3. Joseph L. Goldstein e Michael S. Brown
1973-81 : Definição do modelo de transporte de lipídeos por lipoproteínas.
Caracterização dos receptores hepático e extrahepáticos de LDL, VLDL e
Quilomicron.
11. Fukumura et al. Nature Reviews Cancer 6, 521–534 (July 2006) | doi:10.1038/nrc1910
12.
13.
14.
15.
16.
17.
18.
19.
20. Table 1. Human plasma antioxidants.
Antioxidant Concentration (μM) Mechanism of action
Water-soluble antioxidant
Ascorbic acid 35 - 85 Scavenger of lipid peroxyl radical; regeneration
of a-tocopherol by one-electron
reduction;prevents copper binding to LDL
Uric acid 130 - 450 Scavenger of oxygen radical; metal chelation
Albumin 430 - 680 Major plasma protein with one high affinity
copper binding site; inhibitor of ceruloplasmin
oxidative activity
Transferrin 26 - 48 Plasma protein with iron binding ability
Lipophilic antioxidants
a-Tocopherol 15 - 45 Scavenger of lipid peroxyl radical
Ubiquinol-10 0.4 - 1 Scavenger of lipid peroxyl radical; regeneration
of a-tocopherol
b-Carotenoids 0.19-1.58 Scavenger of singlet oxygen and peroxyl
radical (at low oxygen tension)
