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1. EVALUATION OF LIVER
FUNCTION
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3. FUNCTIONS OF THE
LIVER
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
Synthesize most plasma protein



More than 90% of all protein
100% of albumin synthesis occur in the liver
Major exceptions

Immunoglobulins - B lymphocytes

von Willebrand's factor - Endothelial cells and
megakaryocytes
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4. C OAGULATION
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
FACTORS
All the coagulation factors except von
Willebrand factor are synthesized in the liver
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5. U REA
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Toxic ammonia is converted to urea
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6. SERUM BILIRUBIN
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
Measure of hepatic excretory function
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7. E XCRETED
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Cholesterol

Bile acids
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INTO BILE

8. W HICH PROTEIN PRODUCED IN THE
LIVER HAS THE SHORTEST HALF - LIFE ?
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
Factor VII - 4-6 hours

Transthyretin factor - 1-2 days

Transferrin - 6 days
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9. A LBUMIN
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Half-life - 20 days
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Decreases in its serum levels in liver disease
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More slowly than those of proteins with shorter
half-lives.
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10. PROTHROMBIN TIME
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
Measures extrinsic clotting system
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
Factor VII is activated by tissue factor
Expressed as INR (international normalized
ratio.
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11. GLUCOSE
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