The lecture on computational rationality by Antti Oulasvirta explores cognitive principles that govern human-computer interactions, emphasizing the adaptive behaviors influenced by the environment and the decision-making processes involved. It discusses strategies for modeling human cognition as rational agents under constraints, including the challenges of generalization, planning, and exploration. Applications of these principles span across machine learning, cognitive science, and neuroscience, aiming to enhance our understanding of decision-making and behavior in real-world settings.