This document discusses innovation for sustainable development in Africa, focusing on local case studies. It begins with an introduction that provides context on innovation and sustainable development challenges in Africa. It then presents 10 case studies grouped under five themes: enhancement of agriculture and fisheries, water management, protection of ecosystems, health improvement, and sustainable tourism. The case studies highlight innovative local solutions that address sustainable development issues. They also draw lessons on factors for success, such as linking environmental and economic goals, utilizing local knowledge, ensuring community involvement, and employing self-sustaining business models.