This document discusses motor neuron disease (MND), including its causes, symptoms, diagnosis and treatment approaches from both modern and Unani medicine perspectives. MND is a progressive neurodegenerative disorder affecting motor neurons in the brain and spinal cord. It typically affects individuals after age 50 and leads to paralysis and eventual death due to respiratory failure. Unani medicine views MND as resulting from an excess of cold, phlegm-producing foods that cause obstruction in the nervous system. The document recommends a Munzij Mushil therapy using herbs to evacuate morbid matter as the main Unani treatment, which claims to show benefits without side effects. It concludes that collaborative research on Unani medicine's disease concepts could lead to

2. • MND is a progressive
neurodegenerative disorder
which affects motor neurons
of brain & spinal cord.
• This progressive
degeneration of motor
neurons leads to atrophy,
paralysis, & eventually death
due to respiratory failure.

4. • Usually after the age of 50 years
• Very uncommon before the age of 30 years
• Affects male more than females.

5. 5%
Genetic Origin
95%
Acquired origin
• Autosomal dominant inheritance
• Defect lies on chr 21
• Enzyme involved : Superoxide dimutase (SOD1)
•Viral infections
•Exposure to toxins
•Trauma
•Electric Shock

6. UMN+LMN UMN LMN
Primary
Lateral Sclerosis
Amyotrophic
Lateral Sclerosis
Progressive
Muscular Atrophy

7. • GLUTAMATE EXCITOTOXICITY
• OXIDATIVE STRESS
• MITROCHONDRIAL DYSFUNCTION
• PROTEIN AGGREGATION

9. • Loss of capability
• Slowed movements
• Loss of muscle strength
• Spasticity
• Emotional lability
• Hyperreflexia
• Excessive production of saliva
•Loss of muscle strength
•Muscle Atrophy
•Fasciculation
•Flaccidity
•Muscle cramps
•Hyporeflexia
•Nabz-Bati and mutawafit
•Qaroora-ghaleez and mukkadar

10. • Diagnosis is mainly done considering history and physical examination
• Creatinine phospho kinase may be increased 2-3x than normal in most.
• CSF may show mild protein elevation(less than 100 mg/dl)
• EMG studies shows variation

11. • RILUZOLE is main treatment in modern medicine.
• It acts by blocking Glutamate release.
• And slows the progression of disease to an extent.

12. • Unani medicine is based upon theory of
humors.
• It is caused due to dominance of Baroodat
which paves a suitable ground for developing
Ghaleez Luzj Khilt which causes obstruction in
the propagation of Rooh muharrika in A’saab.

13. • Acc. to Unani concept major risk factors include:
1. Middle & Old age
2. Cold Weather & Temperament
3. Balgham producing foods.
• Qusta bin luqa in his writings described the localization of
lesion in treatment of neurologic diseases and their prognosis.
• He maintains that if patient speaks words,the lesion is in
spinal cord,& is treatable.;if speech is not clear or totally
absent ,then lesion is in brain ,and is hard to treat.

15. • Avoid flatulent,cold temperament foods.
• Balanced diet enriched with :

16. •‫كچلہ‬
•‫دارچينی‬
•‫اسگند‬Neuroprotective,inhibits oxidative stress
•‫هلدی‬
•‫منقی‬

17. ‫قنب’بھنگ‬

18. • Istefragh , evacuation of morbid matter (mawad e fasida) is done which tends to produce
the disease.
• Tabiyat naturally tends to evacuate the morbid matter from the body.It is called Istefragh e
tabayi .
• But sometimes,the tabiyat fails to evacuate,then it becomes the duty of physician to
evacuate it,it is called Istefragh e sanavi.
For the evacuation of this morbid matter , the most propagated treatment of Unani system
MUNZIJ MUSHIL THERAPY is most beneficial.

19. • Drugs to be used in this therapy would be:
Munzij Balgham - ‫منضج‬‫بلغم‬
Mushil balgham - ‫مسھل‬‫بلغم‬
Munaqi dimaaq wa Asaab - ‫منقی‬‫دماغ‬‫و‬‫اعصاب‬
Muqawi dimaaq wa Asaab - ‫مقوى‬‫دماغ‬‫و‬‫اعصاب‬
Muhalil - ‫محلل‬
• The treatment to neuronal damage of motor neuron disease appears to show obvious
effect, and no toxic side effects on the human body, with low-cost drugs which
majority of patients can afford.

21. • Make up mind for collaborative study with the unani medicine for
concept of every disease.
• This might lead to successful reaserches.