This document provides an overview of the NIH peer review process for grant applications. It describes how applications are received and referred to Institutes and scientific review groups. Applications are reviewed for scientific merit by these groups. Successful applications are then evaluated by Institutes for relevance before funding decisions are made. The review process considers the applicant's career stage and scores applications based on criteria like significance, approach, and environment. Reviewers look for impact, clarity, and feasibility in applications.
This newsletter provides updates from the Ohio Valley Node of the NIDA Clinical Trials Network. It announces new leadership elected to various NIDA CTN committees. It also summarizes several ongoing and upcoming studies, conferences, and research related to substance use disorders. New initiatives are highlighted, such as a new Special Interest Group on treatment decision tools and a NIDA INVEST fellow joining from Chile. Brief dissemination news and recent research findings are also mentioned.
This document describes a system for detecting microaneurysms in retinal images to aid in the diagnosis of diabetic retinopathy. It first discusses diabetic retinopathy and the need for automated detection systems. It then outlines the proposed system, which uses preprocessing like vessel enhancement, thresholding and morphological operations to detect microaneurysms. A neural network is used to classify pixels in retinal images into vessel and non-vessel after extracting 2D features. The algorithm is implemented in MATLAB and can detect microaneurysms with better accuracy and faster than previous methods. Public retinal image databases are also discussed to test and evaluate such algorithms.
Personal Health Record for individual with cerebral palsyVincent Gibbons
Considerations in constructing and evaluating a PHR for individual with CP or neurodevelopmental difficulty. Part of coursework for OHSU certificate in Medical Informatics, March 2009.
This document discusses how an organ procurement organization (OPO) implemented an effective donation after cardiac death (DCD) program, which increased organ donation and transplantation rates. Key aspects of the program included educating hospital staff on DCD policies and procedures, establishing clear donation pathways and communication processes, and responding rapidly to potential DCD cases. As a result of this program, DCD donors increased from 1% of total donors in 1995 to 22% in 2010, demonstrating the positive impact an effective DCD program can have.
Enabling technologies for research using clinically acquired medical image da...imgcommcall
The document describes two key enabling technologies for clinical research using medical image data: the Clinical Image Bank (CIB) and the Medical Imaging Informatics Bench to Bedside (mi2b2) workbench.
The CIB is a large repository of clinically acquired medical images hosted at Partners Healthcare. The mi2b2 workbench is software that allows researchers to query the CIB to access imaging data for specific patient cohorts identified in their IRB-approved studies while maintaining patient privacy and security.
Together these resources provide researchers a way to leverage large amounts of clinical imaging data for studies aiming to advance both research and clinical care using techniques like radiomics and machine learning.
What happens to your grant once it gets to a study section?
In this presentation, Dr. Paul Martin leverages his experience as a seasoned National Institutes of Health grant reviewer, including his tenure as Chair of the Cancer Immunopathology and Immunotherapy Study Section, to provide insight into the workings of NIH study sections.
Learn how to:
- Identify the fundamentals of grant review, including an overview of study sections and grant scoring;
- Determine differences between "impact" and "significance";
- Recognize effective strategies in writing and how to avoid frequent mistakes.
This document summarizes a workshop on grant writing. It provides an overview of the grant writing process, including identifying mentors, developing a timeline, understanding the various sections of a grant such as specific aims and research strategy, and common pitfalls. It also describes the NIH K43 Emerging Global Leader Award, a mentored career development award for early career scientists from low and middle income countries. The workshop aims to demystify grant writing and provide insights on what grant reviewers look for in a successful proposal.
This newsletter provides updates from the Ohio Valley Node of the NIDA Clinical Trials Network. It announces new leadership elected to various NIDA CTN committees. It also summarizes several ongoing and upcoming studies, conferences, and research related to substance use disorders. New initiatives are highlighted, such as a new Special Interest Group on treatment decision tools and a NIDA INVEST fellow joining from Chile. Brief dissemination news and recent research findings are also mentioned.
This document describes a system for detecting microaneurysms in retinal images to aid in the diagnosis of diabetic retinopathy. It first discusses diabetic retinopathy and the need for automated detection systems. It then outlines the proposed system, which uses preprocessing like vessel enhancement, thresholding and morphological operations to detect microaneurysms. A neural network is used to classify pixels in retinal images into vessel and non-vessel after extracting 2D features. The algorithm is implemented in MATLAB and can detect microaneurysms with better accuracy and faster than previous methods. Public retinal image databases are also discussed to test and evaluate such algorithms.
Personal Health Record for individual with cerebral palsyVincent Gibbons
Considerations in constructing and evaluating a PHR for individual with CP or neurodevelopmental difficulty. Part of coursework for OHSU certificate in Medical Informatics, March 2009.
This document discusses how an organ procurement organization (OPO) implemented an effective donation after cardiac death (DCD) program, which increased organ donation and transplantation rates. Key aspects of the program included educating hospital staff on DCD policies and procedures, establishing clear donation pathways and communication processes, and responding rapidly to potential DCD cases. As a result of this program, DCD donors increased from 1% of total donors in 1995 to 22% in 2010, demonstrating the positive impact an effective DCD program can have.
Enabling technologies for research using clinically acquired medical image da...imgcommcall
The document describes two key enabling technologies for clinical research using medical image data: the Clinical Image Bank (CIB) and the Medical Imaging Informatics Bench to Bedside (mi2b2) workbench.
The CIB is a large repository of clinically acquired medical images hosted at Partners Healthcare. The mi2b2 workbench is software that allows researchers to query the CIB to access imaging data for specific patient cohorts identified in their IRB-approved studies while maintaining patient privacy and security.
Together these resources provide researchers a way to leverage large amounts of clinical imaging data for studies aiming to advance both research and clinical care using techniques like radiomics and machine learning.
What happens to your grant once it gets to a study section?
In this presentation, Dr. Paul Martin leverages his experience as a seasoned National Institutes of Health grant reviewer, including his tenure as Chair of the Cancer Immunopathology and Immunotherapy Study Section, to provide insight into the workings of NIH study sections.
Learn how to:
- Identify the fundamentals of grant review, including an overview of study sections and grant scoring;
- Determine differences between "impact" and "significance";
- Recognize effective strategies in writing and how to avoid frequent mistakes.
This document summarizes a workshop on grant writing. It provides an overview of the grant writing process, including identifying mentors, developing a timeline, understanding the various sections of a grant such as specific aims and research strategy, and common pitfalls. It also describes the NIH K43 Emerging Global Leader Award, a mentored career development award for early career scientists from low and middle income countries. The workshop aims to demystify grant writing and provide insights on what grant reviewers look for in a successful proposal.
Louviere, Stratton & Yokel is an architecture firm that specializes in designing animal research facilities. They provide planning, design, and construction services for clients in government, academia, and the private sector. They are recognized experts in facilities for biocontainment laboratories, animal research spaces, imaging centers, and clinical spaces. The firm believes in collaborative design that produces innovative, aesthetic spaces tailored to client needs.
Louviere, Stratton & Yokel is an architecture firm that specializes in designing animal research facilities. They provide planning, design, and construction services for clients in government, academia, and the private sector. The firm is nationally recognized for its expertise in areas like biocontainment laboratories and animal facilities. It distinguishes itself by combining small firm responsiveness with expertise found at larger national firms.
Louviere, Stratton & Yokel is an architecture firm that specializes in designing animal research facilities. They provide planning, design, and construction services for clients in government, academia, and the private sector. The firm is nationally recognized for its expertise in areas like biocontainment laboratories and animal facilities. They emphasize collaboration between architecture and science to create innovative, functional spaces that meet client needs.
Louviere, Stratton & Yokel is an architecture firm that specializes in designing animal research facilities. They provide planning, design, and construction services for clients in government, academia, and the private sector. The firm is nationally recognized for its expertise in designing high-tech laboratories for animal research, including biocontainment facilities. They emphasize collaboration with scientists to create innovative, functional spaces that meet client needs.
This document discusses Ireland's pilot implementation of the European Injury Database (IDB) in 2005. The National Suicide Research Foundation led the effort to record injury-related emergency department visits. Their experience establishing a database on deliberate self-harm positioned them well for this task. The IDB aims to develop injury surveillance across EU member states by collecting standardized hospital emergency department data. Ireland previously participated in a similar European injury monitoring system between 1986-2000.
This document provides a summary of a pilot implementation of the European Injury Database (IDB) in Ireland in 2005.
Key findings from the IDB data collected from 3 hospitals in Cork, Ireland include:
- Over 2,900 injury presentations were recorded, with males accounting for 63% of cases and those aged 15-29 representing 38% of presentations.
- The most common types of injuries were open wounds (19%), contusions/bruises (12%), and fractures (9%).
- Unintentional injuries accounted for the majority of cases (77%). Assaults represented 12% of injuries while self-harm accounted for 4% of cases.
- The body parts
Lightning talk at the Indivo X 2012 User's Conference: embedding Indivo in the CARRAnet registry provides personal control and patient engagement in research systems. By Marc Natter, MD, Fellow at the Intelligent Health Lab, Children's Hospital Informatics Program.
The document discusses research and the research cycle. It describes both the idealized view of the research cycle as a linear process from idea to fame, as well as the messier reality. It also mentions sources for new ideas such as existing data, literature, conferences, colleagues and team science. Finally, it lists many research centers and resources available at OHSU to support the research process.
Sequencing the entire nation of the Faroe Islands - from sequencing to societ...Copenhagenomics
FarGen aims to implement whole genome sequencing for the entire population of 50,000 people in the Faroe Islands. This will provide a foundation for personalized healthcare focused on prevention and treatment, and establish an infrastructure for research. A pilot study of 100 individuals will test the workflow and monitor the scientific, technical, ethical and social impacts. This initiative aims to develop genomic medicine that benefits both the Faroese population and has global applicability, while respecting ethical standards like informed consent and individual rights.
This document discusses health informatics initiatives in New Zealand. It outlines the goals of Health Informatics New Zealand (HIS-NZ) and the Health Information Strategy Action Committee (HISAC) to develop a national health information strategy. HISAC is working on "action zones" to scope projects like chronic disease management, discharge summaries, and a national primary care collection. The document provides statistics on daily healthcare interactions and seeks input on primary care engagement, funding, and HISAC processes.
The document discusses the International Rare Disease Research Consortium (IRDiRC), which aims to deliver 200 new therapies and means to diagnose most rare diseases by 2020. It outlines IRDiRC's goals of international cooperation and data sharing between public and private funders. Over $1B has been committed worldwide by over 30 member organizations. Progress includes identifying genes for over 3,400 rare diseases and tests for over 3,300. 137 new therapies have been developed so far. Challenges include increasing gene discovery rates and establishing unified databases. Initiatives to address these include PhenoTips and Matchmaker Exchange for matching unsolved cases.
ICMR Guidelines Presented By:Raj Kishor [CRC], Tech Observer the Global CRO,I...Raj Aryan
The document provides an overview of the Indian Council of Medical Research (ICMR). It discusses that ICMR was established in 1911 as the Indian Research Fund Association to sponsor and coordinate medical research in India. ICMR is the apex body in India for the formulation, coordination and promotion of biomedical research. It oversees various research activities including communicable diseases, non-communicable diseases, reproductive and child health, and nutrition. ICMR operates numerous research institutes and centers across India focused on specific disease areas. The document outlines ICMR's achievements in developing drugs, vaccines and conducting various research studies to address India's health priorities.
1. The document discusses establishing a National Registry for Retinal Diseases in India to collect data on inherited retinal diseases.
2. It aims to help with prevalence studies, matching patients to treatments, informing patients of research advances, and quantifying quality of life impacts.
3. The registry will be web-based and collect data from regional registries in a secure and confidential manner to conduct research studies.
At AAAS we did a panel where Vint Cerf and I were co-discussants on the topic of web surveillance for health and security. There, I proposed that the panopticon aspiration needs to be curtailed, and that a framework such as Creative Commons - playfully called "Health Commons" could regulate and make predictable what constitutes legal use of this big data.
The document discusses open source drug discovery (OSDD) for neglected tropical diseases like tuberculosis. Key points:
- OSDD takes a collaborative, open innovation approach to drug discovery by involving research groups, industry, and individual participants in open data sharing.
- Their first disease target is tuberculosis, which infects over 1 million people per year and kills over 1,000 people per day.
- OSDD has built computational resources and databases with community participation to facilitate drug discovery. They have also integrated over 300 tools into their ChemBio toolkit.
- OSDD utilizes grid computing resources like the Garuda Grid in India to enable complex computational analysis for experimental biologists and chemists working on the
This document discusses trends in healthcare and health technology. It notes challenges like rising healthcare costs, aging populations, and physician shortages that are driving new models of care focused on health and wellness. It describes a continuum of care from home care to residential care to acute care, with the goal of high quality of life at lowest cost. It discusses how social networks and health 2.0 platforms can create value by connecting more users. Finally, it outlines how technologies like electronic medical records, clinical decision support systems, personal health records, and health information exchanges can help enable coordinated care across settings to improve outcomes and lower costs.
The diagnosis of mild cognitive impairment due to Alzheimer’s disease:Dario Yac
The document provides recommendations from a workgroup on criteria for mild cognitive impairment (MCI) due to Alzheimer's disease (AD). It outlines two sets of criteria:
1. Core clinical criteria for MCI diagnosis that do not require biomarkers and can be used in any clinical setting. This includes evidence of cognitive decline from the patient or informant and impairment in one or more cognitive domains with preserved functional abilities.
2. Clinical research criteria for use in research settings that incorporate biomarkers based on imaging and cerebrospinal fluid measures. This criteria has four levels of certainty depending on biomarker findings.
Considerable further research is needed to validate the biomarker-based criteria and standardize biomarkers before they can be used
I will discuss the formation and subsequent growth of IRDiRC into an organization with nearly 40 public and private funder members who have collectively pledged over 1 billion euros for rare disease research. I will also present the goals of IRDiRC, the plan that has been developed to achieve them, and the progress that has been made thus far. Finally, I will explore how additional organizations can take part in this international collaborative effort
The document discusses the National Institutes of Health (NIH), which is the primary agency of the United States government responsible for biomedical and public health research. It provides an overview of NIH's structure and budget. Specifically, it notes that NIH is made up of 27 separate institutes and centers and has an annual budget of over $32 billion which is spent on both extramural (over 80% of budget to outside researchers) and intramural (internal NIH campus) research. It also outlines NIH's goal to support fundamental biomedical research and apply new knowledge to improve health outcomes.
This document provides an overview of sexually transmitted infections (STIs) for clinicians. It discusses the most common bacterial, viral and parasitic STIs including their epidemiology, diagnosis and treatment recommendations. Screening and prevention strategies are also reviewed, including behavioral counseling, vaccination, condom use and expedited partner therapy. The impacts of STIs on women's reproductive health are highlighted.
This document discusses the differential diagnosis and management of vulvovaginal disorders. It begins by categorizing common conditions into infections (trichomoniasis, bacterial vaginosis, vulvovaginal candidiasis), skin conditions (fungal vulvitis, contact dermatitis, vulvar dermatoses), and psychogenic causes. It then provides detailed guidelines on evaluating, diagnosing, and treating specific infections like trichomoniasis, bacterial vaginosis, and vulvovaginal candidiasis. It also reviews vulvar conditions like lichen sclerosus, contact dermatitis, and classifications of vulvar dermatoses.
Louviere, Stratton & Yokel is an architecture firm that specializes in designing animal research facilities. They provide planning, design, and construction services for clients in government, academia, and the private sector. They are recognized experts in facilities for biocontainment laboratories, animal research spaces, imaging centers, and clinical spaces. The firm believes in collaborative design that produces innovative, aesthetic spaces tailored to client needs.
Louviere, Stratton & Yokel is an architecture firm that specializes in designing animal research facilities. They provide planning, design, and construction services for clients in government, academia, and the private sector. The firm is nationally recognized for its expertise in areas like biocontainment laboratories and animal facilities. It distinguishes itself by combining small firm responsiveness with expertise found at larger national firms.
Louviere, Stratton & Yokel is an architecture firm that specializes in designing animal research facilities. They provide planning, design, and construction services for clients in government, academia, and the private sector. The firm is nationally recognized for its expertise in areas like biocontainment laboratories and animal facilities. They emphasize collaboration between architecture and science to create innovative, functional spaces that meet client needs.
Louviere, Stratton & Yokel is an architecture firm that specializes in designing animal research facilities. They provide planning, design, and construction services for clients in government, academia, and the private sector. The firm is nationally recognized for its expertise in designing high-tech laboratories for animal research, including biocontainment facilities. They emphasize collaboration with scientists to create innovative, functional spaces that meet client needs.
This document discusses Ireland's pilot implementation of the European Injury Database (IDB) in 2005. The National Suicide Research Foundation led the effort to record injury-related emergency department visits. Their experience establishing a database on deliberate self-harm positioned them well for this task. The IDB aims to develop injury surveillance across EU member states by collecting standardized hospital emergency department data. Ireland previously participated in a similar European injury monitoring system between 1986-2000.
This document provides a summary of a pilot implementation of the European Injury Database (IDB) in Ireland in 2005.
Key findings from the IDB data collected from 3 hospitals in Cork, Ireland include:
- Over 2,900 injury presentations were recorded, with males accounting for 63% of cases and those aged 15-29 representing 38% of presentations.
- The most common types of injuries were open wounds (19%), contusions/bruises (12%), and fractures (9%).
- Unintentional injuries accounted for the majority of cases (77%). Assaults represented 12% of injuries while self-harm accounted for 4% of cases.
- The body parts
Lightning talk at the Indivo X 2012 User's Conference: embedding Indivo in the CARRAnet registry provides personal control and patient engagement in research systems. By Marc Natter, MD, Fellow at the Intelligent Health Lab, Children's Hospital Informatics Program.
The document discusses research and the research cycle. It describes both the idealized view of the research cycle as a linear process from idea to fame, as well as the messier reality. It also mentions sources for new ideas such as existing data, literature, conferences, colleagues and team science. Finally, it lists many research centers and resources available at OHSU to support the research process.
Sequencing the entire nation of the Faroe Islands - from sequencing to societ...Copenhagenomics
FarGen aims to implement whole genome sequencing for the entire population of 50,000 people in the Faroe Islands. This will provide a foundation for personalized healthcare focused on prevention and treatment, and establish an infrastructure for research. A pilot study of 100 individuals will test the workflow and monitor the scientific, technical, ethical and social impacts. This initiative aims to develop genomic medicine that benefits both the Faroese population and has global applicability, while respecting ethical standards like informed consent and individual rights.
This document discusses health informatics initiatives in New Zealand. It outlines the goals of Health Informatics New Zealand (HIS-NZ) and the Health Information Strategy Action Committee (HISAC) to develop a national health information strategy. HISAC is working on "action zones" to scope projects like chronic disease management, discharge summaries, and a national primary care collection. The document provides statistics on daily healthcare interactions and seeks input on primary care engagement, funding, and HISAC processes.
The document discusses the International Rare Disease Research Consortium (IRDiRC), which aims to deliver 200 new therapies and means to diagnose most rare diseases by 2020. It outlines IRDiRC's goals of international cooperation and data sharing between public and private funders. Over $1B has been committed worldwide by over 30 member organizations. Progress includes identifying genes for over 3,400 rare diseases and tests for over 3,300. 137 new therapies have been developed so far. Challenges include increasing gene discovery rates and establishing unified databases. Initiatives to address these include PhenoTips and Matchmaker Exchange for matching unsolved cases.
ICMR Guidelines Presented By:Raj Kishor [CRC], Tech Observer the Global CRO,I...Raj Aryan
The document provides an overview of the Indian Council of Medical Research (ICMR). It discusses that ICMR was established in 1911 as the Indian Research Fund Association to sponsor and coordinate medical research in India. ICMR is the apex body in India for the formulation, coordination and promotion of biomedical research. It oversees various research activities including communicable diseases, non-communicable diseases, reproductive and child health, and nutrition. ICMR operates numerous research institutes and centers across India focused on specific disease areas. The document outlines ICMR's achievements in developing drugs, vaccines and conducting various research studies to address India's health priorities.
1. The document discusses establishing a National Registry for Retinal Diseases in India to collect data on inherited retinal diseases.
2. It aims to help with prevalence studies, matching patients to treatments, informing patients of research advances, and quantifying quality of life impacts.
3. The registry will be web-based and collect data from regional registries in a secure and confidential manner to conduct research studies.
At AAAS we did a panel where Vint Cerf and I were co-discussants on the topic of web surveillance for health and security. There, I proposed that the panopticon aspiration needs to be curtailed, and that a framework such as Creative Commons - playfully called "Health Commons" could regulate and make predictable what constitutes legal use of this big data.
The document discusses open source drug discovery (OSDD) for neglected tropical diseases like tuberculosis. Key points:
- OSDD takes a collaborative, open innovation approach to drug discovery by involving research groups, industry, and individual participants in open data sharing.
- Their first disease target is tuberculosis, which infects over 1 million people per year and kills over 1,000 people per day.
- OSDD has built computational resources and databases with community participation to facilitate drug discovery. They have also integrated over 300 tools into their ChemBio toolkit.
- OSDD utilizes grid computing resources like the Garuda Grid in India to enable complex computational analysis for experimental biologists and chemists working on the
This document discusses trends in healthcare and health technology. It notes challenges like rising healthcare costs, aging populations, and physician shortages that are driving new models of care focused on health and wellness. It describes a continuum of care from home care to residential care to acute care, with the goal of high quality of life at lowest cost. It discusses how social networks and health 2.0 platforms can create value by connecting more users. Finally, it outlines how technologies like electronic medical records, clinical decision support systems, personal health records, and health information exchanges can help enable coordinated care across settings to improve outcomes and lower costs.
The diagnosis of mild cognitive impairment due to Alzheimer’s disease:Dario Yac
The document provides recommendations from a workgroup on criteria for mild cognitive impairment (MCI) due to Alzheimer's disease (AD). It outlines two sets of criteria:
1. Core clinical criteria for MCI diagnosis that do not require biomarkers and can be used in any clinical setting. This includes evidence of cognitive decline from the patient or informant and impairment in one or more cognitive domains with preserved functional abilities.
2. Clinical research criteria for use in research settings that incorporate biomarkers based on imaging and cerebrospinal fluid measures. This criteria has four levels of certainty depending on biomarker findings.
Considerable further research is needed to validate the biomarker-based criteria and standardize biomarkers before they can be used
I will discuss the formation and subsequent growth of IRDiRC into an organization with nearly 40 public and private funder members who have collectively pledged over 1 billion euros for rare disease research. I will also present the goals of IRDiRC, the plan that has been developed to achieve them, and the progress that has been made thus far. Finally, I will explore how additional organizations can take part in this international collaborative effort
The document discusses the National Institutes of Health (NIH), which is the primary agency of the United States government responsible for biomedical and public health research. It provides an overview of NIH's structure and budget. Specifically, it notes that NIH is made up of 27 separate institutes and centers and has an annual budget of over $32 billion which is spent on both extramural (over 80% of budget to outside researchers) and intramural (internal NIH campus) research. It also outlines NIH's goal to support fundamental biomedical research and apply new knowledge to improve health outcomes.
This document provides an overview of sexually transmitted infections (STIs) for clinicians. It discusses the most common bacterial, viral and parasitic STIs including their epidemiology, diagnosis and treatment recommendations. Screening and prevention strategies are also reviewed, including behavioral counseling, vaccination, condom use and expedited partner therapy. The impacts of STIs on women's reproductive health are highlighted.
This document discusses the differential diagnosis and management of vulvovaginal disorders. It begins by categorizing common conditions into infections (trichomoniasis, bacterial vaginosis, vulvovaginal candidiasis), skin conditions (fungal vulvitis, contact dermatitis, vulvar dermatoses), and psychogenic causes. It then provides detailed guidelines on evaluating, diagnosing, and treating specific infections like trichomoniasis, bacterial vaginosis, and vulvovaginal candidiasis. It also reviews vulvar conditions like lichen sclerosus, contact dermatitis, and classifications of vulvar dermatoses.
This document provides information about migraine in women. Some key points:
- Migraine is 3 times more common in women than men. Hormonally-associated migraines affect 12 million women in the US.
- Migraines are often associated with changes in hormone levels, such as during menstruation, pregnancy, use of oral contraceptives, and menopause.
- Diagnosis of migraine involves evaluating symptoms such as headache duration/intensity, nausea, light/sound sensitivity, visual/sensory disturbances (aura).
- Treatment involves both acute symptomatic relief and preventive medications, though choices are more limited during pregnancy/breastfeeding due to safety.
This document discusses 5 case studies involving GI disorders in women. The first case involves a 32-year-old woman with 5 years of diarrhea and abdominal pain. The next best step is reassurance without further testing, as her symptoms are consistent with irritable bowel syndrome. The second case involves a 38-year-old woman with vomiting after gastric bypass surgery, where an internal hernia is the most likely cause. The third case involves a pregnant woman referred for irritable bowel syndrome, where testing her for celiac disease is the next best step. The fourth case involves constipation, where pelvic floor dysfunction is the most likely diagnosis given her exam findings. The fifth case involves a 58-year-old woman with diarrhea
Here are my recommendations for the 56 year old woman with subclinical hypothyroidism:
1. Her diagnosis is subclinical hypothyroidism based on an elevated TSH of 7.1 and normal free T4.
2. Given her age (56), fatigue, and 3-4 lb weight gain, I would recommend a trial of levothyroxine therapy. Treatment is reasonable for patients with TSH >10 or positive thyroid antibodies, which she does not have data for. However, treatment may modestly improve her lipids and symptoms.
3. She should be monitored every 6 months with TSH checks to ensure her TSH is maintained between 0.5-2.0 and that she does not
The document announces the Women's Health 2012 Congress hosted by the NIH Office of Research on Women's Health. It will feature scientific poster awards for Women's Health and Sex Differences Research. The congress focuses on women's health issues and research.
The document discusses how the Affordable Care Act (ACA) aims to improve access to preventive health services for women by requiring new health plans to cover recommended preventive services without cost sharing. This includes services for cancer screening, chronic disease prevention and management, vaccinations, healthy behaviors counseling, pregnancy-related care, and reproductive health services. The new rules apply to new private health plans starting in 2010 and 2012, with some exemptions for grandfathered and religious plans. Implementation will consider factors like network restrictions, separate billing for visits and services, and ensuring adequate provider training and capacity.
The document summarizes the charge given by the Institute of Medicine to convene a committee of experts to review women's preventive health services and identify gaps. The committee was tasked with recommending services to be included in comprehensive national guidelines. After reviewing evidence, the committee made 8 recommendations, including screening for gestational diabetes, HPV testing, counseling on STIs and HIV, contraception services, lactation support, interpersonal violence screening, and annual well-woman visits.
This document summarizes key aspects of the Affordable Care Act (ACA) and how it benefits women's health and preventive care. It discusses how the ACA expands insurance coverage to over 34 million Americans, strengthens consumer protections, and requires insurers to cover preventive services for women at no additional cost. Specifically, it outlines services that must be covered for pregnant women, various cancer and disease screenings, counseling services, contraception and sterilization coverage, lactation support, and violence screening. It also notes that some existing "grandfathered" health plans are exempt from some ACA requirements but still must cover certain new benefits.
Dr. Iglesia has no conflicts of interest to disclose. The objectives of the document are to develop effective treatment plans, communicate treatment goals, minimize medication side effects, and describe new therapies for overactive bladder in women. Overactive bladder affects millions of Americans, especially women, and prevalence increases with age. New therapies aim to change stereotypes about overactive bladder and provide realistic information about prevalence and severity. Behavioral interventions like pelvic floor exercises and bladder training can be effective treatment approaches.
The document discusses cervical cancer screening guidelines and strategies, comparing the use of Pap tests, HPV tests, and primary HPV screening. It provides information on the epidemiology of HPV and progression to cervical cancer, as well as data from studies showing that primary HPV screening can detect more high-grade cervical lesions than cytology alone.
The document discusses depression in women and improving outcomes. Major depression has a significant public health impact and is the leading cause of disability among women worldwide. Women experience depression rates 1.5-2.5 times higher than men ages 15-54. Key ways to improve outcomes include considering differential diagnoses, treating to remission, measuring symptom improvement, using evidence-based interventions personalized to the individual woman, and providing self-help resources.
This document discusses strategies for managing obesity in women. It notes that obesity is influenced by multiple factors including genetics, environment, diet, physical activity, and life events. Key life events that can influence weight gain include pregnancy, menopause, and aging. Maternal obesity increases health risks for both mother and child during pregnancy and the child's future obesity risk. Abdominal obesity, as measured by waist circumference, is a better predictor of health risks than BMI alone. Managing obesity requires addressing its underlying causes through lifestyle changes.
This document is an in memoriam for Trudy L Bush, a professor of epidemiology and preventive medicine at the University of Maryland who passed away in 2001. It summarizes her landmark research on the effects of hormones on various body systems, her trailblazing leadership in the field of women's health, and her tireless commitment to medical education relating to women's health and menopause. The document honors her memory with an annual lecture series.
Evidence based management of cardiovascular disease in women plmiami
1. Evidence Based Management of Cardiovascular Disease in Women discusses the leading causes of death in Americans and how cardiovascular disease is the number one killer of women.
2. The document reviews gender differences in atherosclerosis, such as plaque erosion being more common in women than plaque rupture seen in men, making diagnosis of cardiovascular disease more difficult in women.
3. Prevention strategies discussed include reducing atherosclerosis, preventing plaque rupture and erosion, limiting thrombosis, and recognizing the presence of cardiovascular disease in women.
This document discusses care of cancer survivors and outlines the following key points in 3 sentences:
1) Approximately 3% of the population are cancer survivors, with many being elderly and having multiple comorbidities. 2) Both cancer-related and general medical needs must be addressed in cancer survivors, including surveillance for recurrence, late effects of treatment, and new primary cancers as well as screening and management of comorbidities. 3) The role of primary care physicians in providing ongoing care for cancer survivors along with survivorship care plans is reviewed.
This document discusses factors that influence peak bone mass attained during adolescence and young adulthood. It notes that genetics account for 80% of variability in peak bone mass, and lists several genes associated with bone mineral density and fracture risk. Nutrition, physical activity, body composition, endocrine status like age of menarche, and use of birth control also impact peak bone mass. Regular weight-bearing exercise and adequate calcium, vitamin D, and protein intake during growth can help increase bone mass accrual and attain a higher peak.
This document summarizes best practices in lesbian health based on a presentation by Dr. Patricia Robertson. It finds that lesbians have higher rates of smoking, childhood abuse, obesity, and certain STIs. They have lower rates of Pap smears and mammograms due to cost and prior adverse experiences. The document recommends screening lesbians appropriately, discussing family planning options, ensuring legal protections for partners, and advocating for lesbian health in the community. Providers should encourage disclosure of sexual orientation to provide culturally competent care.
Lee P. Shulman is the Anna Ross Lapham Professor of Obstetrics and Gynecology and Chief of the Division of Clinical Genetics at Northwestern University. He discloses advisory roles and speaking engagements with several genetic testing companies. His research focuses on inherited cancer risk assessment and genetic testing for hereditary cancer syndromes. He provides an overview of the genetics of cancer including tumor suppressor genes and oncogenes, as well as specific hereditary cancer syndromes like BRCA1/2, Lynch syndrome, and Cowden syndrome that increase cancer risk, especially for women's cancers.
This document summarizes evidence-based care of women with rheumatoid arthritis (RA). It discusses that RA is a chronic inflammatory disorder that principally affects the synovial joints. It is characterized by a proliferative response in the synovium leading to bone and cartilage destruction. The document reviews who is affected by RA, common articular features, characteristic deformities, and extra-articular manifestations. It also discusses the natural history of RA and whether there are any gender differences. Current management approaches from 2012 are presented, including early diagnosis, prompt initiation of traditional DMARDs, and appropriate use of biological DMARDs.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
CLASSIFICATION OF H1 ANTIHISTAMINICS-
FIRST GENERATION ANTIHISTAMINICS-
1)HIGHLY SEDATIVE-DIPHENHYDRAMINE,DIMENHYDRINATE,PROMETHAZINE,HYDROXYZINE 2)MODERATELY SEDATIVE- PHENARIMINE,CYPROHEPTADINE, MECLIZINE,CINNARIZINE
3)MILD SEDATIVE-CHLORPHENIRAMINE,DEXCHLORPHENIRAMINE
TRIPROLIDINE,CLEMASTINE
SECOND GENERATION ANTIHISTAMINICS-FEXOFENADINE,
LORATADINE,DESLORATADINE,CETIRIZINE,LEVOCETIRIZINE,
AZELASTINE,MIZOLASTINE,EBASTINE,RUPATADINE. Mechanism of action of 2nd generation antihistaminics-
These drugs competitively antagonize actions of
histamine at the H1 receptors.
Pharmacological actions-
Antagonism of histamine-The H1 antagonists effectively block histamine induced bronchoconstriction, contraction of intestinal and other smooth muscle and triple response especially wheal, flare and itch. Constriction of larger blood vessel by histamine is also antagonized.
2) Antiallergic actions-Many manifestations of immediate hypersensitivity (type I reactions)are suppressed. Urticaria, itching and angioedema are well controlled.3) CNS action-The older antihistamines produce variable degree of CNS depression.But in case of 2nd gen antihistaminics there is less CNS depressant property as these cross BBB to significantly lesser extent.
4) Anticholinergic action- many H1 blockers
in addition antagonize muscarinic actions of ACh. BUT IN 2ND gen histaminics there is Higher H1 selectivitiy : no anticholinergic side effects
Dr. Tan's Balance Method.pdf (From Academy of Oriental Medicine at Austin)GeorgeKieling1
Home
Organization
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
About AOMA: The Academy of Oriental Medicine at Austin offers a masters-level graduate program in acupuncture and Oriental medicine, preparing its students for careers as skilled, professional practitioners. AOMA is known for its internationally recognized faculty, award-winning student clinical internship program, and herbal medicine program. Since its founding in 1993, AOMA has grown rapidly in size and reputation, drawing students from around the nation and faculty from around the world. AOMA also conducts more than 20,000 patient visits annually in its student and professional clinics. AOMA collaborates with Western healthcare institutions including the Seton Family of Hospitals, and gives back to the community through partnerships with nonprofit organizations and by providing free and reduced price treatments to people who cannot afford them. The Academy of Oriental Medicine at Austin is located at 2700 West Anderson Lane. AOMA also serves patients and retail customers at its south Austin location, 4701 West Gate Blvd. For more information see www.aoma.edu or call 512-492-303434.
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga
GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort.
Can Traditional Chinese Medicine Treat Blocked Fallopian Tubes.pptxFFragrant
There are many traditional Chinese medicine therapies to treat blocked fallopian tubes. And herbal medicine Fuyan Pill is one of the more effective choices.
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
The Children are very vulnerable to get affected with respiratory disease.
In our country, the respiratory Disease conditions are consider as major cause for mortality and Morbidity in Child.
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
Visit Us: https://drdeepikashomeopathy.com/service/irregular-periods-treatment/
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
1. Strategies for NIH Grant Success:
Overview of the NIH Peer Review Process
Cheryl Kitt, Ph.D.
Deputy Director, CSR
Women's Health 2012: The 20th Annual Congress
National Institutes of Health
U.S. Department of Health and Human Services March 15, 2012
2. National Institutes of Health
Office of the Director
National Institute Eunice Kennedy
National Institute National Institute
National Institute of Arthritis and National Cancer Shriver National Institute
on Alcohol Abuse of Allergy and
on Aging Musculoskeletal Institute of Child Health and
and Alcoholism Infectious Diseases
and Skin Diseases Human Development
National Institute on National Institute National Institute
National Institute
Deafness and Other of Dental and of Diabetes and National Institute National Eye
of Environmental
Communication Craniofacial Digestive and on Drug Abuse Institute
Health Sciences
Disorders Research Kidney Diseases
National Institute
National Institute National Heart, National Human
National Institute of Neurological National Institute
of General Lung, and Blood Genome Research
of Mental Health Disorders and of Nursing Research
Medical Sciences Institute Institute
Stroke
National Center
National Institute of John E. Fogarty National Center National Center on
for Complementary National Library
Biomedical Imaging International for Research Minority Health and
and Alternative of Medicine
and Bioengineering Center Resources Health Disparities
Medicine
Center for
Center for
Clinical Center Information
Technology Scientific Review
3. Preparing an Application
Electronic Application Process
Prepare to Apply & Find Opportunity* Prepare Submit, Track &
Register Application View
• Register with • Submit in • Follow • Submit via your
Grants.gov & eRA response to Application organizational
Commons FOA Guide & representative
Instructions • Use error correction
window
• Use eRA Commons
to track
*Funding Opportunity Announcement (FOA)
4. Review Process for a Research Grant
National Institutes of Health
Center for Scientific Review
Assigns to IC & IRG/Study Section
Initiates Study Section
Research Idea Submits Application
Reviews for Scientific Merit
Institute
Evaluates for Relevance
Allocates Funds
Advisory Councils and Boards
Conducts
Recommends Action
Research
Institute Director
Takes Final Action
5. All Applications Go Through
Center for Scientific Review (CSR)
Focal Point for Initial Review at NIH
• Receives all NIH
applications
• Refers them to NIH
Institutes/Centers and to
scientific review groups
• Reviews grant applications
for scientific merit
• ICs review RFAs, P’s, T’s,
K’s
8. Your Career Stage Is Considered
• If you submit an R01 grant application:
If you are a New Investigator (PD/PI who has not yet competed
successfully for a substantial NIH research grant; for multiple PD/PI R01s-all
PD/PIs must meet requirements for NI status
or Early Stage Investigator (PD/PI who qualifies as a New Investigator
AND is within 10 years of completing the terminal research degree or is within
10 years of completing medical residency (or equivalent)
• Clustered for review in the study section
9. CSR Study Sections
• Each CSR standing study
section has about 23-40
members
• CSR standing study
sections convene face-to-
face, or virtual (electronic)
meetings
• As many as 60-100
applications are reviewed
by each study section
• Scientific Review Officer-
Designated Federal
Official with overall
responsibility for the
review process
10. What Reviewers Look for In Applications
Impact
Make It Exciting
Be Very Clear
Realistic Aims & Timelines – Not Overly
Ambitious
Be Brief With Things That Everybody Knows
Note the Study Limitations
Proofread the Application
11. Scoring
Overall Impact/Priority Score*:
• Reflects the reviewers’ assessment of the likelihood
for the project to exert a sustained, powerful influence on
the research field(s) involved
Core Criteria*:
Significance
Investigator(s)
Innovation
Approach
Environment
*each scored from 1-9
12. Scoring
Applications scored on five review criteria and overall
impact using a scale of 1-9.
o Discussed applications receive an overall impact score
from each eligible (i.e., without conflicts of interest) panel
member and these scores are averaged to one decimal
place, and multiplied by 10.
All applications receive scores:
o Not Discussed applications receive only initial criterion
scores from the three assigned reviewers
13. Scoring Descriptions
Impact Score
Additional Guidance on Strengths/Weaknesses
Descriptor
1 Exceptional Exceptionally strong with essentially no weaknesses
High
2 Outstanding Extremely strong with negligible weaknesses
Impact
3 Excellent Very strong with only some minor weaknesses
4 Very Good Strong but with numerous minor weaknesses
Moderate
5 Good Strong but with at least one moderate weakness
Impact
6 Satisfactory Some strengths but also some moderate weaknesses
7 Fair Some strengths but with at least one major weakness
Low
8 Marginal A few strengths and a few major weaknesses
Impact
9 Poor Very few strengths and numerous major weaknesses
14. Fellowship Reviews
Overall Impact/Merit. Likelihood fellowship will enhance candidate's
potential for, and commitment to, a productive independent
scientific research
•Applicant
•Sponsors, Collaborators, and Consultants
•Research Training Plan
•Training Potential
•Institutional Environment & Commitment to Training
15. Career Awards (K)
Overall Impact. Reviewers should provide their assessment of the
likelihood for the candidate to maintain a strong research program,
taking into consideration the criteria below in determining the
overall impact/priority score.
•Candidate
•Career Development Plan/Career Goals & Objectives/Plan to
Provide Mentoring
•Research Plan
•Mentor(s), Co-mentor(s), Consultant(s), Collaborator(s)
•Environment and Institutional Commitment to the Candidate
16. Investigators
• Personal Statement:
• Why your experience and qualifications makes you particularly
well-suited for your role(s) in the project
• Publications:
• Recommended: no more than 15---up to five of the best; up to five
of the most relevant to the proposed research; up to five of the most
recent
• If Early Stage Investigators or New Investigators, do you have
Investigators
appropriate experience and training?
• If Established, have you demonstrated ongoing record of
accomplishments that have advanced their field(s)?
17. Innovation
• Does application challenge/seek to shift current research
or clinical practice paradigms by utilizing novel theoretical
concepts, approaches or methodologies, instrumentation,
or interventions?
• Concepts, approaches or methodologies,
instrumentation, or interventions novel to one field of
research or novel in a broad sense?
• Refinement, improvement, or new application of
theoretical concepts, approaches or methodologies,
instrumentation, or interventions proposed?
18. Approach
• Are the overall strategy, methodology, and analyses well-
reasoned and appropriate to accomplish the specific aims
of the project?
• Are potential problems, alternative strategies, and
benchmarks for success presented?
• If the project is in the early stages of development, will the
strategy establish feasibility and will particularly risky
aspects be managed?
19. Environment
• Will the scientific environment in which the work will be
done contribute to the probability of success?
• Are the institutional support, equipment and other
physical resources available to the investigators
adequate for the project proposed?
• Will the project benefit from unique features of the
scientific environment, subject populations, or
collaborative arrangements?
20. Other Issues Reviewers Consider Before
Final Scoring
• Protections of human subjects
• Inclusions of women, children and minorities
• Appropriate use of vertebrate animal
• Management of hazardous conditions
21. Critiques (Summary Statements)
Discussed applications receive a resume and summary of
the panel’s discussion at the meeting.
•ALL applications are scored and receive critiques
Not discussed applications receive criterion scores only
Overall Impact Paragraph
• Each assigned reviewer writes a paragraph summarizing
the factors that informed his/her Overall Impact score
22. After the Review
• NIH Program Officer = Point of Contact
• Wait for summary statement
• Read summary statement carefully
before calling!
23. http://www.csr.nih.gov/video/video.asp
What Happens to Your NIH Grant Application Video
http://www.csr.nih.gov/video/2010/FinalCaptioned_Edited_PeerReviewPr
kittc@csr.nih.gov
301-435-8403
24. CSR Early Career Reviewer Program
National Institutes of Health
U.S. Department of Health and Human Services
25. Purpose of the ECR Program
• To train and educate qualified scientists without
significant prior review experience so that they may
develop into critical and well trained reviewers
• To benefit faculty scientific careers by exposing them to
an experience that will make them more competitive
as applicants
• To enrich the existing pool of NIH reviewers by
recruiting scientists from less research-intensive
institutions
25
26. Definition of ECR:
• Has not reviewed for CSR beyond 1 mail review and
has not been to a face-to-face meeting (except ARRA
face-face-meetings)
• Has a faculty appointment or equivalent
• Has an active research program and is publishing in
high-impact journals
• Does not necessarily have NIH or equivalent funding
26
27. Responsibilities of ECR
• Attends study section meeting (face-to-face meetings
but no Fellowship panels)
• Is assigned no more than 2 applications as 3rd reviewer
• Writes a full critique of each application
• Participates in no more than one study section per year
and no more than twice total
27
28. Progress of ECR Program
• The administrators of 343 less research-intensive
institutions (AREA eligible) were emailed a request for
suggestions of faculty who would be candidates for the
ECR program
• There are currently over 500 names in the database
• Over 300 additional researchers have applied for the
program and once vetted they will be added to the
database
ECRs Included in 2012/01 Council Round:
127 ECRs participated across over 240 eligible
study sections
o ~50% women
28
29. CSR Web Site: http://www.csr.nih.gov
CSREarlyCareerReviewer@mail.nih.gov
Editor's Notes
So we now see that on a cyclic basis applications are handled by CSR which…
Let ’s examine more closely how CSR actually executes its roles. Nearly all of the study sections and recurring special review panels that you are familiar with come under the aegis of CSR – not one of the 24 funding ICs. Altogether, CSR has about 240 study sections and recurring special emphasis panels. These are organized into ‘Integrated Review Groups’ (IRGs) or departments where there are closely allied scientific disciplines and expertises brought to bear to evaluate science with related broad themes – e. g. the Biological Chemistry & Macromolecular Biophysics IRG or the Biology of Development and Aging IRG. These IRGS are in turn organized into 5 major scientific Divisions according to broad biomedical themes.