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Constructing S.T.E.A.M.:
a PHYSICSian scientist’s perspective
Sherry-Ann Brown, MD, PhD
@drbrowncares, drbrowncares@gmail....
S.T.E.M.
@drbrowncares
drbrowncares@gmail.com
S.T.E. M.
@drbrowncares
drbrowncares@gmail.com
S.T.E.A.M.
www.myschoolhouse.com
@drbrowncares
drbrowncares@gmail.com
Star Trek: The Next Generation sixth
season episode ...
The Cerebellum
• Latin, little brain
• Constitutes only 10% of the total volume of the brain, but contains more
than half ...
@drbrowncares
drbrowncares@gmail.com
Page 34
www.myschoolhouse.com
Climbing Fiber Stimulus 
Depolarization throughout PN 
Extracellular Calcium entry into
cell!
Parallel Fiber Stimulus 
...
Hernjak et al, Biophysical Journal 2005
Parallel fiber
stimulus
Climbing fiber
stimulus
@drbrowncares
drbrowncares@gmail.c...
@drbrowncares
drbrowncares@gmail.com
www.myschoolhouse.com
Coincident
Incident
Hernjak et al, Biophysical Journal 2005
Parallel fiber
stimulus
Climbing fiber
stimulus
@drbrowncares
drbrowncares@gmail.c...
Purkinje neuron
Reconstructed Experimental 3D Geometry of
Purkinje Cell Dendrite Branchlet
@drbrowncares
drbrowncares@gmai...
Hernjak et al, Biophysical Journal 2005
Parallel fiber
stimulus
Climbing fiber
stimulus
@drbrowncares
drbrowncares@gmail.c...
PIP2 Diffusion in the spine membrane
@drbrowncares
drbrowncares@gmail.com
Max
8120
1400
Min
SIX Spines - Simulation
Max
8120
1400
Min
@drbrowncares
drbrowncares@gmail.com
@drbrowncares
drbrowncares@gmail.com
www.myschoolhouse.com
Hernjak et al, Biophysical Journal 2005
Parallel fiber
stimulus
Climbing fiber
stimulus
@drbrowncares
drbrowncares@gmail.c...
Preserved
electronic PATH
in red, spine of
interest in blue
@drbrowncares
drbrowncares@gmail.com
Neuronal
morphology
The Dendrite as an Electrical Circuit
@drbrowncares
drbrowncares@gmail.com
Simplification of
Purkinje Neuronal Morphology
Miyasho et al., Brain Research, 2001
@drbrowncares
drbrowncares@gmail.com
Comparison of Electrical Activity in
the Full and Reduced Models - soma
-80
-40
0
40
80
0 500Time (ms)
Membrane
Potential(...
Hernjak et al, Biophysical Journal 2005
@drbrowncares
drbrowncares@gmail.com
Calcium Pathways In The Cell
Aim 3:
Ataxia
Mo...
Impact
@drbrowncares
drbrowncares@gmail.com
www.myschoolhouse.com
Citations
Textbooks (11) + Journal articles (33)
@drbrowncares
drbrowncares@gmail.com
S.T.E.A.M. Collection
© 2010 Sherry-Ann Brown
Coincident Incident
How Will I Dance?
Just One More Step
@drbrowncares
drbro...
@drbrowncares
drbrowncares@gmail.com
@drbrowncares
drbrowncares@gmail.com
@drbrowncares
drbrowncares@gmail.com
www.myschoolhouse.com
My Thesis Committee
CCAM, MD/PhD Program
University of Connecticut Health Center
NIH
Primary Investigator:
Dr. Leslie M. L...
Stepping In & Out
Sherry-Ann Brown, MD, PhD
CI Planning Meeting 2015
Thesis reception: S.T.E.A.M. poetry collection poster...
Towards Patient Avatars
www.myschoolhouse.com
@drbrowncares
drbrowncares@gmail.com
Shear & Tensile Stress
Injury to Arteries (and Nerves)
@drbrowncares
drbrowncares@gmail.com
Who I Am
www.myschoolhouse.com
@drbrowncares
drbrowncares@gmail.com
Who I Am
www.myschoolhouse.com
@drbrowncares
drbrowncares@gmail.com
S.T.E.A.M. in Action
www.myschoolhouse.com
@drbrowncares
drbrowncares@gmail.com
@drbrowncares
drbrowncares@gmail.com
Sherry-Ann Brown, MD, PhD
@drbrowncares, drbrowncares@gmail.com
www.myschoolhouse.com
Constructing S.T.E.A.M.:
a PHYSICSia...
Ohm’s Law & Blood Circulation
Ohms Law Darcy’s Law
V = I x R BP = Q x VR
"The heart is the only organ of all organs that c...
• In a noncompressible fluid system, flow is the same
at any given point
• Flow = area x velocity
• area x velocity = a...
Turbulent Blood Flow
www.cvphysiology.com
F ∝ V ⋅ r2
area x velocity
@drbrowncares
drbrowncares@gmail.com
Heart Murmurs
Heart
Aorta
Aorta
Heart
Normal Narrow
www.cvphysiology.com
@drbrowncares
drbrowncares@gmail.com
Heart Murmurs
http://www.boxerbreedcouncil.co.uk/as.htm
@drbrowncares
drbrowncares@gmail.com
Sherry-Ann Brown, MD, PhD
@drbrowncares, drbrowncares@gmail.com
www.myschoolhouse.com
Constructing S.T.E.A.M.:
a PHYSICSia...
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Constructing S.T.E.A.M.: a PHYSICSian scientist’s perspective

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The time has come to teach arts and science together. Physicists, students, and physics lovers worldwide, and all others can use poetry and various art forms to capture the essence of science to enhance learning. Science, technology, engineering, arts, and mathematics (S.T.E.A.M.) come together in this talk, from the perspective of a physician, poet, and scientist.

Read more about creative expression in science and medicine relevant to the brain at http://journal.frontiersin.org/article/10.3389/fneur.2015.00003/full

@drbrowncares

Published in: Science
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Constructing S.T.E.A.M.: a PHYSICSian scientist’s perspective

  1. 1. Constructing S.T.E.A.M.: a PHYSICSian scientist’s perspective Sherry-Ann Brown, MD, PhD @drbrowncares, drbrowncares@gmail.com www.myschoolhouse.com
  2. 2. S.T.E.M. @drbrowncares drbrowncares@gmail.com
  3. 3. S.T.E. M. @drbrowncares drbrowncares@gmail.com
  4. 4. S.T.E.A.M. www.myschoolhouse.com @drbrowncares drbrowncares@gmail.com Star Trek: The Next Generation sixth season episode "Second Chances"
  5. 5. The Cerebellum • Latin, little brain • Constitutes only 10% of the total volume of the brain, but contains more than half of all its neurons • Coordinates posture, gaze, speech, handwriting, and other motor functions The Cerebellum, Principles of Neural Science. 2000 McGraw Hill. ATAXIA n. Greek. Loss of motor coordination. @drbrowncares drbrowncares@gmail.com
  6. 6. @drbrowncares drbrowncares@gmail.com Page 34 www.myschoolhouse.com
  7. 7. Climbing Fiber Stimulus  Depolarization throughout PN  Extracellular Calcium entry into cell! Parallel Fiber Stimulus  IP3 Production  Calcium mobilization from ER! ER = endoplasmic reticulum Cerebellar Purkinje Neuron (PN) @drbrowncares drbrowncares@gmail.com
  8. 8. Hernjak et al, Biophysical Journal 2005 Parallel fiber stimulus Climbing fiber stimulus @drbrowncares drbrowncares@gmail.com Calcium Pathways In The Cell
  9. 9. @drbrowncares drbrowncares@gmail.com www.myschoolhouse.com Coincident Incident
  10. 10. Hernjak et al, Biophysical Journal 2005 Parallel fiber stimulus Climbing fiber stimulus @drbrowncares drbrowncares@gmail.com Calcium Pathways In The Cell Aim 1: 3D Model
  11. 11. Purkinje neuron Reconstructed Experimental 3D Geometry of Purkinje Cell Dendrite Branchlet @drbrowncares drbrowncares@gmail.com
  12. 12. Hernjak et al, Biophysical Journal 2005 Parallel fiber stimulus Climbing fiber stimulus @drbrowncares drbrowncares@gmail.com Calcium Pathways In The Cell Aim 1: 3D Model
  13. 13. PIP2 Diffusion in the spine membrane @drbrowncares drbrowncares@gmail.com Max 8120 1400 Min
  14. 14. SIX Spines - Simulation Max 8120 1400 Min @drbrowncares drbrowncares@gmail.com
  15. 15. @drbrowncares drbrowncares@gmail.com www.myschoolhouse.com
  16. 16. Hernjak et al, Biophysical Journal 2005 Parallel fiber stimulus Climbing fiber stimulus @drbrowncares drbrowncares@gmail.com Calcium Pathways In The Cell Aim 1: 3D Model Aim 2: Electric Model
  17. 17. Preserved electronic PATH in red, spine of interest in blue @drbrowncares drbrowncares@gmail.com Neuronal morphology
  18. 18. The Dendrite as an Electrical Circuit @drbrowncares drbrowncares@gmail.com
  19. 19. Simplification of Purkinje Neuronal Morphology Miyasho et al., Brain Research, 2001 @drbrowncares drbrowncares@gmail.com
  20. 20. Comparison of Electrical Activity in the Full and Reduced Models - soma -80 -40 0 40 80 0 500Time (ms) Membrane Potential(mV) -80 -40 0 40 80 0 500Time (ms) Membrane Potential(mV) @drbrowncares drbrowncares@gmail.com Full model Reduced model
  21. 21. Hernjak et al, Biophysical Journal 2005 @drbrowncares drbrowncares@gmail.com Calcium Pathways In The Cell Aim 3: Ataxia Model Aim 1: 3D Model Aim 2: Electric Model
  22. 22. Impact @drbrowncares drbrowncares@gmail.com www.myschoolhouse.com
  23. 23. Citations Textbooks (11) + Journal articles (33) @drbrowncares drbrowncares@gmail.com
  24. 24. S.T.E.A.M. Collection © 2010 Sherry-Ann Brown Coincident Incident How Will I Dance? Just One More Step @drbrowncares drbrowncares@gmail.com
  25. 25. @drbrowncares drbrowncares@gmail.com
  26. 26. @drbrowncares drbrowncares@gmail.com
  27. 27. @drbrowncares drbrowncares@gmail.com www.myschoolhouse.com
  28. 28. My Thesis Committee CCAM, MD/PhD Program University of Connecticut Health Center NIH Primary Investigator: Dr. Leslie M. Loew Dr. Ion Moraru Dr. James Schaff Dr. Ann Cowan Dr. Raquell Holmes Dr. James Watras Mr. Frank Morgan Ed & Elena Karen, Donna, Debbie Anu, Fei, Li Ye; Boris, Igor, Pavel Sofya, Jon, Stacy Dr. Art Hand Dr. Bill Lytton Dr. Marja Hurley @drbrowncares drbrowncares@gmail.com
  29. 29. Stepping In & Out Sherry-Ann Brown, MD, PhD CI Planning Meeting 2015 Thesis reception: S.T.E.A.M. poetry collection poster, art & photography @drbrowncares drbrowncares@gmail.com
  30. 30. Towards Patient Avatars www.myschoolhouse.com @drbrowncares drbrowncares@gmail.com
  31. 31. Shear & Tensile Stress Injury to Arteries (and Nerves) @drbrowncares drbrowncares@gmail.com
  32. 32. Who I Am www.myschoolhouse.com @drbrowncares drbrowncares@gmail.com
  33. 33. Who I Am www.myschoolhouse.com @drbrowncares drbrowncares@gmail.com
  34. 34. S.T.E.A.M. in Action www.myschoolhouse.com @drbrowncares drbrowncares@gmail.com
  35. 35. @drbrowncares drbrowncares@gmail.com
  36. 36. Sherry-Ann Brown, MD, PhD @drbrowncares, drbrowncares@gmail.com www.myschoolhouse.com Constructing S.T.E.A.M.: a PHYSICSian scientist’s perspective
  37. 37. Ohm’s Law & Blood Circulation Ohms Law Darcy’s Law V = I x R BP = Q x VR "The heart is the only organ of all organs that can not endure injury. This is expected because when the main power source is destroyed, no additional force can be brought by the organs that depend on it" (Aristotle - 384 BC). www.slideshare.net, http://www.scielo.br/scielo.php?pid=S0102-76382010000100006&script=sci_arttext&tlng=en @drbrowncares drbrowncares@gmail.com
  38. 38. • In a noncompressible fluid system, flow is the same at any given point • Flow = area x velocity • area x velocity = area x velocity • F ∝ V ⋅ r2 cm³►cm² cmx Conservation of Mass Principle Compliments of Dr. Hector Michelena, Mayo Clinic @drbrowncares drbrowncares@gmail.com
  39. 39. Turbulent Blood Flow www.cvphysiology.com F ∝ V ⋅ r2 area x velocity @drbrowncares drbrowncares@gmail.com
  40. 40. Heart Murmurs Heart Aorta Aorta Heart Normal Narrow www.cvphysiology.com @drbrowncares drbrowncares@gmail.com
  41. 41. Heart Murmurs http://www.boxerbreedcouncil.co.uk/as.htm @drbrowncares drbrowncares@gmail.com
  42. 42. Sherry-Ann Brown, MD, PhD @drbrowncares, drbrowncares@gmail.com www.myschoolhouse.com Constructing S.T.E.A.M.: a PHYSICSian scientist’s perspective

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