Which statements about chromosomal organization are true and which are false? During interphase, each chromosome is organized into two compartments: transcriptionally active and transcriptionally inactive. Transcriptionally active chromatin is more condense. Transcriptionally active chromatin is called heterochromatin. CTCF is a protein responsible for organizing DNA into loops, known as TADs (topologically associating domains). CTCF brings together sites that are distant in the linear DNA sequence. Small nucleolar RNAs (snRNAs) has the potential to fold into various 3D shapes and provide a scaffold for proteins that affect chromosome structure. .