This document summarizes the body's responses to hypoxia, or low oxygen levels. It describes the immediate, urgent reactions of key systems to hypoxia, including increased heart rate and blood flow. It then outlines the long-term, permanent compensations the body makes, such as growing more mitochondria and capillaries to improve oxygen use and delivery. The body also makes metabolic and hormonal adaptations to optimize energy production and use oxygen more efficiently despite low oxygen levels.