2. Overview
ā¢ The diagnostic criteria of multiple sclerosis(
MS)
ā¢ Classification of idiopathic inflammatory
demyelinating disorders
ā¢ Clinical course of MS
ā¢ Current and emerging MS therapies
5. Radiologically Isolated Syndrome
(RIS)
ā No typical symptoms of CNS demyelination
ā No formally accepted diagnostic criteria
ā MRI : Typical MS lesions
ā CSF abnormalities
ā Clinical MS Attack:
ā 35% over 5 years
ā MRI progression:
ā¢ 59-83% in 2 years
ā DMT is initiated only in case
of clinical/MRI progression
Okuda DT et al, Neurology2011:76()8, 686-692
6. Diagnostic Criteria for MS
ā¢ An effort to make the diagnostic process more
objective
ā¢ Formal criteria were devised to codify the typical MS
features into indisputable diagnostic criteria
ā¢ The primary driving force is identification of patients
for research trials. āa consensus on which patient has
MSā
ā¢ Criteria are designed to be specific
ā¢ There are patients with MS who do not meet those
criteria
ā¢ āA patient has MS when an an experienced neurologist
says he or she has MSā
7. Schumacher Criteria- 1965
ā¢ Onset of symptoms between 10 and 50 years
ā¢ Objective abnormalities on neurologic
examination
ā¢ The signs and symptoms indicate CNS white
matter damage
ā¢ The lesions are disseminated in space ( 2 or more
separate lesions)
ā¢ The lesions are disseminated in time (2 attacks at
least 1 month apart)
ā¢ No better explanation
8.
9. The Mc Donald Criteria
ā¢ āthe world consists of three types of person: those who
have multiple sclerosis; those who do not; and those
who mightā. Polman CH et al,Ann Neurology, 2001
Episodes
from history
Objective clinical signs Additional data needed
from MRI or clinical
follow up
2 attacks
2 attacks
1 attack
1 attack
Progressive
course over 1
year
2 lesions
1 lesion
2 lesions
1 lesion
None
DIS
DIT
Both DIS&DIT
DIS demonstrated by 2 :
1- MRI brain
2. MRI cord
3. CSF oligoclonal bands
16. CASE
ā¢ On 18/3/08 patient complained of ocular pain on
moving the left eye with blurred vision.
ā¢ 2 days later she developed left frontal headache.
ā¢ Seen by the ophthalmologist who diagnosed her as
optic neuritis and advised to be on neurobion.
ā¢ She had several attacks of Rt. Upper limb heaviness
in the last 2 years, each was lasting for a week.
ā¢ Her cousin has MS .
17. CASE : Examination
ā¢ Her vision was 20/200 in the left eye and 20/40 in the
right eye. There was a central scotoma, and red and
blue colors were less intense in the left eye.
ā¢ RAPD on the left
ā¢ Left fundus: disc is congested and swollen.
ā¢ Central Scotoma
ā¢ Treated with pulse IV methylprednisolone for 3 days
and improved followed by short prednisolone taper
23. Clinically Isolated Syndrome (CIS)
ā¢ MRI:
ā Low risk: 1 or no other asymptomatic brain lesion
ā High risk: 2 or > asymptomatic lesions
ā¢ Treatment approved for high risk patients
ā IFN-B, GA reduces second attack: ARR 15%
24. Baseline MRI and Risk of CDMS for
Monofocal onset CIS (BENEFIT
Placebo N=93)
26. TOPIC
Primary end point:
Conversion to CDMS (as defined by the occurrence of a relapse)
Key inclusion criteria:
ā¢ Patients 18 to 55 years of age with a first acute/subacute neurologic event
consistent with demyelination.
ā¢ MS symptom onset within 90 days of randomization.
ā¢ Screening MRI scan with 2 T2 lesions 3 mM diameter that are characteristic
of MS.
Screened
(N=846)
Placebo
(n=197)
Teriflunomide 7 mg
(n=205)
R Long-Term Extension
Teriflunomide 14 mg
(n=216)
108-Week Treatment Phase
Randomized
n=618
Miller A. Plattform presentation ECTRIMS 2013
27. Primary / Key Secondary Endpoint
Primary Endpoint:
Time to Clinically Definite MS
(CDMS)
43%
Safety / Tolerability:
Adverse events observed in the trial were consistent with previous clinical trials
with Aubagio.
Miller A. Plattform presentation ECTRIMS 2013
21%
p=0.43
66
59%
p=0.00
08
Gd-enhancing T1 Lesions)
28. CIS: When To Initiate Therapy?
ā¢ Patients with normal MRI or with fewer than 2
ā Low risk of developing early clinical attacks
ā Clinical and MRI monitoring
ā Without immediately commencing immunotherapy
(DMT)
ā¢ Those with abnormal MRI with2or> lesions
consistent with MS or with evidence of
intrathecal synthesis of antibodies should be
considered for DMT,
ā¢ Patients with atypical clinical or MRI presentation
require further diagnostic evaluation.
29. Relapsing-Remitting MS
ā¢ Subacute repeated onset of CNS dysfunction with
resolution ( sometimes incomplete , over days to
weeks)
ā¢ Revised McDonald criteria
ā¢ MRI: Periventricular, brainstem, juxtacortical
prominent T2, often Gad enhancing lesions, T1
hypointense (black holes)
ā¢ Treatment: Interferon-B, Glatiramer acetate,
natalizumab, mitoxantrone
30. Features Consistent With MS
ā¢ Relapses and remissions
ā¢ Age Onset between ages 15 and 50
ā¢ Optic neuritis
ā¢ Lhermitte's sign
ā¢ Internuclear ophthalmoplegia
ā¢ Fatigue
ā¢ Uhthoff's phenomenon
31. Features Inconsistent With MS
ā¢ Steady progression
ā¢ Onset before age 10 or after age 50
ā¢ Cortical deficits such as aphasia, apraxia, alexia,
neglect
ā¢ Rigidity, sustained dystonia
ā¢ Convulsions
ā¢ Early dementia
ā¢ Deficit developing within minutes
32. Secondary Progressive MS
ā¢ Majority of RRMS many years following onset
ā¢ Progressive impairment (spastic gait
disturbance) between or in absence of attacks
ā¢ No clear effect of DMT without ongoing
attacks or inflammation
ā¢ Role of DMTs in SPMS patients:
ā with ongoing relapses
ā Substantial ongoing accrual on new MRI
inflammatory lesions
33. Primary Progressive MS
ā¢ Presents with progressive myelopathic gait,
cerebellar ataxia or cognitive impairment without
clear history of any clinical attacks
ā¢ Clinical progression must be for at least 1 year
and accompanied by a combinstion of
brain&spinal abnormalities and/or CSF
anormalities consistent with MS
ā¢ Lack of clinical attacks/ relative paucity of MRI
lesions
ā¢ No approved DMTs
34. Multiple Sclerosis (MS)
ā¢ Multiple Sclerosis is the commonest disabling
neurological condition to afflict young adults
ā¢ MS is an autoimmune disease triggered by
environmental agents acting in a genetically
susceptible people
ā¢ Auto-aggresive autoimmune attack on the
myelin sheath and other components of CNS
ā¢ Current&emerging DMTs are based in the above
paradigm
ā¢ Is MS a primary neurodegenerative disease
37. Demographic
Characteristics of Multiple
Sclerosis in Kuwait
0
5
10
15
20
25
30
35
Mean Current
age
Mean age at
presentation
Mean duration
of Disease
Years
SDĀ±5.4
SDĀ±9.3
Total recruited patients in study: 195
Gender Distribution N(M/F): 195(76/119)
Cross sectional or retrospectively included
patients:134
Newly diagnosed drug naĆÆve patient:65
SDĀ±10.3
38. Clinical Characteristics of Multiple Sclerosis in Kuwaiti Population
20.50%
11.70%
9.40% 8.60%
7.30%
2.10% 1.50% 1.20% 0.60%
0.00%
5.00%
10.00%
15.00%
20.00%
25.00%
Sensory Brain stem
and
cerebeller
Visual Motor Multiple
Symptoms
Sphicter
disturbance
L' Hermitte
sign
Seizures Others
Presenting symptoms
39. PRESENTING SYMPTOMS IN MS Total %
SENSORY LOSS IN LIMBS 30.7
VISUAL LOSS 15.9
MOTOR WEAKNESS 14.2
DIPLOPIA 6.8
GAIT DISTURBANCE 4.8
NCOORDINATION 2.9
SENSORY LOSS-FACE 2.8
LHERMITTEāS 1.8
VERTIGO 1.7
BLADDER SYMPTOMS 1
AUTE TRANSVERSE MYELOPATHY 0.7
PAIN 0.5
OTHERS 2.5
POLYSYMPTOMATIC 13.7
42. MS Therapy: Deciding on which
Medication
ā¢ Determine Therapeutic Goals
ā To reduce clinical relapse
ā To reduce accumulation of new MRI lesions
ā ļŖ new T2 lesions
ā ļŖGadolinium-enhancing lesions
ā ļŖblack holes
ā ļŖBrain and spinal cord atrophy
ā¢ Reduce short-term relapse related disability
43. How To Determine of The Goals are
Met?
ā¢ Compare with baseline relapse rate
ā Recall bias
ā Regression to the mean
ā¢ Assessment of improvement or stability in
neurological impairment
ā Assess functional ambulatory limitation
ā¢ May indicate progression
ā¢ MRI ongoing/new inflammatory activity
ā Serial MRI to assess radiologic stability, worsening or
improvement- q12-24 month except
44. How To Determine of The Goals are
Met?
ā¢ If goals of DMT or symptomatic treatment are
being met ļØno change in DMT unless
problems with medication tolerability
ā¢ A detailed evaluation of common and
idiopathic side effects will be required
ā Switching of medication based on adherence and
tolerability ma be needed
45. What if Goals are not being Met
ā¢ If pre-therapy relapse rate is not improved
ā A therapeutic switch may be indicated
ā¢ Relapse rate is incomplete indicator of ongoing
inflammatory disease activity
ā Cranial and spinal MRI
ā¢ May show therapy resistant inflammatory disease
ā¢ Guide switch to a more potent anti-inflammatory
medication
ā¢ Clinical attack or definitive worsening disability is may
lacking
46. Case 2
ā¢ Mr. A.M.J is a 33 years old Kuwaiti male, diagnosed to
have MS in 2008.
ā¢ In Jan 2008, he developed diplopia, followed by
paresthesia in feet, ascending to abdomen, chest and
forearms.
ā¢ These symptoms persisted
ā¢ By June 2008, he was ataxic and on a wheel chair,
when he sought medical advice
ā¢ MRI was consistent with MS
ā¢ Marked imrovement was noted in sensory symptoms
after pulse steroids.
47. Case 2
ā¢ His symptoms showed a rapid progression, by
Sept 2008, he had optic neuritis, sphincteric
disturbance, and positive Lhermitteās sign.
ā¢ In Oct 2008, he started to take Rebif.
ā¢ His disease remained stable, with no new
relapses and no new lesions on MRI till 2011.
ā¢ In April 2011, he went for CCSVI treatment
and discontinued Rebif without our
knowledge or advice.
48. CASE 1
ā¢ Lhermitteās sign was positive
ā¢ Cranial nerves were normal
ā¢ No motor weakness
ā¢ Mild sensory deficit for light touch and vibration
on left side
ā¢ Plantars were flexor bilaterally
ā¢ Rombergās sign was mildly positive
ā¢ Moderate left sided dysmetria, with tandem
ataxia
ā¢ EDSS :2; AI :1.
52. Case 2
ā¢ In August 2011 he reported dizziness, ataxia and diplopia
ā¢ He was treated with pulse steroids with marked recovery.
ā¢ He was clinically stable, and was advised to restart Rebif.
ā¢ In Jan 2012, EDSS:1, AI:0.
ā¢ MRI in June 2012 showed new cerebellar lesions, with no
enhancement.
ā¢ In Oct 2012, he came in with a mild relapse and was
treated with pulse steroids.
ā¢ An MRI in Dec 2012 showed worsening lesion load, and he
was advised to start Tysabri after JCV serology.
ā¢ He started Tysabri in Dec 2012, and till 5 months post
Tysabri , there were no active lesions.
53. Case 2
ā¢ In Sept 2013, patient came with another
severe relapse , with homonymous
hemianopia, sphincteric problems, gait ataxia,
and sensory disturbance.
ā¢ Treated with pulse steroids with partial
improvement in urinary symptoms and ataxia,
but not in visual symptoms.
56. Case 2
ā¢ MRI showed marked worsening, with
tumefactive enhancing lesions
ā¢ A CSF study was done, which was normal,
negative for JCV.
ā¢ Considering this as a failure of Tysabri, it is
planned to treat him with Rituximab
57. Is Clinical Worsening due to Attack
related Disease or Progression?
ā¢ If it is due to non-inflammatory MS
progressive disease
ā Neurodegenerative MS
ā ?subclinical ( and sub-radiologic) inflammation
unresponsive to current DMTs
ā Switching to alternative MS therapy is futile
ā¢ Escalating therapy If clinical impairment is
strongly associated with ongoing relapses or
marked new inflammatory MRI activity
59. IFNĪ²-1b
SC qod
GA
SC qd
IFNĪ²-1a
IM qwk
Mitox
IV q 90 d
wks
IFNĪ²-1a
SC tiw
Natalizumab
IV q 4 wks
Fingolimod
0.5 mg gd
Teriflun
PO qd
Laquin
PO
Daclizumab
SC
BG-12
PO bid
Alemtuz
IV
The Changing Landscape of MS Disease Modifying Treatment
Of Approved and Emerging Therapies
60. How are MS medication is selected?
ā¢ Injectable interferon-Ī² and glatiramer acetate
remain the first line DMT for many clinicians
ā Their side effects are manageable with minimum
of serious side effects
ā¢ First line DMTs are effective in reducing clinical
attacks and new MRI lesions
61. Injectable therapies
Oral therapies
Consider side effects
BG 12
Fingolimod
Terflunomide
Natalizumab
GlatiramerInterferon
Ī²
Relapsing inflammatory MS clinical course
First line
First line?
Severe relapsing
inflammatory MS/JCV
negative
Inadequate
response/inj
intolerance
Inadequate
response/oral
intolerance
Parallel switch
Inadequate
response/JCV
negative
62. Drawback of injectable Medication
ā¢ Interferon-Ī²
ā āFlue-like illnessā often transient
ā Liver enzyme monitoring
ā Rarely depression
ā¢ Glatiramer acetate
ā Flushing, eosinophilia, rare allergic reaction,
injection-site reactions (skin liopatrophy)
ā Conbination therapy+interferon-Ī²1a IM/weekly
and glatiramer acetate does not appear to be
significantly more efficacious than monotherapy
Lublin FD et al, Ann Neurology 2013
69. BG-12
ļ Integrated analysis
ā¢ Compared with PBO, BG-12 240 mg BID and TID
significantly reduced ARR, risk of relapse, adjusted ARR
requiring steroids, disability progression, and MRI
outcomes.
ā¢ Demonstrated consistent benefits on clinical efficacy
across prespecified subgroups of RRMS pts with varied
baseline demographics and disease characteristics
ā¢ Overall incidence of AEs, SAEs, and discontinuations
due to AES similar across tx groups; flushing and GI
events most common AEs
75. Daclizumab
ā¢ Effects similar in patients with highly active MS
compared with pts with less aggressive disease
prior to tx initiation
ā¢ Treatment resulted in significant increase in
number of pts who were disease- activity free
following 1 year of tx in SELECT trial
ā¢ Patients had reductions in % change in volume of
T1-hypointense and T2-hyperintense lesions over
52 wks of treatment vs increases in PBO group
76.
77. S1P receptor modulators/ agonists
ā¢ In phase 2b study, ponesimod significantly reduced inflammatory
MRI activity at all doses tested, with a significant dose response;
lower ARR also observed with ponesimod compared with PBO, and
was generally well tolerated
ā¢ Primary endpoint met in phase 2 DreaMS trial: ONO-4641
demonstrated significant efficacy on all key MRI measures of
disease activity at all 3 doses compared with PBO, and was
generally
ā¢ well tolerated Compared with PBO, reduction in mean CUAL
observed as early as
ā¢ month 1 for siponimod 0.25 mg/day and 2.0 mg/day, and in all
doses at month 2 in phase 2 BOLD trial; effect maintained at each
month up to month 6; similar pattern for new/enlarging T2 lesions
for all siponimod doses at month 2 and maintained at each month
up to month 613
78. Glatiramer acetate
ā¢ Compared with PBO, GA 40 mg SC TIW
significantly reduced:
ā¢ ARR by 34.4.% (P < .0001) Cumulative # GdE
lesions by 44.8% (P < .0001) Cumulative #
new/enlarging T2 lesions by 34.7%
ā¢ (P < .0001) Safety profile consistent with GA 20
mg/day SC
80. Teriflunomide
ā¢ Compared with PBO, 7 mg/day and 14 mg/day
teriflunomide significantly reduced ARR by 22.3% and
36.3%, respectively (P = .0183 and P = .0001, respectively)
ā¢ Compared with PBO, 14 mg/day teriflunomide significantly
reduced 12-wk CDP (HR = .685; P = .0442)
ā¢ Both teriflunomide doses generally well tolerated; safety
profile consistent with prior studies
ā¢ Update from TEMSO trial Mean reductions in lymphocyte
and neutrophil observed in TEMSO were small in
magnitude and were reversible after treatment
discontinuation or on treatment in some cases; no other
clinically significant complications to blood cytopenias
reported
81. a)Adjusted for Expanded Disability Status Scale (EDSS) score strata at baseline and takes duration of treatment into
account .ARR, annualised relapse rate; RRR, relative risk reduction
0.369
0.370
0.539
0 0.1 0.2 0.3 0.4 0.5 0.6
14 mg
7 mg
Placebo
Teriflunomide
Adjusteda annualized relapse rate
RRR: 31.2%
p=0.0002
RRR: 31.5%
p=0.0005
TEMSO: Relapse Rate
83. TENERE: Annualized relapse rate
ā¢ The ARR in the 14 mg teriflunomide group was
not statistically different from the ARR in the
RebifĀ® group
ā¢ The estimated ARR was higher in the 7mg
treatment group
0 0.1 0.2 0.3 0.4 0.5
Annualized Relapse Rate
Teriflunomide14 mg
N=109
Teriflunomide 7 mg
N=111
0.216RebifĀ®
N=104
0.259
0.410
Genzyme, Press release, Cambridge, MA ā December 20, 2011
85. Fingolimod
ā¢ Treatment with fingolimod 0.5 mg:
ā Significant benefits on relapse-related outcomes within first 3 months
and on volume loss over 6 months compared with PBO in FREEDOMS
and FREEDOMS II studies; concordant results from 2 large phase 3
trials, along with phase 2 data, allow better definition of expectations
regarding time lag between initiation and effects of fingolimod
treatment
ā¢ Fingolimod treatment initiation effects in pooled population from
FREEDOMS, FREEDOMS II (vs PBO), and TRANSFORMS (vs IM IFN Ć -
1a) a transient, mostly asymptomatic decrease in heart rate;
symptomatic bradycardia and Mobitz I and 2:1 AVBs were dose-
dependent; AVB first occurrences most common <6 h post-dose5
ā¢ Analysis of TRANSFORMS trial demonstrated advantage of
switching to fingolimod over remaining on IFN Ć -1a IM with regard
to time to relapse in RRMS6
86. LN
T-cell FTY720-P
Prevents T-cell invasion
of central nervous
system
S1P receptor
Sphingosine-1-phosphate (S1P) receptor modulator
Internalises S1P1, blocks lymphocyte
egress from lymph node (LN) while
sparing immune surveillance by
peripheral memory T-cells
FTY720 traps circulating
lymphocytes in
peripheral lymph nodes
Multiple sclerosis
FTY720
Fingolimod: Mechanism of Action
87. FREEDOMS (Fingolimod)
Annualized Relapse Rate
0.160.18
0.40
0.0
0.1
0.2
0.3
0.4
Annualisedrelapserate
Placebo
(n = 418)
Fingolimod 0.5 mg
(n = 425)
Fingolimod 1.25 mg
(n = 429)
-54% vs placebo
p < 0.001
-60% vs placebo
p < 0.001
ITT population; negative binomial regression model adjusted for treatment group, country, number of relapses in previous 2 years
and baseline Expanded Disability Status Scale (EDSS) as covariates
88. *Analysis performed using a negative binomial regression model adjusted for treatment group and country
**Analysis performed using rank ANCOVA adjusted for treatment group, country and number of lesions at baseline
Gd+, gadolinium-enhancing; MRI, magnetic resonance imaging
Fingolimod
0.5 mg
(n = 370)
Fingolimod
1.25 mg
(n = 337 )
0
2
4
6
8
10
12
9.8
(13.2)
2.5
(7.2)
2.5
(5.5)
Placebo
(n = 339)
# new/enlarging T2 lesions at month 24
from baseline*
Fingolimod
1.25 mg
(n = 343 )
0
0.2
0.4
0.6
0.8
1
1.2
Mean(SD)lesionnumber
Placebo
(n = 332)
Fingolimod
0.5 mg
(n = 369)
0.2
(1.1)
1.1
(2.4)
0.2
(0.8)
# T1 Gd+ lesions at month 24**
p < 0.001
p < 0.001
p < 0.001
p < 0.001
FREEDOMS (Fingolimod)
MRI Lesion Activity
89. FREEDOMS (Fingolimod)
Disability (Disability) Progression
Placebo
Fingolimod 0.5 mg
Fingolimod 1.25 mg
Patientswith3-monthconfirmedEDSS
progression(%)
Days on study
Fingolimod 1.25 mg vs placebo, HR = 0.68, p = 0.012
Fingolimod 0.5 mg vs placebo, HR = 0.70, p = 0.026
0
5
10
15
20
25
30
0 90 180 270 360 450 540 630 720
HR, hazard ratio
Editor's Notes
70
90
T2- lesions:
% relative reduction vs Placebo is 74% for both fingolimod dose groups
T1-Gd- lesions
% relative reduction vs Placebo is 82% for both fingolimod dose groups
Both oral fingolimod dose groups achieved significant improvements in disability progression over 2 years
Risk reduction for 3-month confirmed EDSS progression was -32% for the oral fingolimod 0.5 mg dose group and -30% for the 1.25 mg dose group