03-14 Lecture Outline- Ali
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The lecture outline discusses the somatosensory system including touch, proprioception, and pain. It will cover (1) peripheral receptors and their properties, (2) central pathways for tactile and proprioceptive information, and (3) cortical maps. The second part will discuss pain including (1) nociceptors, (2) signal transduction, (3) central pain pathways and modulation. The lecture aims to provide an overview of the somatosensory system including the first three subsystems for touch, proprioception, and pain.
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- Definition as an unpleasant sensory and emotional experience associated with actual or potential tissue damage.
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03-14 Lecture Outline- Ali
- 1. February 25, 2013 Farzana 1 Page 1 of 1 Farzana Z Ali HBY 554 TA LECTURE OUTLINE FOR MARCH 14, 2013 Part I: Touch (1st subsystem) and Proprioception (2nd subsystem) 1. Peripheral receptors: Somatic Sensory Afferents a. Mechanism of sensory transduction b. Dermatomes c. Functional properties: axon diameter, receptive field (size, density), temporal dynamics, channels expressed/filter properties d. Mechanoreceptors i. Cutaneous mechanoreception- body surface fine touch, vibration and pressure ii. Proprioception- within body muscles, tendons and joints 2. Central pathways a. Tactile information from the body: Dorsal Column-Medial Lemniscal System b. Tactile information from the face: Trigeminothalamic System c. Proprioceptive information from the body: collateral branches, cerebellar function d. Proprioceptive information from the face: mesencephalic trigeminal nucleus e. Somatosensory components of the thalamus 3. Cortical maps 4. Cortical circuit plasticity in adults Part II: Pain: 3rd subsystem (painful stimuli, changes in temperature, coarse touch) 1. Nociceptors: Aδ mechanosensitive, Aδ mechanothermal, and polymodal C fibers 2. Nociceptive signal transduction 3. Central pathways: a. Anterolateral system b. Parallel pain pathways: Body and Face VPL/ VPM: sensory discriminative location, intensity and quality Midline thalamic nuclei: affective-motivational unpleasant feeling, fear and anxiety, autonomic activation c. Descending pathways 4. Visceral pain a. Referred pain b. Dorsal Column pathway 5. Sensitization: a. Peripheral b. Central 6. Phantom pain 7. Placebo effect 8. Pain modulation