This study compares sentinel lymph node biopsy to elective neck dissection in patients with early stage (T1/T2) oral squamous cell carcinoma without clinical or radiological evidence of neck lymph node metastasis (N0). The study uses a matched pair analysis to compare outcomes between the two neck staging procedures. Sentinel lymph node biopsy aims to stage the neck while avoiding unnecessary dissection in patients who do not have occult metastasis, whereas elective neck dissection removes lymph nodes prophylactically without knowing their status. The study found that sentinel lymph node biopsy identified occult metastasis in approximately 20-30% of N0 patients, suggesting it may help avoid elective neck dissection in the majority who are metastasis-free.

1. International Journal of Oral
and Craniofacial Science
ISSN: 2455-4634
Peertechz Journals

2. Research Article
Sentinel Lymph Node Biopsy vs. Elective Neck Dissection in
Patients with T1/T2 N0 Oral Squamous Cell Carcinoma: A
Matched Pair Analysis
 Guilherme Machado de Carvalho*, Vanessa Goncalves Dias, Hugo
Kohler, Carlos Takahiro Chone, Alexandre Caixeta Guimaraes, Agricio
Nubiato Crespo
 *Corresponding author: Guilherme Carvalho, Professor, Ear, Nose,
Throat and Head and Neck Surgery Department, Campinas University,
UNICAMP, PO BOX 6111, Postal Code: 13081-970, Sao Paulo, Brazil, Tel:
+55 19 35217523; Fax: +55 19 35217563;
 Dates: Received: 12 July, 2016; Accepted: 04 August, 2016; Published:
05 August, 2016
 Citation: de Carvalho GM, Dias VG, Kohler H, Chone CT, Guimarães AC,
et al. (2016) Sentinel Lymph Node Biopsy vs. Elective Neck Dissection in
Patients with T1/T2 N0 Oral Squamous Cell Carcinoma: A Matched Pair
Analysis. Int J Oral Craniofac Sci 2(1): 047-051. DOI: 10.17352/2455-
4634.000018.

3. Abstract
 Background: The management of the clinically
and radiological negative neck in patients with
early squamous cell carcinoma of head and neck
(HNSCC) is still controversial. As approximately 20
to 30% of these patients harbor occult neck
disease, most of them is submitted to elective
neck dissection with no benefit in great majority
of those cases. Sentinel lymph node biopsy (SLB) is
a potential method for staging of lymphatic
metastasis in HNSCC and the status of the sentinel
node predicts the presence of metastasis in the
remainder of the nodes within the nodal basin.

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