This document contains exam questions for a bioinformatics course. Part A includes short answer questions about topics like GenBank, the central dogma of molecular biology, sequence alignment tools like BLAST and ClustalW, and structure visualization tools like RasMol. Part B includes longer answer questions about topics such as proteomic databases, DNA replication, secondary databases, protein synthesis, pairwise sequence alignment, PAM matrices, neighbor-joining trees, microarray image analysis, identifying protein coding regions, and using bioinformatics in drug discovery. The document tests students' knowledge of key concepts and tools used in bioinformatics.

1. BTS — VIII — 04.13 — 0159
B. Tech. Degree VIII Semester Examination April 2013
CS/EB/EC/IT 804 (B) BIOINFORIVIATICS
(2006 Scheme)
Time : 3 Hours Maximum Marks : 100
PART A
(Answer ALL questions)
(8 x 5 = 40)
I. Write short answers on:
Gen Bank
Central dogma of molecular biology
BLOSUM
ClustalW
BLAST
FASTA
Star trees
RasMol
PART B
(4 x 15 = 60)
II. (a) Write briefly on web based proteomic databases. (7)
(b) Explain DNA replication. (8)
OR
III. (a) Write a brief note on secondary databases. (7)
(b) Discuss protein synthesis. (8)
Explain global comparison for pairwise sequence alignment of two sequences. (15)
OR
Write notes on: (15)
PAM
Neighbor-joining method
What are microarrays? Write about the microarray image analysis. (15)
OR
Explain identification of protein coding regions. (15)
Discuss on drug discovery using bioinformatics tools. (15)
OR
(a) Compare the gene structures in prokaryotes and eukaryotes. (7)
(b) Explain molecular visualization. (8)
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