Many drugs interact with plasma or tissue proteins to form drug-protein complexes. The formation of these complexes is called drug-protein binding. Drug-protein binding can be expressed as a formula where [P] is the free protein concentration, [D] is the free drug concentration, and [PD] is the concentration of the drug-protein complex. There are several factors that can affect drug-protein binding, including the physiochemical properties and concentration of the drug, the quantity and quality of available binding proteins, drug interactions that compete for or alter protein binding sites, and the patient's health conditions such as age, liver or kidney function.

3. Slide
Title
PRESENTED TO
KHADIZA KHANAM
B.PHARM & M.PHARM(RU)
LECTURER DEPARTMENT
OF PHARMACY,
VARENDRA UNIVERSITY
PRESENTED BY
SAIMAAKTER
ID: 151211046
MD AMANULLAH
ID: 151211064

4. Many drugs interacts with plasma or tissue protein
or with other macromolecule, such as melanin and
DNA, to form drug macromolecule complex. The
formation of a drug protein complex is called
drug-protein binding. It can be expressed as
follows…….
[P]+[D]= [PD]
Where, [p]= Free protein concentration
[D]= Free drug concentration
[PD]= Concentration of drug-protein complex
Protein Binding of Drugs

5. Type of Drug-Protein Binding

6. Factor Affecting Drug-Protein Binding
Factors related to the drug protein:
The drug
a. Physiochemical properties of the drug
b. Total concentration of the in the body
The protein
a. Quantity of the protein available for binding
b.Quality of the protein synthesized
The affinity between drug and protein

7. • Continue…
DDrug interactions:
a. a. Competition for the drug by other substances at
a protein binding site
b.b. Alteration of the protein that modifies the
affinity of the drug
The pathophysiologic condition of the patient.

8. Factors related to the patient:
AGE
Hepatic
insufficiencyRenal failure