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Genes and Behavior Kandel Chapter 3
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hydrogen bonds between C and G, and between T and A determine the stability of the “double elix” forming DNA and other similar nucleic acids
Human cromosomes
Crush course in gene expression: Gene expression = using genes for producing proteins There are only 4 nucleotide bases (T, C, A, G) and pairing is forced: (T-A and C-G) A gene is a sequence of bases encoding for a protein . Cromosomes (DNA, in the nucleus) are series of genes linked together (exons,  ~5% of the total length) , with long non-coding regions inpterposed in between (introns,  ~95% of the total length )
[object Object],[object Object],[object Object]
[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Genetics Overview ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
“ Nature or nurture” problem ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Example: phenylketonuria ,[object Object],[object Object],[object Object],[object Object]
Identical Twin Studies - Raised Apart - Raised Together
Psychological features dependent on genetic or on environmental factors in three different studies
Knock-in or knock-out transgenic animals are valid tools for neuroscience research
Single Genes Contribute to Behavior ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
In Drosophila two genes linked to circadian oscillations have been thoroughly studied: PER(iod) and TIM(less) genes They act in tandem as inhibitors of transcription. One of them is light-sensitive: light impairs its function and the complex stops working as transcription inhibitor
Circadian Rhythm and Genes ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Circadian Mutants ,[object Object],[object Object],[object Object]
In mice a circadian rhythm gene has been identified: CLOCK Yellow indicates light. The black dots represent motor activity (mice are nocturnal animals) Circadian rythms are compromised in the -/- homozygotic animal
Other mutations affecting behavior ,[object Object],[object Object],[object Object],[object Object],[object Object]
Huntington disease: As in many other genetic diseases, the mistaken repeat of a triplet (CAG) produces an anomalous protein, of yet unknown function, that is associated with HD symptoms. The longer the repeat, the younger the age of onset of the disease.
 
 
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[object Object],[object Object]

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Genes Behavior Kandel Chapter Crash Course

  • 1. Genes and Behavior Kandel Chapter 3
  • 2.
  • 3. Hydrogen bonds between C and G, and between T and A determine the stability of the “double elix” forming DNA and other similar nucleic acids
  • 5. Crush course in gene expression: Gene expression = using genes for producing proteins There are only 4 nucleotide bases (T, C, A, G) and pairing is forced: (T-A and C-G) A gene is a sequence of bases encoding for a protein . Cromosomes (DNA, in the nucleus) are series of genes linked together (exons, ~5% of the total length) , with long non-coding regions inpterposed in between (introns, ~95% of the total length )
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.
  • 12. Identical Twin Studies - Raised Apart - Raised Together
  • 13. Psychological features dependent on genetic or on environmental factors in three different studies
  • 14. Knock-in or knock-out transgenic animals are valid tools for neuroscience research
  • 15.
  • 16. In Drosophila two genes linked to circadian oscillations have been thoroughly studied: PER(iod) and TIM(less) genes They act in tandem as inhibitors of transcription. One of them is light-sensitive: light impairs its function and the complex stops working as transcription inhibitor
  • 17.
  • 18.  
  • 19.
  • 20. In mice a circadian rhythm gene has been identified: CLOCK Yellow indicates light. The black dots represent motor activity (mice are nocturnal animals) Circadian rythms are compromised in the -/- homozygotic animal
  • 21.
  • 22. Huntington disease: As in many other genetic diseases, the mistaken repeat of a triplet (CAG) produces an anomalous protein, of yet unknown function, that is associated with HD symptoms. The longer the repeat, the younger the age of onset of the disease.
  • 23.  
  • 24.  
  • 25.
  • 26.