2. Anatomy
Modified sweat gland between the superficial and deep
layers of the chest wall
Cooper’s Ligament Fibrous band of tissue
l
3. Hormonal Effects
Estrogen
Development of the breast and
lactiferous ducts
Progesterone
Secretory acinar tissue – lobules
Prolactin
Synergizes the effect of estrogen and
progesterone
9. Examination of LNS
Sitting posture
Pulp of the fingers
Axillary group of LNs
Pectoral group
Brachial group
Subscapular group
Central group
Apical group
Supraclavicular nodes
12. Question
22 yo female presents with a new right breast
mass. Complains of mild tenderness. No other
complaints. On physical exam, there is a 1 cm
nodule at the 2:00 position. Your diagnostic test
of choice is….
Mammogram
Ultrasound
Excisional biopsy
Incisional biopsy
15. BREAST SONOGRAPHY
Not a screening tool
Palpable vs cystic
Mammographic detected lesion
Indications
If Mammography is uncertain
To differentiate solid from cystic lesion
If asymmetric density
Visualise lesions near chest wall.
Interventional procedures.
Evaluate site of lumpectomy.
Lesion at periphery of breast.
Evaluating after surgical augmentation.
16. Ultrasound
Benign
Pure and intensely
hyperechoic
Elliptical shape (wider
than tall)
Lobulated
Complete tine capsule
Malignant
Hypoechoic, spiculated
Taller than wide
Duct extension
microlobulation
17. Features of malignant lesion on
Sonomammography
STAVROS CRITERIA
Spiculation
Hypoechoic
Irregular margins
Posterior shadowing
Depth :width ratio <1
Microlobulation
19. Mammography views
Screening tool
Age of 40
Estimated reduction in mortality 15-25%
10% false positive rate
Densities & calcifications
Mediolateral oblique Craniocaudal
20. Mammography evaluation
Mass lesion
Density
Asymmetry
Malignant
Calcification
Benign
calcification
Well circumcribed –benign
Spiculated-malignant 95%
Low density benign ,high-malignant
Asymmetric involution in bbd.HRT
Trauma ,Intraductal CA
Fine ,numerous CA,only sign in early
noninvasive CA
Scattered ,round circumscribed
Ductectasia- needlelike
Arterial -parallel line
Fibroadenoma –popcorn
Microcystic disease-teacup
Fat necrosis-oilcyst calcification
21. Breast Imaging Reporting And
Data System BI-RADS
BI-RADS
Classification
Features
0 Need additional imaging
1 Negative – routine in 1 yr
2 Benign finding – routine in 1 yr
3 Probably benign, 6mo follow-up
4 Suspicious abnormality, biopsy
recommended
5 Highly suggestive of malignancy;
appropriate action should be taken
22. Calcification
Macrocalcifications
Large white dots
Almost always noncancerous and require no
further follow-up.
Microcalcifications
Very fine white specks
Usually noncancerous but can sometimes be a sign
of cancer.
Size, shape and pattern
23.
24.
25.
26. BREAST MRI
To distinguish scar from
recurrence
Gold standard for
imaging breast with
implants
Detection of vertebral
body metastasis &
musculoskeletal
pathology
Visualisation of axilla
27. BREAST MRI
Indications
Radiologically dense breasts when
mammography fails.
If Axillary node +ve and breast
normal after mammo and sonography.
To rule out multifocality
multicentricity before BCS.
To assess induction chemotherapy.
Followup after BCS.
•Contrast enhanced more sensitive
28. MRI
High risk patients
Personal history of breast ca
LCIS, atypia
1st degree relative with breast cancer
Very dense breast
High sensitivity (95-100%)
10-20% will have a biopsy
31. FINE NEEDLE ASPIRATION
CYTOLOGY
Uses 21gauge needle & 10 ml
syringe
Multiple passes through lump
without releasing negative
pressure
Aspirate is smeared onto slide
& fixed
Differentiates solid & cystic
lesions
32. FNA
Fast, inexpensive
96% accuracy
Institution dependent
Unable to differentiate
b/w in situ vs CA
33. CORE NEEDLE BIOPSY
If fnac is inconclusive
Advantages
significant core of tissue obtained
can distinguish invasive from intra ductal
carcinoma
Grading of tumor
To know ER/PR and Her 2 status
Disadvantage
seeding of malignant cells along needle tract
38. When core needle biopsy is inconclusive
Whole tumour is removed preferably
if <4 cm in size
INCISION BIOPSY
Removal of small portion of
tumour
> 4cm in size
EXCISION BIOPSY
40. OPEN BIOPSY(EXCISIONAL BIOPSY)
Most accurate and the Best Diagnostic
Procedure for a Suspicious Breast Lesion.
Complete excision with a rim of normal tissue
Plan the incision in such a way that
subsequent radical surgery can easily include
the scar.
Follow Langer’s line
41.
42. MAMMOTOME
Used for taking
stereotactic biopsy from
mammographically
detected breast lesions that
are not clinically palpable.
45. DUCTOSCOPE
A fiber optic scope less
than a millimeter thick is
inserted into the milk duct
at the nipple and threaded
deep into the breast through
the duct.
An imaging system
displays the output of the
scope on a computer
monitor.
Samples of epithelial cells
can be collected
onto microscope slides for
further analysis.
46. DUCTOSCPOY
INDICATIONS
Patients with pathologic nipple
discharge
Patients who are at high-risk for
developing cancer but have normal
breast on examination and imaging
studies.
47.
48. DUCTAL FLUID COLLECTION
After application of a numbing cream, a small clear
cap with a syringe attached is placed over the
nipple. This device (the nipple aspirator) is similar
to a small breast pump and is used to see if fluid
will come out of the nipple.
•To encourage fluid production,women are
instructed in breast massage and heat packs
may be used on the breasts.
•If fluid is not produced, the lavage is not performed.
49. If fluid is obtained with the nipple
aspirator,then the lavage procedure is
started.
One or two small dilators to help open the
duct.
Then the ductal lavage catheter is inserted
and a small amount of lidocaine, as
anesthetic may be injected through the
catheter for comfort.
50. Saline, is injected through the
catheter into the duct and the breast
massaged to bring ductal cells into the
chamber of the catheter.
An empty syringe attached to the
catheter is used to collect the cells from
the catheter chamber.
The cells are then placed in a
preservative and sent to the cyto -
pathologist where they are processed
and read much like a Pap smear.
54. BREAST IMAGING EMERGING
TECHNOLOGIES
Digital mammography
Use of FDG-PET
Breast scintimammography
(nuclear medicine breast imaging- Miraluma
Tc-99m sestamibi compound)
Computerised thermal imaging(CTI)
Computerised tomographic
lasermammography (CTLM)
56. TUMOR MARKERS IN BBD
Expression of P53 in immunohistochemical
staining identifies the sub group with maligant
potential
Overexpresson of HER-2 in benign
proliferative lesion predicts increased risk
57. Case scenario 1
25 year old female patient presented with a
lump in the breast.She gives a history of slow
growing lump not associated with any pain or
discharge from nipple & is very much anxious.
59. Fibroadenomas
Second most common tumor of breast
ANDI
Represent a hyperplastic or proliferative process in a
single lobule
Etiology is unknown, thought to be due to hormonal
influence
Risk of malignant transformation is rare
Resulting carcinoma is often a lobular carcinoma
Mimic malignancy in pregnancy,HRT
60. Types
Simple/solitary/small(2-3 cm)
Multiple(>5)
Juvenile-in young women between the ages of 10 -
18.
Giant(>5cm)-rapidly growing,more common in
afro-caribbean population
Complex -contain other histological changes such as
sclerosing adenosis, duct epithelial Hyperplasia,
epithelial calcification.
Associated with slightly increased risk of cancer
61. Clinical features
Between the ages of 15-25 years & size of 2-3cm
Painless lump- capsulated,smooth, firm, well
defined, nontender, BREAST MOUSE
Confused with phyllodes
Microscope-
intracanalicular pericanalicular
63. Treatment
conservative
Surgery
Very large/increasing in size
Suspicious cytology
Surgery is desirable
Extracapsular excision with a 1cm rim of
normal tissue
Newer techniques-laser ablation
&cryoablation
66. Phyllodes Tumor
Proliferation of connective tissue with ductal
elements
Whorled and cellular stroma
Firm, lobulated
2 to 40 cm in size
10% malignant
Treatment
Wide excision
67. Histopathology
Proliferation of intralobular stroma
Fusiform fibroblast
3 types:-
benign
borderline
malignant
(cellularity,atypia,mitoses &invasion by edges)
68. Phylloides vs Fibroadenoma
Phyllodes Fibroadenoma
Age Older(40-50y) Younger
Duration Rapid growth Slower
progression
Recurrence Common Less common
Size Large ,bosselated Smaller
Mammogram Round density with
smooth borders
Same
Ultrasound Cystic spaces +/- Same
Cytology More cellular,
malignant type
Same as low grade
phyllodes
71. Traumatic Fat Necrosis
Clinical features - Pain & lump in the breast
Lump is hard - extensive fibrosis caused by
tissue reaction
D.D : Carcinoma breast
Mammography findings - density lesion; can
have calcifications; may mimic carcinoma
breast
Treatment - excision of the lump
72. Breast cyst
Definition – non integrated involution of breast tissue
Age group – 30-50
Multiple and bilateral
Can mimic malignancy
Confirmed by USG and
aspiration
74. No routine followup
No residual mass
No cyst recurrence
Surgical biopsy
Residual mass
Cyst recurrence (X3)
Non blood stained aspirate
FNAC/Surgical biopsy
Blood stained aspirate
Fine needle aspiration
Cyst
(Clinical diagnosis)
Routine followup
75. Case scenario2
28 year old lady presenting with complaints of
pain in both her breast for the past 6 years &
increases just prior to menstruation, no pain
during her pregnancy and lactation.
86. The ANDI (Aberrations of Normal
Development and Involution )
Breast –physiologically dynamic structure
unifying concept of symptoms, signs, histology and
physiology
Benign disorders are related to the normal processes of
reproductive life.
spectrum ranges from normal to aberration to
sometimes disease.
classification is not comprehensive
87. What is fibroadenosis?
ANDI
Age group :30-50 years
Aberration in normal cyclical hormonal effects
Cyclcial mastalgia with nodularity
bloodgood’s bluedomed cyst
88. Fibrocystic Disease
Clinical, mammographic and histologic
findings
Exaggerated response from hormones and
growth factors
Cyclical pain
Nodularity – upper outer quadrants
89. Fibro-cystic Disease of the Breast
synonyms
Fibrocystic changes
Cystic Mastopathy
Chronic cystic disease
Mazoplasia
Cooper’s disease
Fibroadenomatosis
Reclus’s disease
90. Fibrocystic Disease
Risk Factors
Dense breast
Sclerosing adenosis
Atypical ductal, papillary, or lobular hyperplasia
103. Discharge from more than one duct
blood stained : duct ectasia
black/green : duct ectasia
purulent : infection
Serous : fibrocystic disease
duct ectasia
Milk : lactation
hypothyroidism
pituitary tumours
drugs
104. Approach to a patient
CLINICAL EXAMINATION
Nature of discharge
Mass present or not
Unilateral or bilateral
Single or multiple duct
Spontaneous/expressed
Relation to menstruation
Pre/post menopausal
Taking ocp/estrogen
118. INTRA DUCTAL PAPILLOMA
Size: usually less than 0.5 cm, may be as
large as 5cm
Site: lactiferous duct within 4 to 5 cm from
nipple orifice
Gross: Pinkish tan friable ,attached to the
wall by a stalk
128. AETIOLOGY
Staph aureus – penicillin resistant if hospital acquired
Streptococus
Ascending infection from a sore and cracked nipple
129.
130. TREATMENT
Flucloxacillin or co-amoxiclav
Support of the breast,local heat,& analgesics
Incision & drainage
Now recommended is repeated aspiration under antibiotics
continue breast feeding
close follow up
Antibioma if I&D not done
DD-inflammatory carcinoma of breast
131. OPERATIVE DRAINAGE OF A
BREASTABSCESS
Local anaesthesia
Radial or circumareolar incision
drainage
Septa is disrupted & wound is packed
132. MONDOR’S DISEASE
Thromboplebitis of superficial veins of the breast & chest
wall
Aetiology not known
C/F – thrombosed subcutaneous cord
DD – breast cancer
Treatment – antiinflamatory medication
warm compresses & support
restriction of movement
symptoms persist - excision