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Presentation by Heinrich Widmann, DKRZ
The European Data Infrastructure (EUDAT) project establishes a pan-European e-infrastructure supporting multiple and diverse research communities in their research data management. This Collaborative Data Infrastructure (CDI) is based on the FAIR principles and implements community-driven and generic services to tackle the specific challenges of international and interdisciplinary research data management.
The EUDAT metadata service B2FIND plays a central role in this context as a repository and a search portal for the diverse metadata collected from heterogeneous sources. For this we built up a comprehensive joint metadata catalogue and an open data discovery portal and offer support for new communities interested in publishing their data within EUDAT.
CloudLightning - Project and Architecture OverviewCloudLightning
This is a PowerPoint presentation delivered by Prof John Morrison (UCC) on 9 December 2016 at the IC4 and Host in Ireland Workshop: Data Centres in Ireland.
See an overview on our portfolio , reference cases and approch to digital transformation projects we accompany. Feel free to come back in case of any questions and/or comments.
FIWARE Wednesday Webinars - Cities as Enablers of the Data Economy: Smart Dat...FIWARE
Cities as Enablers of the Data Economy: Smart Data Models for Cities - 21 October 2020
Corresponding webinar recording: https://youtu.be/b0EWq5E5jAc
Speaker: Alberto Abella (Data Modeling Expert and Technical Evangelist, FIWARE Foundation)
Chapter: Smart Cities
Difficulty: 2
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Worried about the learning curve to introduce Deep Learning in your organization? Don’t be. The DEEP-HybridDataCloud project offers a framework for all users, including non-experts, enabling the transparent training, sharing and serving of Deep Learning models both locally or on hybrid cloud system. In this webinar we will be showing a set of use cases, from different research areas, integrated within the DEEP infrastructure.
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EUDAT-B2FIND: A FAIR-friendly and Interdisciplinary Data CatalogueBlue BRIDGE
Presentation by Heinrich Widmann, DKRZ
The European Data Infrastructure (EUDAT) project establishes a pan-European e-infrastructure supporting multiple and diverse research communities in their research data management. This Collaborative Data Infrastructure (CDI) is based on the FAIR principles and implements community-driven and generic services to tackle the specific challenges of international and interdisciplinary research data management.
The EUDAT metadata service B2FIND plays a central role in this context as a repository and a search portal for the diverse metadata collected from heterogeneous sources. For this we built up a comprehensive joint metadata catalogue and an open data discovery portal and offer support for new communities interested in publishing their data within EUDAT.
CloudLightning - Project and Architecture OverviewCloudLightning
This is a PowerPoint presentation delivered by Prof John Morrison (UCC) on 9 December 2016 at the IC4 and Host in Ireland Workshop: Data Centres in Ireland.
See an overview on our portfolio , reference cases and approch to digital transformation projects we accompany. Feel free to come back in case of any questions and/or comments.
FIWARE Wednesday Webinars - Cities as Enablers of the Data Economy: Smart Dat...FIWARE
Cities as Enablers of the Data Economy: Smart Data Models for Cities - 21 October 2020
Corresponding webinar recording: https://youtu.be/b0EWq5E5jAc
Speaker: Alberto Abella (Data Modeling Expert and Technical Evangelist, FIWARE Foundation)
Chapter: Smart Cities
Difficulty: 2
Audience: Technical Domain Specific
Worried about the learning curve to introduce Deep Learning in your organization? Don’t be. The DEEP-HybridDataCloud project offers a framework for all users, including non-experts, enabling the transparent training, sharing and serving of Deep Learning models both locally or on hybrid cloud system. In this webinar we will be showing a set of use cases, from different research areas, integrated within the DEEP infrastructure.
The DEEP solution is based on Docker containers packaging already all the tools needed to deploy and run the Deep Learning models in the most transparent way. No need to worry about compatibility problems. Everything has already been tested and encapsulated so that the user has a fully working model in just a few minutes. To make things even easier, we have developed an API allowing the user to interact with the model directly from the web browser.
Presentation from Daan Broeder (KNAW, CLARIN ERIC) on SH & eInfra Projects at the EOSC-hub Week, 10 May 2019.
EOSC for Social Sciences and Humanities panel
Controlled vocabularies and ontologies in Dataverse data repositoryvty
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The Covid-19 Museum has an ambition to create a platform to deposit, consult, aggregate and study heterogeneous data about the pandemics using features of a distributed web service. To achieve this purpose, Dataverse has been selected as a reliable FAIR data repository with built-in search engine and functionality that allows adding computing resources to explore archived resources both on data and metadata. Presentation by
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On 10 September 2020, 1600-17:00 CEST, OCRE, in partnership with EARSC, held its webinar: OCRE Dynamic Earth Observation Procurement to provide suppliers of digital Earth Observation services an overview of the upcoming OCRE procurement. https://www.ocre-project.eu/events/ocre-dynamic-earth-observation-procurement-webinar-hosted-eocafe
SSHOC: Social Sciences and Humanities Open Cloud
Realising the Social Sciences and Humanities part of the European Open Science Cloud
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European Research Projects as EOSC Service ProvidersPedro Príncipe
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5. RDA community - Expectations from 14th plenary (Marieke Willems, Trust-IT)SSHOC
Links to the RDA Community and Expectations for P14
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Presented at the 2nd SSHOC Consortium Meeting, Florence, 14-15 October 2019
EOSC-hub Contribution to the European Open Science Cloud WGs - TNC 2019, Tallin, June 2019
The presentation provides an overview of the main project contributions to the EOSC working group, including:
(1) Services of the EOSC federating infrastructure that provide the frame through which the research-facing services can be integrated into EOSC (EOSC Portal website and its Marketplace, Federated AAI, Monitoring, Accounting, Helpdesk)
(2) Interoperability guidelines, such as Accounting record standard and exchange guidelines, Incident record management and monitoring information, Service description metadata, Technical interoperability guidelines for generic and thematic services.
(3) Federated service management guidelines and a prototype of the EOSC Service Management System in compliance to the FitSM standard.
8. Launching the community engagement strategy: The WP6 Survey (Irena Vipavc ...SSHOC
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SSHOC kick off meeting - 1.1.1 Where Social Sciences and Humanities Meet: Inv...SSHOC
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Khiet Truong, Dirk Heylen, Deniece Nazareth, Gerben Westerhof - University of Twente
SSHOC pools together Research Infrastructural excellence from the Social Sciences & Humanities Cluster Communities.
A new cloud-based infrastructure to make data, tools and training available for scholars in the social sciences and humanities.
An ambitious number of 47 organisations, experienced and skilled in Social Science & Humanities Infrastructures have gathered from all over Europe to collaborate together on SSHOC, the Social Science and Humanities Open Science Cloud project, coordinated by the Consortium of European Social Science Data Archives (CESSDA). The project starts its journey in January 2019 and runs through to April 2022 with a funding support of 14.5 million euros to realise the transition from the current landscape with disciplinary silos and separated e-infrastructure facilities into a fully-fledged cloud-based infrastructure where data are FAIR, tools and training readily accessible, thus providing a significant contribution towards achieving the vision put forward by the European Cloud Initiative - and support the implementation of European Open Science Cloud.
For the first time all European Social Science and Humanities’ Research Infrastructures join forces to build the social sciences and humanities’ part of the European Open Science Cloud.
All SSH ESFRI Landmarks and Projects (CESSDA, ESS, DARIAH, CLARIN and SHARE), relevant international SSH data infrastructures and the Association of European Research Libraries (LIBER) participate in the SSHOC project ensuring an inclusive approach. The consortium has the expertise to cover the whole data cycle: from data creation and curation to optimal re-use of data and can address training and advocacy to increase actual re-use of data. The consortium is also very well placed to address SSH specific challenges such as the distributed character of its infrastructures, multi-linguality, huge internal complexity of some of the data it deals with and secured access to sensitive data.
SSHOC partners and collaborating organisations:
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Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
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What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
4. An Overview of Sugarcane White Leaf Disease in Vietnam.pdf
2. EOSC-hub (Daan Broeder, CLARIN ERIC)
1. This project is funded from the EU Horizon 2020 Research and Innovation Programme (2014-2020) under Grant Agreement No. 823782
EOSC-hub
Daan Broeder, CLARIN ERIC
2. This project is funded from the EU Horizon 2020 Research and Innovation Programme (2014-2020) under Grant Agreement No. 823782
Disclaimer
Both CLARIN ERIC and myself are involved in the EOSC-hub project BUT
this presentation does not reflect the official EOSC-hub point of view
Its based on observations and expectations of myself and a few colleagues
Focussing on the relevance of EOSC-hub for SSHOC and the communities in
general
3. This project is funded from the EU Horizon 2020 Research and Innovation Programme (2014-2020) under Grant Agreement No. 823782
EOSChub and EOSC
EOSChub Project (both ideas and partners) is an initiative from a number of
previous EU e-Infrastructure projects EGI, EUDAT, Indigo DataCloud, ...
Large project (30ME) with almost all the usual suspects on board
Providing core infrastructure services for the research infrastructure
landscape that should then develop into the EOSC
Storage and computing services provisioning
Federating and common core e.g. common AAI, monitoring, …
Includes a fair number of community (thematic) services e.g. CLARIN metadata
framework
EOSC Portal: EOSC Website, EOSC Service catalogue, EOSC Marketplace
Services have been professionalized (policies, compliance, operations,
monitoring, description, …) and integration with one another where practical
4. This project is funded from the EU Horizon 2020 Research and Innovation Programme (2014-2020) under Grant Agreement No. 823782
What does this mean for you and for SSHOC?
EOSChub is of course interested to engage with the cluster projects; one
contact - many communities; such contacts lends mass and credibility to the
project
Only limited capacity available, costs need ro be covered, except for the Early Adopters
Program(EAP)
SSHOC has proposed the ‘new’ SSHOC EURHISFIRM project partner to participate in the
EOSChub EAP call 1
2nd call closes this week: https://www.eosc-hub.eu/eosc-early-adopter-programme-2nd-call
For now, SSHOC results consolidation (services, data, …) can only be a
matter for the individual SSHOC RI stakeholders
This does not prevent individual organizations & RIs to work with EOSChub:
Making use of EOSC services (capacity)
Become visible in the EOSC Portal & Marketplace
Advise and expertise for relevant services could be organized and provided by
SSHOC
5. This project is funded from the EU Horizon 2020 Research and Innovation Programme (2014-2020) under Grant Agreement No. 823782
Is EOSChub EOSC?
EOSC is still under construction and has its own governance structure
ESOChub is just a project 2018-2020; but it will offer a proposal to EOSC for
adoption
That proposal will likely be the complete EOSC-hub result: architecture, rules
of engagement, service portfolio
EOSC may ask for changes: e.g. less clutter, less overlap, less expensive, …
Existing investments over many years in the eInfra projects and services will
not be abandoned
There is much valuable expertise and excellent services involved that we
should preserve
Some cherry-picking by research communities is called for
6. This project is funded from the EU Horizon 2020 Research and Innovation Programme (2014-2020) under Grant Agreement No. 823782
Tentative analysis SSHOC - EOSC services matching
Hosting services
Hosting (curated) data
Hosting data processing workflows/pipelines
Generalised/improved versions
of existing thematic EOSC services
Requirement shared by many projects
Overlapping ambitions
with EOSC-hub Marketplace?
7. This project is funded from the EU Horizon 2020 Research and Innovation Programme (2014-2020) under Grant Agreement No. 823782
Status SSHOC service analysis, added services from the
stakeholders
Services not
directly linked
to SSHOC DoA
DARIAH
Data Deposit
Recommendatio
n Service
(DDRS)
production-ready
dev version (will be
released in 2019) DARIAH none B2FIND
DARIAH dariahTeach
e-learning platform
for DH training
material
CLARIN/DARIA
H
DH Course
Registry
CLARIN CLARIN portal existing CLARIN none none
CLARIN
Depositing
services existing CLARIN none
VLO, B2FIND,
Switchboard
metadata
exchange, data
processing
CLARIN
Virtual Language
Observatory existing CLARIN
is a EOSChub
thematic service
B2SHARE,
Switchboard
metadata
exchange, data
processing
CLARIN
Easy access to
protected
resources existing CLARIN none none
CLARIN
Language
Resource
Inventory existing CLARIN none VLO, B2FIND
metadata
exchange
CLARIN Content Search existing CLARIN none
CESSDA Data Catalogue existing CESSDA
submission in
progress b2find
complement/com
petitor
CESSDA
Vocabulary
Service existing CESSDA none
CESSDA
European
Question Bank development CESSDA none
CESSDA
Data
Management
Expert Guide existing CESSDA none
non-SSHOC related
Common DARIAH/CLARIN service
8. This project is funded from the EU Horizon 2020 Research and Innovation Programme (2014-2020) under Grant Agreement No. 823782
(Still) next steps
Continuing the SSHOC – EOSC inventory and services matching analysis
Include also secondary systems, needed for the functioning of SSHOC results
Include supported community services for analysis of integration opportunities
Will allow to discuss suitability and detect gaps wrt. ESOC service portfolio
First analysis shows that all results can be handled by the SSHOC partner infrastructure
themselves with one or two exceptions (long tail of science)
SSHOC as a consumer mainly needs hosting and storage services
SSHOC as an EOSC contributor can help by publishing and integrating our services and data
in the EOSC-portal and other discovery services
Would be good if other cluster projects could be convinced to make a similar inventory and
analysis
Keep discussing the possible models of stakeholder solutions versus central EOSC-hub
solutions; this is of course also part of governance discussions in WP8
9. This project is funded from the EU Horizon 2020 Research and Innovation Programme (2014-2020) under Grant Agreement No. 823782
THANK YOU!
10. This project is funded from the EU Horizon 2020 Research and Innovation Programme (2014-2020) under Grant Agreement No. 823782
EOSC Alignment, what is it?
From the proposal: first of the 6 Main SSHOC impacts reads:
“The SSH are seamlessly integrated in EOSC”
We need to discover what the EOSC status and potential is
…. need to shape EOSC also to our vision. It is our cloud too!
Specific questions for SSHOC:
Can the cluster projects act as a separate conduit of products and results
to EOSC?
Can EOSC offer a platform for hosting results of collaboration initiatives
such as cluster-projects?
What would be needed?
at the level of hosting data, services and operations
but especially at the level of business models and governance
11. This project is funded from the EU Horizon 2020 Research and Innovation Programme (2014-2020) under Grant Agreement No. 823782
SSHOC: Many partners, one EOSC alignment strategy?
Main SSHOC stakeholders: CESSDA, CLARIN, DARIAH, E-
RIHS, ESS, SHARE
Different levels of infrastructure coherence and maturity
Different levels of current EOSC and e-Infra involvement:
CLARIN ERIC and some DARIAH partners are involved in EOSC-hub
other partners were involved in the EOSC pilots, and
SSH participation in EOSC(-hub) boards (i.e. Ron Dekker)
From a diversity perspective things look bright, but is it helpful to
forge a single EOSC Alignment strategy?
The relation between alignment of individual SSHOC
stakeholders and SSHOC - EOSC alignment is an important issue
for discussion
12. This project is funded from the EU Horizon 2020 Research and Innovation Programme (2014-2020) under Grant Agreement No. 823782
Opportunities
The EOSC alignment question forces us to analyse and discuss
the options wrt. sustainability and sharing solutions already at an
early stage:
1. Using/sharing data management services from EOSC-hub
2. Sharing community-specific services with others, also outside SSH, and
how to do that cost-effectively
3. Identifying sustainable EOSC-hub solutions
4. Determining where community solutions are still preferable
Especially (2) should allow communities to claim their part in
EOSC and the accompanying funding and governance
responsibilities
13. This project is funded from the EU Horizon 2020 Research and Innovation Programme (2014-2020) under Grant Agreement No. 823782
Tentative analysis SSHOC - EOSC services matching
Hosting services
Hosting (curated) data
Hosting data processing workflows/pipelines
Generalised/improved versions
of existing thematic EOSC services
Requirement shared by many projects
Overlapping ambitions
with EOSC-hub Marketplace?
14. This project is funded from the EU Horizon 2020 Research and Innovation Programme (2014-2020) under Grant Agreement No. 823782
Next steps
Continue the SSHOC – EOSC services match analysis, also
covering secondary systems, needed for the functioning of
SSHOC services
Discuss within SSHOC the merits and possible models of
stakeholder solutions versus EOSC-hub solutions
Continue discussion with EOSC-hub
about solutions for the different services needed: hosting services,
sustainable
flexibility range wrt. community specific usability requirements
how can EOSC-hub support collaborative initiatives as SSHOC