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A 35-year-old obese woman with a history of depression and previous self-harm
comes to the ED after an unwitnessed overdose. She claims to have taken 30
tablets of paracetamol four hours previously, along with a bottle of wine. She has a
history of chronic alcohol use and takes no regular medications.
Q1: What are the presenting features of PCM poisoning?
Q2: How would you manage this patient?
Patentname:wwf
Age:35
Address:ShahAlam
Occupation:Businesswoman
CC
Vomitingaftertaking30 oral tablets.
HOPI
Patientisknowncase of depression andself-harmtendency.Havingvomitingaftertook30 tabletsof
paracetamol 4 hours ago (9pm) at home.She alsodrinksa bottle of wine.She tookbothsubstances
to feel calmand try to sleep despiteknowingitisharmful toher.She vomited5times,the vomitus
contentare foodparticle.Nobloodstained.Notassociatedwithabdominal pain.
PASTMEDICAL HISTORY
DiagnosedwithMajordepressivedisordersince 5years – not compliance of medication
Chronicalcoholismonrehabilitationsince 2years
 Usuallydrank2-3 bottle of alcohol (beer) everyday
 She feel thatalcohol helphertofeel betteranddoesn’tfeel guiltyandcuttingdownthe
amount
 Drinksinthe morningtohelpwithhangover
 Joinedalcohol anonymousbutdoesn’thelphertobecome better
No chronicillnesslike diabetesmellitusandhypertension
No otherpsychiatricillness
PASTSURGERY HISTORY
No significanthistory
FAMILY HISTORY
No significanthistory
No otherpsychiatricillnessormedical illnessrunsinthe family
SOCIALHISTORY
Nota smoker
No othersubstance abuse
Single
Live withmother(65 yearold)
ABCDE
A: Secure airway:patentandclear
B: maintainoxygenonroomair: SpO2>94%
C: 2 large bore IV cannular: drawbloodforinvestigation
PHYSICALEXAMINATION
General appearance
 Patientsislyingonbed,seemlethargic.Conscioustotime,place andperson
 Signof dehydration –drymouth, coatedtongue
 Healedscar at the rightwrist
Vital
 BloodP – 110 / 70
 Pulse rate
 Respiratoryrate
 temperature
Systemicexamination
 All systemare normal
INVESTIGATION
Full bloodcount
Serumacetominophne
Serumelectrolyte
Bloodglucose
Creatinine
Liverfunctiontest – serumtransaminase,bilirubin,protrombintime(INR)
Renal functiontest - BUN
ECG
Q1: What are the presenting features of PCM poisoning?
Q2: How would you manage this patient?
Acetamenophen toxicity
Acetamenophen toxicity

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Acetamenophen toxicity

  • 1. A 35-year-old obese woman with a history of depression and previous self-harm comes to the ED after an unwitnessed overdose. She claims to have taken 30 tablets of paracetamol four hours previously, along with a bottle of wine. She has a history of chronic alcohol use and takes no regular medications. Q1: What are the presenting features of PCM poisoning? Q2: How would you manage this patient? Patentname:wwf Age:35 Address:ShahAlam Occupation:Businesswoman CC Vomitingaftertaking30 oral tablets. HOPI Patientisknowncase of depression andself-harmtendency.Havingvomitingaftertook30 tabletsof paracetamol 4 hours ago (9pm) at home.She alsodrinksa bottle of wine.She tookbothsubstances to feel calmand try to sleep despiteknowingitisharmful toher.She vomited5times,the vomitus contentare foodparticle.Nobloodstained.Notassociatedwithabdominal pain. PASTMEDICAL HISTORY DiagnosedwithMajordepressivedisordersince 5years – not compliance of medication Chronicalcoholismonrehabilitationsince 2years  Usuallydrank2-3 bottle of alcohol (beer) everyday  She feel thatalcohol helphertofeel betteranddoesn’tfeel guiltyandcuttingdownthe amount  Drinksinthe morningtohelpwithhangover  Joinedalcohol anonymousbutdoesn’thelphertobecome better No chronicillnesslike diabetesmellitusandhypertension No otherpsychiatricillness
  • 2. PASTSURGERY HISTORY No significanthistory FAMILY HISTORY No significanthistory No otherpsychiatricillnessormedical illnessrunsinthe family SOCIALHISTORY Nota smoker No othersubstance abuse Single Live withmother(65 yearold) ABCDE A: Secure airway:patentandclear B: maintainoxygenonroomair: SpO2>94% C: 2 large bore IV cannular: drawbloodforinvestigation
  • 3. PHYSICALEXAMINATION General appearance  Patientsislyingonbed,seemlethargic.Conscioustotime,place andperson  Signof dehydration –drymouth, coatedtongue  Healedscar at the rightwrist Vital  BloodP – 110 / 70  Pulse rate  Respiratoryrate  temperature Systemicexamination  All systemare normal INVESTIGATION Full bloodcount Serumacetominophne Serumelectrolyte Bloodglucose Creatinine Liverfunctiontest – serumtransaminase,bilirubin,protrombintime(INR) Renal functiontest - BUN ECG
  • 4. Q1: What are the presenting features of PCM poisoning?
  • 5. Q2: How would you manage this patient?