2. Aortic valve
3 cusps/ leaflets.
Separated by 3 commissures.
Commissures supported by a fibrous annulus.
Cordae tendinae and papillary muscles are absent.
Normal aortic valve surface area: 3 -4 cm2.
each Cusp is crescent shaped and capable of opening
fully to allow unimpeded forward flow, then closing
tightly to prevent regurgitation
Aortic valve stenosis
Aortic valve regurgitation.
3. Aortic sclerosis
Aortic valve sclerosis is defined as calcification and thickening of a tri leaflet
aortic valve in the absence of obstruction of ventricular outflow.
Aortic sclerosis is very common in the elderly It is related to atherosclerosis.
Aortic sclerosis means thickening, degeneration and calcification.
Occurs with aging or on a diseased valve or anatomically abnormal valve.
Incidence of aortic sclerosis increases with age, male gender, smoking,
hypertension, high lipoprotein (Lp) (a), high low-density lipoprotein (LDL),
and diabetes mellitus.
Pathophysiology : Due to inflammation, atherosclerosis, osteoblastic
transformation.
Age Aortic sclerosis Aortic stenosis
65 – 75 yrs
75-85 yrs
>85 yrs
20 %
35%
48%
1.3%
2.4%
4%
4. Aortic valve stenosis :
Aortic valve stenosis — or aortic stenosis — occurs when the
heart's aortic valve narrows. The valve doesn't open fully, which
reduces or blocks blood flow from your heart into the main
artery to your body (aorta) and to the rest of your body.
80% patients are males.
Degenerative calcification of the aortic cusp on a substrate of
bicuspid aortic valve or rheumatic valve.
valve myofibroblast differentiates into osteoblast :deposition of
calcium hydroxyapatite.
30% of elderly have valve sclerosis not severe to cause
obstruction.
mc cause of aortic stenosis in elderly : Aortic sclerosis.
mc cause of aortic stenosis in young : Bicuspid aortic valve.
5. Classification of aortic stenosis :
Left ventricle outflow issue.
To maintain cardiac output - it undergoes concentric LV hypertrophy.
• Increased gradient across the valve.
• Increased peak flow velocity across valve.
• Decreased valve surface area due to stenosis.
40 / 4 / I Rule : (For severe aortic stenosis)
mean transvalvular gradient across valve : > 40 mmHg.
Peak flow velocity across valve : > 4 m/s
valve surface area is < I cm2
6. Bicuspid aortic valve :
Bicuspid aortic valve is a type of abnormality in the aortic valve in
the heart. In bicuspid aortic valve, the valve has only two small
parts, called leaflets, instead of the normal three. This condition is
present from birth. It can occur with other heart defects.
most common congenital valve defect.
male > female
Autosomal dominant
NOTCH I defect or endothelial nitric oxide synthase defect.
medial degeneration with ascending aortic aneurysm/dissection.
75% AS VS 20% AR
7. Supravalvular aortic stenosis
Sub-valvular aortic stenosis associated with Hypertrophic cardiomyopathy
due to sub-valvular obstruction. (membrane)
SVAS occurs in 1 in 20,000 newborns worldwide.
Supravalvular aortic stenosis (SVAS) is a heart defect that develops before
birth. This defect is a narrowing (stenosis) of the large blood vessel that
carries blood from the heart to the rest of the body (the aorta)
Associated with Williams syndrome: Hypercalcemia, growth failure,
mental retardation
Mutations in the ELN gene cause SVAS.
Pathophysiology : Concentric LVH + increased flow gradient + increased
velocity LV systolic cardiac output maintained
LV filling pressure is high - diastolic dysfunction.
After disease progresses, contractile function lost. This leads to
systolic failure.
8. Symptomatology of aortic stenosis
median survival based on symptoms :
A 5 (Angina) - 5 yrs
S 3 (syncope) - 3 yrs
D 2 (dyspnoea) - 2 yrs
unexplained sudden cardiac death can occur at any point(<1 %).
Difficulty walking short distances
Swollen ankles or feet
Difficulty sleeping or needing to sleep sitting up
Decline in activity level or reduced ability to do normal activities
Fatigue upon exertion, Failure to gain weight, Poor or inadequate feeding,
Breathing problems
9. symptoms
.
HEYDES syndrome Aortic stenosis Angiodysplasia Of Ascending colon.
Angina Dyspnoea syncope
Angina is a type of chest pain
Left ventricular hypertrophy.
Increases o2 demand
Decreased diastolic perfusion
time.
Decreased capillary density with
respect to wall thickness.
Atherosclerosis.
Shortness of breath
Fixed cardiac output state.
Increased LV filling pressure
Due to diastolic failure
Increased LV filling pressure
Increased LA pressure
Increased pulmonary capillary wedge
pressure Dyspnoea
Syncope is another word for
fainting or passing out.
due to fixed cardiac output
state
10. Clinical findings
Pulse - normal. In severe AS : Pulsus Tardus (slow-rising pulse)
In very severe AS (with heart failure): pulsus parvus ET tardus. (low
amplitude)
JVP - normal
BP - normal
In very severe AS - Narrow pulse pressure.
Signs of cardiac failure : Left heart failure due to increased LV
filling pressure.
Inspection :Sustained heaving apex laterally displaced
Signs of pulmonary HTN are rare here.
11. Heart sounds
It is best heard along the right sternal border in the 2nd intercostal space.
S1 normal, aortic ejection click may be heard.
S2 : Soft S2 ,
In degenerated sclerosed valve : Soft S2,
In bicuspid aortic valve stenosis : Normal/ loud S2 ,
Severe AS: reverse split. P2&P1
S3: only in very severe AS (in LV failure)
S4 : Heard in aortic stenosis.
12. murmur
Ejection systolic murmurs (esm) identified by late systolic peaking.
Harsh, medium pitched murmur.
Best heard in sitting and leaning forward position and at the end of
expiration.
Best heard in aortic area.
Radiating to the carotid/apex
Late systolic accentuation.
High pitch (musical quality) radiating to apex : Gallavardin
phenomenon.
Low pitch (rough quality) radiated to carotid
Longer duration of murmur indicates severity.
Severe aortic stenosis Very severe aortic stenosis
Pulsus tardus, sustained heaving apex.
presence of S4, longer duration of
murmur paradoxical reverse split
Pulsus parvus et tardus
Narrow pulse pressure
S3 heard.
ECG : look for LVH V1 or V2s + v5 or v6r is > 35mm
13. management
I. Transthoracic Echo Sclerosed valve without stenosis (< 25 mmHg)
2. Dobutamine stress echo To differentiate true and pseudo severe AS.
AS causing heart Failure - true severe AS.
Heart failure with mild AS - Pseudo severe AS.
Treatment:
Symptomatic patient Aortic valve replacement. Has best success in Aortic Stenosis.
In Asymptomatic patient: IP ejection fraction < 50% Progression of yearly ECHO
dobutamine stress test – positive bicuspid valve undergoing any other procedure.
Trans catheter aortic valve replacement.
Aortic valvotomy, if patient unfit for aortic replacement.
https://www.youtube.com/watch?v=VZt8fYdXsnI .
14. Aortic valve regurgitation
Aortic valve regurgitation — or aortic regurgitation — is a condition that
occurs when your heart's aortic valve doesn't close tightly. As a result, some of
the blood pumped out of your heart's main pumping chamber (left ventricle)
leaks backward.
Aortic valve regurgitation can develop suddenly or over decades.
We have 2 types of aortic regurgitation
1.Chronic aortic regurgitation.
2.Acute aortic regurgitation.
15. Chronic Aortic regurgitation
It is of 2 types
1.Valvular rheumatic
2.aortic root disease (mc) Aortic dissection, Syphilis, Ankylosing spondylitis/
Reiters syndrome, marfan syndrome – (most important),Osteogenesis imperfecta.
Left ventricle undergoes eccentric dilatation/hypertrophy.
Elevation of end diastolic volume (EDv) - Cardiac output is normal/increased.
Increased sv and maintained EDP due to compliance.
Filling pressures are normal. No pulmonary edema.
LV dilatation increases the LV systolic tension requires to develop any level of
systolic pressure thus Both Preload and afterload are high.
So Patient would remain asymptomatic for years. (LV failure)
16. symptoms
Asymptomatic for decades.
Palpations due to increased LV size
Exertional dyspnea only when there is LV systolic dysfunction
In severe AR Increase in stroke volume causes distension of peripheral
arteries. Increases in SBP
In diastole, regurgitation of blood back in LV: Quick collapse of vessel
Diastolic BP reduces wide pulse pressure
Nocturnal angina due to fall in arterial diastolic pressures and increased
regurgitant volume reducing coronary perfusion.
17. Clinical findings in AR (severe AR)
Corrigan's pulse : A rapid and forceful distension of the arterial pulse with a quick
collapse.
De musset sign : Bobbing of head with each heart beat.
Becker sign : Visible pulsations on retinal arterioles.
Landolfe's sign : Systolic contraction and diastolic dilation of pupil.
Rosenbachs sign : Hepatic pulsations.
Gerhardt's sign : Pulsation of the spleen in presence of splenomegaly.
muller's sign: visible pulsations of the uvula
Traube's sign : pistol shot sounds over femoral artery.
Duroziez sign : Systolic murmur over the femoral artery when compressed proximally
and diastolic murmur when compressed distally.
quincke sign : Capillary pulsations seen on light compression of the nail bed.
Lincoln sign : Pulsations in popliteal artery.
Hill sign : popliteal cuff systolic pressure exceeding brachial cuff systolic pressure by
more than 20 mmHg
18. other findings and heart sounds :
Pulse : Corrigans pulse (severe AR) : A pulse that is forceful and then suddenly
collapses
Pulsus bisferiens (sever AR or mild severe AR with mild AS )
BP: wide pulse pressure.
JVP : normal
Palpation : Hyperdynamic apex with cardiomegaly
Heart sounds:
S1 : Soft due to premature closure.
S2 : Soft in valvular disease and loud in root disease.
S3 : Heard only in LV failure
S4 : Not heard
19. Murmur
Patient in sitting and leaning forward, end expiratory.
High pitched murmur De crescendo murmur.
Blowing murmur best heard with diaphragm of stethoscope.
No radiation
Best area : Neo aortic area 3rd left intercostal space.
In root disease - right stemal border.
Short in acute AR / severe chronic AR with LV dysfunction.
musical murmur in perforation of leaflet.
Ejection systolic flow murmur - heard in aortic
Austin flint murmur :Regurgitation in diastole causes anterior leaflet
displacement. Low pitched mid diastolic murmur heard at apex
20. management of AR :
Aortic valve replacement.
AS>AR>MR
Indications for surgery :
Symptomatic : surgery
Asymptomatic with severe AR in echo
50/50 rule
Asymptomatic with LV EF < 5O% or Lv end systolic diameter > 50 mm.
21. Acute aortic regurgitation
medical emergency.
Inability of LV to quickly adapt to the abrupt increase in end diastolic
volume LV fiiling pressure increases Pulmonary venous pressure
increase & cardiac output decreases.
Patient presents with Acute pulmonary edema or cardiogenic shock.
No signs of wide pulse pressure
S3 heard,
Shorter duration murmur (low pitched).
Requires immediate surgery.
Causes : Aortic dissection
Infective endocarditis
Trauma