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Archives of Pulmonology
and Respiratory Care
Peertechz Journals
CASE REPORT
Inhaled GM-CSF in a Pulmonary Alveolar
Proteinosis Patient Refractory to Plasmapheresis
Combined with Multiple Whole Lung Lavages
 Francesca Mariani, Elena Paracchini, Davide Piloni, Zamir Kadija,
Elena Salvaterra, Laura Divizia, Giuseppe Rodi, Carmine Tinelli,
Federica Meloni and Ilaria Campo*
 *Corresponding author: Ilaria Campo, Pneumology Unit, Fondazione
IRCCS Policlinico San Matteo, viale Golgi 19, 27100 Pavia, Italy, Tel:
+39 0382 501007; Fax: +39 0382 502269;
 Dates: Received: 10 March, 2017; Accepted: 04 April, 2017
Published: 06 April, 2017
 Citation: Mariani F, Paracchini E, Piloni D, Kadija Z, Salvaterra E, et
al. (2017) Inhaled GM-CSF in a Pulmonary Alveolar Proteinosis Patient
Refractory to Plasmapheresis Combined with Multiple Whole Lung
Lavages. Arch Pulmonol Respir Care 3(1): 016-019.
Abstract
 A autoimmune Pulmonary Alveolar Proteinosis (PAP) patient with
persistent disease underwent 3 Whole Lung Lavages (WLLs), 10
plasmapheresis sessions and further 3 WLL, from October 2004
to May 2007. Nevertheless HRTC and pulmonary function test
(PFT) showed a persistent residual disease of mild degree. At
the beginning of 2010, the patient was admitted to inhaled rGM-
CSF (Sargramostim) therapy as compassionate treatment. GM-
CSF was administered by Akita 2 nebulizer (Vectura), as follow:
250 mcg/ day every other week for 12 weeks, then 250 mcg/day
on 2 consecutive days every 2 weeks for 6 months. Follow up
visits were scheduled at 3, 10, 18, 30 months and after that
once a year. Functional and HRCT data and PaO2 were collected.
Since the start of the inhaled GM-CSF therapy, the patient no
more required WLL. Furthermore we found a signifi cant
increase in DLCO% (p=0.013) and FVC% (p=0.023) while %FEV1
show a positive trend.
Thank you
For more information Read Online Article…
https://www.peertechz.com/articles/inhaled-gm-csf-in-a-pulmonary-alveolar-
proteinosis-patient-refractory-to-plasmapheresis-combined-with-multiple-whole-
lung-lavages.pdf
For
Full
Article
PDF

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inhaled-gm-csf-in-a-pulmonary-alveolar-proteinosis-patient-refractory-to-plasmapheresis-combined-with-multiple...-archives-of-pulmonology-and-respirato-peertechz-journal

  • 1. Archives of Pulmonology and Respiratory Care Peertechz Journals
  • 2. CASE REPORT Inhaled GM-CSF in a Pulmonary Alveolar Proteinosis Patient Refractory to Plasmapheresis Combined with Multiple Whole Lung Lavages  Francesca Mariani, Elena Paracchini, Davide Piloni, Zamir Kadija, Elena Salvaterra, Laura Divizia, Giuseppe Rodi, Carmine Tinelli, Federica Meloni and Ilaria Campo*  *Corresponding author: Ilaria Campo, Pneumology Unit, Fondazione IRCCS Policlinico San Matteo, viale Golgi 19, 27100 Pavia, Italy, Tel: +39 0382 501007; Fax: +39 0382 502269;  Dates: Received: 10 March, 2017; Accepted: 04 April, 2017 Published: 06 April, 2017  Citation: Mariani F, Paracchini E, Piloni D, Kadija Z, Salvaterra E, et al. (2017) Inhaled GM-CSF in a Pulmonary Alveolar Proteinosis Patient Refractory to Plasmapheresis Combined with Multiple Whole Lung Lavages. Arch Pulmonol Respir Care 3(1): 016-019.
  • 3. Abstract  A autoimmune Pulmonary Alveolar Proteinosis (PAP) patient with persistent disease underwent 3 Whole Lung Lavages (WLLs), 10 plasmapheresis sessions and further 3 WLL, from October 2004 to May 2007. Nevertheless HRTC and pulmonary function test (PFT) showed a persistent residual disease of mild degree. At the beginning of 2010, the patient was admitted to inhaled rGM- CSF (Sargramostim) therapy as compassionate treatment. GM- CSF was administered by Akita 2 nebulizer (Vectura), as follow: 250 mcg/ day every other week for 12 weeks, then 250 mcg/day on 2 consecutive days every 2 weeks for 6 months. Follow up visits were scheduled at 3, 10, 18, 30 months and after that once a year. Functional and HRCT data and PaO2 were collected. Since the start of the inhaled GM-CSF therapy, the patient no more required WLL. Furthermore we found a signifi cant increase in DLCO% (p=0.013) and FVC% (p=0.023) while %FEV1 show a positive trend.
  • 4. Thank you For more information Read Online Article… https://www.peertechz.com/articles/inhaled-gm-csf-in-a-pulmonary-alveolar- proteinosis-patient-refractory-to-plasmapheresis-combined-with-multiple-whole- lung-lavages.pdf For Full Article PDF