degrees
B3 v17 BS01 FI03 25.00++++++++++++ mm 270 degrees
B3 v18 FI03 FI04 35.00++++++++++++ mm 270 degrees
B3 v19 FI04 PD03 25.00++++++++++++ mm 270 degrees
March 20, 201415©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
3D	
  View	
  
March 20, 201416©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
March 20, 201417©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
March 20, 201418©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
2D	
  Layout	
  
March 20, 201419©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
March 20, 201420©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
March 20, 201421©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
March 20, 201422©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
March 20, 201423©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
BeamWise™:	
  Automated	
  3D	
  Model	
  	
  
&	
  Document	
  Crea9on	
  
March 20, 201424©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
BeamWise™	
  	
  
Automa9ng	
  Biophotonics	
  System	
  Design	
  
•  Kine9c	
  River	
  
–  system	
  design	
  
•  Design	
  Parametrics	
  
–  CAD	
  modeling	
  
plaborm	
  
•  PlanEnergy	
  
–  tool	
  development	
  
•  SKMurphy	
  
–  concept,	
  biz	
  
development	
  
March 20, 201425©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
Kine9c	
  River:	
  What	
  ELSE	
  We	
  Do	
  
March 20, 201426©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
	
  Giacomo	
  Vacca,	
  Ph.D.	
  
•  Kine-c	
  River	
  (founder)	
  
•  Abbo>	
  Labs	
  (Res.	
  Fellow)	
  
•  Picarro	
  
•  Lightwave	
  Micro	
  
•  Exxon	
  Research	
  &	
  Engr.	
  
•  28	
  patents	
  issued/pending	
  	
  
March 20, 201427©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
Kine9c	
  River	
  Mission	
  
Kine9c	
  River	
  is	
  a	
  biophotonics	
  consul9ng	
  and	
  
product	
  development	
  company	
  with	
  a	
  passion	
  for	
  
crea9ng	
  and	
  enabling	
  tools	
  for	
  innova9ve	
  and	
  
disrup9ve	
  life	
  science	
  research,	
  biomedical	
  
instrumenta9on,	
  and	
  clinical	
  diagnos9cs.	
  
Where	
  Light	
  Meets	
  Life™	
  
March 20, 201428©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
Danube	
  I:	
  1st-­‐Gen	
  FLT	
  Flow	
  Cytometer	
  
•  Full	
  custom	
  build	
  
•  Collab.	
  with	
  New	
  Mexico	
  State	
  U.	
  
•  Concept,	
  design,	
  build,	
  test,	
  support	
  
•  Op9cs,	
  microfluidics,	
  control	
  SW	
  
•  	
  20-­‐ns	
  light-­‐cell	
  interac9on	
  9me	
  
2-­‐ns	
  life-me	
  
resolu-on	
  
March 20, 201429©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
Kine9c	
  River	
  Clients	
  
•  Beckman	
  Coulter	
  (part	
  of	
  Danaher)	
  
•  Dolomite	
  Microfluidics	
  
•  EMD	
  Millipore	
  (part	
  of	
  Merck	
  KGaA)	
  
•  Gerson	
  Lehrman	
  Group	
  
•  NanoCellect	
  
•  Na9onal	
  Instruments	
  
•  Houston	
  Lab	
  (New	
  Mexico	
  State	
  University)	
  
•  Na9onal	
  Cancer	
  Ins9tute	
  (NIH)	
  
•  Product	
  Realiza9on	
  Group	
  
•  Nolan	
  Lab	
  (Stanford	
  School	
  of	
  Medicine)	
  
•  TempSync	
  
•  [others]	
  
March 20, 201430©	
  2014	
  Design	
  Parametrics,	
  Incorporated,	
  
Kine9c	
  River	
  Corpora9on,	
  Plan	
  Energy	
  Ltd.	
  
www.BeamWise.net	
  
Kine9c	
  River	
  Key	
  Exper9se	
  
System	
  Domain	
  
Knowledge	
  
System	
  Design	
  
Microfluidics	
   2D	
  /	
  3D	
  CAD	
  
Op9cs	
  
LiveIdeas™
BeamWise™

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Advances in Optical Design: G. Vacca Seminar at Northern California OSA, March 20, 2014

  • 1. March 20, 20141©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net   Advances  in  Op-cal  Design     OSA,  Northern  California  Sec9on   March  20,  2014   Giacomo  Vacca,  Ph.D.1,  Hannu  Leh9mäki2,  Tapio  Karras3,  Sean  Murphy4   1Kine9c  River  Corp.,  2Plan  energy  Ltd.,  3Design  Parametrics  Inc.,  4SKMurphy  Inc.  
  • 2. March 20, 20142©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net  
  • 3. March 20, 20143©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net  
  • 4. March 20, 20144©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net  
  • 5. March 20, 20145©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net   Semrock’s  SearchLight™  
  • 6. March 20, 20146©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net   Example:  Flow  Cytometry   © 2011 Life Tech light  source(s)   flow  cell   forward-­‐sca[er   detector(s)   fluorescence   detector(s)   side-­‐sca[er   detector(s)   spectral   filters  
  • 7. March 20, 20147©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net  
  • 8. March 20, 20148©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net   New  Design  Tools:   LiveIdeas  and  BeamWise  
  • 9. March 20, 20149©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net   LiveIdeas™:  Op9mize  Design  
  • 10. March 20, 201410©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net   BeamWise™     Automa9ng  Biophotonics   System  Design   •   Beam-­‐anchored  tool   •   Builds  3D  CAD  model  using:     –  simulator  results   –  func9onal  layout   –  optomechanical  component  data   •   Creates  2D  drawings  &  parts  lists  for  manufacturing   •   Supports  explora9on  of  design  op9ons    with  efficient  change  management  
  • 11. March 20, 201411©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net   BeamWise™:  Automated  3D  Model     &  Document  Crea9on  
  • 12. March 20, 201412©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net   Step-­‐by-­‐Step  Walkthrough  
  • 13. March 20, 201413©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net  
  • 14. March 20, 201414©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net   Network( Path(ID NetList( Vector From To Magnitude Mag.( Units Direction Dir.( Units B1 v01 SO01 MI01 50.00++++++++++++ mm 270 degrees B1 v02 MI01 LE01 50.00++++++++++++ mm 180 degrees B1 v03 LE01 LE02 50.00++++++++++++ mm 180 degrees B1 v04 LE02 LE03 150.00++++++++++ mm 180 degrees B1 v05 LE03 MI02 50.00++++++++++++ mm 180 degrees B1 v06 MI02 LE04 75.00++++++++++++ mm 90 degrees B1 v07 LE04 LE05 50.00++++++++++++ mm 90 degrees B1 v08 LE05 FC01 75.00++++++++++++ mm 90 degrees B1 v09 FC01 LE06 50.00++++++++++++ mm 90 degrees B1 v10 LE06 PD01 50.00++++++++++++ mm 90 degrees (B2,+B3) v11 FC01 MO01 38.00++++++++++++ mm 0 degrees (B2,+B3) v12 MO01 LE07 65.00++++++++++++ mm 0 degrees (B2,+B3) v13 LE07 BS01 70.00++++++++++++ mm 0 degrees B2 v14 BS01 FI01 25.00++++++++++++ mm 0 degrees B2 v15 FI01 FI02 35.00++++++++++++ mm 0 degrees B2 v16 FI02 PD02 25.00++++++++++++ mm 0 degrees B3 v17 BS01 FI03 25.00++++++++++++ mm 270 degrees B3 v18 FI03 FI04 35.00++++++++++++ mm 270 degrees B3 v19 FI04 PD03 25.00++++++++++++ mm 270 degrees
  • 15. March 20, 201415©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net   3D  View  
  • 16. March 20, 201416©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net  
  • 17. March 20, 201417©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net  
  • 18. March 20, 201418©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net   2D  Layout  
  • 19. March 20, 201419©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net  
  • 20. March 20, 201420©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net  
  • 21. March 20, 201421©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net  
  • 22. March 20, 201422©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net  
  • 23. March 20, 201423©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net   BeamWise™:  Automated  3D  Model     &  Document  Crea9on  
  • 24. March 20, 201424©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net   BeamWise™     Automa9ng  Biophotonics  System  Design   •  Kine9c  River   –  system  design   •  Design  Parametrics   –  CAD  modeling   plaborm   •  PlanEnergy   –  tool  development   •  SKMurphy   –  concept,  biz   development  
  • 25. March 20, 201425©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net   Kine9c  River:  What  ELSE  We  Do  
  • 26. March 20, 201426©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net    Giacomo  Vacca,  Ph.D.   •  Kine-c  River  (founder)   •  Abbo>  Labs  (Res.  Fellow)   •  Picarro   •  Lightwave  Micro   •  Exxon  Research  &  Engr.   •  28  patents  issued/pending    
  • 27. March 20, 201427©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net   Kine9c  River  Mission   Kine9c  River  is  a  biophotonics  consul9ng  and   product  development  company  with  a  passion  for   crea9ng  and  enabling  tools  for  innova9ve  and   disrup9ve  life  science  research,  biomedical   instrumenta9on,  and  clinical  diagnos9cs.   Where  Light  Meets  Life™  
  • 28. March 20, 201428©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net   Danube  I:  1st-­‐Gen  FLT  Flow  Cytometer   •  Full  custom  build   •  Collab.  with  New  Mexico  State  U.   •  Concept,  design,  build,  test,  support   •  Op9cs,  microfluidics,  control  SW   •   20-­‐ns  light-­‐cell  interac9on  9me   2-­‐ns  life-me   resolu-on  
  • 29. March 20, 201429©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net   Kine9c  River  Clients   •  Beckman  Coulter  (part  of  Danaher)   •  Dolomite  Microfluidics   •  EMD  Millipore  (part  of  Merck  KGaA)   •  Gerson  Lehrman  Group   •  NanoCellect   •  Na9onal  Instruments   •  Houston  Lab  (New  Mexico  State  University)   •  Na9onal  Cancer  Ins9tute  (NIH)   •  Product  Realiza9on  Group   •  Nolan  Lab  (Stanford  School  of  Medicine)   •  TempSync   •  [others]  
  • 30. March 20, 201430©  2014  Design  Parametrics,  Incorporated,   Kine9c  River  Corpora9on,  Plan  Energy  Ltd.   www.BeamWise.net   Kine9c  River  Key  Exper9se   System  Domain   Knowledge   System  Design   Microfluidics   2D  /  3D  CAD   Op9cs   LiveIdeas™ BeamWise™