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Genetics of Obesity: The thrifty gene hypothesis

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Stephen Magness
Stephen Magness

A look at the genetics and epigenetics of Obesity and the Thrifty Gene hypotehsis

Health & Medicine
1 of 20
The Thrifty Gene Hypothesis
James Neel-1962 ,[object Object],[object Object]
Feast-Famine Cycle
Physical Activity ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],Chakravarthy, M. V. & Booth, F. W. (2004). Eating, exercise, and “thrifty” genotypes: connecting the dots toward and evolutionary understanding of modern chronic diseases. J Appl Physiol , 96 (1), 3–10.
Feast-Famine and Physical Activity Cycle Model Chakravarthy, M. V. & Booth, F. W. (2004). Eating, exercise, and “thrifty” genotypes: connecting the dots toward and evolutionary understanding of modern chronic diseases. J Appl Physiol , 96 (1), 3–10.
Modern Problem Chakravarthy, M. V. & Booth, F. W. (2004). Eating, exercise, and “thrifty” genotypes: connecting the dots toward and evolutionary understanding of modern chronic diseases. J Appl Physiol , 96 (1), 3–10.
Critiques and Problems
Complex-Not just one gene
The Natural Selection Driver ,[object Object],[object Object],[object Object],[object Object],Prentice, A. M., Hennig, B. J. & Fulford, A. J. (2008). Evolutionary origins of the obesity epidemic: natural selection of thrifty genes or genetic drift following predation release? International Journal of Obesity , 32, 1607–1610.
When did genetic changes start? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
We all have thrifty genes? ,[object Object],[object Object],[object Object]
[object Object]
Thrifty Epigenome: The missing link? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
Mismatch ,[object Object],Godfrey, K. M., Lillycrop, K. A., Burdge, G. C., Gluckman, P. D. & Hanson, M. A. (2007). Epigenetic mechanism and the mismatch concept of the developmental origins of health and disease. Pediatric Research , 61 (5), 5–10.
Evidence ,[object Object],[object Object],[object Object],[object Object]
 
Conclusion ,[object Object],[object Object],[object Object],[object Object],[object Object]
References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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