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Diuretics
• The medication that enhances urine flow is a diuretic. Diuretics
encourage the body's clearance of extra water, salt, toxins, and
accumulated metabolic waste products like urea. They help the body
get rid of extra fluid (edoema) that builds up in the tissues as a result
of numerous diseases.
• There are many different kinds of diuretics, but the majority of them work by reducing the volume
of fluid that the kidneys' tubules reabsorb before returning it to the circulation.
• The most popular diuretics, the benzothiadiazides (such as chlorothiazide), prevent the kidney
tubules from reabsorbing salt and water. The salt and water are ultimately expelled rather than being
reabsorbed, which increases the flow of urine.
• Additionally, these medicines are used to lower excessive blood pressure (hypertension).
Nephron
Chemical Classification
• Carbonic anhydrase inhibitors: Acetazolamide, Methazolamide,
Dichlorphenamide.
• Thiazides: Chlorthiazide, Hydrochlorothiazide, Hydroflumethiazide,
Cyclothiazide.
• Loop diuretics: Furosemide, Bumetanide, Ethacrynic acid.
• Potassium sparing Diuretics: Spironolactone, Triamterene, Amiloride.
• Osmotic Diuretics: Mannitol
Carbonic anhydrase inhibitors
• Acetazolamide
• Methazolamide
• Dichlorphenamide
Thiazides
Thiazides and hydrothiazides act at the cortical diluting segment, or DT, according
to their mode of action. Here, at the luminal membrane, they block Na+-Cl-
symport.
• Hydroflumethiazide
• Cyclothiazide
Loop diuretics
• Furosemide
• Bumetanide
• Ethacrynic acid
Potassium sparing Diuretics
• Spironolactone
• Triamterene
• Amiloride
Osmotic Diuretics
• Mannitol
diuretics.pptx

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diuretics.pptx