Constructing S.T.E.A.M.: a PHYSICSian scientist’s perspective
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www.drbrowncares.com The time has come to teach arts and science together. Physicists, students, and physics lovers worldwide, and all others can use poetry and various art forms to capture the essence of science to enhance learning. Science, technology, engineering, arts, and mathematics (S.T.E.A.M.) come together in this talk, from the perspective of a physician, poet, and scientist. Read more about creative expression in science and medicine relevant to the brain at http://journal.frontiersin.org/article/10.3389/fneur.2015.00003/full @drbrowncares
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Constructing S.T.E.A.M.: a PHYSICSian scientist’s perspective
- 1. Constructing S.T.E.A.M.: a PHYSICSian scientist’s perspective Sherry-Ann Brown, MD, PhD @drbrowncares, drbrowncares@gmail.com www.myschoolhouse.com
- 4. S.T.E.A.M. www.myschoolhouse.com @drbrowncares drbrowncares@gmail.com Star Trek: The Next Generation sixth season episode "Second Chances"
- 5. The Cerebellum • Latin, little brain • Constitutes only 10% of the total volume of the brain, but contains more than half of all its neurons • Coordinates posture, gaze, speech, handwriting, and other motor functions The Cerebellum, Principles of Neural Science. 2000 McGraw Hill. ATAXIA n. Greek. Loss of motor coordination. @drbrowncares drbrowncares@gmail.com
- 7. Climbing Fiber Stimulus Depolarization throughout PN Extracellular Calcium entry into cell! Parallel Fiber Stimulus IP3 Production Calcium mobilization from ER! ER = endoplasmic reticulum Cerebellar Purkinje Neuron (PN) @drbrowncares drbrowncares@gmail.com
- 8. Hernjak et al, Biophysical Journal 2005 Parallel fiber stimulus Climbing fiber stimulus @drbrowncares drbrowncares@gmail.com Calcium Pathways In The Cell
- 10. Hernjak et al, Biophysical Journal 2005 Parallel fiber stimulus Climbing fiber stimulus @drbrowncares drbrowncares@gmail.com Calcium Pathways In The Cell Aim 1: 3D Model
- 11. Purkinje neuron Reconstructed Experimental 3D Geometry of Purkinje Cell Dendrite Branchlet @drbrowncares drbrowncares@gmail.com
- 12. Hernjak et al, Biophysical Journal 2005 Parallel fiber stimulus Climbing fiber stimulus @drbrowncares drbrowncares@gmail.com Calcium Pathways In The Cell Aim 1: 3D Model
- 13. PIP2 Diffusion in the spine membrane @drbrowncares drbrowncares@gmail.com Max 8120 1400 Min
- 14. SIX Spines - Simulation Max 8120 1400 Min @drbrowncares drbrowncares@gmail.com
- 16. Hernjak et al, Biophysical Journal 2005 Parallel fiber stimulus Climbing fiber stimulus @drbrowncares drbrowncares@gmail.com Calcium Pathways In The Cell Aim 1: 3D Model Aim 2: Electric Model
- 17. Preserved electronic PATH in red, spine of interest in blue @drbrowncares drbrowncares@gmail.com Neuronal morphology
- 18. The Dendrite as an Electrical Circuit @drbrowncares drbrowncares@gmail.com
- 19. Simplification of Purkinje Neuronal Morphology Miyasho et al., Brain Research, 2001 @drbrowncares drbrowncares@gmail.com
- 20. Comparison of Electrical Activity in the Full and Reduced Models - soma -80 -40 0 40 80 0 500Time (ms) Membrane Potential(mV) -80 -40 0 40 80 0 500Time (ms) Membrane Potential(mV) @drbrowncares drbrowncares@gmail.com Full model Reduced model
- 21. Hernjak et al, Biophysical Journal 2005 @drbrowncares drbrowncares@gmail.com Calcium Pathways In The Cell Aim 3: Ataxia Model Aim 1: 3D Model Aim 2: Electric Model
- 23. Citations Textbooks (11) + Journal articles (33) @drbrowncares drbrowncares@gmail.com
- 24. S.T.E.A.M. Collection © 2010 Sherry-Ann Brown Coincident Incident How Will I Dance? Just One More Step @drbrowncares drbrowncares@gmail.com
- 28. My Thesis Committee CCAM, MD/PhD Program University of Connecticut Health Center NIH Primary Investigator: Dr. Leslie M. Loew Dr. Ion Moraru Dr. James Schaff Dr. Ann Cowan Dr. Raquell Holmes Dr. James Watras Mr. Frank Morgan Ed & Elena Karen, Donna, Debbie Anu, Fei, Li Ye; Boris, Igor, Pavel Sofya, Jon, Stacy Dr. Art Hand Dr. Bill Lytton Dr. Marja Hurley @drbrowncares drbrowncares@gmail.com
- 29. Stepping In & Out Sherry-Ann Brown, MD, PhD CI Planning Meeting 2015 Thesis reception: S.T.E.A.M. poetry collection poster, art & photography @drbrowncares drbrowncares@gmail.com
- 31. Shear & Tensile Stress Injury to Arteries (and Nerves) @drbrowncares drbrowncares@gmail.com
- 36. Sherry-Ann Brown, MD, PhD @drbrowncares, drbrowncares@gmail.com www.myschoolhouse.com Constructing S.T.E.A.M.: a PHYSICSian scientist’s perspective
- 37. Ohm’s Law & Blood Circulation Ohms Law Darcy’s Law V = I x R BP = Q x VR "The heart is the only organ of all organs that can not endure injury. This is expected because when the main power source is destroyed, no additional force can be brought by the organs that depend on it" (Aristotle - 384 BC). www.slideshare.net, http://www.scielo.br/scielo.php?pid=S0102-76382010000100006&script=sci_arttext&tlng=en @drbrowncares drbrowncares@gmail.com
- 38. • In a noncompressible fluid system, flow is the same at any given point • Flow = area x velocity • area x velocity = area x velocity • F ∝ V ⋅ r2 cm³►cm² cmx Conservation of Mass Principle Compliments of Dr. Hector Michelena, Mayo Clinic @drbrowncares drbrowncares@gmail.com
- 39. Turbulent Blood Flow www.cvphysiology.com F ∝ V ⋅ r2 area x velocity @drbrowncares drbrowncares@gmail.com
- 42. Sherry-Ann Brown, MD, PhD @drbrowncares, drbrowncares@gmail.com www.myschoolhouse.com Constructing S.T.E.A.M.: a PHYSICSian scientist’s perspective