Differences - IDDM VS NIDDM

1. DIFFERENCES
D R N I L E S H N K A T E , P R O F E S S O R , P H Y S I O L O G Y , / D I F F E R E N C E S Page 8
Difference Between
IDDM (TYPE I) & NIDDM (TYPE II)
IDDM (TYPE I) NIDDM (TYPE II)
1
Defect – Insulin
Deficiency due to B
cell destruction.
Defect – Resistance of
target tissue to
insulin.
2
Prevalence – 10-
20%
80-90%
3
Age of onset < 40
years.
Age of onset > 40
years.
4 Body wt - Low Body wt - High
5
Gene focus –
chromosome 6
Gene focus –
chromosome 1
6
Duration of
symptoms - weeks
Duration of
symptoms – months,
years.
7
Acute complication
- Ketoacidosis
Acute complication –
Hyperosmolar coma.
8
Ketonuria -
Present
Ketonuria - Absent
9
Treatment -
Insulin
Treatment – oral
Hypoglycemic.
10 Mortality – High Mortality – Low.