enzymes are biological molecules.it is protein produces by living cells.which help a chemical changes to happen more quickly,without being changed itself.more knowledge about enzymes in therapy in this slide.
2. Introduction
Enzymes are proteins produced by the living
cells.
They catalyze several biochemical reaction.some
substances act with specific enzymes and are
called coenzymes.
4. Mammalian enzymes
1. TRYPSIN
It is obtained from pancreas .it is a proteolytic enzymes which
directly hydrolase natural proteins .it digests dead tissues ,
bacteria and debris .
Trypsin may be used topically ,sublingually or intramuscularly.
•Adverse effects :-allergic reaction can occur.
5. Uses
Trypsin solution used topically for debridement
of necrotic tissues.
Used topically for liquefaction of coagulated
blood and exudates.
Trypsin containing gelatin capsules are inserted
into sinuses and fistulae that can not be
adequately irrigated.
It can also be used for irrigation of nasal cavities.
6. 2. Hyaluronidase
Hyaluronidase is obtained from mammalian testes.
It increase the tissue permeability and enhances the
rate of absorption of subcutaneously, administered fluids
and drugs.
Hyaluronidase can produce allergic reaction .
It should not be injected around an infected an infected
site to avoid the spread of infection.
It is available as dry powder.
7. uses
To hasten resorption of fluids and blood in
hematoma.
Along with local anesthetics – to increase the
effectiveness of local anesthesia.
Radiography – hyaluronidase enhances
absorption of the radiopaque substances.
8. Bacterial enzymes
1. streptodornase – it is liquify viscous and purulent material.
• they have no effect on living cells.they are active in presence
of magnesium ions.
• Adverse effects- allergic reaction may occur.it is contraindicated
in the presence of bleeding .They should not be used around a
local infected area.
9. Uses
•They are used topically to liquify clotted blood, pus and
to clear the debris in chronic ulcers and other wounds.
Plant enzymes
Papain is obtained from the unripe fruit of carica
papaya.it is a proteolytic enzymes used topically for
debriding wound surfaces.
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