ulcer physiology

1. NUR FARRA NAJWA
BINTI ABDUL AZIM
082015100035
PEPTIC ULCER
(MANAGEMENTS)

2. OBJECTIVE
 To understand the basic classification of treatments.
 To understand the mechanism of each treatments.
 To distinguish different treatment used depends on
condition.
 To list the drugs by treatments used.

3. INTRODUCTION
 Specific treatments
 Act specifically
 Receptors
 Drugs
 Bacteria
 Non-specific treatments
 Surgery
• During and after treatments
• Avoid alcohol
• Avoids ciggarates
• Follow up with endoscopy

4. TREATMENTS
Gastric pits
Gastric glands
Chief cell
Parietal
cell
G- cell
Endocromaffin
cell
HCL
Ach
Histamine
Gastrin
PPI
Gastrin
blockers
H2
blockers
Muscarinic
blockers
SPECIFIC
TREATMENTS
NSAIDS
H. Pylori
bacteria

5. TREATMENT
H2
Receptor
Blocker
Block H2
receptor
Block
histamine
release
Less HCL
secretion
Famotidine,
Ranitidine,
Cimetidine,
Nizatidine
Proton Pump
Inhibitor
Inhibit activity
of H+ K+ ATPas
Inhibit HCL
secretion Omeprazole

6. TREATMENT
Muscarinic
Blockers
Block M1
and M3
receptors
Acetylcholine
not act on
parietal cell
Inhibit HCL
secretion
Atropine
Gastrin
Blockers
Reduce HCL
secretion
Proglumide

7. TREATMENTS
Antibiotics
Helicobacter
pylori
bacteria
Kill the
bacteria
Amoxicillin
NSAIDS
Stops or
limit the
uses
Aspirin,
ibuprofen
For Healing
And Coating
Sucralfate,
misoprostol,
Bismuth subsalicylate

8. TREATMENTS
NON-SPECIFIC
TREATMENTS
Altered
Behaviour
Altered
Physiology
ANATACIDS
• relieves pain
immediately
and temporary
YOGA THERAPY
ADEQUATE SLEEP
REST
AVOIDS
•Spicy food
•Alcohol
Use COLD
MILK

9. TREATMENTS
SURGICAL
*VAGOTOMY
*GASTRECTOMY
*ANTEROCTOMY
*PYLOROPLASTY
Porforated
Not heal
with
medicine
Bleed
Away with
medicine
then comes
back

10. SUMMARY TREATMENTS
SPECIFIC
HCL
SECRETION
- Proton pump
inhibitors
- H2 blockers
-Muscarinic blockers
-Gastric blockers
OTHERS
- Antibiotics
- NSAIDS
- Healing and
coating
NON-
SPECIFIC
STRESS
-Food
-Drugs
-Therapy
SURGERY

11. REFERENCES
 Barrett Ganong’s Review Of Physiology 24th Edition
 Textbook Of Medical Physiology, GK Pal

12. ANY QUESTIONS??