We put adenosine triphosphate under inspection.

1. ATP
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2. What is ATP?

3. According to Wikipedia, adenosine triphosphate (ATP) is a nucleoside triphosphate (a molecule containing a nucleoside
bound to three phosphates) used in cells as a coenzyme, often called the “molecular unit of currency” of intracellular energy
transfer.
In plain english, it is fuel for enzymes to function within the body for various processes.

4. What does ATP do?

5. ATP stores the energy we need to do just about
anything and is present in the cytoplasm and
nucleoplasm of every cell; essentially all the
physiological mechanisms that require energy for
operation obtain it directly from ATP – ATP also
transports chemical energy within cells for metabolism.
Metabolic processes that use ATP as an energy source
convert it back into its prior forms. ATP is therefore
continuously recycled in the human body, and turns over
its own body weight equivalent (≈ 250 g) in ATP daily.

6. How can ATP help?

7. Trial #1
16 volunteers (8 male and 8 female;
ages: 21–34 years) were enrolled in a
double-blinded, placebo-controlled
study. The participants were given a
supply of capsules (each containing
200 mg per capsule) and instructed to
take two capsules each day (total dose
= 400 mg/day), one in the morning
before breakfast and one in the
evening before dinner.

8. The study demonstrated that supplementation with ATP tended to reduce muscle fatigue while improving a participant’s
ability to maintain a higher force output through successive sets of exhaustive exercise.

9. Trial #2
Participants were randomly assigned
to receive either 400 mg per day of
ATP or placebo, consumed orally via a
two-piece gelatin capsule 30 minutes
prior to resistance training sessions.
Muscle strength was assessed via
1RM testing of the back squat, bench
press, and deadlift. Peak power was
recorded using Monark Anaerobic
Wingate Software.

10. The overall verdict was that oral supplementation with ATP in combination with high intensity, periodized resistance training
increases muscle mass, strength, and power compared with a placebo-matched control. Moreover, when faced with greater
training frequencies, oral ATP may prevent typical declines in performance that are characteristic of overreaching.

11. Each subject was assigned in a
randomized, double-blind manner to
enterically coated high-dose ATP (225
mg) or low-dose ATP (150 mg) or a
visibly similar placebo. Subjects were
examined on three occasions: ((i)
baseline; (ii) acutely (7 days later, no
prior supplementation and 75 min after
ATP ingestion); and (iii) after 14 days
of daily ingestion.
Trial #3

12. It was concluded enterically coated oral ATP supplementation may provide small ergogenic effects on muscular strength
under some treatment conditions. However, subsequent comments revealed future research is warranted before ATP
supplementation is recommended to athletes seeking to use ATP as an ergogenic aid.

13. To sum it up, ATP can aid with:
● Post-exercise blood flow
● Reducing muscle fatigue
● Improving higher force output
● Increasing muscle mass, strength, and power
● Ergogenic effects on muscular strength
Adenosine-5′-triphosphate (ATP) supplementation
improves low peak muscle torque and torque fatigue
during repeated high intensity exercise sets. (J Int Soc
Sports Nutr. 2012)
Effects of oral adenosine-5′-triphosphate
supplementation on athletic performance, skeletal
muscle hypertrophy and recovery in resistance-trained
men. (Nutr Metalab London 2013)
Effects of oral ATP supplementation on anaerobic power
and muscular strength. (Med Sci Sports Exerc. 2004)

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