2. Anti Spasmodic
Are the Smooth muscle relaxants in GI
prevent spasms of the stomach, intestine or urinary
bladder
are given for abdominal pain, IBS symptoms
4. ANTI CHOLINERGIC
block the neurotransmitter acetylcholine in CNS and PNS.
combine reversibly with muscarinic cholinergic receptors thus
preventing access of neurotransmitter acetylcholine
TWO TYPES
ANTI MUSCARINIC
ANTI NICOTINIC
5.
6.
7.
8. Antimuscarinic drugs
block cholinergic transmission at
parasympathetic postganglionic nerve
endings → cause smooth muscle to
relax.
dicyclomine and propantheline are
probably the most useful in IBS,
Avoid pt with GERD→ can
worsen the conditions
9. smooth muscle relaxants
Alverine and peppermint oil also
have direct smooth muscle
relaxing activity.
peppermint oil block calcium
influx thus cause smooth muscle
relax
10. Common Uses
• For spasm (colic), bloating and abdominal pain
• To reduce the movement ( motility) of the intestine
• Overactive bladder
• Movement problems in Parkinson's disease
• Diarrhea
• Motion sickness
• Nausea and/or vomiting
• Muscle spasms
• Chronic obstructive pulmonary disease (COPD)
• Asthma
11. MECHANISM OF ACTION :
Food in
GUT Relax &
contract
of
muscles
in gut.
Pain
and
bloating
Anti muscarinic
attach to the
muscarinic
receptors
Relax the
smooth
muscle in
intestine.
12. Hyoscine Butylbromide -Buscopan
Also known as scopolamine butylbromide
MOA:
• has anticholinergic action.
• Has high affinity for muscarinic receptors located on the
smooth-muscle cells of the GI tract exerts a smooth-muscle
relaxing/spasmolytic effect.
13. Indications
• crampy abdominal pain
• esophageal spasms
• renal colic
• bladder spasms
• also used to improve respiratory secretions at the
end of life
• Can taken by Oral , im or IV
• (Dosage
• 10mg oral x TDS, 20mg/ml Inj x TDS)
14. Side effects
• sleepiness,
• vision changes,
• dry mouth,
• rapid heart rate,
• triggering of glaucoma and
• severe allergies
15. Dicyclomine:
muscarinic antagonist used as an antispasmodic
and in urinary incontinence
Has direct smooth muscle relaxant
action
Has weak anti cholinergic
Exerts anti spasmodic action
Also has anti-emetic
property
22. Indications:
Intestinal, biliary, renal colic
Irritable bowel syndrome
Uterine spasm ( dysmenorrhea)
headache,
also used to relieve cervical spasm during labor.
Dose
Drotin 40-80 mg tds
ADR
Headache Dizziness Constipation
Flushing
Fall in BP can occur on iv inj