Ian Crowlesmith, our Embase expert reviewed the following in this webinar: - Drugs and adverse drug reaction in Embase vs MEDLINE - Searching for Adverse events and side effects in Embase - Using keywords when searching for adverse events - Adverse events of devices

1. Embase® is a registered trademark of Elsevier BV.
SEARCHING FOR ADVERSE
EVENTS ON EMBASE
Presented by Ian Crowlesmith
25 September 2013
i.crowlesmith@elsevier.com
Your host:
Ann-Marie Roche

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• Webinar control panel:
• ‘chat’ for questions or ‘ask a
question’
• minimize option for full screen
view
• Q&A halfway and last 10-15 minutes
of the webinar
NEED TO KNOW

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AGENDA
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase
1. Embase vs MEDLINE
2. Adverse reactions on Embase
3. Searching side effects
4. Using keywords
5. Adverse events of devices

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SEARCHING FOR ADVERSE
EVENTS ON EMBASE
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase
1. Embase vs MEDLINE
2. Adverse reactions on Embase
3. Searching side effects
4. Using keywords
5. Adverse events of devices

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DEFINITIONS OF ADVERSE EVENTS
ON EMBASE AND MEDLINE
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase
Embase
PubMed / MEDLINEfirst 4 of >100 terms
"chemicals and drugs category/adverse effects"[MeSH Terms]
NOT ("chemicals and drugs category/toxicity"[MeSH Terms]
OR "chemicals and drugs category/poisoning"[MeSH Terms])
Search using:
Search using: "chemicals and drugs”/exp/dd_ae
only in humans

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ADVERSE DRUG REACTIONS REPORTED BY FDA
US AND NON-US ORIGIN (2003-2011)
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase
http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Surveillance/Adverse
DrugEffects/ucm070441.htm

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ADVERSE DRUG REACTIONS: EMBASE VS MEDLINE
BASED ON SUBHEADINGS LINKED TO “CHEMICALS AND DRUGS”
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase
0
10,000
20,000
30,000
40,000
50,000
1990
1995
2000
2005
2010
Embase
MEDLINE
Publication year
Records
per year Embase includes all of MEDLINE
Subheadings introduced
in Embase (1988)
Search strategy for Embase:
"chemicals and drugs”/exp/dd_ae

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SEARCHING FOR ADVERSE
EVENTS ON EMBASE
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase
1. Embase vs MEDLINE
2. Adverse reactions on Embase
3. Searching for side effects
4. Using keywords
5. Adverse events of devices

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ADVERSE REACTIONS IN EMBASE
BROWSING EMTREE TO FIND DRUG NAMES
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase

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ADVERSE REACTIONS IN EMBASE
DRUG SEARCH
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase

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ADVERSE REACTIONS IN EMBASE
FILTERED TO LIST INDEXED DRUGS
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase

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ADVERSE REACTIONS TO CISPLATIN
FILTERED TO LIST INDEXED DISEASES
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase

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ADVERSE REACTIONS TO CISPLATIN
IN-DEPTH DRUG INDEXING
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase

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ADVERSE REACTIONS TO CISPLATIN
EMBASE VS MEDLINE
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase
Embase

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OTHER ADVERSE EVENTS IN EMBASE
DRUG TOXICITY (SCOPE NOTE)
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase

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ADVERSE EVENTS IN EMBASE
DRUG TOXICITY VS ADVERSE DRUG REACTION
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase

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ADVERSE EVENTS IN EMBASE
ADDITIONAL SEARCH OPTIONS
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase
This is a conference abstract
This is an In-Process record

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SEARCHING FOR ADVERSE
EVENTS ON EMBASE
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase
1. Embase vs MEDLINE
2. Adverse reactions on Embase
3. Searching for side effects
4. Using keywords
5. Adverse events of devices

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SIDE EFFECTS IN EMTREE
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase
first 12
of over
100
terms

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SEARCHING SIDE EFFECTS ON EMBASE
DISEASE SEARCH
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase

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SEARCHING SIDE EFFECTS ON EMBASE
FILTER TO LIST INDEXED DISEASES
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase

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INDEXING OF SIDE EFFECTS ON EMBASE
SIDE EFFECTS OF CISPLATIN
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase

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SEARCHING FOR ADVERSE
EVENTS ON EMBASE
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase
1. Embase vs MEDLINE
2. Adverse reactions on Embase
3. Searching for side effects
4. Using keywords
5. Adverse events of devices

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SEARCHING ADVERSE EVENTS USING KEYWORDS
“ADVERSE” AS A KEYWORD
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase

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KEYWORDS FOR SEARCHING ADVERSE EVENTS
REPRESENTATIVE KEYWORDS
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase

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SEARCHING ADVERSE EVENTS USING KEYWORDS
UNIQUE RECORDS RETRIEVED FOR CISPLATIN
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase
This is an In-Process record
Outside AE definition for
both Embase & MEDLINE

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SEARCHING FOR ADVERSE
EVENTS ON EMBASE
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase
1. Embase vs MEDLINE
2. Adverse reactions on Embase
3. Searching for side effects
4. Using keywords
5. Adverse events of devices

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ADVERSE EVENTS FOR MEDICAL DEVICES
REPORTED BY FDA (2004-2008)
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase
http://clinicaldevice.typepad.com/cdg_e_conferences/adverse-events-and-effects/

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MEDICAL DEVICES ON EMTREE
NEW TREE STRUCTURE (2013)
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase

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FINDING ADVERSE EVENTS FOR MEDICAL DEVICES
DISEASE SUBHEADING “COMPLICATION”
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase

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SEARCHING FOR ADVERSE EVENTS ON DEVICES
USING DISEASE SUBHEADING “COMPLICATION”
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase

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SEARCHING FOR ADVERSE EVENTS ON DEVICES
RECORDS RETRIEVED USING KEYWORDS
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase

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SEARCHING FOR ADVERSE EVENTS ON DEVICES
TYPICAL RECORD FOUND USING KEYWORDS
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase
This record is a conference abstract !

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SEARCHING FOR ADVERSE EVENTS ON EMBASE
SUMMARY
Keyword searches
• Use keywords saved in „hedges‟
(saved searches) or alerts.
• Useful for Articles-in-Press, In-
Process & Conference records.
• This will increase sensitivity at
the cost of precision.
Medical devices
• Search adverse effects using
disease subheading CO.
• Also consider expanding search
using keywords.
• Over 3000 medical devices are
now available in Emtree.
Adverse drug reactions
• Use drug subheading AE where
possible. Focus is on human.
• Consider expanding search
using keywords.
• This will increase sensitivity at
the cost of precision.
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase

35. THANK YOU
ANY QUESTIONS?
35
Ian Crowlesmith
Senior Product Manager, Content
Development
i.crowlesmith@elsevier.com
Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase

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Ian Crowlesmith | 25 September 2013 | Searching for Adverse Events on Embase
For more information and questions please
use the contact details on our online
page, where you may also find all training
and support materials and our full webinar
schedule.
Our next Embase webinar is on October 23
and this will be an introduction to Embase
for new users.
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