7. Use .Continued.
3.Urinary tract infection.
Mechanism of Action:
Inhibits bacterial cell wall
synthesis by binding to one or
more of the penicillin-binding
proteins (PBPs).
15. Distribution :
20%protien bound,widely dist.,may
Cross in flamed meninges ;crosses
Placenta,secreted into breast milk.
Absorption:
After IM administration serum levels
significantly lower than
aftereqivalent IV dose.
16. Metabolism:
It‘s very little and metabolized in
the liver.
Elimination:
Excreted in urine .
Half –life elimination:2hours
17. Formulation:
Powder for injection as hydrochloride
:500mg,1g,2g.
Route and dosage:
1.Mild to moderate infections:
Adult: IV/IM 0.5-1g q12h times 7-10d
18. 2.Moderate to severe infections:
Adult:IV 1-2g q12h time 10d.
3.Febrile neutropenia:
Adult :IV 2g q8h for 7d or until resolu-
Tion of neutropenia.
Elderly :IV/IM should be based on renal
function and severity of infection.
20. 1.monitoring laboratory tests:
Prothrombin time ;peform culture and
sensitivity studies prior to initiating
drug therapy.
2.compatibility:
Discontinue other solution at the same
site to avoid compatibility problems.
21. Cont.
C.Monitor for S/S of hypersensitivity.
D.Assess bowel function (severe diarrihea)
E.Monitor urine output (if decreased,notify
prescriber).
F.Assess for opportunistic infection(fever,
Malaise,rash,itching,redness,chills,or
increased cough)
22. Additional Nursing lssues:
1.Physical assessment:
A. Determine history of hypersensitivity
reaction to cephalosporins, penicillins,or
other drug before therapy is initiated.
B.Lab tests perform culture and sensitivity
tests before initiation of therapy. Dosage
may be started pending test results.
23. 2.Geriatric Consideration:
Adjust dose for changes in renal function.
3.Patient and Family Education:
A.Promptly report any S/S hypersensitivity
,superinfection and pseudomembranous
colitis.
B.Do not breast feed while taking this drug
without consulting physician.
26. References
1.Pharmacology,2nd edition-Mary J.Mycek,
ph.D.and Richard.D.,Harvey ,ph.D.
2.Drug information hand book for nursing.
Including
assessment,administration,monitoring
guidelines and patient education.
3.Prentice hall (nurses drug guide 2006)