Yissum is one of the top 15 technology transfer companies in the world, with over 6,100 patents and 1,750 inventions licensed over 46 years. It works to commercialize research from The Hebrew University of Jerusalem and affiliated hospitals. Yissum is taking a more active role in technology transfer by creating funding platforms for projects at all stages of development and securing different funding opportunities. This helps bridge the "valley of death" between academic research and commercialization. New business models under consideration include a royalty-based funding model, utilizing Yissum's holdings in spin-off companies through IPO, and establishing an incubator to jointly invest and manage multiple early-stage projects.

1. Yissum: Innovative Approaches to Technology
Transfer
Yaacov Michlin, President & CEO
October 2010

2. 2
46 Years of Transferring Technologies
Among the top 15 Technology Transfer Companies in the world
6,100 patents
1,750 inventions
450 licenses
68 spin-offs

3. 3
A Heritage of Excellence
5 Campuses
5 affiliated hospitals
3,500 Research
projects >100 Research
centers
Over 400 Researchers
in applied sciences
1,600 Post-Graduate
students in
biotechnology
1,000 researchers
(staff members)
23,000 students
30% of all Israeli
academic scientific
research
43% of Israel’s
biotechnology
research>1/3 of PhD
students in Israel

4. 4
Israel’s Top University
Israel is ranked 4th
in the world in
investments in biotechnology per GDP *
Israel is ranked 3rd
in the world for the
number of start-ups in the field of
biotechnology *
The Hebrew University :* *
No. 1 in Israel
No. 5 in Asia-Pacific region
No. 72 worldwide
No. 21 worldwide in Computer Science
No. 51-77 worldwide in Natural Sciences
& Mathematics
Only Israeli university in top 100
* OECD Report 2009
* * U of Texas Institute of Higher Education, Shanghai Jiaotong University 2010
Scale of Academic Excellence * *
Haifa Univ.
Bar-Ilan
Univ.
Ben-Gurion
Univ.
Technion
Weizmann
Inst.
Tel Aviv
Univ.
The Hebrew University
of Jerusalem

5. Taking Technology Transfer to The Next
Level:
Traditionally: Technology Transfer
Companies filed for patents and searched
for Licensees
Now Yissum takes an active approach in
finding new ways to bring academic
research to commercialization:
Creating a comprehensive platform for
financial investment in a variety of
projects
Securing different funding
opportunities for projects at different
stages of development
We actively ensure that our projects
get a better starting point for future
R&D
5

6. New Technologies Face The Valley of Death
6
Over 120 new
projects were
created in 2009
About 90 have
commercial value
Screening
process
30are
commercialized
60 have
commercial value
but need further
R&D and funding
Creation of spin-off
companies which
receive investments
Valley of Death
$$$$$$
Licensing
agreements with
strong commercial
terms
By introducing new
creative funding routs
15-30 of these projects
can have a better
starting point that shall
increase their chances
for commercialization.

7. Bridging the Valley of Death: Today
Academic
Grants
Baby
Seed
Nofar
Magneton,
Incubators
Independent
Companies
Extensive
Long Term
Collaboration
An internal
Yissum
Program
Such as
Roche
Funding through
the OCS
The Valley of Death
Yissum’s services for the researchers –
aimed at bridging the gap between
academic financing and
commercialization stage
Direct investment in one of Yissum’s 45
spin off companies
7

8. Bridging The Valley of Death: Tomorrow’s
New Business Models
Additional
Funding
Matching
Funds With
Big Industrial
Companies
Long-Term
External
Royalty-Based
Funding Model
IPO: Yissum’s
Holdings in
Spin Off
Companies
Yissum’s
Incubator
8

9. 1. Royalty-Based Funding Model:
No
9

10. 2. IPO:
No
10

11. 11
15 New promising projects
per year
10 approved by OCS after
recommendation of Yissum
investment committee (per year)
Minimum 1 million NIS per year per project
Funding
2-3 years later
Licensing Closing Project
3. Financial Advantages in owning an
Incubator:
A joint investment
committee
Project management
using Yissum and HU
infrastructure

12. The next generation in Technology Transfer:
Shared investment and shared
revenues while investing in multiple
early-stage projects
Join us in a Conceptual Change in TechnologyJoin us in a Conceptual Change in Technology
Transfer:Transfer:
IPO
Industry
Matching
Funds
Incubator/
spin offs
Royalty-
Based
Funding
12

13. Yaacov Michlin
Yaacov.Michlin@yissum.co.il
Thank you