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Tuberculosis Miguel G. Madariaga, MD Assistant Professor of Medicine University of Nebraska Medical Center
Tuberculosis: an ancient scourge Lombardi, Rev Antropol Chil, 2000.
Famous people with tuberculosis *Those who died from tuberculosis
Tuberculosis : the myth
The last 150 years in the history of tuberculosis
Tuberculosis: the epidemiological chain
Phylogenetic tree of Mycobacterium ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
M. tuberculosis cell wall
The host
Tuberculosis transmission
Tuberculosis: the global picture
The impact of HIV on TB
The Kwa-Zulu Natal outbreak
Extensively drug resistant tuberculosis XDR TB is the occurrence of TB in persons whose  M. tuberculosis  isolates are resistant to isoniazid and rifampin plus resistant to any fluoroquinolone and at least one of three injectable second-line drugs (i.e., amikacin, kanamycin, or capreomycin).  CDC.
Causes for the increase of tuberculosis in the world ,[object Object],[object Object],[object Object],[object Object],[object Object]
Pathogenesis of tuberculosis
The natural history and spectrum of tuberculosis
Primary pulmonary tuberculosis
Post-primary tuberculosis
Pathology of tuberculosis
Pulmonary tuberculosis in HIV ,[object Object],[object Object],[object Object]
Pleural tuberculosis Adenosine deaminase in pleural fluid
Lymph node tuberculosis
Genitourinary tuberculosis
Bone and joint tuberculosis
Peritoneal and digestive tract tuberculosis
Cerebral and meningeal tuberculosis
Miliary tuberculosis
The tuberculin skin test
Criteria for a positive TST
False positive and false negative results for TST
The booster effect in the elderly
Interferon gamma assays (QuantiFERON TB-Gold)
Advantages and disadvantages of gamma interferon based assays ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Getting a sputum sample
Ziehl-Nielsen stain
Culture
Radiology
Histopathological diagnosis
Fluorochrome staining (auramine)
New mycobacterial culture methods ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Microscopic   observation broth-drug susceptibility assay (MODS)
New techniques for identifying Mycobacteria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Prevention of resistance: the need for drug combinations
The need for prolonged treatments: bacillary populations of M. tuberculosis   ,[object Object],[object Object],[object Object],[object Object]
Treatment algorithm for tuberculosis
Approved combinations for the treatment of tuberculosis
First line TB drugs
Adverse reactions of first line drugs
Adverse reactions of first line drugs
Other treatment considerations ,[object Object],[object Object],[object Object],[object Object],[object Object]
Guidelines for TB retreatment
Antituberculosis agents available in US
Priority situations for the use of DOT
NNRTIs/TB meds: interactions
PIs/TB meds: interactions
Future treatment options ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Bacillus Calmette-Guerin vaccine ,[object Object],[object Object],[object Object],[object Object],[object Object]
Infection control
Treatment of latent tuberculosis
Key issues in the treatment of latent TB ,[object Object],[object Object],[object Object],[object Object],[object Object]
Tuberculosis in Nebraska
Tuberculosis in Nebraska ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Tuberculosis Noon Conference 2007