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Emergency
presentations in
psychiatry & their
management
Semaw A. (ICCMH)
3/15/2024 1
Overview
• Safety and violence in the ER setting
• Definition of ‘emergency psychiatry’
• Physical restraints
• Pharmacologic support
• Suicide
• Psychosis, affective disorders,
substance use and personality
disorders
3/15/2024 2
General safety measures in
the ER
Keep your eye on your immediate
surroundings!
• Look for potential weapons such as
things that can be thrown
• Look for objects that the patient
could use for self harm
• Give yourself and the patient equal
access to the door
3/15/2024 3
Definition
A psychiatric emergency is any unusual
behaviour, mood or thought, which if not
rapidly attended to, may result in harm to a
patient or others.
3/15/2024 4
Psychiatric emergencies arise in
the context of
Chronic psychiatric illness
Consequence of medical illness that
presents with psychiatric symptoms
Adverse drug reaction
Intoxication
Drug-drug interaction.
When a patient is the victim of severe physical
or emotional trauma, and is unable to respond
adequately without professional intervention.
3/15/2024 5
Where does it occur?
A psychiatric emergency may occur in a home, on the
street, in an outpatient department, on a psychiatric
unit, on a medical or surgical unit of a general
hospital, or in the emergency department.
3/15/2024 6
Laboratory Studies to Assess
Potential Organic Causes of
Acutely Altered Behavior
Complete blood count
Electrolytes
Blood alcohol concentration or breath analyzer
Blood glucose concentration
Calcium level
Urine assay for substances of abuse
3/15/2024 7
Common Medical Illnesses That
Often Present as Psychiatric
Emergencies
Hypothyroidism
Hyperthyroidism
Diabetic ketoacidosis
Hypoglycemia
Urinary tract infection
Pneumonia
3/15/2024 8
Common Medical Illnesses
That Often Present as
Psychiatric Emergencies Cont.
Myocardial infarction
Alcohol intoxication
Alcohol withdrawal
Chronic obstructive pulmonary disease
Acute liver disease
Substance withdrawal
3/15/2024 9
Common Psychiatric Emergencies
• Abuse of child or adult
• Adjustment disorder Adolescent crises
• Akathisia,acute dystonia
• Alcohol intoxication or withdrawal
• Amnesia, anxiety, delirium, dementia
• Catatonia
• Family crises, marital crises
3/15/2024 10
.
• Grief and bereavement
• Mania
• Neuroleptic malignant syndrome
• Paranoia
• Rape
• Psychosis
• Repeaters
• Suicidal behaviour
• Panic attacks
• Seizures, in status epilepticus=common presentation
• Acute violence
•
3/15/2024 11
Back to safety issues in the
Psychiatric emergency room!
• The comfort zone for most people is
hand shaking distance.
 The comfort zone for paranoid or agitated
patients may be 2-3 X the usual distance.
• Remember the patients’ history when
you are in their personal space. When
you do a physical exam and you invade
their space they may react defensively.
3/15/2024 12
Assessing the risk of violence
• Immediate past, recent past and
more distant history of violence is
the best predictor of future
violence.
• Circumstances of violence and
characteristics of people involved are
important.
• Substance dependence or abuse
carries a 30X increase risk than the
general population!!
3/15/2024 13
.
• Antisocial personality disorder with
comorbid substance abuse or
dependence carries greater than
100X the risk compared to the
general population.
• Mental illness carries a 9X greater
risk than the general population
particularly paranoid schizophrenia
and confused states related to
medical problems.
3/15/2024 14
Clinical factors associated with violence
• A history of violent acts
• Inability to control anger
• History of impulsive behavior (reckless)
• Paranoid ideation or frank psychosis
• Lack of insight in psychotic patients
• Command hallucinations
• The stated desire to hurt or kill a person
• Acting out PD (Antisocial, Borderline)
• Presence of dementia, delirium or intoxication
3/15/2024 15
3/15/2024 16
Behavioral Predictors of violence
• Angry words
• Loud language
• Abuse language
• Physical agitation such as making
fists,pacing and akasthisia
3/15/2024 17
Violence Signs predicting assault:
• Threats
• Anger
• Demanding immediate attention
• Loud voice
• Excitement
• Staring eyes
• Flared nostrils
• Hands clenched or gripping
• Pacing about in the room
• Possessing weapons
• Pushing furniture
• Uncooperativeness and suspiciousness
• Slamming objects
• Sudden movements
3/15/2024 18
Managing the Violent
Patient
• Hospital or clinical setting:
• Staff:
– Sufficient in number
– Well trained in seclusion & restraint techniques
• Seclusion & restraint is a measure to prevent injury to
the patient and other, not a punishment!!
3/15/2024 19
De-escalation of
agitated/violent patient
• The initial approach to a person with behavioural
disturbance should be focused on attempts to de-escalate
the behaviour.
• It takes the form of a verbal loop in which the clinician
actively listens to the patient, finds a way to respond that
agrees with or validates the patient’s position as far as
possible, and then explains what the clinician wants the
patient to do
• All staff involved in this process should be trained and
skilled in de-escalation.
3/15/2024 20
De-escalation technique
• Approach in a calm, confident and non-threatening
manner, with a non-aggressive stance with arms relaxed.
• Be empathic, non-judgemental and respectful. Listen to
the patient’s concerns.
• Introduce yourself, your role and the purpose of the
discussion, lead the discussion and engage the patient.
While other staff should remain in the vicinity to offer
support, it is imperative that only one staff member
verbally engage the patient
3/15/2024 21
Cont…
• Emphasise your desire to help. Ask what they want and
what they are worried about.
• Focus on the here and now, identify what is achievable,
rather than declining all requests, small concessions can
build trust and rapport.
• Avoid potentially provocative statements such as “calm
down” or “if you don’t settle down ….x will happen”
“you’d better stop that right now…or else” as this is likely
to escalate the patients behaviour in response to the
perceived threat.
3/15/2024 22
How to de-escalate a patient
• Use a calm voice
• Sit down with the patient
• Maintain adequate physical distance
of at least 6 feet
• Attempt to establish rapport
• Listen to the patient’s concerns
3/15/2024 23
Video showing verbal de-
escalation
3/15/2024 24
When verbal de-escalation
is not enough;
• When there is risk of imminent harm
and verbal de-escalation has been
ineffective either pharmacologic
supports or physical restraints may
be needed.
3/15/2024 25
Physical restraints
• Have restraints, stretcher and
restraint keys ready
• Use a show of force with 5 or more
trained staff who may need to
physically lay hands on the patient.
Sometimes gathering that many
clinicians will persuade the patient to
comply.
• Try to have the patient into lying on
the stretcher
3/15/2024 26
.
• If the patient will not comply the
team will put the patient in
restraints.
• Remember people can bite and spit so
one of the team will control the head
during the restraining procedure.
• A minimum of two points ( one arm
and one leg).
3/15/2024 27
Once the patient is in
restraints;
• Search the patient for potentially harmful
objects such as lighters, knives or other sharp
items
• Perform a brief survey for any physical injuries to
the patient including head injury and observe
movement in all 4 limbs
• Check the head and eyes including eye movements
and pupillary response.
• Take the pt to seclusion room
3/15/2024 28
Video showing physical
restraint
3/15/2024 29
Cont…
3/15/2024 30
Pharmacologic Support:
Benzodiazepines
• Lorazepam is one of the most useful meds
in the emergency setting. In the first 24
hours agitation is as effectively addressed
with lorazepam as antipsychotics even if
psychosis is present.
• Lorazepam is best absorbed IM. Diazepam
and chlordiazepoxide have erratic
absorption. PO or IV administration of
diazepam is effective and actually has a
more rapid absorption than PO lorazepam.
3/15/2024 31
.
• The primary reason not to use a
benzodiazapine is its sedative hypnotic
effect which can be additive with other
such agents (ex. Alcohol) resulting in
excessive sedation and respiratory
depression.
• Patients can have a paradoxical reaction
and actually become more agitated. This is
seen in about 5% of the population.
3/15/2024 32
Antipsychotics (Rapid
tranquilization)
• Antipsychotics can be quite effective
in reducing agitation.
• There are options in the following
forms:
– PO
– IM
– Quick dissolving tabs
3/15/2024 33
Rapid tranquilization
Principles
• Use oral, then IM as necessary.
• The intramuscular route is preferred over the intravenous
one from a safety point of view. ƒ
• Vital signs must be monitored after parenteral treatment is
administered. ƒGive small amounts. It is far easier to deal
with not giving enough than giving too much. Always
give time for the drug to work.
3/15/2024 34
Cont…
• Mixing drugs in the same syringe is hazardous and must
NEVER be done. ƒ
• Consider concurrent antipsychotics and the potential risk
of inadvertent high dose therapy. ƒ
ƒ
• Consider any on-going physical risks in relation to other
medical disorders, other drug treatment and any potential
for substance misuse.
3/15/2024 35
Treatment choices of RT
• If a patient has previously responded to a particular drug
for rapid tranquillisation, use again. ƒ
• If the patient is antipsychotic naïve, use low doses and
monitor for response and side effects closely. ƒ
• Oral medication should be considered initially.
• IM preparations currently recommended for use in rapid
tranquillisation are lorazepam, haloperidol and IM
olanzapine. In general, IM lorazepam is preferred. ƒ
• When using an IM typical antipsychotic agent, such as
haloperidol, an anticholinergic agent should be routinely
available to manage dystonia and other extrapyramidal
side effects.
3/15/2024 36
Extrapyramidal symptoms(EPS)
• Haloperidol is the most likely to cause
extrapyramidal symptoms (eps) followed
by risperidone with the other atypicals
having less eps risk.
• EPS is most likely to occur in young males
and older women.
 EPS is usually noted as muscle tightness in
limbs,tongue thickness and neck tightness.
More rarely laryngeal and pharyngeal
spasm and a sense of choking.
3/15/2024 37
EPS treatment
• Be ready to give O2 if breathing problems develop
• PO, IM or IV diphenhydramine (Benadryl) 50mg q
4-5 hrs. IV form acts very quickly so great to use
if pt has IV access already. If not may need to
use IM. IM takes about 30 minutes to improve sx
and po takes around 60 minutes.
• Benztropine (Cogentin) 1-2mg PO or IM q 8-12
hours.
3/15/2024 38
NMS Treatment
• Stop antipsychotics & lithium
• Medical ICU
– Supportive therapy
• Antipyretics, cooling blanket
• Rehydration
• Short term antihypertensive & oxygen
• Intubation & ventilator support
• Parentral nutrition
• Heparin, dialysis
• Physical therapy
3/15/2024 39
Cont…
– Specific Rx for NMS:
• Levodopa-carbidopa
• bromocriptine
• Dantrolene
Course and prognosis
• symptoms evolve over 24 to 72 hours
• untreated syndrome lasts 10 to 14 days
• mortality rate can reach 10 to 20 % even
higher.
3/15/2024 40
suicide
3/15/2024 41
Causes
This may occur in the following conditions
Depressive illness
Schizophrenia
Dissociative (Conversion) disorder
Dementia
Under the influence of alcohol and/or drugs
Following rape
Acute psychotic state
3/15/2024 42
Suicide behavior
Comprises the following elements
Wish to die
Wish to commit suicide
Communication of the intention to commit
suicide
Making suicide plan
Execution of suicide plan
3/15/2024 43
Motives/Reason for deliberate
self-harm
• To die
• Escape from unbearable anguish
• Get relief
• Change the behavior of others
• Escape from a situation
• Show desperation to others
• Get back at other people/make them feel guilty
• To Get help
3/15/2024 44
Methods of committing
suicide
 Hanging
 Ingesting poison or inhaling poisonous substance
 Jumping from height
 Drowning
 Using guns
3/15/2024 45
Prevalence
80 people commit suicide every hour world wide.
Up to 40% of the general population experience the
wish to die at least once in their lifetime.
In Ethiopia,
• 0.9-3.2% of the general population attempt
suicide
• Prevalence of completed suicide is 7.7/100,000
persons per year.
• The rate for those 15 to 24 years of age has
increased two- to threefold.
• Suicide is currently ranked the 8th overall cause
of death in the United States.
3/15/2024 46
Etiology
95% of suicides occur within the context of
a mental disorder, particularly depression.
Difficulties in interpersonal relationships
Adverse socioeconomic circumstances
Chronic physical illness e.g. cancer,
HIV/AIDS
3/15/2024 47
Risk Factors
High
Negative ideas about life-hopelessness
Presence of mental illness particularly depression
Presence of suicidal behavior
Previous history of suicide attempt
Family history of suicide attempt or completed
suicide
Presence of general medical illness
3/15/2024 48
Risk Factors cont…
Others
Sex: more males commit suicide than females
Age: those aged more than 44 years tend to
commit rather than attempt suicide
Concomitant alcohol and other drug abuse
raise the risk of suicide
Loss of rational thinking as occurs in delirium,
schizophrenia or manic excitement raises the
risk of suicide.
Poverty and unemployment
3/15/2024 49
Risk factors
• Psychiatric
– Depression
– Schizophrenia
– Alcohol & other substance use problems
– Panic disorder
– Personality disorder – cluster B, impulsive &
unstable
– Co morbidity
– Tend to be young, & when admitted suicide
rate highest in the 1st week of admission and
the 1st 3-6 months after discharge.
3/15/2024 50
Risk factors cont…
• Social
– "the suicide rate varies inversely with the integration of social
groups of which the individual forms a part.“
Egoistic suicide - a lack of meaningful family ties or social
interactions. Due to an individual see being alone or an
outsider.
– These individuals are unable to find their own place in
society and have problems adjusting to groups.
– They received little and no social care. Suicide is seen
as a solution for them to free themselves from
loneliness or excessive individuation.
–
3/15/2024 51
 Anomic suicide - relationship between an individual and
society is broken by social or economic adversity.
 Caused by the lack of social regulation and it
occurs during high levels of stress and
frustration.
For example, when individuals suffer extreme
financial loss, the disappointment and stress that
individuals face may drive them towards
committing suicide as a means of escape.
 Altruistic suicide: results from excessive integration in
society. It occurs when social group involvement is
too high.
 Individuals are so well integrated into the group
that they are willing to sacrifice their own life
in order to fulfil some obligation for the group.
3/15/2024 52
 Individuals kill themselves for the collective
benefit of the group or for the cause that the
group believes in.
 An example is someone who commits suicide for
the sake of a religious or political cause
 Fatalistic suicide: occurs when individuals are kept under tight
regulation.
 These individuals are placed under extreme rules or high
expectations are set upon them, which removes a person’s
sense of self or individuality.
 Slavery and persecution are examples of fatalistic suicide
where individuals may feel that they are destined by fate to be in
such conditions and choose suicide as the only means of
escaping such conditions.
3/15/2024 53
3/15/2024 54
Risk factors cont…
• Psychological
– Aggression turned inward against an introjected,
ambivalently cathected love object.
– Loss of a love object or have sustained a narcissistic
injury, who experience overwhelming moods like
rage and guilt, or who identify with a suicide victim
3/15/2024 55
Risk factors cont…
• Biological
– Reduced central serotonin is associated with suicide
– Genetics
– Physical disorders CNS (epilepsy, MSL, head injury,
CVD, Huntington, dementia, HIV/AIDS). Endocrine
(Cushing’s). GI (Ulcer, Cirrhosis). GUT (Prostatic
hypertrophy, end-stage renal disease). Any chronic
intractable pain -
3/15/2024 56
Communication of
suicide wish
 Direct communication
• “if you think that I am not the head of this home, I
will leave this world for you.”
 Indirect communication
• “I am fade up with life”; “I wish I were not born”
 Suicide note
• the presence of suicide note for a previous attempt
• plan to leave a suicide note before executing a
planned suicide act
3/15/2024 57
Assessment of suicide risk
A highly suicidal patient
Is severely depressed or has overt signs of florid
psychosis
Has attempted or tried to attempt suicide before
coming to you
Has an urgent wish to die, possibility within the
week or so; natural death is too far
Has active plans for implementing suicide plan
Will feel disappointed if suicide bid fails
May have communicated the suicide intention to
someone else.
3/15/2024 58
Modified SAD PERSONS Scale
0-5 low risk
6-8 Require psychiatry consultation
>8 Probably require hospital admission
3/15/2024 59
Management
• Detect suicide behavior in every patient with clinical
interview.
• Detect the presence of psychiatric disorder
Depression
Chronic general medical illness
Psychosocial stressors.
• Start medication for appropriate psychiatric disorder
Dispense drugs on weekly basis only till the risk of
suicide has substantially been removed
• Discuss the prevention of suicide behavior with colleague in-
charge of general medical care (as appropriate)
3/15/2024 60
Management cont…
Dealing with
Interpersonal problems and psychosocial stressors – current
and ongoing
• Narrate the nature of his/her current and ongoing life
difficulties
• Describe his/her previous, current or ongoing stressors
• Develop hierarchy of his/ her usual responses to life
stressors
• Evaluate the effectiveness of each of these responses
• Develop alternative responses and strategies his/her
difficulties, etc
• Develop homework for the patient to carry out
3/15/2024 61
Management plan
• In-pt vs. Out-pt
• social support?, impulsive behavior? Suicidal
plans?
• Remove or treat risk factors
• underlying medical problems (delirium 20
treatable conditions, alcohol and substance
abuse/withdrawal etc)
• physical (in unpredictable and impulsive
patients) &/or chemical restraint (anxiolitics,
antidepressants, neuroleptics)
• Psychotherapy (supportive, family therapies)
• Electroconvulsive therapy (ECT)
• REFER the pt where he/she can be best helped
for follow-up
3/15/2024 62
Take home points
• Safety is always the first concern in
the emergency setting.
• To maintain safety both physical
restraints and pharmacologic support
may be needed.
• Assess carefully for suicide.
• Screen for addiction, affective,
psychotic and personality disorders.
3/15/2024 63
3/15/2024 64
3/15/2024 65

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16. Emergency psychiatry common illness in

  • 1. Emergency presentations in psychiatry & their management Semaw A. (ICCMH) 3/15/2024 1
  • 2. Overview • Safety and violence in the ER setting • Definition of ‘emergency psychiatry’ • Physical restraints • Pharmacologic support • Suicide • Psychosis, affective disorders, substance use and personality disorders 3/15/2024 2
  • 3. General safety measures in the ER Keep your eye on your immediate surroundings! • Look for potential weapons such as things that can be thrown • Look for objects that the patient could use for self harm • Give yourself and the patient equal access to the door 3/15/2024 3
  • 4. Definition A psychiatric emergency is any unusual behaviour, mood or thought, which if not rapidly attended to, may result in harm to a patient or others. 3/15/2024 4
  • 5. Psychiatric emergencies arise in the context of Chronic psychiatric illness Consequence of medical illness that presents with psychiatric symptoms Adverse drug reaction Intoxication Drug-drug interaction. When a patient is the victim of severe physical or emotional trauma, and is unable to respond adequately without professional intervention. 3/15/2024 5
  • 6. Where does it occur? A psychiatric emergency may occur in a home, on the street, in an outpatient department, on a psychiatric unit, on a medical or surgical unit of a general hospital, or in the emergency department. 3/15/2024 6
  • 7. Laboratory Studies to Assess Potential Organic Causes of Acutely Altered Behavior Complete blood count Electrolytes Blood alcohol concentration or breath analyzer Blood glucose concentration Calcium level Urine assay for substances of abuse 3/15/2024 7
  • 8. Common Medical Illnesses That Often Present as Psychiatric Emergencies Hypothyroidism Hyperthyroidism Diabetic ketoacidosis Hypoglycemia Urinary tract infection Pneumonia 3/15/2024 8
  • 9. Common Medical Illnesses That Often Present as Psychiatric Emergencies Cont. Myocardial infarction Alcohol intoxication Alcohol withdrawal Chronic obstructive pulmonary disease Acute liver disease Substance withdrawal 3/15/2024 9
  • 10. Common Psychiatric Emergencies • Abuse of child or adult • Adjustment disorder Adolescent crises • Akathisia,acute dystonia • Alcohol intoxication or withdrawal • Amnesia, anxiety, delirium, dementia • Catatonia • Family crises, marital crises 3/15/2024 10
  • 11. . • Grief and bereavement • Mania • Neuroleptic malignant syndrome • Paranoia • Rape • Psychosis • Repeaters • Suicidal behaviour • Panic attacks • Seizures, in status epilepticus=common presentation • Acute violence • 3/15/2024 11
  • 12. Back to safety issues in the Psychiatric emergency room! • The comfort zone for most people is hand shaking distance.  The comfort zone for paranoid or agitated patients may be 2-3 X the usual distance. • Remember the patients’ history when you are in their personal space. When you do a physical exam and you invade their space they may react defensively. 3/15/2024 12
  • 13. Assessing the risk of violence • Immediate past, recent past and more distant history of violence is the best predictor of future violence. • Circumstances of violence and characteristics of people involved are important. • Substance dependence or abuse carries a 30X increase risk than the general population!! 3/15/2024 13
  • 14. . • Antisocial personality disorder with comorbid substance abuse or dependence carries greater than 100X the risk compared to the general population. • Mental illness carries a 9X greater risk than the general population particularly paranoid schizophrenia and confused states related to medical problems. 3/15/2024 14
  • 15. Clinical factors associated with violence • A history of violent acts • Inability to control anger • History of impulsive behavior (reckless) • Paranoid ideation or frank psychosis • Lack of insight in psychotic patients • Command hallucinations • The stated desire to hurt or kill a person • Acting out PD (Antisocial, Borderline) • Presence of dementia, delirium or intoxication 3/15/2024 15
  • 17. Behavioral Predictors of violence • Angry words • Loud language • Abuse language • Physical agitation such as making fists,pacing and akasthisia 3/15/2024 17
  • 18. Violence Signs predicting assault: • Threats • Anger • Demanding immediate attention • Loud voice • Excitement • Staring eyes • Flared nostrils • Hands clenched or gripping • Pacing about in the room • Possessing weapons • Pushing furniture • Uncooperativeness and suspiciousness • Slamming objects • Sudden movements 3/15/2024 18
  • 19. Managing the Violent Patient • Hospital or clinical setting: • Staff: – Sufficient in number – Well trained in seclusion & restraint techniques • Seclusion & restraint is a measure to prevent injury to the patient and other, not a punishment!! 3/15/2024 19
  • 20. De-escalation of agitated/violent patient • The initial approach to a person with behavioural disturbance should be focused on attempts to de-escalate the behaviour. • It takes the form of a verbal loop in which the clinician actively listens to the patient, finds a way to respond that agrees with or validates the patient’s position as far as possible, and then explains what the clinician wants the patient to do • All staff involved in this process should be trained and skilled in de-escalation. 3/15/2024 20
  • 21. De-escalation technique • Approach in a calm, confident and non-threatening manner, with a non-aggressive stance with arms relaxed. • Be empathic, non-judgemental and respectful. Listen to the patient’s concerns. • Introduce yourself, your role and the purpose of the discussion, lead the discussion and engage the patient. While other staff should remain in the vicinity to offer support, it is imperative that only one staff member verbally engage the patient 3/15/2024 21
  • 22. Cont… • Emphasise your desire to help. Ask what they want and what they are worried about. • Focus on the here and now, identify what is achievable, rather than declining all requests, small concessions can build trust and rapport. • Avoid potentially provocative statements such as “calm down” or “if you don’t settle down ….x will happen” “you’d better stop that right now…or else” as this is likely to escalate the patients behaviour in response to the perceived threat. 3/15/2024 22
  • 23. How to de-escalate a patient • Use a calm voice • Sit down with the patient • Maintain adequate physical distance of at least 6 feet • Attempt to establish rapport • Listen to the patient’s concerns 3/15/2024 23
  • 24. Video showing verbal de- escalation 3/15/2024 24
  • 25. When verbal de-escalation is not enough; • When there is risk of imminent harm and verbal de-escalation has been ineffective either pharmacologic supports or physical restraints may be needed. 3/15/2024 25
  • 26. Physical restraints • Have restraints, stretcher and restraint keys ready • Use a show of force with 5 or more trained staff who may need to physically lay hands on the patient. Sometimes gathering that many clinicians will persuade the patient to comply. • Try to have the patient into lying on the stretcher 3/15/2024 26
  • 27. . • If the patient will not comply the team will put the patient in restraints. • Remember people can bite and spit so one of the team will control the head during the restraining procedure. • A minimum of two points ( one arm and one leg). 3/15/2024 27
  • 28. Once the patient is in restraints; • Search the patient for potentially harmful objects such as lighters, knives or other sharp items • Perform a brief survey for any physical injuries to the patient including head injury and observe movement in all 4 limbs • Check the head and eyes including eye movements and pupillary response. • Take the pt to seclusion room 3/15/2024 28
  • 31. Pharmacologic Support: Benzodiazepines • Lorazepam is one of the most useful meds in the emergency setting. In the first 24 hours agitation is as effectively addressed with lorazepam as antipsychotics even if psychosis is present. • Lorazepam is best absorbed IM. Diazepam and chlordiazepoxide have erratic absorption. PO or IV administration of diazepam is effective and actually has a more rapid absorption than PO lorazepam. 3/15/2024 31
  • 32. . • The primary reason not to use a benzodiazapine is its sedative hypnotic effect which can be additive with other such agents (ex. Alcohol) resulting in excessive sedation and respiratory depression. • Patients can have a paradoxical reaction and actually become more agitated. This is seen in about 5% of the population. 3/15/2024 32
  • 33. Antipsychotics (Rapid tranquilization) • Antipsychotics can be quite effective in reducing agitation. • There are options in the following forms: – PO – IM – Quick dissolving tabs 3/15/2024 33
  • 34. Rapid tranquilization Principles • Use oral, then IM as necessary. • The intramuscular route is preferred over the intravenous one from a safety point of view. ƒ • Vital signs must be monitored after parenteral treatment is administered. ƒGive small amounts. It is far easier to deal with not giving enough than giving too much. Always give time for the drug to work. 3/15/2024 34
  • 35. Cont… • Mixing drugs in the same syringe is hazardous and must NEVER be done. ƒ • Consider concurrent antipsychotics and the potential risk of inadvertent high dose therapy. ƒ ƒ • Consider any on-going physical risks in relation to other medical disorders, other drug treatment and any potential for substance misuse. 3/15/2024 35
  • 36. Treatment choices of RT • If a patient has previously responded to a particular drug for rapid tranquillisation, use again. ƒ • If the patient is antipsychotic naïve, use low doses and monitor for response and side effects closely. ƒ • Oral medication should be considered initially. • IM preparations currently recommended for use in rapid tranquillisation are lorazepam, haloperidol and IM olanzapine. In general, IM lorazepam is preferred. ƒ • When using an IM typical antipsychotic agent, such as haloperidol, an anticholinergic agent should be routinely available to manage dystonia and other extrapyramidal side effects. 3/15/2024 36
  • 37. Extrapyramidal symptoms(EPS) • Haloperidol is the most likely to cause extrapyramidal symptoms (eps) followed by risperidone with the other atypicals having less eps risk. • EPS is most likely to occur in young males and older women.  EPS is usually noted as muscle tightness in limbs,tongue thickness and neck tightness. More rarely laryngeal and pharyngeal spasm and a sense of choking. 3/15/2024 37
  • 38. EPS treatment • Be ready to give O2 if breathing problems develop • PO, IM or IV diphenhydramine (Benadryl) 50mg q 4-5 hrs. IV form acts very quickly so great to use if pt has IV access already. If not may need to use IM. IM takes about 30 minutes to improve sx and po takes around 60 minutes. • Benztropine (Cogentin) 1-2mg PO or IM q 8-12 hours. 3/15/2024 38
  • 39. NMS Treatment • Stop antipsychotics & lithium • Medical ICU – Supportive therapy • Antipyretics, cooling blanket • Rehydration • Short term antihypertensive & oxygen • Intubation & ventilator support • Parentral nutrition • Heparin, dialysis • Physical therapy 3/15/2024 39
  • 40. Cont… – Specific Rx for NMS: • Levodopa-carbidopa • bromocriptine • Dantrolene Course and prognosis • symptoms evolve over 24 to 72 hours • untreated syndrome lasts 10 to 14 days • mortality rate can reach 10 to 20 % even higher. 3/15/2024 40
  • 42. Causes This may occur in the following conditions Depressive illness Schizophrenia Dissociative (Conversion) disorder Dementia Under the influence of alcohol and/or drugs Following rape Acute psychotic state 3/15/2024 42
  • 43. Suicide behavior Comprises the following elements Wish to die Wish to commit suicide Communication of the intention to commit suicide Making suicide plan Execution of suicide plan 3/15/2024 43
  • 44. Motives/Reason for deliberate self-harm • To die • Escape from unbearable anguish • Get relief • Change the behavior of others • Escape from a situation • Show desperation to others • Get back at other people/make them feel guilty • To Get help 3/15/2024 44
  • 45. Methods of committing suicide  Hanging  Ingesting poison or inhaling poisonous substance  Jumping from height  Drowning  Using guns 3/15/2024 45
  • 46. Prevalence 80 people commit suicide every hour world wide. Up to 40% of the general population experience the wish to die at least once in their lifetime. In Ethiopia, • 0.9-3.2% of the general population attempt suicide • Prevalence of completed suicide is 7.7/100,000 persons per year. • The rate for those 15 to 24 years of age has increased two- to threefold. • Suicide is currently ranked the 8th overall cause of death in the United States. 3/15/2024 46
  • 47. Etiology 95% of suicides occur within the context of a mental disorder, particularly depression. Difficulties in interpersonal relationships Adverse socioeconomic circumstances Chronic physical illness e.g. cancer, HIV/AIDS 3/15/2024 47
  • 48. Risk Factors High Negative ideas about life-hopelessness Presence of mental illness particularly depression Presence of suicidal behavior Previous history of suicide attempt Family history of suicide attempt or completed suicide Presence of general medical illness 3/15/2024 48
  • 49. Risk Factors cont… Others Sex: more males commit suicide than females Age: those aged more than 44 years tend to commit rather than attempt suicide Concomitant alcohol and other drug abuse raise the risk of suicide Loss of rational thinking as occurs in delirium, schizophrenia or manic excitement raises the risk of suicide. Poverty and unemployment 3/15/2024 49
  • 50. Risk factors • Psychiatric – Depression – Schizophrenia – Alcohol & other substance use problems – Panic disorder – Personality disorder – cluster B, impulsive & unstable – Co morbidity – Tend to be young, & when admitted suicide rate highest in the 1st week of admission and the 1st 3-6 months after discharge. 3/15/2024 50
  • 51. Risk factors cont… • Social – "the suicide rate varies inversely with the integration of social groups of which the individual forms a part.“ Egoistic suicide - a lack of meaningful family ties or social interactions. Due to an individual see being alone or an outsider. – These individuals are unable to find their own place in society and have problems adjusting to groups. – They received little and no social care. Suicide is seen as a solution for them to free themselves from loneliness or excessive individuation. – 3/15/2024 51
  • 52.  Anomic suicide - relationship between an individual and society is broken by social or economic adversity.  Caused by the lack of social regulation and it occurs during high levels of stress and frustration. For example, when individuals suffer extreme financial loss, the disappointment and stress that individuals face may drive them towards committing suicide as a means of escape.  Altruistic suicide: results from excessive integration in society. It occurs when social group involvement is too high.  Individuals are so well integrated into the group that they are willing to sacrifice their own life in order to fulfil some obligation for the group. 3/15/2024 52
  • 53.  Individuals kill themselves for the collective benefit of the group or for the cause that the group believes in.  An example is someone who commits suicide for the sake of a religious or political cause  Fatalistic suicide: occurs when individuals are kept under tight regulation.  These individuals are placed under extreme rules or high expectations are set upon them, which removes a person’s sense of self or individuality.  Slavery and persecution are examples of fatalistic suicide where individuals may feel that they are destined by fate to be in such conditions and choose suicide as the only means of escaping such conditions. 3/15/2024 53
  • 55. Risk factors cont… • Psychological – Aggression turned inward against an introjected, ambivalently cathected love object. – Loss of a love object or have sustained a narcissistic injury, who experience overwhelming moods like rage and guilt, or who identify with a suicide victim 3/15/2024 55
  • 56. Risk factors cont… • Biological – Reduced central serotonin is associated with suicide – Genetics – Physical disorders CNS (epilepsy, MSL, head injury, CVD, Huntington, dementia, HIV/AIDS). Endocrine (Cushing’s). GI (Ulcer, Cirrhosis). GUT (Prostatic hypertrophy, end-stage renal disease). Any chronic intractable pain - 3/15/2024 56
  • 57. Communication of suicide wish  Direct communication • “if you think that I am not the head of this home, I will leave this world for you.”  Indirect communication • “I am fade up with life”; “I wish I were not born”  Suicide note • the presence of suicide note for a previous attempt • plan to leave a suicide note before executing a planned suicide act 3/15/2024 57
  • 58. Assessment of suicide risk A highly suicidal patient Is severely depressed or has overt signs of florid psychosis Has attempted or tried to attempt suicide before coming to you Has an urgent wish to die, possibility within the week or so; natural death is too far Has active plans for implementing suicide plan Will feel disappointed if suicide bid fails May have communicated the suicide intention to someone else. 3/15/2024 58
  • 59. Modified SAD PERSONS Scale 0-5 low risk 6-8 Require psychiatry consultation >8 Probably require hospital admission 3/15/2024 59
  • 60. Management • Detect suicide behavior in every patient with clinical interview. • Detect the presence of psychiatric disorder Depression Chronic general medical illness Psychosocial stressors. • Start medication for appropriate psychiatric disorder Dispense drugs on weekly basis only till the risk of suicide has substantially been removed • Discuss the prevention of suicide behavior with colleague in- charge of general medical care (as appropriate) 3/15/2024 60
  • 61. Management cont… Dealing with Interpersonal problems and psychosocial stressors – current and ongoing • Narrate the nature of his/her current and ongoing life difficulties • Describe his/her previous, current or ongoing stressors • Develop hierarchy of his/ her usual responses to life stressors • Evaluate the effectiveness of each of these responses • Develop alternative responses and strategies his/her difficulties, etc • Develop homework for the patient to carry out 3/15/2024 61
  • 62. Management plan • In-pt vs. Out-pt • social support?, impulsive behavior? Suicidal plans? • Remove or treat risk factors • underlying medical problems (delirium 20 treatable conditions, alcohol and substance abuse/withdrawal etc) • physical (in unpredictable and impulsive patients) &/or chemical restraint (anxiolitics, antidepressants, neuroleptics) • Psychotherapy (supportive, family therapies) • Electroconvulsive therapy (ECT) • REFER the pt where he/she can be best helped for follow-up 3/15/2024 62
  • 63. Take home points • Safety is always the first concern in the emergency setting. • To maintain safety both physical restraints and pharmacologic support may be needed. • Assess carefully for suicide. • Screen for addiction, affective, psychotic and personality disorders. 3/15/2024 63