2. Structural Classification of Proteins (SCOP)
• SCOP database describes structural and evolutionary relationship between
proteins of known structures.
• SCOP was created in 1994 in the Centre for Protein Engineering and the
Laboratory of Molecular Biology. It was maintained by Alexey G. Murzin and
his colleagues in the centre for protein engineering.
• SCOP database is a largely manual classification of protein structures and
amino acid sequences.
• The SCOP database is freely accessible on the internet.
3. Structural Classification of Proteins (SCOP)
• The source of protein structures is the Protein Data Bank(PDB). SCOP
database has been linked from the PDB to obtain the structural class
information of each protein directly.
• On the other hand, one can search the SCOP database for obtaining the
structural class, fold, and domain information
4.
5. Structural Classification of Proteins (SCOP)
SCOP describes protein structures using a hierarchical classification
scheme:
• Class: Classes based mainly secondary structure contain and
organization; e.g., beta sheets.
• Fold: Each class contains a number of distinct folds. Folds grouping
structurally similar superfamilies; For example, the "All-α proteins"
class contains >280 distinct folds
• Superfamily: The domains in a fold are grouped into superfamilies,
which have at least a distant common ancestor.
6. Structural Classification of Proteins (SCOP)
•SCOP describes protein structures using a hierarchical classification scheme:
• Family: The domains in a superfamily are grouped into families, which
containing proteins with similar sequences but typically distinct functions.
• Protein domain: The domains in families are grouped into protein domains,
which is either originated from different biological species or represent
different isoforms within the same species.
• Species: Species representing a distinct protein sequence and its naturally
occurring or artificially created variants.
• Domain: part of a protein. For simple proteins, it can be the entire protein.
