This document summarizes a study that synthesized and characterized mixed ligand complexes of L-leucine and sulfamethoxazole with Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), and Hg(II) ions. The complexes were prepared in ethanol-water solution and characterized using techniques like FT-IR, UV-Vis, magnetic susceptibility, and conductivity measurements. FT-IR analysis indicated that both ligands act as bidentate ligands, coordinating through carboxylate and amine groups for L-leucine and sulfonyl oxygen and amine nitrogen for sulfamethoxazole. The complexes were also found to have octahedral geometry and
Synthesis, characterization and in vitro Antimicrobial activity of Cu (II) an...IOSR Journals
Abstract: Four Cu(II) and two Ni(II) complexes of azo carboxylate ligands were synthesized and characterized
by conductivity ,UV-visible and Infrared spectroscopy. The comparison of IR spectra of uncoordinated ligands
and their metal complexes indicated that ligands were coordinated to the metal through carboxylic oxygen atom
in bidented fashion. The electronic spectral data suggested square planner geometry of the complexes. The
conductivity study of the complexes indicated Cu(II) complexes are nonelectrolyte while Ni(II) complexes are
electrolyte in nature. All the complexes were tested for their in vitro antibacterial and antifungal activity against
different microbes and compared with standard drugs, Amphotericin-B and Ciprofloxacin. It was observed that
Ni(II)complexes are more effective than the corresponding Cu(II)complexes.Cu(II) complexes were found to be
inactive against the tested fungal species but they show moderate activity against the tested bacterial species.
One of the Ni(II) complex was found to be active in both fungal and bacterial species and also found to be more
effective than the other complexes.
METALLO - BIOACTIVE COMPOUNDS AS POTENTIAL NOVEL ANTICANCER THERAPYijac123
Mono and bi-organometallic complexes of Cu(II), Ni(II), Mn(II), Zn(II) and Ag(I) complexes with
oxaloamide ligand has much potential as therapeutic and diagnostic agents. The ligand allows the
thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for
functionalization. Specific examples involving the design of metal complexes as anticancer agents are
discussed. These complexes have been synthesized and characterized by (1H-NMR, mass, IR, UV-VIS,
ESR) spectra, magnetic moments and conductance measurements, elemental and thermal analyses. Molar
conductances in DMF solution indicates that, the complexes are non-electrolytes. The ESR spectra of solid
Cu(II) complexes (2-5) show an axial type indicating a d(X2-y2) ground state with a significant covalent
bond character. However, Mn(II) complex(9), shows an isotropic type indicating an octahedral geometry.
Cytotoxic evolution IC50 of the ligand and its complexes have been carried out. Cu(II) Complexes show
enhanced activity in comparison to the parent ligand or standard drug. Copper is enriched in various
human cancer tissues and is a co-factor essential for tumor angiogenesis processes. However, the use of
copper binding ligand to target tumor, copper could provide a novel strategy for cancer selective
treatment.
Synthesis and Characterization of Thermal Analysis of La (Ii) Macrocyclic Com...inventionjournals
The macrocyclic complex compounds of La(II) containing a ligand having tetraoxotetrahydrazin moity are synthesized by template condensation of malonodihydrazide (C3H8N4O2) with different aldehydes. The complexes are characterized on the basis of elemental analysis, UV-visible & IR spectroscopy, magnetic moment and conductance measurement and other physical properties.Antibacterial activity of the derived complex compounds, as well as already used standard compound kanamycin, was tested on fourteen pathogenic bacteria. Given results were then compared to the efficacy of the Antibacterial activity of standard compound kanamycin used for control of these pathogenic bacteria.
SYNTHESIS AND CHARACTERIZATION OF THERMAL ANALYSIS OF La (II) MACROCYCLIC COM...inventionjournals
The macrocyclic complex compounds of La(II) containing a ligand having tetraoxotetrahydrazin moity are synthesized by template condensation of malonodihydrazide (C3H8N4O2) with different aldehydes. The complexes are characterized on the basis of elemental analysis, UV-visible & IR spectroscopy, magnetic moment and conductance measurement and other physical properties.Antibacterial activity of the derived complex compounds, as well as already used standard compound kanamycin, was tested on fourteen pathogenic bacteria. Given results were then compared to the efficacy of the Antibacterial activity of standard compound kanamycin used for control of these pathogenic bacteria.
Chemical speciation studies on complexation of ditopic ligands: Interaction o...iosrjce
IOSR Journal of Applied Chemistry (IOSR-JAC) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of applied chemistry and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Chemical Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Ruthenium(III) Catalyzed Oxidation of Sugar Alcohols by Dichloroisocyanuric A...Ratnakaram Venkata Nadh
Kinetics of ruthenium(III) catalyzed oxidation of biologically important sugar alcohols (myo-inositol,
D-sorbitol, and D-mannitol) by dichloroisocyanuric acid was carried out in aqueous acetic acid—perchloric
medium. The reactions were found to be first order in case of oxidant and ruthenium(III). Zero order
was observed with the concentrations of sorbitol and mannitol whereas, a positive fractional order was found
in the case of inositol concentration. An inverse fractional order was observed with perchloric acid in oxidation
of three substrates. Arrhenius parameters were calculated and a plausible mechanism was proposed
Synthesis, characterization and in vitro Antimicrobial activity of Cu (II) an...IOSR Journals
Abstract: Four Cu(II) and two Ni(II) complexes of azo carboxylate ligands were synthesized and characterized
by conductivity ,UV-visible and Infrared spectroscopy. The comparison of IR spectra of uncoordinated ligands
and their metal complexes indicated that ligands were coordinated to the metal through carboxylic oxygen atom
in bidented fashion. The electronic spectral data suggested square planner geometry of the complexes. The
conductivity study of the complexes indicated Cu(II) complexes are nonelectrolyte while Ni(II) complexes are
electrolyte in nature. All the complexes were tested for their in vitro antibacterial and antifungal activity against
different microbes and compared with standard drugs, Amphotericin-B and Ciprofloxacin. It was observed that
Ni(II)complexes are more effective than the corresponding Cu(II)complexes.Cu(II) complexes were found to be
inactive against the tested fungal species but they show moderate activity against the tested bacterial species.
One of the Ni(II) complex was found to be active in both fungal and bacterial species and also found to be more
effective than the other complexes.
METALLO - BIOACTIVE COMPOUNDS AS POTENTIAL NOVEL ANTICANCER THERAPYijac123
Mono and bi-organometallic complexes of Cu(II), Ni(II), Mn(II), Zn(II) and Ag(I) complexes with
oxaloamide ligand has much potential as therapeutic and diagnostic agents. The ligand allows the
thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for
functionalization. Specific examples involving the design of metal complexes as anticancer agents are
discussed. These complexes have been synthesized and characterized by (1H-NMR, mass, IR, UV-VIS,
ESR) spectra, magnetic moments and conductance measurements, elemental and thermal analyses. Molar
conductances in DMF solution indicates that, the complexes are non-electrolytes. The ESR spectra of solid
Cu(II) complexes (2-5) show an axial type indicating a d(X2-y2) ground state with a significant covalent
bond character. However, Mn(II) complex(9), shows an isotropic type indicating an octahedral geometry.
Cytotoxic evolution IC50 of the ligand and its complexes have been carried out. Cu(II) Complexes show
enhanced activity in comparison to the parent ligand or standard drug. Copper is enriched in various
human cancer tissues and is a co-factor essential for tumor angiogenesis processes. However, the use of
copper binding ligand to target tumor, copper could provide a novel strategy for cancer selective
treatment.
Synthesis and Characterization of Thermal Analysis of La (Ii) Macrocyclic Com...inventionjournals
The macrocyclic complex compounds of La(II) containing a ligand having tetraoxotetrahydrazin moity are synthesized by template condensation of malonodihydrazide (C3H8N4O2) with different aldehydes. The complexes are characterized on the basis of elemental analysis, UV-visible & IR spectroscopy, magnetic moment and conductance measurement and other physical properties.Antibacterial activity of the derived complex compounds, as well as already used standard compound kanamycin, was tested on fourteen pathogenic bacteria. Given results were then compared to the efficacy of the Antibacterial activity of standard compound kanamycin used for control of these pathogenic bacteria.
SYNTHESIS AND CHARACTERIZATION OF THERMAL ANALYSIS OF La (II) MACROCYCLIC COM...inventionjournals
The macrocyclic complex compounds of La(II) containing a ligand having tetraoxotetrahydrazin moity are synthesized by template condensation of malonodihydrazide (C3H8N4O2) with different aldehydes. The complexes are characterized on the basis of elemental analysis, UV-visible & IR spectroscopy, magnetic moment and conductance measurement and other physical properties.Antibacterial activity of the derived complex compounds, as well as already used standard compound kanamycin, was tested on fourteen pathogenic bacteria. Given results were then compared to the efficacy of the Antibacterial activity of standard compound kanamycin used for control of these pathogenic bacteria.
Chemical speciation studies on complexation of ditopic ligands: Interaction o...iosrjce
IOSR Journal of Applied Chemistry (IOSR-JAC) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of applied chemistry and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Chemical Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Ruthenium(III) Catalyzed Oxidation of Sugar Alcohols by Dichloroisocyanuric A...Ratnakaram Venkata Nadh
Kinetics of ruthenium(III) catalyzed oxidation of biologically important sugar alcohols (myo-inositol,
D-sorbitol, and D-mannitol) by dichloroisocyanuric acid was carried out in aqueous acetic acid—perchloric
medium. The reactions were found to be first order in case of oxidant and ruthenium(III). Zero order
was observed with the concentrations of sorbitol and mannitol whereas, a positive fractional order was found
in the case of inositol concentration. An inverse fractional order was observed with perchloric acid in oxidation
of three substrates. Arrhenius parameters were calculated and a plausible mechanism was proposed
SYNTHESIS AND CHARACTERIZATION OF SCHIFF BASE METAL COMPLEXES DERIVED FROM NA...chemsurya
New Schiff base metal complexes having general structural formulae ML2Cl2 where M= Co(II), Ni(II) and Cu(II), and MLCl2 where M=Zn(II), Cd(II) and Hg(II) were synthesized by the condensation of indoline-2,3-dione (Isatin) and naphtho[2,1-b]furan-2-carbohydrazide. Tentative structures for the synthesized compounds have been elucidated based on analytical, IR, 1HNMR, and Mass spectral studies. Further selected compounds were tested for their antimicrobial activity.
Synthesis and characterization of some metal complexes of 2- Phenyl-3,4-dihyd...IOSRJAC
2-Phenyl-3,4-dihydro-quinazolin-4-yloxy)-acetic acid (L1) metal complexes with Mn2+ , Co2+, Ni2+ Cu2+ , and Zn2+ ions were studied and the structure of the complexes were elucidated using elemental analyses, infrared (IR), 1H nuclear magnetic resonance (NMR), magnetic moment and thermal analysis measurements. Besides the characterization of complexes by physicochemical technique, Biological activities of the synthesized complexes were examined against some microbial strains for evaluation of antibacterial and antifungal activities.
Synthesis and Spectral Characterization of UO2(VI), Th(IV) and ZrO(IV) Complexes with benzimidazolyl-2-hydrazones of diacetyl monoxime and benzil monoxime
Ranjan Kumar Mohapatra1, Pradeep Kumar Das2
International Journal of Engineering and Science Invention (IJESI) is an international journal intended for professionals and researchers in all fields of computer science and electronics. IJESI publishes research articles and reviews within the whole field Engineering Science and Technology, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Antifungal Activities of Some Divalent and Trivalent Metal Chelates with 2-am...Taghreed Al-Noor
Five metal chelates of Co(II), Ni(II), Cu(II), Zn(II) and Cr(III) ions with mixed
ligands of a Schiff base: Namely, (E)-2-(4-(dimethylamino)benzylidene)amino)phenol derived from
4-dimethylaminobenzaldehyde and 2-aminophenol as main ligand (HL1) and 2-aminobenzoic acid as co-ligand
(HL2) have been synthesized and characterized by using several physiochemical tools. An octahedral structure was
suggested for all the chelates. The antifungal activity the ligands and their mixed ligand chelates against some pathogenic
fungi was studied by using agar well diffusion method. The obtained data showed that some of the chelates
have most active against A. niger, A. flavus, Alternaria alternata, Rhizopus stolonifer.
Vibrational Characterization and Antioxidant Activity of Newly Synthesized Ga...peertechzpublication
The gallium(III) complex of orotic acid (HOA) was synthesized and its structure was determined
by means of analytical and spectral analyses. Detailed vibrational analysis of HOA, sodium salt of HOA
(NaOA) and Ga(III)-OA systems based on both the calculated and experimental spectra confi rmed the
suggested metal-ligand binding mode. Signifi cant differences in the IR and Raman spectra of the complex
were observed as compared to the spectra of the ligand and confi rmed the suggested metal-ligand
binding mode.
Synthesis and Thermal Study of Co (II), Ni (II), Cu (II) Mixed Ligand Complex...IOSR Journals
The mixed ligand complexes of Co (II), Ni (II) and Cu (II) with histidine (His.) and 8-hydroxyquinoline (Qui.) have been synthesized and characterized.The resulting complexes were characterized by vibrational and electronic spectral data, thermogravimetric studies , metal analysis and molar conductance measurements. The histidine acts as tridentate ligand, coordinating through the two nitrogen atoms of imidazole ring and the amino group and carboxylate oxygen whereas 8-hydroxyquinoline shows a bidentate nature and the coordination occurs through nitrogen of imine group and oxygen of phenol group. The experimental data suggest that a mononuclear octahedral structure with general formula [M (His.)(Qui.) H2O ] where M= Co (II), Ni (II) and [Cu (His.)(Qui.)H2O] .H2O, thermo gravimetric studies reveal the presence of coordinated water molecules in all complexes. The molar conductance measurements reveal non-electrolytic nature of complexes.
A new Schiff base 4-chlorophenyl)methanimine
(6R,7R)-3-methyl-8-oxo-7-(2-phenylpropanamido)-5-thia-1-
azabicyclo[4.2.0]oct-2-ene-2-carboxylate= (HL)= C23H20
ClN3O4S) has been synthesized from β-lactam antibiotic
(cephalexin mono hydrate(CephH)=(C16H19N3O5S.H2O) and 4-
chlorobenzaldehyde . Figure(1) Metal mixed ligand complexes
of the Schiff base were prepared from chloride salt of
Fe(II),Co(II),Ni(II),Cu(II),Zn(II) and Cd (II), in 50% (v/v)
ethanol –water medium (SacH ) .in aqueous ethanol(1:1)
containing and Saccharin(C7H5NO3S) = sodium hydroxide.
Several physical tools in particular; IR, CHN, 1H NMR, 13C
NMR for ligand and melting point molar conductance, magnetic
moment. and determination the percentage of the metal in the
complexes by flame(AAS). The ligands and there metal
complexes were screened for their antimicrobial activity against
four bacteria (gram + ve) and (gram -ve) {Escherichia coli,
Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus}.
The proposed structure of the complexes using program, Chem
office 3D(2006). The general formula have been given for the
prepared mixed ligand complexes Na2[M(Sac)3(L)], M(II) = Fe
(II), Co(II) , Ni(II), Cu (II), Zn(II) , and Cd(II).
HL= C29H24 ClN3O4S, L= C29H23 ClN3O4S -.
Synthesis, spectroscopic, electrochemical, magnetic properties and super oxid...IOSR Journals
Five new mixed-ligand nickel (II) complexes; viz; [Ni (BHM)(PMDT)]1; [Ni(BHM)(dien)] 2; [Ni(BHM)(L1)]3; [Ni(BHM)(L2)] 4, [Ni(BHM)(L3)] 5; where H2BHM= N’-(1E)-(5-bromo-2-hydroxyphenyl) methylidene] benzoylhydrazide, PMDT= N,N,N’,N,”N”-Pentamethyldiethylenetriamine; dien= diethylenetriamine; L1 = N,N- dimethyl-N’ (Pyrid-2-yl-methyl) ethylenediamine; L2= N-methyl-N’-(pyrid-2-ylmethyl)ethylenediamine; L3 = N,N-dimethyl-N’-(6-methyl)pyrid-2-ylmethyl) ethylenediamine, have been synthesized and characterized by using elemental analyses, FAB (fast atomic bombardment), magnetic measurements, electronic absorption , conductivity measurements, cyclic voltammetry (CV) and IR- spectroscopy . All the complexes yielded an irreversible couple that can be assigned to a NiII→ NiI redox process. Infrared spectra, ligand field spectra and magnetic susceptibility measurements agree with the observed octahedral environment. H2BHM is a diprotic tridentate Schiff base ligand (ONO donor atom) whereas L1-L3 possessing N3 coordination sites. The SOD activities have been measured using alkaline DMSO as a source of superoxide radical (O2–) and nitro blue tetrazolium (NBT) as O2– scavenger.
In Vitro Antioxidant evaluation and DNA binding ability of Ni(II), Co(II), Cu...IOSRJAC
: In the present study, the antioxidant and DNA binding properties of Ni(II), Co(II), Cu(II) and Zn(II) metal complexes containing bidentate Schiff base for their possible free radicals scavenging properties associated with various diseases were considered. The different models such as 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferrous ion chelation(FIC),ferric reducing antioxidant power(FRAP),total antioxidant activities(phosphomolybdenum methods) and hydroxyl radical(•OH) radical scavenging activities at different concentrations for antioxidant and DNA absorption spectroscopic analysis were assayed for DNA binding studies. The metal complexes were found to be significant dose-dependent antioxidant activities comparable with that of the classical antioxidants, ascorbic acid, ethylene diaminetetraacetic acid(EDTA) and DNA binding potential withkb 4.990×10-5M -1 ,4.989×10-5M -1 ,4.994×10-5M -1 and 5.012×10-5M -1 respectively.The compounds exhibited are very reactive towards DPPH radicals, OH radicals and Fe(II) ions and they also actively reduces Fe(III) ion to Fe(II) and Mo(VI) ion to Mo(V) form. The obtained results indicate the importance of Schiff base metal complexes as a source of synthetic antioxidants and anticancer drugs.
Micellar Effect On Dephosphorylation Of Bis-4-Chloro-3,5-Dimethylphenylphosph...IOSR Journals
The rate enhancement depends on the hydrophobicity of the nucleophile. The micellar catalyzed reaction between bis-4-chloro-3,5-dimethylphenylphosphate ester and hydroxide or hydroperoxide anions has been examined in buffered medium (pH 8-10). First order rate constant (Kψ) for the reaction of hydroxide ion with bis-4-CDMPP go through maxima with the increasing concentration of cetyltrimethylammoniumbromide (CTABr). Micelles of CTABr very effective catalyst to the reactions of phosphate diesters. Rate constants measured with OH2- ions are approximately twice and thrice than that of OH- ions in presence of CTABr.
Mixed Ligand, Palladium(II) and Platinum(II) Complexes of Tertiary Diphosphin...Karwan Omer
Palladium(II) and platinum(II) complexes containing the mixed ligands tertiary
diphosphinesdppm. dppp and dppf with Thioester ligand S-1H benzo[d] imidazole-2-yl benzothioate
(HSBIBT) have been prepared by the reaction of PdCl2 and PtCl2 with one equiv of tertiary
diphosphines ligands to form [Pd(k2-dppf)Cl2], [Pd(k2-dppp)Cl2] and [Pt(k2-dppmCl)Cl2] complexes
and then add the ligand HSBIBT to these complexes to form mixed ligand complexes. The prepared
complexes have been characterized by single-crystal X-ray diffraction, elemental analysis, magnetic
susceptibility, molar conductance, IR spectral data and UV-Visible. The results suggested that the
ligand HSBIBT bonded to the metal through N atom and square planner geometries were assigned
for the complexes.
International Journal of Engineering and Science Invention (IJESI)inventionjournals
International Journal of Engineering and Science Invention (IJESI) is an international journal intended for professionals and researchers in all fields of computer science and electronics. IJESI publishes research articles and reviews within the whole field Engineering Science and Technology, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Synthesis, Characterization and antimicrobial activity of some novel sulfacet...iosrjce
IOSR Journal of Applied Chemistry (IOSR-JAC) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of applied chemistry and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Chemical Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
SYNTHESIS AND CHARACTERIZATION OF SCHIFF BASE METAL COMPLEXES DERIVED FROM NA...chemsurya
New Schiff base metal complexes having general structural formulae ML2Cl2 where M= Co(II), Ni(II) and Cu(II), and MLCl2 where M=Zn(II), Cd(II) and Hg(II) were synthesized by the condensation of indoline-2,3-dione (Isatin) and naphtho[2,1-b]furan-2-carbohydrazide. Tentative structures for the synthesized compounds have been elucidated based on analytical, IR, 1HNMR, and Mass spectral studies. Further selected compounds were tested for their antimicrobial activity.
Synthesis and characterization of some metal complexes of 2- Phenyl-3,4-dihyd...IOSRJAC
2-Phenyl-3,4-dihydro-quinazolin-4-yloxy)-acetic acid (L1) metal complexes with Mn2+ , Co2+, Ni2+ Cu2+ , and Zn2+ ions were studied and the structure of the complexes were elucidated using elemental analyses, infrared (IR), 1H nuclear magnetic resonance (NMR), magnetic moment and thermal analysis measurements. Besides the characterization of complexes by physicochemical technique, Biological activities of the synthesized complexes were examined against some microbial strains for evaluation of antibacterial and antifungal activities.
Synthesis and Spectral Characterization of UO2(VI), Th(IV) and ZrO(IV) Complexes with benzimidazolyl-2-hydrazones of diacetyl monoxime and benzil monoxime
Ranjan Kumar Mohapatra1, Pradeep Kumar Das2
International Journal of Engineering and Science Invention (IJESI) is an international journal intended for professionals and researchers in all fields of computer science and electronics. IJESI publishes research articles and reviews within the whole field Engineering Science and Technology, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Antifungal Activities of Some Divalent and Trivalent Metal Chelates with 2-am...Taghreed Al-Noor
Five metal chelates of Co(II), Ni(II), Cu(II), Zn(II) and Cr(III) ions with mixed
ligands of a Schiff base: Namely, (E)-2-(4-(dimethylamino)benzylidene)amino)phenol derived from
4-dimethylaminobenzaldehyde and 2-aminophenol as main ligand (HL1) and 2-aminobenzoic acid as co-ligand
(HL2) have been synthesized and characterized by using several physiochemical tools. An octahedral structure was
suggested for all the chelates. The antifungal activity the ligands and their mixed ligand chelates against some pathogenic
fungi was studied by using agar well diffusion method. The obtained data showed that some of the chelates
have most active against A. niger, A. flavus, Alternaria alternata, Rhizopus stolonifer.
Vibrational Characterization and Antioxidant Activity of Newly Synthesized Ga...peertechzpublication
The gallium(III) complex of orotic acid (HOA) was synthesized and its structure was determined
by means of analytical and spectral analyses. Detailed vibrational analysis of HOA, sodium salt of HOA
(NaOA) and Ga(III)-OA systems based on both the calculated and experimental spectra confi rmed the
suggested metal-ligand binding mode. Signifi cant differences in the IR and Raman spectra of the complex
were observed as compared to the spectra of the ligand and confi rmed the suggested metal-ligand
binding mode.
Synthesis and Thermal Study of Co (II), Ni (II), Cu (II) Mixed Ligand Complex...IOSR Journals
The mixed ligand complexes of Co (II), Ni (II) and Cu (II) with histidine (His.) and 8-hydroxyquinoline (Qui.) have been synthesized and characterized.The resulting complexes were characterized by vibrational and electronic spectral data, thermogravimetric studies , metal analysis and molar conductance measurements. The histidine acts as tridentate ligand, coordinating through the two nitrogen atoms of imidazole ring and the amino group and carboxylate oxygen whereas 8-hydroxyquinoline shows a bidentate nature and the coordination occurs through nitrogen of imine group and oxygen of phenol group. The experimental data suggest that a mononuclear octahedral structure with general formula [M (His.)(Qui.) H2O ] where M= Co (II), Ni (II) and [Cu (His.)(Qui.)H2O] .H2O, thermo gravimetric studies reveal the presence of coordinated water molecules in all complexes. The molar conductance measurements reveal non-electrolytic nature of complexes.
A new Schiff base 4-chlorophenyl)methanimine
(6R,7R)-3-methyl-8-oxo-7-(2-phenylpropanamido)-5-thia-1-
azabicyclo[4.2.0]oct-2-ene-2-carboxylate= (HL)= C23H20
ClN3O4S) has been synthesized from β-lactam antibiotic
(cephalexin mono hydrate(CephH)=(C16H19N3O5S.H2O) and 4-
chlorobenzaldehyde . Figure(1) Metal mixed ligand complexes
of the Schiff base were prepared from chloride salt of
Fe(II),Co(II),Ni(II),Cu(II),Zn(II) and Cd (II), in 50% (v/v)
ethanol –water medium (SacH ) .in aqueous ethanol(1:1)
containing and Saccharin(C7H5NO3S) = sodium hydroxide.
Several physical tools in particular; IR, CHN, 1H NMR, 13C
NMR for ligand and melting point molar conductance, magnetic
moment. and determination the percentage of the metal in the
complexes by flame(AAS). The ligands and there metal
complexes were screened for their antimicrobial activity against
four bacteria (gram + ve) and (gram -ve) {Escherichia coli,
Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus}.
The proposed structure of the complexes using program, Chem
office 3D(2006). The general formula have been given for the
prepared mixed ligand complexes Na2[M(Sac)3(L)], M(II) = Fe
(II), Co(II) , Ni(II), Cu (II), Zn(II) , and Cd(II).
HL= C29H24 ClN3O4S, L= C29H23 ClN3O4S -.
Synthesis, spectroscopic, electrochemical, magnetic properties and super oxid...IOSR Journals
Five new mixed-ligand nickel (II) complexes; viz; [Ni (BHM)(PMDT)]1; [Ni(BHM)(dien)] 2; [Ni(BHM)(L1)]3; [Ni(BHM)(L2)] 4, [Ni(BHM)(L3)] 5; where H2BHM= N’-(1E)-(5-bromo-2-hydroxyphenyl) methylidene] benzoylhydrazide, PMDT= N,N,N’,N,”N”-Pentamethyldiethylenetriamine; dien= diethylenetriamine; L1 = N,N- dimethyl-N’ (Pyrid-2-yl-methyl) ethylenediamine; L2= N-methyl-N’-(pyrid-2-ylmethyl)ethylenediamine; L3 = N,N-dimethyl-N’-(6-methyl)pyrid-2-ylmethyl) ethylenediamine, have been synthesized and characterized by using elemental analyses, FAB (fast atomic bombardment), magnetic measurements, electronic absorption , conductivity measurements, cyclic voltammetry (CV) and IR- spectroscopy . All the complexes yielded an irreversible couple that can be assigned to a NiII→ NiI redox process. Infrared spectra, ligand field spectra and magnetic susceptibility measurements agree with the observed octahedral environment. H2BHM is a diprotic tridentate Schiff base ligand (ONO donor atom) whereas L1-L3 possessing N3 coordination sites. The SOD activities have been measured using alkaline DMSO as a source of superoxide radical (O2–) and nitro blue tetrazolium (NBT) as O2– scavenger.
In Vitro Antioxidant evaluation and DNA binding ability of Ni(II), Co(II), Cu...IOSRJAC
: In the present study, the antioxidant and DNA binding properties of Ni(II), Co(II), Cu(II) and Zn(II) metal complexes containing bidentate Schiff base for their possible free radicals scavenging properties associated with various diseases were considered. The different models such as 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferrous ion chelation(FIC),ferric reducing antioxidant power(FRAP),total antioxidant activities(phosphomolybdenum methods) and hydroxyl radical(•OH) radical scavenging activities at different concentrations for antioxidant and DNA absorption spectroscopic analysis were assayed for DNA binding studies. The metal complexes were found to be significant dose-dependent antioxidant activities comparable with that of the classical antioxidants, ascorbic acid, ethylene diaminetetraacetic acid(EDTA) and DNA binding potential withkb 4.990×10-5M -1 ,4.989×10-5M -1 ,4.994×10-5M -1 and 5.012×10-5M -1 respectively.The compounds exhibited are very reactive towards DPPH radicals, OH radicals and Fe(II) ions and they also actively reduces Fe(III) ion to Fe(II) and Mo(VI) ion to Mo(V) form. The obtained results indicate the importance of Schiff base metal complexes as a source of synthetic antioxidants and anticancer drugs.
Micellar Effect On Dephosphorylation Of Bis-4-Chloro-3,5-Dimethylphenylphosph...IOSR Journals
The rate enhancement depends on the hydrophobicity of the nucleophile. The micellar catalyzed reaction between bis-4-chloro-3,5-dimethylphenylphosphate ester and hydroxide or hydroperoxide anions has been examined in buffered medium (pH 8-10). First order rate constant (Kψ) for the reaction of hydroxide ion with bis-4-CDMPP go through maxima with the increasing concentration of cetyltrimethylammoniumbromide (CTABr). Micelles of CTABr very effective catalyst to the reactions of phosphate diesters. Rate constants measured with OH2- ions are approximately twice and thrice than that of OH- ions in presence of CTABr.
Mixed Ligand, Palladium(II) and Platinum(II) Complexes of Tertiary Diphosphin...Karwan Omer
Palladium(II) and platinum(II) complexes containing the mixed ligands tertiary
diphosphinesdppm. dppp and dppf with Thioester ligand S-1H benzo[d] imidazole-2-yl benzothioate
(HSBIBT) have been prepared by the reaction of PdCl2 and PtCl2 with one equiv of tertiary
diphosphines ligands to form [Pd(k2-dppf)Cl2], [Pd(k2-dppp)Cl2] and [Pt(k2-dppmCl)Cl2] complexes
and then add the ligand HSBIBT to these complexes to form mixed ligand complexes. The prepared
complexes have been characterized by single-crystal X-ray diffraction, elemental analysis, magnetic
susceptibility, molar conductance, IR spectral data and UV-Visible. The results suggested that the
ligand HSBIBT bonded to the metal through N atom and square planner geometries were assigned
for the complexes.
International Journal of Engineering and Science Invention (IJESI)inventionjournals
International Journal of Engineering and Science Invention (IJESI) is an international journal intended for professionals and researchers in all fields of computer science and electronics. IJESI publishes research articles and reviews within the whole field Engineering Science and Technology, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Synthesis, Characterization and antimicrobial activity of some novel sulfacet...iosrjce
IOSR Journal of Applied Chemistry (IOSR-JAC) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of applied chemistry and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Chemical Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Synthesis, structural characterization and biological activity of Cu(II), Co(...IJAEMSJORNAL
A novel series of metal complexes of 2-(thiazol-2-ylimino) thiazolidin-4-one ligand were prepared; the corresponding ligand was synthesized from reaction 2-Chloro-N-(thiazol-2-yl) acetamide with ammonium thiocyanate. The complexes are characterized by FTIR, UV-Vis, molar conductance and mass spectroscopy. The low molar conductance values indicate that the complexes are non-electrolytes.Spectroscopic studies confirmed that the ligand bonded to the metals through the sulphur atoms. Coordination number of copper and nickel complexes is four with square planar geometry, while the cobalt complex has octahedral geometry.In vitro antibacterial activity of ligand and its metal complexes was evaluated using well diffusion method and compared to the standard drug (tetracycline). The antibacterial activitywas examined against Escherichia coli, and pseudomonas aeruginosa, as gram negative bacteria and Staphylococcus aureus as gram positive bacteria. It was found that Nickel complex has the highest antibacterial activity among the synthesized compounds with Zone inhibition diameter in the range 25-29 mm.
Spectral studies of 5-({4-amino-2-[(Z)-(2-hydroxybenzylidene) amino] pyrimidi...IOSR Journals
Some transition metal ions Complexes with 5-({4-amino-2-[(Z)-(2-hydroxybenzylidene) amino]
pyrimidin-5-yl} methyl)-2,3,4-trimethoxybenzene were prepared and characterized by elemental analyses,
Infrared , magnetic moment, electronic spectra , mass spectra, X-ray powder diffraction, molar conductance
and thermal analysis (TGA). The complexes have general formulae [ML2.2H2O] {where M = Mn (II), Co (II), Ni
(II), Cu (II), Zn (II), Pd (II) and Pt (II). The coordination behavior of the metal ions towards to the investigated
Schiff base takes place through –C=N,-NH2 and –OH groups. The obtained C, H and N elemental analysis data
showed the Metal: Ligand ratio is 1:2 [M: L] ratio. The molar conductance data reveal that all the metal
complexes are non-electrolytic in nature. From the magnetic moments the complexes are paramagnetic except
Zn metal ion complexes have octahedral geometry with coordination number eight. The thermal behavior of
these complexes shows that, the hydrated complexes have loses two water molecules and immediately followed
by decomposition of the anions and ligand molecules in the second and third stage. The Schiff bases and metal
complexes show good activity against some bacteria. The antimicrobial results indicate that, the metal
complexes have better antimicrobial activity as compared to the prepared Schiff base.
Anthranillic acid and tributylphosphine4652 6725-1-pbTaghreed Al-Noor
Mixed ligand complexes of bivalent metal ions, viz; Co(II), Ni(II), Cu(II) and Zn(II) of the
composition [M(A)2((PBu3)2]in(1:2:2)(M:A:(PBu3). molar ratio, (where A- Anthranilate ion
,(PBu3)= tributylphosphine. M= Co(II),Ni(II),Cu(II) and Zn(II).
The prepared complexes were characterized using flame atomic absorption, by FT-IR,
UV/visible spectra methods as well as magnetic susceptibility and conductivity measurements. The
metal complexes were tested in vitro against three types of pathogenic bacteria microorganisms:
(Staphylococcus, Klebsiella SPP .and Bacillas)to assess their antimicrobial properties. Results. The
study shows that all complexes have octahedral geometry; in addition, it has high activity against
tested bacteria. Based on the reported results, it may be concluded that.The results showed that the
deprotonated ligand(nthranilc acid ) to anthranilate ion (A-) by using (KOH) coordinated to metal
ions as bidentate ligand through the oxygen atom of the carboxylate group (−COO−), and the
nitrogen atom of the amine group (-NH2), where the Tributylphosphine coordinated as a
International Journal of Engineering and Science Invention (IJESI)inventionjournals
International Journal of Engineering and Science Invention (IJESI) is an international journal intended for professionals and researchers in all fields of computer science and electronics. IJESI publishes research articles and reviews within the whole field Engineering Science and Technology, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Synthesis and Characterization of New Complexes of 2-(6-Methoxybenzo[d]thiazo...IOSR Journals
Abstract: The synthesis and characterization of manganese (ІІ), cobalt (ІІ), nickel (ІІ), copper (ІІ), zinc (ІІ), cadmium (ІІ) and mercury (ІІ) bidentate 2-(6-methoxybenzo[d]thiazol-2-ylamino)-2-phenyl acetonitrile ligand which was prepared from Benz aldehyde and 6-methoxybenzo[d]thiazol-2-amine in the presence of KCN and acidic medium. The complexes were synthesized by treating an ethanolic solution of the ligand with appropriate amount of metal salts [1:2] [M: L] ratio. The complexes were characterized by using metal and elemental chemical analysis, molar conductance, magnetic susceptibility measurements, FTIR , electronic spectral and mole ratio method. According to the obtained data the probable coordination geometries of manganese (ІІ), cobalt (ІІ), nickel (ІІ), copper (ІІ) zinc (ІІ), cadmium (ІІ) and mercury (ІІ) in these complexes are octahedral. All complexes were found to be non-electrolyte in absolute ethanol, and the complexes were formulated as [ML2Cl2] XH2O. Keywords: 2-(6-methoxybenzo[d]thiazol-2-ylamino)-2-phenyl acetonitrile, N2-donor, transition metals.
Synthesis and Crystal Structure of Anickel (II) and Zinc (II) Complex From 1,...IOSRJAC
:The title mononuclear nickel and zinc complexes, Ni(C11H9N4S3)2andZn(C11H9N4S3)2 .2(C3H7NO), were prepared by the reaction of Nickel(II) or Zinc(II)acetate with 1,5-bis[(2- thiophenyl)methylidene]thiocarbonohydrazide in a methanol solution. It features mono-deprotonated bisbidentate ligands, which coordinate to metal (II) ions by hydrazylN and thiocarbony lS atoms, yielding a tetracoordinated metal ions complexes. In Ni(II) complex the geometry around the metal ion is described as square planar. In the Zn(II) the metal atom shows severely tetrahedral distortion from anideal square-planar coordination geometry, as reflected by the dihedral angle between ZnN2and ZnS2 planes of 73.03(13)°. Two intramolecular hydrogen bonds are observed between the solvate dmf molecules and the coordinated ligands:N2—H2N…O1i and N6—H6N…O2 ii in this complex
Multiple Equilibria and Chemical Distribution of Some Bio Metals With β-Amide...IOSR Journals
Abstract: Solution Chemistry of some bivalent metal ions (viz. CoII , NiII ,CuII ,ZnII ) with β-amide α-aminosuccinate (Asparagine)/ α-aminoisoverate( Valine ) (A) and 5-methyl 2,4- dioxopyrimidine ( Thymine ) (B)ligands have been analyzed. Formation constant of quaternary metal complexes and complexation equilibria at 30±1ºC and at constant ionic strength (I=0.1M NaNO3 ) have been explored potentiometrically. Formation of quaternary species in addition to hydroxyl, protonated, binary and ternary species have been reported. Overall formation constant have been evaluated using SCOGS computer program.Species distribution curves of complexes have been plotted as a function of pH to visualize the equlibria system and was refined using ORIGIN program.The metal ligand formation constant of MA,MB,MAB and M1M2AB type of complexes follow Irving William order. The order of stability constants of quaternary systems have been observed as: Cu – Ni > Cu –Zn > Cu–Co > Ni – Zn > Ni – Co > Co –Zn. Solution structures of metal complexes with said ligands have been compared and discussed.
Design, Synthesis and Structural Inspection of Some Novel Di- And Tri-Azometh...CrimsonPublishersACSR
In this study, NBA imine compound was synthesized via an easy one-pot condensation of 3-nitro-benzaldyhide with 2-amino benzoic acid in 1:1 ratio and DAPH imine compound derived from 2,6-diacetyl pyridine and phenyl hydrazine hydrochloride. Consequences of the newly synthesized compounds
hooked up with the aid of FT-IR, elemental analyses, 13C-NMR ,1H-NMR and digital spectral research.
Experiments had been consistent with their chemical structures. Theoretical DFT calculations had been
implemented to confirm the molecular geometry of the investigated chemo-sensors. The sensor property
of all organized imines had been tested upon addition of the metal ions, consisting of Cr(III) ,Fe(II) ,Co(II) ,
Ni(II) ,Cu(II) ,Zn(II) ,Mn(II), VO(II) and Pd(II) .The interactions among receptors and ions are effortlessly
monitored with the aid of UV-visible spectroscopy. DAPH receptor confirmed color modification from
blood red to excessive deep green color to Co(II) ,a yellow color to Cu(II) and different colors to different
ions. Where the NBA receptor showed color modification from light yellow to excessive deep orange color
to Fe(II), pale orange to Pd(II) and different colors for other ions.
Synthesis, Characterization, Antibacterial and DNA Binding Studies of Mn (II)...IOSRJAC
Mn (II) complex of the Schiff base (L), 3-(2-(2-hydroxy-3-methoxybenzylidene) hydrazinyl) quinoxalin-2(1H)-one (VHQO) was prepared and characterized by IR, UV-VIS, Mass, Elemental analysis, TGDTA, magnetic susceptibility and conductivity measurements. VHQO behaved as monobasic, tridentate ligand and formed 1:2 complex (ML2) with the metal ion (M) coordinating through ring nitrogen, azomethine nitrogen and phenolic oxygen. Thermal analysis of the complex indicated the absence of lattice and coordinated water. Based on the spectral and analytical data, octahedral geometry was assigned to the complex. Antibacterial activity of the complex against gram positive bacteria, Bacillus subtillis, Staphylococcus aureus, and gram negative bacteria, Escherichia coli, Proteus vulgaris, Pseudomonas aeroginosa , and Klebsiella pneumonia was studied. The interaction of the complex with Calf Thymus DNA (CT-DNA) was studied by absorption spectroscopy and the intrinsic binding constant was calculated.
Shanghai ranking's global ranking of academic subjects 2020 chemistry convertedTaghreed Al-Noor
Shanghai Ranking's Global Ranking of Academic Subjects 2020 – Chemistry
http://www.shanghairanking.com/Shanghairanking-Subject-Rankings/chemistry.html
2020 تصنيف شنغهاي للجامعات حسب الموضوع – الكيمياء
Shanghai Ranking's Global Ranking of Academic Subjects 2020 Chemistry
prof .Taghreed H Al-Noor أ. د تغريد هاشم النور
جامعة بغداد University of Baghdad
that causes COVID-19 is called SARS-CoV
2020 - www.compoundchem.com @
prof .Taghreed H Al-Noor أ.د تغريد هاشم النور
University of Baghdad,Chair ACS Iraq chapter
Virtual International Scientific Conference Curriculum The Role Of Higher Education And Scientific Research Formations And National Institutions In Confronting The Corona Pandemic Forensic DNA Center for Research and Training / Al-Nahrain University .American Chemical Society ACS and its role in confronting Corona pandemic )
Prof. Taghreed Hashim Al.Noor Chairman chapter Iraq of the American Chemical Society
Asian Journal of Biochemistry is an International peer-reviewed journal dedicated to publish the results of original research in form of original articles, reviews and short communications. Scope of the journal includes: Structure, function and regulation of biologically active molecules; gene structure and expression; biochemical mechanisms; protein biosynthesis; protein folding; membrane structure-function relationships; bioenergetics and immunochemistry. Asian Journal of Biochemistry now accepting new submissions. Submit your next paper via online submission system.
ACS Iraq chapter
Supported
45Mins5th International Turkic World
Conference on Chemical Sciences and
Technologies (ITWCCST 2019)” which will take place in Sakarya,
Turkey between 25-29 October 2019.
1SecondScientific Committee
Taghreed H AL-NOOR
University of Baghdad, Iraq chair ACS IRAQ member in
http://2019.itwccst.org/?page_id=149
Catalysis, chemical engineering 2019 taghreed al noorTaghreed Al-Noor
Synthesis, spectroscopic characterization, biological Activity and dye on
cotton fabric of mixed ligand metal complexes derived From curcumin and Lphenyl alanine, schiff Base and anthranilic acid
DFT, cytotoxicity and molecular docking studies of (E)-2((2- hydroxybenzylide...Taghreed Al-Noor
Kathmandu Symposia on Advanced Materials (KaSAM)-2018; October 26-29, 2018, Kathmandu, Nepal
DFT, cytotoxicity and molecular docking studies of (E)-2((2-
hydroxybenzylidene) amino-3-mercaptopropanoic acid and its Co(II),
Ni(II) and Cu(II) complexes
M.M. El-ajaily1*, S.S. Mahmoud2, R.N. El-daghare1, A.K. Sarangi3, R.K. Mohapatra3* and T.H.
Al-Noor4
1Chemistry Department, Faculty of Science, Benghazi University, Benghazi, Libya
2Chemistry department, Faculty of Science, Cairo University, Giza, Egypt
3Department of Chemistry, Government College of Engineering, Keonjhar, Odisha, India
4Chemistry Department, Ibn-Al-Haithem College of Education for Pure Science, Baghdad University,
Baghdad, Iraq
*E-mail: ranjank_mohapatra@yahoo.com
The cytotoxicity studies of a Schiff base; (E)-2((2-hydroxybenzylidene)amino-3-mercaptopropanoic acid
(HL) derived from the condensation of 2-hydroxybenzaldehyde and L-cysteine and its Co(II), Ni(II)
and Cu(II) complexes have been reported against four cancer cell lines. The evaluation of the growth
inhibitory on human cancer cells is studied for the chelates against HCT-116, MCF-7, HFB-4,
HepG-2 cell lines. The obtained results (Fig. 1) revealed that the compounds are active against human
hepatocellular carcinoma cell line (HepG-2).
Scimago journal & country rank taghreed al noorTaghreed Al-Noor
Scimago Journal & Country Rank
ترتيب الدول من ناحية نشر الباحثين في المجلات العالمية المصنفة و
H index جودة البحوث من خلال عدد الاقتباسات
حسب موقع
)SJR (Scimago Journal Rank الترتيب خاص بسنة 201
ACS GCCE Chemical Society ACS GCCE Chemical Society ACS GCCE Chemical Society ACS GCCE Chemical Society ACS GCCE Chemical Society ACS GCCE Chemical Society ACS GCCE Chemical Society ACS GCCE Chemical Society Capacity Building Workshop Capacity Building Workshop Capacity Building Workshop Capacity Building Workshop Capacity Building Workshop Capacity Building Workshop Capacity Building Workshop 14 -18 October, 2018 October, 2018October, 2018 October, 2018
•
3rd Internatioanl Medical Congress, will be hold in Kerbala, Iraq in 14-15 De...Taghreed Al-Noor
3rd Internatioanl Medical Congress, will be hold in Kerbala, Iraq in 14-15 December 2018 by Nab'a Al-Hayat Foundation for Medical Sciences and Health Care, and in collaboration with (University of Kerbala, University of Kufa, Directory of Research -Ministry of Health Oman, University of Sussex, University of Komar, University of Diyala, University of Qaddisya, University of Al-Anbar, University of Al-Mustansariya and Helal Iran Pharmaceutical Complex.
Facial Acne Therapy by Using Pumpkin Seed Oil with Its Physicochemical Proper...Taghreed Al-Noor
The herbal remedy individually or in combination with standard medicines has been used in diverse medical treatises for the cure of different diseases. Pumpkin seed oil is one of the recognized edible oil and has substantial medicinal properties due to the presence of unique natural edible substances. Inflammation is an adaptive response that is triggered by noxious stimuli and conditions, which involves interactions amongst many cell types and mediators, and underlies many pathological processes. Unsaturated fatty acids (UFAs) can influence inflammation through a variety of mechanisms, and have been indicated as alternative anti-inflammatory agents to treat several inflammatory skin disorders. Pumpkin seed oil is rich in (UFAs), that its topical anti-inflammatory properties have been investigated. For that reason, the goal of this article was to evaluate the effects of pumpkin seed oil on acute and chronic cutaneous inflammation experimental models. The extracted pumpkin seed oil had an acceptable initial quality, when it was extracted using soxhlet extraction method and was characterized using standard methods .The physicochemical parameters of purified oil were determined. The boiling point of pumpkin seed oil was (158.90 oC) that equal to the values obtained in literature for some oil seeds, but lower than the boiling point of the oils studied, plus the melting point of pumpkin seed oil was (15.39 oC) that lead to a characteristic in cold cream manufacture. The iodine value was (104 ± 0.03 mg of KOH/g) of oil, indicated a high degree of unsaturation. The saponification value was (181± 3.2 mg KOH/g), this value indicated the pumpkin seed oil had fatty acids with higher number of carbon atoms. As a final point, the acid value was
Bidentate Schiff base ligand 3-(3,4-Dihydroxy-phenyl)-2-[(4-dimethylamino-benzylidene)-amino]-2-methyl-propionic acid was prepared and characterized by spectroscopic techniques studies and elemental analysis. The Cd(II), Ni(II), Cu(II), Co(II), Cr(III),and Fe(III) of mixed-ligand complexes were structural explicate through moler conductance , [FT-IR, UV-Vis & AAS], chloride contents, , and magnetic susceptibility measurements. Octahedral geometries have been suggested for all complexes. The Schiff base and its complexes were tested against various bacterial species, two of {gram(G+) and gram(G-)} were shown weak to good activity against all bacteria.
1. Advances in Physics Theories and Applications www.iiste.org
ISSN 2224-719X (Paper) ISSN 2225-0638 (Online)
Vol.27, 2014
8
Preparation, Characterization, and Antibacterial Properties of
mixed ligand Complexes of L-leucine and Sulfamethoxazole
with Mn(II),Co(II),Ni(II),Cu(II),Zn(II),Cd(II)and Hg(II) ions
Raheem Taher Mahdi , *Taghreed H. Al- Noor , Ahmed .H. Ismail
Chemistry Department, College of Science, Al-Mustansiriyah University, IRAQ
*Chemistry Department, Ibn -AI-Haithem College of Education, University of Baghdad, IRAQ
*Corres. author : drtaghreed2@gmail.com, & dr.raheem.T@gmail.com
Abstract:
The research includes the synthesis and identification of the mixed ligands complexes of M+ 2
Ions in
general composition ,[M(Leu)2(SMX)] Where L-leucine(C6H13NO2)symbolized (LeuH) as a primary ligand and
Sulfamethoxazole (C10H11N3O3S)symbolized (SMX)) as a secondary ligand .
The ligands and the metal chlorides were brought in to reaction at room temperature in(v/v) ethanol /water as
solvent containing NaOH. The reaction required the following [(metal: 2(Na+
Leu-
): (SMX)] molar ratios with M(II)
ions, Were M(II) Mn(II),Co(II),Ni(II),Cu(II),Zn(II),Cd(II)and Hg(II). The UV–Vis and magnetic moment
data revealed an octahedral geometry around M(II), The conductivity data show a non-electrolytic nature of the
complexes. The antimicrobial activities of ligands and their mixed ligand complexes were screened by disc diffusion
method.
Keywords: Sulfamethoxazole(antibiotic), L-leucine, Mixed ligand, Metal complexes, Antimicrobial activity.
INTRODUCTION :
L- leucine is one of the twenty major amino acids and is considered an essential amino acid [1]. ( figure 1-
Formula 1) It is branched chain amino acid and taken up by brain and muscle. In leucine metabolism, transamination
gives -keto isocaproic acid, which is converted into corresponding CoA, this is similar to oxidative decarboxylation
of alfaketoglutarate and pyruvate. The enzyme complex is very important in the body of living organism. A
deficiency of the enzyme causes maple syrup urine disease. In this disease the urine gives odor of maple syrup or
burnt sugar deterioration is rapid and results in mental retardation. [2].The amino acid L-leucine and various
transition metals are important in the biological functions of humans, animals, and plants. [1-2].
(C10H11N3O3S) (IUPAC name = 4-amino-N-(5-methylisoxazol-3-yl)- Sulfamethoxazole
4-amino-N-(5-methylisoxazol-3-yl)-benzenesulfonamide ( figure 1- Formula 2) is a sulfonamide bacteriostatic
antibiotic. It is most often used as part of a synergistic combination with trimethoprim in a 5:1 ratio in
co-trimoxazole, also It is commonly used to treat urinary tract infections. In addition it can be used as an alternative
to amoxicillin-based antibiotics to treat sinusitis. It can also be used to treat toxoplasmosis.[4] It is also applicable for
antiseptique, atitubercular and anti-inflammatory agent.
2. Advances in Physics Theories and Applications www.iiste.org
ISSN 2224-719X (Paper) ISSN 2225-0638 (Online)
Vol.27, 2014
9
…
Sulfamethoxazole (2) L-leucine (1)
figure -1-
The investigation of metal sulfonamide compounds has received much attention due to the fact that sulfonamides
were the first effective chemotherapeutic agents to be employed for the prevention and cure of bacterial infections in
humans [4-5]. The sulphur containing ligands are well known for their anticarcinogenic, antibacterial,tuberculostatic,
antifungal, insecticidal, and acaricidal activities [5]. Such sulfonamide derivatives widely used in clinical medicine
as pharmacological agents with a wide variety of biological actions, were designed from the simple sulfanilamide
lead molecule [6], also Schiff base known as anticancer and antiviral agents [7]., and its metal complexes have been
widely studied because they have industrial, anti-fungal, anti-bacterial, anticancer herbicidal applications,
anti-tubercular activities [8].N-Substituted sulfonamides are still among the most widely used antibacterial agents in
the world, mainly because of their low cost, low toxicity, and excellent activity against bacterial diseases. [6],
Literature survey shows that no studies on the synthesis and characterization of mixed ligand complexes of L-
leucine and Sulfamethoxazole(antibiotic) have been reported.
In this paper we present the synthesis and study of Mn(II),Co(II),Ni(II),Cu(II),Zn(II),
Cd(II)and Hg(II) complexes with amino acid (L-leucine) as a primary ligand and Sulfamethoxazole (antibiotic)
as a secondary ligand.
2. Experimental
2.1. Materials and instruments
All chemicals were purchased from Merck / Aldrich. The reagents were used without further purification .
Double distilled water was used.
b- Instruments: FT-I.R spectra were recorded as K Br discs using Fourier transform Infrared Spectrophotometer
Shimadzu 24 FT-I.R 8400s. Electronic spectra of the prepared complexes were measured in the region (200- 1100)
nm for 10-3
M solutions in N, N-dimethylsulphoxide (DMSO) at 25ºC using shimadzu-U.V-160.A Ultra Violet
Visible- Spectrophotometer with 1.000 ± 0.001 cm matched quartz cell. While percentage of the metal in the
complexes were determined by Atomic Absorption(A.A)Technique using Japan A.A-67G Shimadzu. Electrical
conductivity measurements of the complexes were recorded at at room temperature for 10-3
M solutions of the
samples in (DMSO) using pw9527 Digital conductivity meter (Philips). Melting points were recorded by using
Stuart melting point apparatus. ,Magnetic susceptibility measurements were measured using Bruker magnet BM6
instrument at 298K following the Farady’s method. The proposed molecular structure of the complexes were
drawing by using chem. office program, 3DX (2006).
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2.2. Preparation of Complexes :
The complexes of the series [M (SMX)(Leu)2]. were prepared by the following general method :
(A) Sodium leucinate(Na+
Leu-
): The amino acid L-leucine [0.262 gm, 2 m mol] was dissolved in 10 ml
H2O/ethanol (50%) mixture containing Na OH (2 m mol 0.8 g) in a flask and stirred at room temperature (20 ºC).,
the solution was deprotonated according to the Scheme (1).
(B) General synthesis of the mixed ligand metal complexes[11]
A metal(II) chloride [(0.197g , MnCl2.4H2O , CoCl2.6H2O(0.237g,1mmol),NiCl2.6H2O (0.237g, 1mmol),
CuCl2.2H2O(0.136g, 1mmol), ZnCl2 (0.137g, 1mmol), CdCl2 (0.183g, 1mmol),and HgCl2 (0.271g,1mmol)]dissolved
in in ethanol: water (1:1) 25ml respectively was added gradually with stirring to solution of Sodium leucinate
(Na+
Leu-
).(0.253gm , 1mmole) of Sulfamethoxazole (SMX) was added to the mixture in each case by using
stichiometric amount [(1:2:1) [(metal: 2(Na+
Leu-
): (SMX)] molar ratios, the above reaction mixture to raise the pH
upto ~6.0 and the mixture was stirred for (20 -30mint)at room temperature. scheme (1) After one day a colored
microcrystalline solid was obtained which was filtered. and washed with ethanol. The solid was recrystallized from
a H2O/ethanol (50%) mixture. and dried in vacuum over anhydrous CaCl2. The yields range from 75 to 92 %. The
decomposition temperatures range from: 216-340 ºC.
3-Results and Discussion
Resent study involves synthesis of seven new metal mixed ligand complexes with their Characterization using
spectroscopic techniques and studying their Antibacterial Properties Application .A number of metallic complexes of
L-leucine and Sulfamethoxazole with Mn(II),Co(II),Ni(II),Cu(II),Zn(II),Cd(II)and Hg(II) ions ,were synthesized
from ethanol –aqueous medium 1:1 ratio ;General schem (1) of reaction as follow .The physical properties of the
complexes are shown in (Table 1), All the complexes are colored, non-hygroscopic The complexes decomposed at
high temperature on heating. These are insoluble in water or most of the organic solvents like methanol, benzene and
carbon tetrachloride , DMF but soluble in DMSO.
The observed molar conductance (ΛM) of 10-3
solutions of the complexes in DMSO. lie in very low range (3-28)
Ω-1
cm2
mol-1
supporting their non-electrolytic behavior [9]. The atomic absorption measurements (Table-1-
Calculated values in parentheses) for all complexes gave approximated values for theoretical values .The analysis
data (Table-1) of metal complexes are consistent with their general formulation as 1:2:1, mixed ligand complexes of
the type [M (Leu)2 (SMX)].
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S
O
O
NH
O
NH2N
NH2
CH
CH2C
O
OCH
CH3H3C
H2N
CH
C
CH2
O
O
CH
CH3
CH3
Mn
NH2
O
HO + 2NaOH
1:1 H2O:C2H5OH
NH2
O
NaO
S
O
O
H
N
ON
H2N +
NH2
O
NaO
1:1H2O:C2H5OH
2 2
+ MCl2
M(II) = Mn(II),Co(II),Ni(II),Cu(II),Zn(II),Hg(II),andCd(II)
+2H2O
2
Scheme (1) : Preparation of [M(Leu)2(SMX)] complexes
Fourier-transform infrared spectra and m[of coordination :
The relevant vibration bands of the free ligands and the complexes are in the region 400–4000 cm−1
[8-15]. The
most important infrared spectral bands that provide conclusive structural evidence for the coordination of the ligands
to the central metal ions .
The assignment of some of the most characteristic FT-IR band of the complexes are shown in Tables (2-4)
together with those of two ligands recorded for comparative purposes and facilitate the spectral analysis . In
amino acids, NH3+ appears in 3130-3030 cm-1
region [9]. Table (2), displays the (FT-IR) spectrum for the
(L-leucine )exhibited a band around υ(3458) cm-1
that corresponds to the stretching vibration of (N-H) + (O-H),
while another strong absorption band at υ (3055) cm-1
is due to the (N-H2)sym while the bands at (8511) cm-1
and (8108) cm-1
were assigned to the (-COO)asy and (-COO)sym respectively. Δ (-COO)asy-sym =171 cm-1
.
[8-10].
A general tendency in the relationship between (COO_
) (the difference between the wave numbers of the
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asymmetric ( asym) and the symmetric (sym) stretches of carboxylate group from the FT-IR spectra) and the types
of coordination of the (COO-
) group to metal ions by examining the structures.
In the experimental FT-IR spectra of leucinate the wave numbers of asymmetric and symmetric stretching vibrations
of carboxylic anion change their position along the series of metals
M(II) Mn(II),Co(II),Ni(II),Cu(II),Zn(II),Cd(II)and Hg(II) (see Table 4). Namely, the band of sym(COO-
) is shifted
toward higher wave numbers in spectra of mixed ligand, whereas the band of asym(COO-
) is shifted towards lower
wave numbers[11].Thus, (L-leucine ) molecule acts as bidentate monobasic ligands, coordinating through
deprotonated carboxylic oxygen(-COO-) group, and its nitrogen of (-NH2) group [12, 13]. Table (3), displays the
(FT-IR) spectrum for the (sulfamethoxazole).
In case of (SMX) molecule the δ (N–H) vibrations of –NH2(aromatic sec. amine) occur at
3468 and 3378 cm−1
for free (SMX) due to as (NH2) and s (NH2),respectively. The hypochromic effect (decreasing
in the intensity of (NH) vibrations in case of mixed ligand complexes rather than (SMX) alone as well as the
blue shifted in the wave numbers from 3299 cm-1
[12, 13]
to range ( 3208 cm-1
) (mixed complex). Such these changes clearly indicate that the lone pair of electron of NH2 and
in sulfamethoxazole donor is participated in the complexation process with metals. acting as bidentate ligand. Where
as sulfoxide (S=O) stretching occurs at , 1365 [ν, νas(SO2 ], (1148and 1025)cm−1
[s, νs(SO2)]. The band of C=C occurs
at 1622-1469 cm-1
,aromatic (C=C) at 1469 cm-1
and alkenes (C=C) at 1622-1680 cm-1
, cm−1
[12]. and imine peak
(C=N) 1622 cm-1
.The (C–N) of isoxazol-3-yl group occurs at 1309 cm−1
, this band remains ~ (in the same region
free ligand and in solid complexes. Thus, indicating its non involvement in coordination of the ligand with the metal
ions .Finally, the bands at 1336 and 1162cm–1
represent the asymmetric and symmetric stretching frequencies,
respectively, of the sulfonyl group (S =O str) [12, 13].In case of complexes, [M(Leu)2(SMX)] , whereas sulfoxide
stretching shifts to higher and lower frequencies respectively at ~106/55 cm−1
due to coordination of the sulfonyl
oxygen with metals in all the complexes. Hence in these complexes sulfamethoxazole, also acts as bidentate ligand
coordinating through the oxygen of the sulphone group and nitrogen of the amine group. All the complexes are in
agreement with octahedral geometry as proposed.[14,15].In the IR spectra new bands have been observed in the region
600- 400cm-1
which may be due to (M-N) and (M-O) bonds respectively. [14-17]
Magnetic Susceptibility:
Magnetic susceptibility was determined at room temperature using solid sample by Gouy method.
Diamagnetic correction of metal- ligand system was calculated using the Pascal's constant. .The magnetic moments
of the complexes shown in( Table -3) were calculated from the measured magnetic susceptibilities after employing
diamagnetic corrections and revealed their diamagnetic nature as expected for Zn(II), Hg(II),Cd(II), with
(3d10
,4d10
,5d10
)configurations .The magnetic moment values o,[Mn(Leu)2(SMX)] lie in 6.182 BM indicating high
spin octahedral stereochemistry of the complex. The magnetic moments of , [ Co (Leu)2(SMX)]complex lie in
4.635 BM which are in agreement with the generally accepted values for high spin octahedral Co(II) complexes. The
magnetic moment values for the [Ni(Leu)2(SMX)]complex lie in 3,007 BM which reveals the octahedral
stereochemistry of the ligands around Ni(II) ion. The observed magnetic moments of [Cu (Leu)2(SMX)] lie in
1.478BM showing one unpaired electron with paramagnetic nature and suggested a distorted octahedral geometry in
teams of Jahn-Teller effect. [17- 18]
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Vol.27, 2014
13
Electronic spectral :
The (U.V- Vis) spectrum for the spectrum of Leucine show an absorption band at 305 nm (32786 cm-1
) in
(DMSO) solvent, this band is attributed to (*).The UV -Vis spectrum of the free ligand (SMX)in (DMSO)
solvent appeared a high intense absorption bands at 275 nm (36363 cm-1
)
(ε max=1951 L. mol -
. cm-1
) ,this band is attributed to (*).[19-20]
The parameters ligand Field Splitting Energy 10 Dq, Racah's Interelectronic Repulsion Parameters (B'),
Nephelauxetic Ratio β and B' are calculated.[21]
The [Mn (SMX) (Leu)2] complex with d5 configuration exhibits absorption bands in the region 11135, 11402 &
19083 cm-1
. These bands may be attributed to number of spin forbidden transitions involving 6A1g ground and
several higher energy quartet states, which were in consistent with octahedral geometry around Mn (II) metal ions.
10 D q =11.135 ,1/ 2 = 0.97, 2/ 1 =1.02 from Tanabe-Sugano diagram for d5
octahedral field, These values are
found in accordance as reported in the literature for Mn(II) octahedral complexes.
The (U.V- Vis) [Co (SMX) (Leu)2] spectrum, exhibits four peaks , the first high intense peak at (257
nm)( 38910 cm-1
)( ε max =1225 molar-1
. cm-1
), is due to the ligand field, and at 11135, 11402 and 19083 cm-1
,
there are assigned to 4T1g(F)→ 4T2g(F) (υ1) 4T1g(F)→ 4A2g(F) (υ2) and 4T1g(F)→ 4T1g(p) (υ3)
transition respectively, which are characteristic of octahedral stereo geometry : .[ 22-24].
,1/ 2 = 0.97, 2/ 1=1.02 from Tanabe-Sugano diagram for d7
octahedral field the value of 10Dq equal to 11.135
cm-1
, B'=950 cm-1
, β =0.997 cm-1
.The Co(II) complex under present investigation process interelectronic repulsion
parameter (B' ) 950 cm-1
. The Racha parameter (B) is less than free ion value (973) suggesting a considerable
orbital overlap and delocalization of electrons on the metal ion. The nephelauxetic ratio (β) for the present Co(II)
complex (0.997). This is less than one, suggesting partial covalence in the metal ligand bond. [23- 25] suggest the
octahedral geometry .
(U.V- Vis) [Cu(SMX) (Leu)2] spectrum, exhibits two peaks , the first high peak at (265
nm)( 37735 cm-1
)( ε max =1905molar-1
. cm-1
) is due to the (CT) , while the second weak broad peak at (610
nm)( 16393 cm-1
)( ε max =112 molar-1
. cm-1
), which assigned to (2Eg→2T2g), transition . Hence the Cu(II) mixed
ligand complexes showed distorted octahedral geometry.
The (U.V- Vis) spectrum of [Ni (SMX) )(Leu)2], exhibits five peaks , the first middle peak at (251
nm)(37453cm-1
)( εmax =1391 molar-1
.cm-1
) is due to the ligand field and the second high peak at (263 nm)( 38022
cm-1
)( ε max =1.248 molar-1
. cm-1
) is due to (C.T) , third, fourth, and fifth peaks assignment of the electronic spectral
bands for, Ni(II) are 3A2g →3T2g(F) 1=(891nm) 11223 cm-1
)( ε max =72 molar-1
. cm-1
), 3A2g (F) →3T1g(F) 2=
(885 nm)( 11299 cm-1
)( ε max =56 molar-1
. cm-1
),and at (873 nm)
( 11454cm-1
)( ε max =5 molar-1
. cm-1
) can be assigned to the ,3A2g(F) →3T1g(p) (3), 2/ 1 =1.006 , 1/ 2
=0.99, 10Dq=11.223, B'=966 cm-1
, β=0.85, typical of Ni(II) ground state 3A2g(F)] octahedral complexes.
The 2/1 = 1.006 value are found in the usual range (1.056-1.082) reported for the majority of
octahedral Ni(II) compounds. [21]
The electronic spectra of d10
[Zn(II) ,C d(II)and Hg(II)]complexes do show the charge transfer , and the
magnetic susceptibility shows that all complexes have diamagnetic moments., because d-d transitions are not
possible hence electronic spectra did not give any fruitful information. in fact this result is a good agreement with
previous work of octahedral geometry. [21-22]
Antibacterial Activities studies:
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Vol.27, 2014
14
The zone inhibition of bacterial growth were measured in mm depending upon the diameter as shown in
Table (6) Figure. (2)
Table 6 reveal that the synthesized compounds were potent as bacteriostatic agents.
The synthesized metal complexes were screened for their antimicrobial activity by well plate method in nutrient agar .
The invitro antibacterial activity was carried against 4 hold cultures of pathogenic bacteria like gram (+)and gram (-) at
37o
C. In order to ensure that solvent had no effect on bacteria, a control test was performed with DMSO and found
inactive in culture medium. All the metal complexes showed good activity against gram (+)Acineto .Ni(II) complex
have no effect on E-coli., staphylococcus and Psedomonas. S-aureus and gram (-) Except Ni(II) complex. Table
(5).while the Mn(II) complex was active against two organisms staphylococcus and Acineto. The staphylococcus was
affected vigorously by mixed ligand, Hg(II), Co(II), Cu (II) ,Zn(II)and Cd(II) respectively. E-coli. was moderately
affected by the ligands, Zn(II),and Co(II), complexes.[23-24] .In metal complexes, on chelation the polarity of the
metal ion will be reduced to a greater extent due to the overlap of the ligand orbital and partial sharing of the positive
charge of the metal ion with donor groups. Further, it increases the delocalization of π- electrons over the whole
chelate ring. This increased lipophillicity enhances the penetration of the metal complexes into lipid membranes and
block the metal binding lists in the enzymes [25] .
CONCLUSION:
We have successfully synthesized the mixed ligand complex of
M (II)=Mn(II),Co(II),Ni(II),Cu(II),Zn(II),Cd(II)and Hg(II) containing O-N donor ligands. The complex was also
characterized by molar conductance, magnetic susceptibility measurement and also by FT- IR, UV- visible
spectroscopy. The UV–Vis and magnetic moment data revealed an octahedral geometry around M(II), (schem1
-3D).The conductivity data show a non-electrolytic nature of the complexes.
REFERENCES:
[1]Schonheimer R, The dynamic state of body constituent, Harvard Univ. Pr. Cambridge (Mass)(1942).
[2]Bhimrao C. Khade, Pragati M. Deore, Sudhakar R. Bhusare1 and Balasaheb R. Arbad, (2010),International
Journal of Pharmaceutical Sciences Review and Research, Volume 4, Issue 2, September – October 2010; Article 002
[3] Moamen S. Refat , Sabry A. El-Korashy ,Ibrahim M. El-Deena, Shaima M. El-Sayed , (2010), Journal of
Molecular Structure 980 , 124–136
[4] Parihar M. S. and Khan. F. (2008), Ecl. Quím., São Paulo, 33(1): 29-34.
[5] Wang; G. (2005), Journal of Zhuanli Shenqing Gongkai Shuomingshu, 6pp
[6] Forgacs, P. Wengenack N. L., Hall L., Zimmerman S. K., Silverman M. L. and Roberts G. D.; (2009). Journal of
Agen. Chemo.,53, 4789-4793.
[7] Trikudanathan S. and McMahon G. T.;. Clini. Prac. Endo. Meta. (2008)., 4, 262-271
[8]Dai, Hui-Xiong; Antonia F. Stepan, Mark S. Plummer, Yang-Hui Zhang, and Jin-Quan Yu Divergent C, ( 2011)., J.
Am. Chem. Soc, April 13.
[9] Geary, W. J. (1971) The Use of Conductivity Measurements in Organic Solvents for the
Characterization of Coordination Compounds. Coord. Chem. Rev., 7, 81-122.
[10] Bellamy, L.J. (1978) The Infra Red Spectra of Complexes Molecules. Vol. 1. Chapmann &Hall, London,.
[11] Kalinowska, M. wisłocka, R.S´,Lewandowski W. (2007), J. Mol. Struct. 572 ,834–
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836.
[12] Wilkinson G. (1987) (Ed.), Comprehensive Coordination Chemistry,vol. 5, Pergamon, Oxford,.
[13]Nakamoto; K ,(1996) “Infrared spectra of Inorganic and coordination compounds “4ED th ;J .Wiely and Sons,
New york,
[14] Garfinkal, (1958). D., J.T. J. Amer. Chem. Soc. 80, 3807-3812.
[15]Moamen S. Refat ,Sabry A. El-Korashyc ,Shaima M. El-Sayed. Bellamy L.J, (1975),
The infrared Spectra of Complex Molecules, Chapman & Hall, London,
[16] Silverstein, R. M. (2009), Spectrophotometric Identification of Organic Compounds, John Wiley, New York, NY,
USA.
[17] Maurya, R. C. Chourasia J. and Sharma P., Indian j. of chemistry, (2007), 46A, 1594-1604.
[18] Karthikeyan G. , Mohanraj K. , Elango K. P. and Girishkumar, K. (2006), Russian Journal of Coordination
Chemistry; 32(5) 380–385.
[19]Lever, A.B.P. (1984), Inorganic Electronic spectroscopy, Elsevier, New York.
[20] Mohamed G. G., Nour El-Dien, Khalil, S. M.and Mohammad, A. S. (2009) Journal of Coordination Chemistry,
vol. 62, no. 4, pp. 645–654.
[21] Baulhausen, C.J. (1962) "An Introduction to Ligand Field " Mc Graw Hill, 1st ed, New York.
[22] Sharma R.C, Giri P.P, Devendra Kumar and Neelam(2012), J. Chem. Pharm. Res., 4(4): 1969-1973.
[23]Taghreed H. Al-Noor , Ahmed . T. AL- Jeboori , Manhel Reemon , Journal of Chemistry and Materials
Research , 2013 Vol.3 No.3, 114-124.
[24]Taghreed H. Al-Noor , Ahmed T.. AL- Jeboori , Manhel Reemon ,( 2013 )Journal Advances in Physics
Theories and Applications Vol.18, 1-10.
[25]Vaghasia Y, Nair R, Soni M, Baluja S, Chanda S. J Serb Chem Soc( 2004);69:991.
9. Advances in Physics Theories and Applications www.iiste.org
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Vol.27, 2014
16
Table 3-FT-R spectral data of Sulfamethoxazole
(C-S)
(S-N
(SO2)
sy
(C–O)
C–N
SO2
asy
C–H
def
(N–H)
Ring
breathing
bands
(C=C)
(C–H)
+
; CH3
(C–H);
aroma
ticy
as
(N–H);
–s NH2
& –NH
831
vs
987w1157
1143
1091
1266
ms
1309
s
1365 s1504
1469
1597 vs1622
vs
2929 w,
2858
3378
3143 s
3468as
3033s
Table 1 : Analytical and some physical data of the complexes
N
O.
Complexes Formula
weight
g/mol
Color Yield
%
Decomposition
temperatures
C
Λ m
Ω-1
.cm2
.mole-1
Metal%
(theory)
1 [Mn(SMX)(Leu)2] 569.55 Brown 86 261-264 28 (9.65)
9.98
2 [Co(SMX)(Leu)2] 573.54 Viol 75 254-258 19 (10.28)
11.08
3 [Ni(SMX)(Leu)2] 573.30 Green 78 240-247 18 (10.24)
8.63
4 [Cu(SMX)(Leu)2] 577.16 Blue 92 241-250 18 (10.99)
8.63
5 [Zn(SMX)(Leu)2] 580.02 White 80 216-220 17 (11.28)
9.98
6 [Cd(SMX)(Leu)2] 627.02 White 85 280-285 11 (17.93)
15.37
7 [Hg(SMX)(Leu)2] 715.20 White 90 291-296 3 (28.05)
Table 2-FT-R spectral data of Leucine
Δ
(-COO)
asy-sym
(-COO)sym
(-COO)asy
(C–H) +
; CH3
Δ
(N-H2)sym
(N-H)+
(O-H)
Leucine
1084108vs4546vs2958,2874m3473055s3417mC6H13NO2
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17
Table 4-FT-R spectral data of complexes
M-OM-N
(SO2)
sy
C–N
-COO)
sym
COO)a
sy
SO2
asy
C–H
defor
mation
def
(N–H)
Ring
breathing
bands
C=C
C–H
+
; CH3
(C–H)
aromaticy
as
(N–H);
s NH2
& –NH
No.
497
459
515
522
1172 m
1049
m
1025
mw
1307
w
13611
m
140840311516 s
1469 s
1581
vs
1660
w
2956 vs,
2872w
3392s
, 3271vs
3419m1
Mn
574640
601
1179 m1313
w
13331467s4034-1621vs1654
vs
2958
,2878w
3394vs
,3234
3460s2
Co
522
497
609
584
m
1120 m
1091 s
1058m
1307
w
4011s1471s40151469w1595vs1635
vs
2953vs
,2929s
3298vs3459vs3
Ni
522
w
495
w
570
557
1136vs
1111vs
1053m
1307
w
1375s1496m
s
s
4031
1494m
1454m
1566s1620
vs
2958vs
,2929s
3246vs,
3128s
3387m
3317vs
4
Cu
561
497
642
586
1155m
1116vs
1078vs
1307
m
1344s1452ss
4144
1469s1560s1612
vs
2958vs
,2928s
2870s
3302vs3481w
3325s
5
Zn
555651
m
599
m
1193m
1122s
1078vs
1305
m
1342s1452ss
4134
1471s1560s1591
vs
2956vs
,2920s
2874v
3252vs3350vs6
Cd
530
505
684
545
1168m
1134
1078
1307
m
1359m1404s1475
s
1502vs1531vs1674
vs
1631
2926m3336
3242s
3470vs
3375vs
7
Hg