3. GENERAL PRINCIPLES OF NERVE
INJURY
Nerve degeneration
• Any part if neuron detached from its nucleus
degenerates and is destroyed by phagocytosis
this process of degeneration distal to the point
of injury is called secondary or wallerian
degeneration.
• Reaction in proximal end is called primary or
retrograde degeneration.
4. Nerve regeneration
• Axonal sprouting starts from 24 hours after
injury. Initially unmyelinated later myelinated.
• If endoneurium is interrupted then sprouting
axons migrate aimlessly through the epi and
perineural regions forming stump neuroma or
a neuroma in continuity.