SlideShare a Scribd company logo
1 of 27
Optimal protein intake and meal frequency to support maximal protein synthesis and muscle mass. Layne Norton, B.S. Division of Nutritional Sciences University of Illinois
Overview ,[object Object],[object Object],[object Object],[object Object],[object Object]
Background ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],Background
Determining Optimal Intake ,[object Object],[object Object],[object Object],[object Object],[object Object]
Leucine in regulation of protein synthesis ,[object Object],mTOR (+) [Leucine] p70S6K (+) 4E-BP1-eIF4E eIF4E eIF4G (+) eIF4E-eIF4G (+) Protein Synthesis (+)
[object Object],[object Object],[object Object],Plasma Leucine (µM) * FSR (%/day) *unpublished data *
[object Object],[object Object],[object Object],Combined data sets % Increase from controls
Leucine content of various protein sources Protein Source Leu % of total protein) Amount of protein from source to reach 3-4g Leucine Amount of food source required Whey Protein Isolate 12.0% 25-33g 27-36g Milk Protein Isolate 9.8% 31-41g 34-46g Casein 9.3% 32-43g variable depending upon casein powder type Egg 8.6% 35-47g 280-376g or approx 4.5-6.5 large whole eggs Fish 8.1% 38-50g 158-208g Beef 8.0% 38-51g 126-170g Pork  8.0% 38-51g 133-179g Chicken 7.5% 41-54g 132-174g Wheat 6.8% 44-59g 440-590g or 15-20 slices of bread
Recap ,[object Object],[object Object],[object Object],[object Object]
Optimal Frequency ,[object Object],[object Object]
[object Object],[object Object],[object Object],Plasma Leucine (µM) MPS (%/day) * * * * * * * † *different from baseline P<0.05; †p<0.10 *different from baseline P<0.05 Time (minutes) Time (minutes)
The Refractory Phenomenon ,[object Object],[object Object],[object Object]
Possible explanations? ,[object Object],* * * * Does not explain refractory nature of MPS. mmol/kg wet tissue Time (minutes) Intramuscular Leucine
Possible Explanations? ,[object Object],[object Object],[object Object],[object Object],Gamma form/total 4E-BP1 Phosphorylation Gamma +Beta forms/total p70S6K Phosphorylation * * * * * * * * * *different from baseline P<0.05 *different from baseline P<0.05 Time (minutes) Time (minutes)
Possible Explanations? ,[object Object],Time (minutes) ‡ ‡ * * eIF4G bound to eIF4E/total 4E eIF4E*eIF4G Binding Unlikely to be responsible for MPS becoming refractory
Possible Explanations? ,[object Object],[object Object],[object Object]
Possible Explanations? ,[object Object],[object Object],[object Object],[object Object],[object Object],Insulin Time (minutes) Insulin (pmol/L) * *
Possible Explanations? ,[object Object],[object Object],[object Object]
Possible explanations? ,[object Object],[object Object]
Optimal Meal Frequency? ,[object Object],[object Object],[object Object],[object Object],[object Object]
General recommendations? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Other Considerations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Future research ,[object Object],[object Object],[object Object],[object Object]
References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Acknowledgments ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Questions?

More Related Content

Similar to Optimal Protein Intake And Meal Frequency To Support Maximal Protein Synthesis and Muscle Mass

Comprehensive Review Of Whey Vs Casein Protein
Comprehensive Review Of Whey Vs Casein ProteinComprehensive Review Of Whey Vs Casein Protein
Comprehensive Review Of Whey Vs Casein Proteindunny3rd
 
Excel PT PPT- Endurance and Strength Nutrition
Excel PT PPT- Endurance and Strength Nutrition Excel PT PPT- Endurance and Strength Nutrition
Excel PT PPT- Endurance and Strength Nutrition Jordan Feigenbaum
 
High Protein Diet Literature Review
High Protein Diet Literature ReviewHigh Protein Diet Literature Review
High Protein Diet Literature Reviewjmoore87
 
Nutrition, Macronutrients and Micronutrients and their deficiency disorders
Nutrition, Macronutrients and Micronutrients and their deficiency disordersNutrition, Macronutrients and Micronutrients and their deficiency disorders
Nutrition, Macronutrients and Micronutrients and their deficiency disordersGaurav Kamboj
 
Fuelling Your NTC Workout
Fuelling Your NTC Workout Fuelling Your NTC Workout
Fuelling Your NTC Workout denoris
 
‘From Molecular to Systems Nutrition. Lessons from mouse to man’ NUGO Dublin...
‘From Molecular to Systems Nutrition. Lessons from mouse to man’ NUGO Dublin...‘From Molecular to Systems Nutrition. Lessons from mouse to man’ NUGO Dublin...
‘From Molecular to Systems Nutrition. Lessons from mouse to man’ NUGO Dublin...Norwich Research Park
 
Systems Nutrition of the Gut-Liver Axis and the Role of the Microbiome
Systems Nutrition of the Gut-Liver Axis and the Role of the MicrobiomeSystems Nutrition of the Gut-Liver Axis and the Role of the Microbiome
Systems Nutrition of the Gut-Liver Axis and the Role of the MicrobiomeNorwich Research Park
 
Nutrient Timing Workshop
Nutrient Timing WorkshopNutrient Timing Workshop
Nutrient Timing Workshopdenoris
 
Life Science Journal, 2012;9( 3)
Life Science Journal, 2012;9( 3)Life Science Journal, 2012;9( 3)
Life Science Journal, 2012;9( 3)nashwa eltablawy
 
Brain Circuits Driving Appetite
Brain Circuits Driving AppetiteBrain Circuits Driving Appetite
Brain Circuits Driving AppetiteInsideScientific
 
Nutrients And Assessment
Nutrients And AssessmentNutrients And Assessment
Nutrients And AssessmentMD Specialclass
 
NDD30503: NUTRITION FOR SPORTS AND EXERCISE
NDD30503: NUTRITION FOR SPORTS AND EXERCISENDD30503: NUTRITION FOR SPORTS AND EXERCISE
NDD30503: NUTRITION FOR SPORTS AND EXERCISEwajihahwafa
 

Similar to Optimal Protein Intake And Meal Frequency To Support Maximal Protein Synthesis and Muscle Mass (20)

Genetic Factors II
Genetic Factors IIGenetic Factors II
Genetic Factors II
 
Comprehensive Review Of Whey Vs Casein Protein
Comprehensive Review Of Whey Vs Casein ProteinComprehensive Review Of Whey Vs Casein Protein
Comprehensive Review Of Whey Vs Casein Protein
 
Excel PT PPT- Endurance and Strength Nutrition
Excel PT PPT- Endurance and Strength Nutrition Excel PT PPT- Endurance and Strength Nutrition
Excel PT PPT- Endurance and Strength Nutrition
 
High Protein Diet Literature Review
High Protein Diet Literature ReviewHigh Protein Diet Literature Review
High Protein Diet Literature Review
 
Nutrition pre during post workout
Nutrition pre during post workoutNutrition pre during post workout
Nutrition pre during post workout
 
Nutrition, Macronutrients and Micronutrients and their deficiency disorders
Nutrition, Macronutrients and Micronutrients and their deficiency disordersNutrition, Macronutrients and Micronutrients and their deficiency disorders
Nutrition, Macronutrients and Micronutrients and their deficiency disorders
 
E761.full
E761.fullE761.full
E761.full
 
Fuelling Your NTC Workout
Fuelling Your NTC Workout Fuelling Your NTC Workout
Fuelling Your NTC Workout
 
Proteins simplified
Proteins simplifiedProteins simplified
Proteins simplified
 
‘From Molecular to Systems Nutrition. Lessons from mouse to man’ NUGO Dublin...
‘From Molecular to Systems Nutrition. Lessons from mouse to man’ NUGO Dublin...‘From Molecular to Systems Nutrition. Lessons from mouse to man’ NUGO Dublin...
‘From Molecular to Systems Nutrition. Lessons from mouse to man’ NUGO Dublin...
 
Systems Nutrition of the Gut-Liver Axis and the Role of the Microbiome
Systems Nutrition of the Gut-Liver Axis and the Role of the MicrobiomeSystems Nutrition of the Gut-Liver Axis and the Role of the Microbiome
Systems Nutrition of the Gut-Liver Axis and the Role of the Microbiome
 
EB2015_Egg_Final
EB2015_Egg_FinalEB2015_Egg_Final
EB2015_Egg_Final
 
Nutrient Timing Workshop
Nutrient Timing WorkshopNutrient Timing Workshop
Nutrient Timing Workshop
 
Life Science Journal, 2012;9( 3)
Life Science Journal, 2012;9( 3)Life Science Journal, 2012;9( 3)
Life Science Journal, 2012;9( 3)
 
Brain Circuits Driving Appetite
Brain Circuits Driving AppetiteBrain Circuits Driving Appetite
Brain Circuits Driving Appetite
 
Leptin ppt
Leptin pptLeptin ppt
Leptin ppt
 
Nutrients And Assessment
Nutrients And AssessmentNutrients And Assessment
Nutrients And Assessment
 
I0342048053
I0342048053I0342048053
I0342048053
 
NDD30503: NUTRITION FOR SPORTS AND EXERCISE
NDD30503: NUTRITION FOR SPORTS AND EXERCISENDD30503: NUTRITION FOR SPORTS AND EXERCISE
NDD30503: NUTRITION FOR SPORTS AND EXERCISE
 
Presentation
PresentationPresentation
Presentation
 

Recently uploaded

DBX First Quarter 2024 Investor Presentation
DBX First Quarter 2024 Investor PresentationDBX First Quarter 2024 Investor Presentation
DBX First Quarter 2024 Investor PresentationDropbox
 
The Ultimate Prompt Engineering Guide for Generative AI: Get the Most Out of ...
The Ultimate Prompt Engineering Guide for Generative AI: Get the Most Out of ...The Ultimate Prompt Engineering Guide for Generative AI: Get the Most Out of ...
The Ultimate Prompt Engineering Guide for Generative AI: Get the Most Out of ...SOFTTECHHUB
 
How to Check CNIC Information Online with Pakdata cf
How to Check CNIC Information Online with Pakdata cfHow to Check CNIC Information Online with Pakdata cf
How to Check CNIC Information Online with Pakdata cfdanishmna97
 
CNIC Information System with Pakdata Cf In Pakistan
CNIC Information System with Pakdata Cf In PakistanCNIC Information System with Pakdata Cf In Pakistan
CNIC Information System with Pakdata Cf In Pakistandanishmna97
 
ERP Contender Series: Acumatica vs. Sage Intacct
ERP Contender Series: Acumatica vs. Sage IntacctERP Contender Series: Acumatica vs. Sage Intacct
ERP Contender Series: Acumatica vs. Sage IntacctBrainSell Technologies
 
Hyatt driving innovation and exceptional customer experiences with FIDO passw...
Hyatt driving innovation and exceptional customer experiences with FIDO passw...Hyatt driving innovation and exceptional customer experiences with FIDO passw...
Hyatt driving innovation and exceptional customer experiences with FIDO passw...FIDO Alliance
 
Harnessing Passkeys in the Battle Against AI-Powered Cyber Threats.pptx
Harnessing Passkeys in the Battle Against AI-Powered Cyber Threats.pptxHarnessing Passkeys in the Battle Against AI-Powered Cyber Threats.pptx
Harnessing Passkeys in the Battle Against AI-Powered Cyber Threats.pptxFIDO Alliance
 
Quantum Leap in Next-Generation Computing
Quantum Leap in Next-Generation ComputingQuantum Leap in Next-Generation Computing
Quantum Leap in Next-Generation ComputingWSO2
 
JavaScript Usage Statistics 2024 - The Ultimate Guide
JavaScript Usage Statistics 2024 - The Ultimate GuideJavaScript Usage Statistics 2024 - The Ultimate Guide
JavaScript Usage Statistics 2024 - The Ultimate GuidePixlogix Infotech
 
Design and Development of a Provenance Capture Platform for Data Science
Design and Development of a Provenance Capture Platform for Data ScienceDesign and Development of a Provenance Capture Platform for Data Science
Design and Development of a Provenance Capture Platform for Data SciencePaolo Missier
 
Observability Concepts EVERY Developer Should Know (DevOpsDays Seattle)
Observability Concepts EVERY Developer Should Know (DevOpsDays Seattle)Observability Concepts EVERY Developer Should Know (DevOpsDays Seattle)
Observability Concepts EVERY Developer Should Know (DevOpsDays Seattle)Paige Cruz
 
WebRTC and SIP not just audio and video @ OpenSIPS 2024
WebRTC and SIP not just audio and video @ OpenSIPS 2024WebRTC and SIP not just audio and video @ OpenSIPS 2024
WebRTC and SIP not just audio and video @ OpenSIPS 2024Lorenzo Miniero
 
Six Myths about Ontologies: The Basics of Formal Ontology
Six Myths about Ontologies: The Basics of Formal OntologySix Myths about Ontologies: The Basics of Formal Ontology
Six Myths about Ontologies: The Basics of Formal Ontologyjohnbeverley2021
 
JohnPollard-hybrid-app-RailsConf2024.pptx
JohnPollard-hybrid-app-RailsConf2024.pptxJohnPollard-hybrid-app-RailsConf2024.pptx
JohnPollard-hybrid-app-RailsConf2024.pptxJohnPollard37
 
Tales from a Passkey Provider Progress from Awareness to Implementation.pptx
Tales from a Passkey Provider  Progress from Awareness to Implementation.pptxTales from a Passkey Provider  Progress from Awareness to Implementation.pptx
Tales from a Passkey Provider Progress from Awareness to Implementation.pptxFIDO Alliance
 
Design Guidelines for Passkeys 2024.pptx
Design Guidelines for Passkeys 2024.pptxDesign Guidelines for Passkeys 2024.pptx
Design Guidelines for Passkeys 2024.pptxFIDO Alliance
 
Less Is More: Utilizing Ballerina to Architect a Cloud Data Platform
Less Is More: Utilizing Ballerina to Architect a Cloud Data PlatformLess Is More: Utilizing Ballerina to Architect a Cloud Data Platform
Less Is More: Utilizing Ballerina to Architect a Cloud Data PlatformWSO2
 
Introduction to use of FHIR Documents in ABDM
Introduction to use of FHIR Documents in ABDMIntroduction to use of FHIR Documents in ABDM
Introduction to use of FHIR Documents in ABDMKumar Satyam
 
Introduction to Multilingual Retrieval Augmented Generation (RAG)
Introduction to Multilingual Retrieval Augmented Generation (RAG)Introduction to Multilingual Retrieval Augmented Generation (RAG)
Introduction to Multilingual Retrieval Augmented Generation (RAG)Zilliz
 
Navigating Identity and Access Management in the Modern Enterprise
Navigating Identity and Access Management in the Modern EnterpriseNavigating Identity and Access Management in the Modern Enterprise
Navigating Identity and Access Management in the Modern EnterpriseWSO2
 

Recently uploaded (20)

DBX First Quarter 2024 Investor Presentation
DBX First Quarter 2024 Investor PresentationDBX First Quarter 2024 Investor Presentation
DBX First Quarter 2024 Investor Presentation
 
The Ultimate Prompt Engineering Guide for Generative AI: Get the Most Out of ...
The Ultimate Prompt Engineering Guide for Generative AI: Get the Most Out of ...The Ultimate Prompt Engineering Guide for Generative AI: Get the Most Out of ...
The Ultimate Prompt Engineering Guide for Generative AI: Get the Most Out of ...
 
How to Check CNIC Information Online with Pakdata cf
How to Check CNIC Information Online with Pakdata cfHow to Check CNIC Information Online with Pakdata cf
How to Check CNIC Information Online with Pakdata cf
 
CNIC Information System with Pakdata Cf In Pakistan
CNIC Information System with Pakdata Cf In PakistanCNIC Information System with Pakdata Cf In Pakistan
CNIC Information System with Pakdata Cf In Pakistan
 
ERP Contender Series: Acumatica vs. Sage Intacct
ERP Contender Series: Acumatica vs. Sage IntacctERP Contender Series: Acumatica vs. Sage Intacct
ERP Contender Series: Acumatica vs. Sage Intacct
 
Hyatt driving innovation and exceptional customer experiences with FIDO passw...
Hyatt driving innovation and exceptional customer experiences with FIDO passw...Hyatt driving innovation and exceptional customer experiences with FIDO passw...
Hyatt driving innovation and exceptional customer experiences with FIDO passw...
 
Harnessing Passkeys in the Battle Against AI-Powered Cyber Threats.pptx
Harnessing Passkeys in the Battle Against AI-Powered Cyber Threats.pptxHarnessing Passkeys in the Battle Against AI-Powered Cyber Threats.pptx
Harnessing Passkeys in the Battle Against AI-Powered Cyber Threats.pptx
 
Quantum Leap in Next-Generation Computing
Quantum Leap in Next-Generation ComputingQuantum Leap in Next-Generation Computing
Quantum Leap in Next-Generation Computing
 
JavaScript Usage Statistics 2024 - The Ultimate Guide
JavaScript Usage Statistics 2024 - The Ultimate GuideJavaScript Usage Statistics 2024 - The Ultimate Guide
JavaScript Usage Statistics 2024 - The Ultimate Guide
 
Design and Development of a Provenance Capture Platform for Data Science
Design and Development of a Provenance Capture Platform for Data ScienceDesign and Development of a Provenance Capture Platform for Data Science
Design and Development of a Provenance Capture Platform for Data Science
 
Observability Concepts EVERY Developer Should Know (DevOpsDays Seattle)
Observability Concepts EVERY Developer Should Know (DevOpsDays Seattle)Observability Concepts EVERY Developer Should Know (DevOpsDays Seattle)
Observability Concepts EVERY Developer Should Know (DevOpsDays Seattle)
 
WebRTC and SIP not just audio and video @ OpenSIPS 2024
WebRTC and SIP not just audio and video @ OpenSIPS 2024WebRTC and SIP not just audio and video @ OpenSIPS 2024
WebRTC and SIP not just audio and video @ OpenSIPS 2024
 
Six Myths about Ontologies: The Basics of Formal Ontology
Six Myths about Ontologies: The Basics of Formal OntologySix Myths about Ontologies: The Basics of Formal Ontology
Six Myths about Ontologies: The Basics of Formal Ontology
 
JohnPollard-hybrid-app-RailsConf2024.pptx
JohnPollard-hybrid-app-RailsConf2024.pptxJohnPollard-hybrid-app-RailsConf2024.pptx
JohnPollard-hybrid-app-RailsConf2024.pptx
 
Tales from a Passkey Provider Progress from Awareness to Implementation.pptx
Tales from a Passkey Provider  Progress from Awareness to Implementation.pptxTales from a Passkey Provider  Progress from Awareness to Implementation.pptx
Tales from a Passkey Provider Progress from Awareness to Implementation.pptx
 
Design Guidelines for Passkeys 2024.pptx
Design Guidelines for Passkeys 2024.pptxDesign Guidelines for Passkeys 2024.pptx
Design Guidelines for Passkeys 2024.pptx
 
Less Is More: Utilizing Ballerina to Architect a Cloud Data Platform
Less Is More: Utilizing Ballerina to Architect a Cloud Data PlatformLess Is More: Utilizing Ballerina to Architect a Cloud Data Platform
Less Is More: Utilizing Ballerina to Architect a Cloud Data Platform
 
Introduction to use of FHIR Documents in ABDM
Introduction to use of FHIR Documents in ABDMIntroduction to use of FHIR Documents in ABDM
Introduction to use of FHIR Documents in ABDM
 
Introduction to Multilingual Retrieval Augmented Generation (RAG)
Introduction to Multilingual Retrieval Augmented Generation (RAG)Introduction to Multilingual Retrieval Augmented Generation (RAG)
Introduction to Multilingual Retrieval Augmented Generation (RAG)
 
Navigating Identity and Access Management in the Modern Enterprise
Navigating Identity and Access Management in the Modern EnterpriseNavigating Identity and Access Management in the Modern Enterprise
Navigating Identity and Access Management in the Modern Enterprise
 

Optimal Protein Intake And Meal Frequency To Support Maximal Protein Synthesis and Muscle Mass

  • 1. Optimal protein intake and meal frequency to support maximal protein synthesis and muscle mass. Layne Norton, B.S. Division of Nutritional Sciences University of Illinois
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 9. Leucine content of various protein sources Protein Source Leu % of total protein) Amount of protein from source to reach 3-4g Leucine Amount of food source required Whey Protein Isolate 12.0% 25-33g 27-36g Milk Protein Isolate 9.8% 31-41g 34-46g Casein 9.3% 32-43g variable depending upon casein powder type Egg 8.6% 35-47g 280-376g or approx 4.5-6.5 large whole eggs Fish 8.1% 38-50g 158-208g Beef 8.0% 38-51g 126-170g Pork 8.0% 38-51g 133-179g Chicken 7.5% 41-54g 132-174g Wheat 6.8% 44-59g 440-590g or 15-20 slices of bread
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15.
  • 16.
  • 17.
  • 18.
  • 19.
  • 20.
  • 21.
  • 22.
  • 23.
  • 24.
  • 25.
  • 26.