This document provides advice on selecting and implementing an electronic laboratory notebook (ELN). It discusses that the needs will vary depending on whether a company is regulated, the industry, and whether work is more chemistry or biology focused. For chemistry, a chemistry-centric ELN can be selected, while for biology the goal is to get the tool out of their way. Large chemical companies have diverse needs that may be difficult to fully understand. The document emphasizes understanding current workflows before selecting a tool and avoiding overcomplex security and records management systems.
Leadership Without Management: Scaling Organizations by Scaling Engineersbcantrill
My talk at Surge 2013. Video is at http://www.youtube.com/watch?v=bGkVM1B5NuI Caution: Should not be consumed by stack-ranking six-sigma black belts with fragile constitutions.
Is Continuous Adoption in Software Engineering Achievable and Desirable? Gail Murphy
ICSE 2016 Software Engineering in Practice keynote.
Continuity in software development is all about shortening cycle times. For example, continuous integration shortens the time to integrating changes from multiple developers and continuous delivery shortens the time to get those integrated changes into the hands of users. Although it is now possible to get multiple new versions of complex software systems released per day, it still often takes years, if ever, to get software engineering research results into use by software development teams. What would software engineering research and software engineering development look like if we could shorten the cycle time from taking a research result into practice? What can we learn from how continuity in development is performed to make it possible to achieve continuous adoption of research results? Do we even want to achieve continuous adoption? In this talk, I will explore these questions, drawing from experiences I have gained in helping to take a research idea to market and from insights learned from interviewing industry leaders.
Technical debt is something often mentioned on the software development floor - but what is it? and what is it not? how can we capture it to reduce it?
Leadership Without Management: Scaling Organizations by Scaling Engineersbcantrill
My talk at Surge 2013. Video is at http://www.youtube.com/watch?v=bGkVM1B5NuI Caution: Should not be consumed by stack-ranking six-sigma black belts with fragile constitutions.
Is Continuous Adoption in Software Engineering Achievable and Desirable? Gail Murphy
ICSE 2016 Software Engineering in Practice keynote.
Continuity in software development is all about shortening cycle times. For example, continuous integration shortens the time to integrating changes from multiple developers and continuous delivery shortens the time to get those integrated changes into the hands of users. Although it is now possible to get multiple new versions of complex software systems released per day, it still often takes years, if ever, to get software engineering research results into use by software development teams. What would software engineering research and software engineering development look like if we could shorten the cycle time from taking a research result into practice? What can we learn from how continuity in development is performed to make it possible to achieve continuous adoption of research results? Do we even want to achieve continuous adoption? In this talk, I will explore these questions, drawing from experiences I have gained in helping to take a research idea to market and from insights learned from interviewing industry leaders.
Technical debt is something often mentioned on the software development floor - but what is it? and what is it not? how can we capture it to reduce it?
2008 03 11 ELNs in different industriesSimon Coles
Looking at ELNs in different industries, which is a very unexplored area. Typically case studies are taken at face value, but you really need to understand the specifics of each situation to really understand the relevance to any particular circumstance.
What is practice, Examples, Best practices that developers should follow. Useful tools that every developer should carry and useful GitHub repositories.
Evaluating & Selecting the Right Cytometer for your LabRyan Duggan
The Paradox of Choice: Presented at the annual GPACA conference 2015. This presentation is geared towards anyone embarking on the process of purchasing a flow cytometer, specifically, but any laboratory technology more generally.
OK, I’m ready to DevOp. Now what?
We’ve heard a lot about the technologies behind DevOps, and even a bit on the processes that some DevOps shops employ. What we haven’t heard too much about directly is a fundamental matter of bootstrapping. If you’re a leader or influencer in a software or IT shop, you’re sold on this DevOps idea but overwhelmed by the difference between where you are now and where you need to be, you’ve come to the right place. We’ve heard all about the unicorns of the movement, and what they are doing. Much time is spent talking about their innovative technologies. But how did they get there? Moreover, how can YOU get there? We’re going to spend some time discussing how to get started and find success on the rocky road to DevOps. We’re going to talk about the roles of executives, middle managers, front line managers, and individual contributors in this transformation. We’ll talk about the layered approach to transforming your culture, and building the processes and tool chains on top of it. At the tactical level, we’re going to talk about an example team and what their first year looks like, what are the major milestones they will reach, and how to measure their success along the way.
This webinar looks at the provider community, their abilities, needs, limitations and tendency to resist change. Few information resources can be successful and cost-effective without the cooperation and support of content providers, and they are unlikely to succeed if their provider community is not on board. Indeed, a strongly resistant provider community can sink even the most elegantly designed information project.
Observation: The Key to a Great User ExperienceTechWell
Observation is an important research technique when we are designing solutions to delight users. Some kinds of information that may make the difference between an acceptable solution and a delightful one can only be obtained by observing users in their native environment. Observing users is much more than simply sitting and watching them work. We observe with a purpose in mind and use all our senses—not just sight—when doing an observation. Geri Winters describes several different observation techniques including observing the environment, silent observation of someone performing a task, cognitive walkthrough with a user, and observing while doing. After explaining when and why you might use each technique, she leads you through a series of exercises designed to practice the techniques. Geri uses stories from real projects to illustrate the importance of observation in the user’s native environment and provides references to resources for further study.
2008 03 11 ELNs in different industriesSimon Coles
Looking at ELNs in different industries, which is a very unexplored area. Typically case studies are taken at face value, but you really need to understand the specifics of each situation to really understand the relevance to any particular circumstance.
What is practice, Examples, Best practices that developers should follow. Useful tools that every developer should carry and useful GitHub repositories.
Evaluating & Selecting the Right Cytometer for your LabRyan Duggan
The Paradox of Choice: Presented at the annual GPACA conference 2015. This presentation is geared towards anyone embarking on the process of purchasing a flow cytometer, specifically, but any laboratory technology more generally.
OK, I’m ready to DevOp. Now what?
We’ve heard a lot about the technologies behind DevOps, and even a bit on the processes that some DevOps shops employ. What we haven’t heard too much about directly is a fundamental matter of bootstrapping. If you’re a leader or influencer in a software or IT shop, you’re sold on this DevOps idea but overwhelmed by the difference between where you are now and where you need to be, you’ve come to the right place. We’ve heard all about the unicorns of the movement, and what they are doing. Much time is spent talking about their innovative technologies. But how did they get there? Moreover, how can YOU get there? We’re going to spend some time discussing how to get started and find success on the rocky road to DevOps. We’re going to talk about the roles of executives, middle managers, front line managers, and individual contributors in this transformation. We’ll talk about the layered approach to transforming your culture, and building the processes and tool chains on top of it. At the tactical level, we’re going to talk about an example team and what their first year looks like, what are the major milestones they will reach, and how to measure their success along the way.
This webinar looks at the provider community, their abilities, needs, limitations and tendency to resist change. Few information resources can be successful and cost-effective without the cooperation and support of content providers, and they are unlikely to succeed if their provider community is not on board. Indeed, a strongly resistant provider community can sink even the most elegantly designed information project.
Observation: The Key to a Great User ExperienceTechWell
Observation is an important research technique when we are designing solutions to delight users. Some kinds of information that may make the difference between an acceptable solution and a delightful one can only be obtained by observing users in their native environment. Observing users is much more than simply sitting and watching them work. We observe with a purpose in mind and use all our senses—not just sight—when doing an observation. Geri Winters describes several different observation techniques including observing the environment, silent observation of someone performing a task, cognitive walkthrough with a user, and observing while doing. After explaining when and why you might use each technique, she leads you through a series of exercises designed to practice the techniques. Geri uses stories from real projects to illustrate the importance of observation in the user’s native environment and provides references to resources for further study.
My talk from SMI ELN conference looking at the ELN landscape:
• Business drivers
- Comparing the different sectors and disciplines
• Build or buy?
• An overview of the solution space
• Patterns of success
My "Chairman's opening remarks" from the SMI ELN Conference in London 27th Jan 2010, drawing people's attention to interesting developments in the consumer space which could bring us towards a true replacement for the paper notebook
Scientists and Lawyers often have quite different perspectives on scientific research and the systems that support it. Reconciling those is one of the keys to a successful electronic lab notebook project.
2009 04 21 Lessons Learned Eln ImplementationsSimon Coles
Discusses the issues of Records Management and Patent Evidence in Laboratories, with particular emphasis on Electronic Lab Notebooks.
Delivered at IQPC Data Management & Knowledge Discovery. 21st April 1009, Frankfurt, Germany.
Generative AI Deep Dive: Advancing from Proof of Concept to ProductionAggregage
Join Maher Hanafi, VP of Engineering at Betterworks, in this new session where he'll share a practical framework to transform Gen AI prototypes into impactful products! He'll delve into the complexities of data collection and management, model selection and optimization, and ensuring security, scalability, and responsible use.
Accelerate your Kubernetes clusters with Varnish CachingThijs Feryn
A presentation about the usage and availability of Varnish on Kubernetes. This talk explores the capabilities of Varnish caching and shows how to use the Varnish Helm chart to deploy it to Kubernetes.
This presentation was delivered at K8SUG Singapore. See https://feryn.eu/presentations/accelerate-your-kubernetes-clusters-with-varnish-caching-k8sug-singapore-28-2024 for more details.
State of ICS and IoT Cyber Threat Landscape Report 2024 previewPrayukth K V
The IoT and OT threat landscape report has been prepared by the Threat Research Team at Sectrio using data from Sectrio, cyber threat intelligence farming facilities spread across over 85 cities around the world. In addition, Sectrio also runs AI-based advanced threat and payload engagement facilities that serve as sinks to attract and engage sophisticated threat actors, and newer malware including new variants and latent threats that are at an earlier stage of development.
The latest edition of the OT/ICS and IoT security Threat Landscape Report 2024 also covers:
State of global ICS asset and network exposure
Sectoral targets and attacks as well as the cost of ransom
Global APT activity, AI usage, actor and tactic profiles, and implications
Rise in volumes of AI-powered cyberattacks
Major cyber events in 2024
Malware and malicious payload trends
Cyberattack types and targets
Vulnerability exploit attempts on CVEs
Attacks on counties – USA
Expansion of bot farms – how, where, and why
In-depth analysis of the cyber threat landscape across North America, South America, Europe, APAC, and the Middle East
Why are attacks on smart factories rising?
Cyber risk predictions
Axis of attacks – Europe
Systemic attacks in the Middle East
Download the full report from here:
https://sectrio.com/resources/ot-threat-landscape-reports/sectrio-releases-ot-ics-and-iot-security-threat-landscape-report-2024/
GraphRAG is All You need? LLM & Knowledge GraphGuy Korland
Guy Korland, CEO and Co-founder of FalkorDB, will review two articles on the integration of language models with knowledge graphs.
1. Unifying Large Language Models and Knowledge Graphs: A Roadmap.
https://arxiv.org/abs/2306.08302
2. Microsoft Research's GraphRAG paper and a review paper on various uses of knowledge graphs:
https://www.microsoft.com/en-us/research/blog/graphrag-unlocking-llm-discovery-on-narrative-private-data/
Essentials of Automations: The Art of Triggers and Actions in FMESafe Software
In this second installment of our Essentials of Automations webinar series, we’ll explore the landscape of triggers and actions, guiding you through the nuances of authoring and adapting workspaces for seamless automations. Gain an understanding of the full spectrum of triggers and actions available in FME, empowering you to enhance your workspaces for efficient automation.
We’ll kick things off by showcasing the most commonly used event-based triggers, introducing you to various automation workflows like manual triggers, schedules, directory watchers, and more. Plus, see how these elements play out in real scenarios.
Whether you’re tweaking your current setup or building from the ground up, this session will arm you with the tools and insights needed to transform your FME usage into a powerhouse of productivity. Join us to discover effective strategies that simplify complex processes, enhancing your productivity and transforming your data management practices with FME. Let’s turn complexity into clarity and make your workspaces work wonders!
Elevating Tactical DDD Patterns Through Object CalisthenicsDorra BARTAGUIZ
After immersing yourself in the blue book and its red counterpart, attending DDD-focused conferences, and applying tactical patterns, you're left with a crucial question: How do I ensure my design is effective? Tactical patterns within Domain-Driven Design (DDD) serve as guiding principles for creating clear and manageable domain models. However, achieving success with these patterns requires additional guidance. Interestingly, we've observed that a set of constraints initially designed for training purposes remarkably aligns with effective pattern implementation, offering a more ‘mechanical’ approach. Let's explore together how Object Calisthenics can elevate the design of your tactical DDD patterns, offering concrete help for those venturing into DDD for the first time!
DevOps and Testing slides at DASA ConnectKari Kakkonen
My and Rik Marselis slides at 30.5.2024 DASA Connect conference. We discuss about what is testing, then what is agile testing and finally what is Testing in DevOps. Finally we had lovely workshop with the participants trying to find out different ways to think about quality and testing in different parts of the DevOps infinity loop.
UiPath Test Automation using UiPath Test Suite series, part 4DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 4. In this session, we will cover Test Manager overview along with SAP heatmap.
The UiPath Test Manager overview with SAP heatmap webinar offers a concise yet comprehensive exploration of the role of a Test Manager within SAP environments, coupled with the utilization of heatmaps for effective testing strategies.
Participants will gain insights into the responsibilities, challenges, and best practices associated with test management in SAP projects. Additionally, the webinar delves into the significance of heatmaps as a visual aid for identifying testing priorities, areas of risk, and resource allocation within SAP landscapes. Through this session, attendees can expect to enhance their understanding of test management principles while learning practical approaches to optimize testing processes in SAP environments using heatmap visualization techniques
What will you get from this session?
1. Insights into SAP testing best practices
2. Heatmap utilization for testing
3. Optimization of testing processes
4. Demo
Topics covered:
Execution from the test manager
Orchestrator execution result
Defect reporting
SAP heatmap example with demo
Speaker:
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
Removing Uninteresting Bytes in Software FuzzingAftab Hussain
Imagine a world where software fuzzing, the process of mutating bytes in test seeds to uncover hidden and erroneous program behaviors, becomes faster and more effective. A lot depends on the initial seeds, which can significantly dictate the trajectory of a fuzzing campaign, particularly in terms of how long it takes to uncover interesting behaviour in your code. We introduce DIAR, a technique designed to speedup fuzzing campaigns by pinpointing and eliminating those uninteresting bytes in the seeds. Picture this: instead of wasting valuable resources on meaningless mutations in large, bloated seeds, DIAR removes the unnecessary bytes, streamlining the entire process.
In this work, we equipped AFL, a popular fuzzer, with DIAR and examined two critical Linux libraries -- Libxml's xmllint, a tool for parsing xml documents, and Binutil's readelf, an essential debugging and security analysis command-line tool used to display detailed information about ELF (Executable and Linkable Format). Our preliminary results show that AFL+DIAR does not only discover new paths more quickly but also achieves higher coverage overall. This work thus showcases how starting with lean and optimized seeds can lead to faster, more comprehensive fuzzing campaigns -- and DIAR helps you find such seeds.
- These are slides of the talk given at IEEE International Conference on Software Testing Verification and Validation Workshop, ICSTW 2022.
zkStudyClub - Reef: Fast Succinct Non-Interactive Zero-Knowledge Regex ProofsAlex Pruden
This paper presents Reef, a system for generating publicly verifiable succinct non-interactive zero-knowledge proofs that a committed document matches or does not match a regular expression. We describe applications such as proving the strength of passwords, the provenance of email despite redactions, the validity of oblivious DNS queries, and the existence of mutations in DNA. Reef supports the Perl Compatible Regular Expression syntax, including wildcards, alternation, ranges, capture groups, Kleene star, negations, and lookarounds. Reef introduces a new type of automata, Skipping Alternating Finite Automata (SAFA), that skips irrelevant parts of a document when producing proofs without undermining soundness, and instantiates SAFA with a lookup argument. Our experimental evaluation confirms that Reef can generate proofs for documents with 32M characters; the proofs are small and cheap to verify (under a second).
Paper: https://eprint.iacr.org/2023/1886
Transcript: Selling digital books in 2024: Insights from industry leaders - T...BookNet Canada
The publishing industry has been selling digital audiobooks and ebooks for over a decade and has found its groove. What’s changed? What has stayed the same? Where do we go from here? Join a group of leading sales peers from across the industry for a conversation about the lessons learned since the popularization of digital books, best practices, digital book supply chain management, and more.
Link to video recording: https://bnctechforum.ca/sessions/selling-digital-books-in-2024-insights-from-industry-leaders/
Presented by BookNet Canada on May 28, 2024, with support from the Department of Canadian Heritage.
The Art of the Pitch: WordPress Relationships and SalesLaura Byrne
Clients don’t know what they don’t know. What web solutions are right for them? How does WordPress come into the picture? How do you make sure you understand scope and timeline? What do you do if sometime changes?
All these questions and more will be explored as we talk about matching clients’ needs with what your agency offers without pulling teeth or pulling your hair out. Practical tips, and strategies for successful relationship building that leads to closing the deal.
Pushing the limits of ePRTC: 100ns holdover for 100 daysAdtran
At WSTS 2024, Alon Stern explored the topic of parametric holdover and explained how recent research findings can be implemented in real-world PNT networks to achieve 100 nanoseconds of accuracy for up to 100 days.
Epistemic Interaction - tuning interfaces to provide information for AI supportAlan Dix
Paper presented at SYNERGY workshop at AVI 2024, Genoa, Italy. 3rd June 2024
https://alandix.com/academic/papers/synergy2024-epistemic/
As machine learning integrates deeper into human-computer interactions, the concept of epistemic interaction emerges, aiming to refine these interactions to enhance system adaptability. This approach encourages minor, intentional adjustments in user behaviour to enrich the data available for system learning. This paper introduces epistemic interaction within the context of human-system communication, illustrating how deliberate interaction design can improve system understanding and adaptation. Through concrete examples, we demonstrate the potential of epistemic interaction to significantly advance human-computer interaction by leveraging intuitive human communication strategies to inform system design and functionality, offering a novel pathway for enriching user-system engagements.
2. Introduction to Me
• CTO & Co-founder of Amphora Research
Systems
• Working on ELNs since 1996
• A number of our customers are here &
speaking
3. Why me?
• We do the Patent Evidence problem
• Keep the lawyers happy
• You still need to make the scientists happy
• So we get a ring-side seat on some of
these problems
4. This Presentation
• Adapted from an all-day workshop given
every year at the Association for Lab
Automation in Palm Springs
• Come and join us in January!
• Hot, Sunny, and informative...
5. So....
• You’ve decided to get an ELN
• Do you
• Buy a tool, and fit your work to the tool?
• Find out how you work, and buy/build a
tool to fit?
6. The “ELN” Word
• Very ambiguous
• Probably best if you didn’t use it
• Say what you mean
7. What do you mean?
• The term “ELN” means different things to
different people
• Somewhere the scientists will work
• A Patent Evidence system (& long term
record)
9. Differences that make a
Difference
• There are 2 key aspects which impact the
character of your ELN implementation
• Regulated Vs Unregulated
• Industry
10. Regulated or not?
• If you are regulated, chances you are talking
about process automation, enforcement,
and compliance
• This isn’t easy, but it is
• Relatively unambiguous
• Fairly well mapped already
12. Chemistry Vs Biology
• In Life Sciences, the biggest distinction is
between Chemists and Biologists
13. Chemistry
• Chemistry is pretty structured
• Buy (or build) them a Chemistry-centric
ELN and let them get on with it
• The selection process is detailed but at
least the work relatively consistently
14. Sources of Chemistry
ELNs
• If you’re a big pharma, you’re probably
already set
• With varying success - this isn’t easy
• Solutions
• Buy off the shelf
• Build from what you have
• Vendor capture
15. Sources of Chemistry
• In Biotechs, you probably can’t afford to
build or do vendor capture
• Unless Cheminformatics is a core strength
• So you’re going to have do as much as you
can with off-the-shelf (customised as
needed)
• Nice selection of vendors, have fun!
16. Biology
• Massive diversity
• Lots of Microsoft Office and other “non
ELN” applications
• Best approach is to get out of their way
17. Examples
• Nadine’s talk about J&J earlier
• Really good example of in-depth analysis
of process
• 98% approval rate on a project that size
is pretty stunning
18. Large Chemicals
• Somewhat boring places you may or may
not have heard of
• But employ 1,000 of scientists and make
most of the fun stuff in your house and car
• e.g. companies like Kodak, BASF, PPG,
Milliken, USG, etc.
19. Large Chemicals
• Massive diversity
• R&D is typically very close to the customer
• Tight timescales
• Low tolerance for “non-value add”
activities
20. Large Chemicals
• The ELN project will “Open the can of
worms” in terms of
• The tools people are using
• The records they are creating
• The patent evidence that is generated
21. General Purpose ELNs
• “You all use the same Paper notebook don’t
you?”
• “So surely you can all use the same
Electronic notebook?”
22. General Purpose ELNs
• You can do it for small numbers of users
and certain styles of work (e.g. e2v)
• Where workflow is important
• For large numbers of users
• The diversity in process will kill you
• You end up building an expensive version
of Word & Excel
27. Front end tools
• Most organisations will end up providing
different front ends to different users
• Examples
• BMS, Solvay, all the other large companies
28. Patents
• As a rule, what you need to do from a
Patent perspective is pretty generic
• You might have some specific needs, but
95% of what you need can be done off the
shelf
• This is one area where you want to stick
with convention
29. Security
• In Life Sciences things are relatively sane
• In Large Chemicals, you get all the fun of
“Chinese Walls” created by Commercial
agreements
30. Security
• This is another whole can of worms
• That didn’t really exist until the ELN came
along
• No one could find anything in the paper
notebook anyway
31. Security
• Ultimately you have to do what the
organisation requires
• But you need to avoid massively complex
regimes
• If you do NDA-related Chinese walls, you
need to have that tagged into the record at
creation
32. Records Management
• The Cinderella of ELN projects
• Desperately important
• Clearly something that’s dependent on your
own processes
34. Our Questions
• Do you
• Buy a tool, and fit your work to the tool?
• Find out how you work, and buy/build a
tool to fit?
35. Conclusion
• Unless you have been specifically charged
with changing the workflow
• Don’t pick the fight
• You’re there to support the science
• Today and in the future
36. Conclusions
• They’ve probably already got what they
need anyway
• Or a very good idea of what they need
• That’s why they asked for an ELN in the
first place
37. Conclusion
• If you are charged with changing the
workflow
• That’s your project, not “ELN” or
whatever
• Try to keep the scope as small as possible
• Size and diversity will kill you
40. Conclusion
• Chemistry - buy, or build, the best you can
• Biology - get out of their way
• Large chemicals - you’ll never fully
understand everything in detail