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HISTORY OF MEDICINE
PRE-HISTORIC MEDICINE
•Prehistoric men believed
that illness and diseases were
a punishment from the Gods
•First physicians were witch
doctors who treated illness
with ceremonies
Other Cures
Trephination : One of the first surgeries
-A hole was cut into the skull to release
Evil Spirits
Prayers and Chants
WAY OF LIFE
Hunter Gatherers
Different tribes comingled – Exchange of tribal folklore – Ever-increasing compendium
of useful, not so useful, and even dangerous remedies developed.
Practical
Causes for Ill
health
1. Falls
2. Bites
3. Fractures
4. Parasites
Rational Cures
• Good Diet
•Setting of bone fractures
•and Dislocations
• Mud, Herbs and other Plants
Evidence for ‘disease and its
management’ in the pre
historic period is limited to
• fossilized bony lesions
• Comparing with Aborigines
• Cave Drawings
Major Threats to Health
Predators Pregnancy
EGYPTIAN MEDICINE-1
Egyptians believed gods,
demons and spirits
played a key role in
causing diseases.
Factors Influencing medicine
Ancient Egypt (3300BC to 525BC) : Dawn of "medical care“ which was greatly
influenced by wealth and trade
Wealth Trade Science &
Technology
Mummification
Egyptian
people
used
Copper:
Disinfectant
Thread & Needle :
Stitch Wounds
Oil Massage: Reduce
pain & Aches
Egyptian
physician
Imhotep
Eye of Horus:
Modern day
prescription
symbol
EGYPTIAN MEDICINE-2
Mashed Pigs Eye for Eye
Problems:
Ancient Egyptian doctors prescribed
mashed pig’s eyes blended with
honey and red ochre for eye problems
The practice of medicine is very specialized among Egyptian, Each physician treats just
one disease.
Crocodile Dung as
Contraceptive:
Crocodile dung mixed with honey and
mud was used as contraceptive
Mouldy Breads for
Treating:
The microbes in mouldy bread
destroyed the pathogens and cured
the infection
Ancient Egypt Wooden
Prosthetic Toe
Early Egyptian dental bridge
The Ancient Medical Documents (300 BC) Ancient Medical Prosthesis
Edwin Smith Papyrus Ebers Papyrus
(1600 BC)
AYURVEDA
Traditional Hindu
Medical system
Native to India –
Diet, Herbal
treatment & Yoga
Panchamahabhut:
Five basic elements
of the Entire
Creation Space , Air,
Fire, Water and
Earth
Ayurveda [Ayus(life), Veda(knowledge) in Sanskrit] - An Ancient Indian Healing Art
Samhitas: Charaka, Sushrutha and Agnivesha-
•Ancient Hindu Medical texts
•Contains material regarding surgery and medicine
•Described properties of 1270 species of plants
•8000 herbal remedies in Ayurveda
•Surgeries as cataract and Rhinoplasty
The world’s first university
Takshashila had 8 year course
on Ayurveda around 600BC
Oldest surviving complete medical system in the World – A highlights the way of life
that teaches how to maintain and protect health
The glories of Hindu medicine
rapidly declined when waves of
invaders attacked India
Establishment of huge ancient
universities -Takhsashila and
Nalanda contributed to the
spread of knowledge to various
parts of the world.
Dhanvantari
Physicians of God
emerged from Ocean of
milk with amrutha and
Herbs in his hands
Dhanvantari
Sushrutha
sushrutha
Samhita
Nagarjuna –
Compiles & revises
sushrutha samhitha
Daksha Prajapathi
Ashwini devatha
(Physician's of God)
Lord Indra
Sage Bharadwaja
(around 5000BC)
Athreya,
Punarvasu
Agnivesa (Agnivesa tantra),
Bhela (Bhela samhitha) ,
Jathukarna, Parasara,
Ksharapani, Haritha
Charaka
(Charaka samhitha)
VAGBHATTA
(Ashtanga Hridaya)
COMPILATION OF
CHARAKA SAMHITA &
SUSHRUTHA SAMHITA
BLOOMING
OF
AYURVEDA
SURGERY
MEDICINE
BRAHMA
CHINESE MEDICINE
Shang Dynasty
(1766-1122 BC)
Origin of Traditional
Chinese medicine
Tang Dynasty
The Suwen, a part of
the Huangdi neijing
expanded and
revised
Jin Dynasty (215-282)
Huangfu Mi
acupuncture and
moxibustion
Chou Dynasty(1122-403 BC)
Confucius(551-479)
Foundational text of Chinese
medicine is the Huangdi neijing,
(or Yellow Emperor's Inner
Canon)
Qing Dynasty
18th century
Proliferation of popular
books as well as more
advanced encyclopedias on
traditional medicine
19th century, Western
medicine was introduced at
the local level by Christian
medical missionaries
CHINESE MEDICINE
The typical Traditional Chinese Medicine therapies
Cupping
Moxibustion
Acupuncture
Herbal Formulas
Acupressure
Tuina (Massage) Qigong Exercise
Principles of Traditional Chinese Medicine
BABYLONIAN MEDICINE
Hammurabi
CODE OF
HAMMURABI
(1800 BCE)
• Legally Established
tariff for services
of Doctors
• Indicates -
medicine was
centuries old at
that time
•procedure of lens
couching for cataract
•But there was no
systematic fund of
knowledge of the human
body
•Diseases – Caused by
demons or angry Gods
Preparation and Sources of
Medicine at Ancient Babylon
bandages, creams and pills
Babylonian cylinder seal and sketch depicting
Nergal, god of plague, symbolized by the
crooked stick.
Babylonians introduced the concepts of diagnosis, prognosis, physical examination and prescriptions.
Patients were treated with various therapies.
BOTH MAGIC AND MEDICINE SERVED AS STRATEGIES FOR HEALING THE SICK.
Extensive Diagnostic Handbook
(Clay Tablets) by Ummammu
Babylonian Queen of Night
Ishtar (Healing Goddess)
GREEK MEDICINE
460-355 B.C.
Logical
Big Thinkers
Hippocrates
Theophrastus
Hippocratic
Collection
(Books)
Oath
4 humours
Clinical
Observation-
Still used today
(Big impact on
Medicine)
Knew Belladona, Peppermint, Aniseed
But Still Believed in Supernatural Ideas too
Asclepius
Hygeia
Panacea
Snake
Library at
Alexandria
While Ancient Civilizations were undoubtedly versed in the use of herbs as medicines,
Extensive Written Records Appeared only During the Time of Greeks.
Extensive
Documentation
•Theophrastus
(compiled 450
medicinal
Plants)
‘Prevention is
better than
Cure’
Galen
4 humours cont…
Use of Opposites
Dissection
Dissected pigs, learnt
brain important but
also made mistakes
Said human form
made by one God
(therefore Catholic
church later backed
him)
ROMAN MEDICINE
The medical knowledge was acquired by Romans by Greek physicians who were brought into Roman
empires, mostly as Slaves
But still believed in Gods and Supernatural ideas too
Adopted Asclepius
Public Health
(Empire needs
Healthy Army)
Aqueducts, Toilets, Baths, Sewers
DARK AGE (400 – 800 A.D)
• Less importance on the value of Public Health facilities
• Low literacy of Public
Europe was ravaged by Epidemics
There was an emphasis on
bandage placement, but
none on sterile practices.
Church taught that God sent illness & repenting would cure all evils many people
at the time believed that pilgrimage would cure them
Time of intellectual and societal stagnation throughout much of Europe, But the torch
of academia continued to burn brightly in the Islamic world.
After Roman Era, Practice of medicine reverted back to primitive medicine dominated by
Superstititon and Dogma
Doctors combined
Galenic medicine with
careful studies of the
stars. This picture
shows how the stars
influence the human
body.
Diagram shows various
points for Bloodletting.
Patients were bled for
common conditions like
fever so that tainted blood
could be removed to
restore proper body
balance. But the picture
doesn’t show a detail about
where veins are.
Trephining involved removal
of a piece of bone from the
skull & was widely practised
in this period. It was mostly
performed to provide
passage for the evil spirits to
escape.
MEDIEVAL MEDICINE (AD 800 –AD 1400)
In 1066 the Normans invaded Europe. This period brought improvements to public
health, travel became safer, Church became rich and trade increased.
Black Death (1348–49)
A frightening Outbreak, Bubonic Plaque originating in Asia,
arrived to Europe. Painful swellings (buboes) of apples size
in the groin and armpits and oozing red and black spots
appeared all over the body, giving the
disease the name the Black Death.
Nearly I/3rd of the European
population died.
Girolamo Fracastoro
• Theory about invisible
germs that spread and
cause diseases
• Refutes Galen’s "miasm
theory” (poisonous air and
fumes)
Church Run
Hospitals
Urine Analysis
Medical School
Wine
as an Antiseptic
Medical
Developme
nt
Other epidemics: Variola, Dysentery, Scurvy, Leprosy
Ibn al-Nafis (1200-1288)
An Arab Doctor,
investigated the
anatomy of heart and
was brave enough to
challenge Galen.
• Renewed Interest in Roman and Greek Medicine
• First hand Knowledge of Arab Medicine
RENAISSANCE MEDICINE
Although new discoveries were made ,
people still did not know what caused illness.
Factors Which favourably affected
progress in medicine
Humanism
‘Re-born’ interest in
Greek and Roman
Medicine, buildings and
Sculpture
lack of sewage and other Public
sanitation system
Bleeding by using leech
was practiced
Quacks were present as
people couldn’t meet doctors
Wars
close study of classic texts
Love of enquiry - willingness to
challenge existing ideas.
The Printing Press
Weakening Power of the Church
Artists attended dissections of human
corpses and did illustrations for medical
books.
Wealth and education
triggered the
Renaissance
Factors which adversely affected progress in
Medicicne
Reappearance of Great Plague of 1665
other infectious diseases were common
RENAISSANCE MEDICINE - PIONEERS
PARACELSUS
Swiss German Physician
Father of Toxicology
pioneered the use of
chemicals and minerals
in medicine.
Introduced Laudanum, an
opium tincture
forerunner of Antisepsis
clinical diagnosis and highly
specific medicines.
AMBROISE PARE
French Battlefield - Later
Kings Surgeon.
Tried less brutal methods -
simple dressings and
soothing ointment for
wounds.
Promotion of ligation of
blood vessels -
Amputation
Promoted artificial limbs as
well as an artificial eye.
ANDREAS VESALIUS
Brussels Anatomist
Physician
author of one of the most
influential books ‘De
humani corporis fabrica. ‘
Vesalius found that the
human breastbone has
three segments, not seven
as Galen claimed.
Encouraged Human
Cadaver Dissection
WILLIAM HARVEY
English Kings Physician
Understood and explained
the circulatory system and
role of heart & Valves
Challenged Galen - Blood
not a body fuel but
constantly recirculating in
the body
All mammals reproduced
via fertilization of egg by
sperm
•Robert Hooke (1665)
•coined the
term cell for
describing biological
organisms
‘CELL’
•Antony leewen Hoek
• ‘’ In the year of 1657, I
discovered very small
living creatures ’’
Microscope
•JohnHunter
• founded surgical
pathology, and raised
surgery to the
respectable science
science
Surgery
• Giovanni Battista
Morgagni 1761
• postmortem
examination of 700
cases, Attempt to
correlate the findings
after death with the
clinical picture
when alive
Pathology
• William Smellie
• leading obstetrician in
London
•systematic discussion on
the safe use of obstetrical
forceps
Obstetrics
•James Lind,
• a British naval surgeon
from Edinburgh,
•recommended fresh
fruits and citrus juices
to prevent scurvy
Scurvy ℞
• Madam De Coudary
• ‘Manual on the art of
Child Birth’
• Cleanest and most
effective way to help a
women through Labour’
Obstetrics
• Sir Humphrey Davy (1799)
discovered Laughing gas
(Nitrous Oxide).
• Had pain relieving
properties but did not
make patients completely
unconscious.
Anaesthesia
MEDICINE IN 17th & 18th CENTURY
The structure of the human body was almost fully known, due to new methods of
microscopy and of injections. Even the body’s microscopic structure was understood.
MEDICINE IN 18th CENTURY
Even in the 18th century the search for a simple way of healing the sick continued.
Jenner is said to have saved more lives than the work of any other human being.
The Scratch that Saved a Million Lives: The Discovery of Vaccines
PHRENOLOGY
Propounded by
Franz Joseph Gall,
Contours of the skull
is a guide to an
individual’s mentality
and character traits.
• The originator of
homeopathy
• Treatment Involves
administration of
minute doses of drugs
A belief in “animal
magnetism”
sponsored by
Franz Anton
Mesmer,
and Pseudo Scientific Doctrines Other disciplines
Mesmerism Samuel Hahnemann
Edward Jenner, Pupil of John Hunter,
invented the worlds first vaccine for
small pox in 1789. Jenner inoculating
James Phipps with cowpox, a virus
similar to smallpox, to create immunity
to SMALL POX.
Cowpox Smallpox
MEDICINE IN 19th CENTURY
PHYSIOLOGY
Portrayal of the history of medicine becomes more difficult in the 19th century.
Discoveries multiply, leading trends in modern medical thoughts are observed
Germ Theory- Discovery of Germs and How They Cause Disease – 1860s
• Johannes Müller,
professor
at the University of
Berlin
• Established
Physiology as a
distinctscience
•IllustriousPupils
of Muller
•Hermann von
Helmholtz
•Rudolf Virchow
Deathblow
to
Galen
4
humours
theory
•Virchow’s work
published in 1858,
gave the deathblow to
the outmoded view
that disease is due to
an imbalance of the
four humours.
•Claude Bernard,
•carefully planned experiments
• Role of pancreas in digestion,
•Presence of glycogen in the
liver,
•vasomotor nerves
•Concept of Internal Milieu
•French chemist Louis Pasteur established the
science of bacteriology
•DiscoveredRabies Vaccine
Process of
Pateurisation
•In 1870s, developed practical applications of
the germ theory of disease.
•use of carbolic acid (Phenol) as an antiseptic.
• Another Pioneer Robert Koch,
showed how bacteria could be
cultivated, isolated, and examined
• discovered M. tuberculosis,in
1882, and Vibrio Cholerae
•Germ Theory: Most spectacular
overarching medical advance of the
19th century
•Viruses were discovered in 1890
MEDICINE IN 19th CENTURY
Discoveries in the field of Anaesthesia
Leading trends in modern medical thoughts started appearing in the Horizon.
Antisepsis and Anesthesia placed surgery on an entirely new footing.
Commendable Changes which improved Public Health and Patients stay in hospital
• 1846 – William. T. G.
Morton,
• For the Relief of
Unbearable Pain:
Discovery and use of
Ether during Surgery
1847
Prof. James Y Simsons
discovered chloroform’s
anaesthetic property
• The Discovery of Sanitation
• First Modern
Epidemiological Study in
Manchester, UK, 1854
• John Snow identified that
cholera was transmitted by
the ingestion of water
contaminated by feces.
CHOLERA SAVED CIVILIZATION
Stethoscope
REDCROSS
ORGANISATION-1864
1850s
Nursing starts to improve.
(Florence Nightingale)
1800
No real pain
relief or
knowledge
of germs or
antiseptics.
In 1816 René Laënnec, a native
of Brittany, who practiced
medicine in Paris, invented a
simple stethoscope, or cylindre.
MEDICINE IN LATE 19th CENTURY
The tremendous increase in scientific knowledge during the 19th century radically altered and
expanded the practice of medicine. To uphold the quality of services , public and professional
bodies to govern the standards for medical training and practice were established.
Sigmund Freud was an Austrian
neurologist and the founder of
psychoanalysis.
• In 1877, Patrick Manson, showed
in China that embryos of
the Filaria worm can cause elephantiasis
and it is transmitted by the mosquito.
• In 1881, In Cuba, Carlos Finlay expressed
the view that yellow fever is transmitted
by the Stegomyia mosquito.
Dawn of Radiology New Field of Psychiatry
Understanding of Parasitology
I’m Looking Through
You: The Discovery of X-
Rays. Wilhelm Conrad
Rontgen 1895
1897, Ronald Ross, a British officer
in the Indian Medical Service,
demonstrated that malaria
parasites are transmitted via
mosquitoes
MEDICINE IN 20th CENTURY
Steady progress was made in the isolation, identification, and study of the active principles of
the endocrine glands. Discovery of microorganisms, antibiotics, Hormones and vaccines – led
to disappearance of fatal epidemics of the past and changed the facet of healthcare.
In 1907, Paul Erlich introduced
chemotherapy (chemicals that
selectively destroy micro
organisms, without causing
damage to the host)systematic
prophylactic BCG vaccine
1923
1928Alexander Fleming
accidental finding that the
presence of molds blocked
coccus culture growth
19XX
In 1940s, Florey & Chain
helps in purification of
penicillin from fermentation
broth
19XX
BloodGrouping
•Karl Landsteiner described ABO
Compatibility and A,B,AB & O Blood group.
•This lead to first successful blood
transfusion.
Endocrinology Begins
•1905- Ernest H. Starling, introduces the
term Hormnes
•George Redmayne Murray
treated myxedema () with an extract of the
thyroidgland.
•1922- Banting & Best discovered Insulin
Immunology
•1906 August von Wassermann gave his
name to the blood test for syphilis
•1908 the tuberculin test was Introduced
From Ancient Molds to Modern Miracles: The Discovery of Antibiotics
In 1941, Due to World War II,
Mass scale production was
done in US instead of UK
1941
In 1943, Streptomycin was
Discovered by Selman A.
Waksman
He coined the term ‘Antibiotic’
In 1932, Gerhard Domagk
found out that
the sulfonamide Prontosil to
be effective
against streptococcus,
Surgical and diagnostic
techniques were developed to
cure once fatal conditions:
Organ transplants 1954
Limbs reattached
Test tube babies 1978
Amniocentesis
Implanted first artificial heart
Second half of 20th Research topics
Oral antidiabetic therapy
- Ionizing radiation and leukaemia
- Sacharin and bladder carcinoma
-Thalidomide effects
-Estrogen supplementation and
endometrial cancer
- breast cancer
- Passive smoking
- HIV/AIDS1983 identified
- Risk factors for accidents
New machines were
developed:
Kidney dialysis machine
Heart lung machine
Computerized axial
tomography (CAT) scan
1980 – WHO announces that
smallpox is eradicated.
1996- Dolly the sheep
becomes the first mammal
cloned from an adult cell
(dies in 2003).
Medicines for the Mind:
The Discovery of Drugs for
Madness, Sadness, and
Fear
Lithium appears to market
1950
Breaking God’s Code: The Discovery of Heredity,
Genetics, and DNA 1953
James Watson and Francis Crick at Cambridge University
described the structure of the DNA molecule.
MEDICINE IN 20th CENTURY
Further progress in medicine, social sciences, technology and economy - led to increased life
expectancy in wealthy populations, and change in morbidity and mortality patterns
MEDICINE IN 21st CENTURY
2000- First draft of human genome is announced; the finalized version is released three years later.
2006 - A "mini-liver"—the size of a small coin—is generated from human cord blood stem cells by
doctors at Newcastle University, U.K.
2007 - Scientists discover how to use human skin cells to create embryonic stem cells.
2014 - The FDA approves the first human clinical trials in the United States for a wearable artificial
kidney designed by Blood Purification Technologies Inc. out of Beverly Hills, California.
2015 -In March, DNA from an extinct woolly mammoth is spliced into that of an elephant.
Scientists then successfully use the "revived" DNA to sequence the mammoth's complete genome.
2016 -The success of an first-time experimental surgery will determine future availability for U.S.
cancer patients and veterans with injuries to the pelvic region. On May 8, 2016, a man named
Thomas Manning is the first man to receive a penis transplant at the Massachusetts General
Hospital. Manning's recovery from the surgery is going well
• Nanotechnology in medici
ne involves applications of
nanoparticles currently
under development, that
involves the use of
manufactured nano-
robots to make repairs at
the cellular level
Nano
Medicine
•Stem cells have
tremendous promise to
help us understand and
treat a range of diseases,
injuries and other
health-related
conditions
Stem Cell
Research
•medical decisions,
practices, interventions
and/or products being
tailored to the individual
patient based on their
predicted response or
risk of disease.
Personalised
Medicine
FUTURE TRENDS IN MEDICINE
TECH TRENDS IN MEDICINE
Augmented reality:
The digital contact lens patented
by google aims to change the
course of diabetes management
by measuring blood glucose levels
from tears.
Artificial Intelligence:
Creating Digital selves based on
neurological information. It means
we could upload our minds to a
computer and live on in a digital
form.
Cyborgs: Cybernetic Organism
Cyborgs will be able to restore
function or enhance abilities due
to the integration of some artificial
component or technology
Medical 3D printing
It will destroy and re-design the whole
pharmaceutical world, but regulation will be a
huge challenge. Bionic ears and simpler organs
will be printed at the patient’s bedside.
Gamifying behaviour change
Adherence and compliance pills as a pill bottle that glows blue
when a medication dose should be taken and red when a dose
is missed; or tiny digestible sensors that can be placed in pills
and can transmit pill digestion data to physicians and family
members.
TECH TRENDS IN MEDICINE
TECH TRENDS IN MEDICINE
New diseases like Virtual PTSD
New types of diseases will appear due
to the excessive use of virtual reality
solutions in gaming and other
industries including healthcare. E.G.,:
virtual post-traumatic stress disorder ,
Addiction.
Real-time diagnostics
With the intelligent surgical knife
(iKnife), the vaporized smoke is
analyzed by a mass spectrometer
to detect the chemicals in the
biological sample to identify
whether the tissue is malignant in
Real Time.
Holographic data input
No hardware will be needed to add
data to a laptop as screens and
keyboards will be projected on the
wall/table. Only small projectors
will be needed, while the data will
be stored exclusively in the cloud.
Crowdsourcing through Social Media
Social media has the potential to become a huge
“mind machine” making it possible to transmit,
share, crowdsource and store medical pieces of
information either for e-patients or medical
professionals
Multi-functional radiology
One multi-functional machine will be able to detect
plenty of medical problems, biomarkers and symptoms at
once.

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History of Medicine.pptx

  • 2. PRE-HISTORIC MEDICINE •Prehistoric men believed that illness and diseases were a punishment from the Gods •First physicians were witch doctors who treated illness with ceremonies Other Cures Trephination : One of the first surgeries -A hole was cut into the skull to release Evil Spirits Prayers and Chants WAY OF LIFE Hunter Gatherers Different tribes comingled – Exchange of tribal folklore – Ever-increasing compendium of useful, not so useful, and even dangerous remedies developed. Practical Causes for Ill health 1. Falls 2. Bites 3. Fractures 4. Parasites Rational Cures • Good Diet •Setting of bone fractures •and Dislocations • Mud, Herbs and other Plants Evidence for ‘disease and its management’ in the pre historic period is limited to • fossilized bony lesions • Comparing with Aborigines • Cave Drawings Major Threats to Health Predators Pregnancy
  • 3. EGYPTIAN MEDICINE-1 Egyptians believed gods, demons and spirits played a key role in causing diseases. Factors Influencing medicine Ancient Egypt (3300BC to 525BC) : Dawn of "medical care“ which was greatly influenced by wealth and trade Wealth Trade Science & Technology Mummification Egyptian people used Copper: Disinfectant Thread & Needle : Stitch Wounds Oil Massage: Reduce pain & Aches Egyptian physician Imhotep Eye of Horus: Modern day prescription symbol
  • 4. EGYPTIAN MEDICINE-2 Mashed Pigs Eye for Eye Problems: Ancient Egyptian doctors prescribed mashed pig’s eyes blended with honey and red ochre for eye problems The practice of medicine is very specialized among Egyptian, Each physician treats just one disease. Crocodile Dung as Contraceptive: Crocodile dung mixed with honey and mud was used as contraceptive Mouldy Breads for Treating: The microbes in mouldy bread destroyed the pathogens and cured the infection Ancient Egypt Wooden Prosthetic Toe Early Egyptian dental bridge The Ancient Medical Documents (300 BC) Ancient Medical Prosthesis Edwin Smith Papyrus Ebers Papyrus (1600 BC)
  • 5. AYURVEDA Traditional Hindu Medical system Native to India – Diet, Herbal treatment & Yoga Panchamahabhut: Five basic elements of the Entire Creation Space , Air, Fire, Water and Earth Ayurveda [Ayus(life), Veda(knowledge) in Sanskrit] - An Ancient Indian Healing Art Samhitas: Charaka, Sushrutha and Agnivesha- •Ancient Hindu Medical texts •Contains material regarding surgery and medicine •Described properties of 1270 species of plants •8000 herbal remedies in Ayurveda •Surgeries as cataract and Rhinoplasty The world’s first university Takshashila had 8 year course on Ayurveda around 600BC Oldest surviving complete medical system in the World – A highlights the way of life that teaches how to maintain and protect health The glories of Hindu medicine rapidly declined when waves of invaders attacked India Establishment of huge ancient universities -Takhsashila and Nalanda contributed to the spread of knowledge to various parts of the world. Dhanvantari Physicians of God emerged from Ocean of milk with amrutha and Herbs in his hands
  • 6. Dhanvantari Sushrutha sushrutha Samhita Nagarjuna – Compiles & revises sushrutha samhitha Daksha Prajapathi Ashwini devatha (Physician's of God) Lord Indra Sage Bharadwaja (around 5000BC) Athreya, Punarvasu Agnivesa (Agnivesa tantra), Bhela (Bhela samhitha) , Jathukarna, Parasara, Ksharapani, Haritha Charaka (Charaka samhitha) VAGBHATTA (Ashtanga Hridaya) COMPILATION OF CHARAKA SAMHITA & SUSHRUTHA SAMHITA BLOOMING OF AYURVEDA SURGERY MEDICINE BRAHMA
  • 7. CHINESE MEDICINE Shang Dynasty (1766-1122 BC) Origin of Traditional Chinese medicine Tang Dynasty The Suwen, a part of the Huangdi neijing expanded and revised Jin Dynasty (215-282) Huangfu Mi acupuncture and moxibustion Chou Dynasty(1122-403 BC) Confucius(551-479) Foundational text of Chinese medicine is the Huangdi neijing, (or Yellow Emperor's Inner Canon) Qing Dynasty 18th century Proliferation of popular books as well as more advanced encyclopedias on traditional medicine 19th century, Western medicine was introduced at the local level by Christian medical missionaries
  • 8. CHINESE MEDICINE The typical Traditional Chinese Medicine therapies Cupping Moxibustion Acupuncture Herbal Formulas Acupressure Tuina (Massage) Qigong Exercise Principles of Traditional Chinese Medicine
  • 9. BABYLONIAN MEDICINE Hammurabi CODE OF HAMMURABI (1800 BCE) • Legally Established tariff for services of Doctors • Indicates - medicine was centuries old at that time •procedure of lens couching for cataract •But there was no systematic fund of knowledge of the human body •Diseases – Caused by demons or angry Gods Preparation and Sources of Medicine at Ancient Babylon bandages, creams and pills Babylonian cylinder seal and sketch depicting Nergal, god of plague, symbolized by the crooked stick. Babylonians introduced the concepts of diagnosis, prognosis, physical examination and prescriptions. Patients were treated with various therapies. BOTH MAGIC AND MEDICINE SERVED AS STRATEGIES FOR HEALING THE SICK. Extensive Diagnostic Handbook (Clay Tablets) by Ummammu Babylonian Queen of Night Ishtar (Healing Goddess)
  • 10. GREEK MEDICINE 460-355 B.C. Logical Big Thinkers Hippocrates Theophrastus Hippocratic Collection (Books) Oath 4 humours Clinical Observation- Still used today (Big impact on Medicine) Knew Belladona, Peppermint, Aniseed But Still Believed in Supernatural Ideas too Asclepius Hygeia Panacea Snake Library at Alexandria While Ancient Civilizations were undoubtedly versed in the use of herbs as medicines, Extensive Written Records Appeared only During the Time of Greeks. Extensive Documentation •Theophrastus (compiled 450 medicinal Plants)
  • 11. ‘Prevention is better than Cure’ Galen 4 humours cont… Use of Opposites Dissection Dissected pigs, learnt brain important but also made mistakes Said human form made by one God (therefore Catholic church later backed him) ROMAN MEDICINE The medical knowledge was acquired by Romans by Greek physicians who were brought into Roman empires, mostly as Slaves But still believed in Gods and Supernatural ideas too Adopted Asclepius Public Health (Empire needs Healthy Army) Aqueducts, Toilets, Baths, Sewers
  • 12. DARK AGE (400 – 800 A.D) • Less importance on the value of Public Health facilities • Low literacy of Public Europe was ravaged by Epidemics There was an emphasis on bandage placement, but none on sterile practices. Church taught that God sent illness & repenting would cure all evils many people at the time believed that pilgrimage would cure them Time of intellectual and societal stagnation throughout much of Europe, But the torch of academia continued to burn brightly in the Islamic world. After Roman Era, Practice of medicine reverted back to primitive medicine dominated by Superstititon and Dogma Doctors combined Galenic medicine with careful studies of the stars. This picture shows how the stars influence the human body. Diagram shows various points for Bloodletting. Patients were bled for common conditions like fever so that tainted blood could be removed to restore proper body balance. But the picture doesn’t show a detail about where veins are. Trephining involved removal of a piece of bone from the skull & was widely practised in this period. It was mostly performed to provide passage for the evil spirits to escape.
  • 13. MEDIEVAL MEDICINE (AD 800 –AD 1400) In 1066 the Normans invaded Europe. This period brought improvements to public health, travel became safer, Church became rich and trade increased. Black Death (1348–49) A frightening Outbreak, Bubonic Plaque originating in Asia, arrived to Europe. Painful swellings (buboes) of apples size in the groin and armpits and oozing red and black spots appeared all over the body, giving the disease the name the Black Death. Nearly I/3rd of the European population died. Girolamo Fracastoro • Theory about invisible germs that spread and cause diseases • Refutes Galen’s "miasm theory” (poisonous air and fumes) Church Run Hospitals Urine Analysis Medical School Wine as an Antiseptic Medical Developme nt Other epidemics: Variola, Dysentery, Scurvy, Leprosy Ibn al-Nafis (1200-1288) An Arab Doctor, investigated the anatomy of heart and was brave enough to challenge Galen. • Renewed Interest in Roman and Greek Medicine • First hand Knowledge of Arab Medicine
  • 14. RENAISSANCE MEDICINE Although new discoveries were made , people still did not know what caused illness. Factors Which favourably affected progress in medicine Humanism ‘Re-born’ interest in Greek and Roman Medicine, buildings and Sculpture lack of sewage and other Public sanitation system Bleeding by using leech was practiced Quacks were present as people couldn’t meet doctors Wars close study of classic texts Love of enquiry - willingness to challenge existing ideas. The Printing Press Weakening Power of the Church Artists attended dissections of human corpses and did illustrations for medical books. Wealth and education triggered the Renaissance Factors which adversely affected progress in Medicicne Reappearance of Great Plague of 1665 other infectious diseases were common
  • 15. RENAISSANCE MEDICINE - PIONEERS PARACELSUS Swiss German Physician Father of Toxicology pioneered the use of chemicals and minerals in medicine. Introduced Laudanum, an opium tincture forerunner of Antisepsis clinical diagnosis and highly specific medicines. AMBROISE PARE French Battlefield - Later Kings Surgeon. Tried less brutal methods - simple dressings and soothing ointment for wounds. Promotion of ligation of blood vessels - Amputation Promoted artificial limbs as well as an artificial eye. ANDREAS VESALIUS Brussels Anatomist Physician author of one of the most influential books ‘De humani corporis fabrica. ‘ Vesalius found that the human breastbone has three segments, not seven as Galen claimed. Encouraged Human Cadaver Dissection WILLIAM HARVEY English Kings Physician Understood and explained the circulatory system and role of heart & Valves Challenged Galen - Blood not a body fuel but constantly recirculating in the body All mammals reproduced via fertilization of egg by sperm
  • 16. •Robert Hooke (1665) •coined the term cell for describing biological organisms ‘CELL’ •Antony leewen Hoek • ‘’ In the year of 1657, I discovered very small living creatures ’’ Microscope •JohnHunter • founded surgical pathology, and raised surgery to the respectable science science Surgery • Giovanni Battista Morgagni 1761 • postmortem examination of 700 cases, Attempt to correlate the findings after death with the clinical picture when alive Pathology • William Smellie • leading obstetrician in London •systematic discussion on the safe use of obstetrical forceps Obstetrics •James Lind, • a British naval surgeon from Edinburgh, •recommended fresh fruits and citrus juices to prevent scurvy Scurvy ℞ • Madam De Coudary • ‘Manual on the art of Child Birth’ • Cleanest and most effective way to help a women through Labour’ Obstetrics • Sir Humphrey Davy (1799) discovered Laughing gas (Nitrous Oxide). • Had pain relieving properties but did not make patients completely unconscious. Anaesthesia MEDICINE IN 17th & 18th CENTURY The structure of the human body was almost fully known, due to new methods of microscopy and of injections. Even the body’s microscopic structure was understood.
  • 17. MEDICINE IN 18th CENTURY Even in the 18th century the search for a simple way of healing the sick continued. Jenner is said to have saved more lives than the work of any other human being. The Scratch that Saved a Million Lives: The Discovery of Vaccines PHRENOLOGY Propounded by Franz Joseph Gall, Contours of the skull is a guide to an individual’s mentality and character traits. • The originator of homeopathy • Treatment Involves administration of minute doses of drugs A belief in “animal magnetism” sponsored by Franz Anton Mesmer, and Pseudo Scientific Doctrines Other disciplines Mesmerism Samuel Hahnemann Edward Jenner, Pupil of John Hunter, invented the worlds first vaccine for small pox in 1789. Jenner inoculating James Phipps with cowpox, a virus similar to smallpox, to create immunity to SMALL POX. Cowpox Smallpox
  • 18. MEDICINE IN 19th CENTURY PHYSIOLOGY Portrayal of the history of medicine becomes more difficult in the 19th century. Discoveries multiply, leading trends in modern medical thoughts are observed Germ Theory- Discovery of Germs and How They Cause Disease – 1860s • Johannes Müller, professor at the University of Berlin • Established Physiology as a distinctscience •IllustriousPupils of Muller •Hermann von Helmholtz •Rudolf Virchow Deathblow to Galen 4 humours theory •Virchow’s work published in 1858, gave the deathblow to the outmoded view that disease is due to an imbalance of the four humours. •Claude Bernard, •carefully planned experiments • Role of pancreas in digestion, •Presence of glycogen in the liver, •vasomotor nerves •Concept of Internal Milieu •French chemist Louis Pasteur established the science of bacteriology •DiscoveredRabies Vaccine Process of Pateurisation •In 1870s, developed practical applications of the germ theory of disease. •use of carbolic acid (Phenol) as an antiseptic. • Another Pioneer Robert Koch, showed how bacteria could be cultivated, isolated, and examined • discovered M. tuberculosis,in 1882, and Vibrio Cholerae •Germ Theory: Most spectacular overarching medical advance of the 19th century •Viruses were discovered in 1890
  • 19. MEDICINE IN 19th CENTURY Discoveries in the field of Anaesthesia Leading trends in modern medical thoughts started appearing in the Horizon. Antisepsis and Anesthesia placed surgery on an entirely new footing. Commendable Changes which improved Public Health and Patients stay in hospital • 1846 – William. T. G. Morton, • For the Relief of Unbearable Pain: Discovery and use of Ether during Surgery 1847 Prof. James Y Simsons discovered chloroform’s anaesthetic property • The Discovery of Sanitation • First Modern Epidemiological Study in Manchester, UK, 1854 • John Snow identified that cholera was transmitted by the ingestion of water contaminated by feces. CHOLERA SAVED CIVILIZATION Stethoscope REDCROSS ORGANISATION-1864 1850s Nursing starts to improve. (Florence Nightingale) 1800 No real pain relief or knowledge of germs or antiseptics. In 1816 René Laënnec, a native of Brittany, who practiced medicine in Paris, invented a simple stethoscope, or cylindre.
  • 20. MEDICINE IN LATE 19th CENTURY The tremendous increase in scientific knowledge during the 19th century radically altered and expanded the practice of medicine. To uphold the quality of services , public and professional bodies to govern the standards for medical training and practice were established. Sigmund Freud was an Austrian neurologist and the founder of psychoanalysis. • In 1877, Patrick Manson, showed in China that embryos of the Filaria worm can cause elephantiasis and it is transmitted by the mosquito. • In 1881, In Cuba, Carlos Finlay expressed the view that yellow fever is transmitted by the Stegomyia mosquito. Dawn of Radiology New Field of Psychiatry Understanding of Parasitology I’m Looking Through You: The Discovery of X- Rays. Wilhelm Conrad Rontgen 1895 1897, Ronald Ross, a British officer in the Indian Medical Service, demonstrated that malaria parasites are transmitted via mosquitoes
  • 21. MEDICINE IN 20th CENTURY Steady progress was made in the isolation, identification, and study of the active principles of the endocrine glands. Discovery of microorganisms, antibiotics, Hormones and vaccines – led to disappearance of fatal epidemics of the past and changed the facet of healthcare. In 1907, Paul Erlich introduced chemotherapy (chemicals that selectively destroy micro organisms, without causing damage to the host)systematic prophylactic BCG vaccine 1923 1928Alexander Fleming accidental finding that the presence of molds blocked coccus culture growth 19XX In 1940s, Florey & Chain helps in purification of penicillin from fermentation broth 19XX BloodGrouping •Karl Landsteiner described ABO Compatibility and A,B,AB & O Blood group. •This lead to first successful blood transfusion. Endocrinology Begins •1905- Ernest H. Starling, introduces the term Hormnes •George Redmayne Murray treated myxedema () with an extract of the thyroidgland. •1922- Banting & Best discovered Insulin Immunology •1906 August von Wassermann gave his name to the blood test for syphilis •1908 the tuberculin test was Introduced From Ancient Molds to Modern Miracles: The Discovery of Antibiotics In 1941, Due to World War II, Mass scale production was done in US instead of UK 1941 In 1943, Streptomycin was Discovered by Selman A. Waksman He coined the term ‘Antibiotic’ In 1932, Gerhard Domagk found out that the sulfonamide Prontosil to be effective against streptococcus,
  • 22. Surgical and diagnostic techniques were developed to cure once fatal conditions: Organ transplants 1954 Limbs reattached Test tube babies 1978 Amniocentesis Implanted first artificial heart Second half of 20th Research topics Oral antidiabetic therapy - Ionizing radiation and leukaemia - Sacharin and bladder carcinoma -Thalidomide effects -Estrogen supplementation and endometrial cancer - breast cancer - Passive smoking - HIV/AIDS1983 identified - Risk factors for accidents New machines were developed: Kidney dialysis machine Heart lung machine Computerized axial tomography (CAT) scan 1980 – WHO announces that smallpox is eradicated. 1996- Dolly the sheep becomes the first mammal cloned from an adult cell (dies in 2003). Medicines for the Mind: The Discovery of Drugs for Madness, Sadness, and Fear Lithium appears to market 1950 Breaking God’s Code: The Discovery of Heredity, Genetics, and DNA 1953 James Watson and Francis Crick at Cambridge University described the structure of the DNA molecule. MEDICINE IN 20th CENTURY Further progress in medicine, social sciences, technology and economy - led to increased life expectancy in wealthy populations, and change in morbidity and mortality patterns
  • 23. MEDICINE IN 21st CENTURY 2000- First draft of human genome is announced; the finalized version is released three years later. 2006 - A "mini-liver"—the size of a small coin—is generated from human cord blood stem cells by doctors at Newcastle University, U.K. 2007 - Scientists discover how to use human skin cells to create embryonic stem cells. 2014 - The FDA approves the first human clinical trials in the United States for a wearable artificial kidney designed by Blood Purification Technologies Inc. out of Beverly Hills, California. 2015 -In March, DNA from an extinct woolly mammoth is spliced into that of an elephant. Scientists then successfully use the "revived" DNA to sequence the mammoth's complete genome. 2016 -The success of an first-time experimental surgery will determine future availability for U.S. cancer patients and veterans with injuries to the pelvic region. On May 8, 2016, a man named Thomas Manning is the first man to receive a penis transplant at the Massachusetts General Hospital. Manning's recovery from the surgery is going well
  • 24. • Nanotechnology in medici ne involves applications of nanoparticles currently under development, that involves the use of manufactured nano- robots to make repairs at the cellular level Nano Medicine •Stem cells have tremendous promise to help us understand and treat a range of diseases, injuries and other health-related conditions Stem Cell Research •medical decisions, practices, interventions and/or products being tailored to the individual patient based on their predicted response or risk of disease. Personalised Medicine FUTURE TRENDS IN MEDICINE
  • 25. TECH TRENDS IN MEDICINE Augmented reality: The digital contact lens patented by google aims to change the course of diabetes management by measuring blood glucose levels from tears. Artificial Intelligence: Creating Digital selves based on neurological information. It means we could upload our minds to a computer and live on in a digital form. Cyborgs: Cybernetic Organism Cyborgs will be able to restore function or enhance abilities due to the integration of some artificial component or technology Medical 3D printing It will destroy and re-design the whole pharmaceutical world, but regulation will be a huge challenge. Bionic ears and simpler organs will be printed at the patient’s bedside. Gamifying behaviour change Adherence and compliance pills as a pill bottle that glows blue when a medication dose should be taken and red when a dose is missed; or tiny digestible sensors that can be placed in pills and can transmit pill digestion data to physicians and family members. TECH TRENDS IN MEDICINE
  • 26. TECH TRENDS IN MEDICINE New diseases like Virtual PTSD New types of diseases will appear due to the excessive use of virtual reality solutions in gaming and other industries including healthcare. E.G.,: virtual post-traumatic stress disorder , Addiction. Real-time diagnostics With the intelligent surgical knife (iKnife), the vaporized smoke is analyzed by a mass spectrometer to detect the chemicals in the biological sample to identify whether the tissue is malignant in Real Time. Holographic data input No hardware will be needed to add data to a laptop as screens and keyboards will be projected on the wall/table. Only small projectors will be needed, while the data will be stored exclusively in the cloud. Crowdsourcing through Social Media Social media has the potential to become a huge “mind machine” making it possible to transmit, share, crowdsource and store medical pieces of information either for e-patients or medical professionals Multi-functional radiology One multi-functional machine will be able to detect plenty of medical problems, biomarkers and symptoms at once.