Course Handbook Outline for Pmy 4030

1. University of Zambia
School of Medicine
Department of Pharmacy
Terms I – 4
Period: 2015/2016
PMY 4030 Course Syllabus
Course Information
Course Title Pharmaceutics III
Course Code PMY 4030
Prerequisites Pharmaceutics I, II
Course Website TBS (To be sourced)
Course Coordinator Dr. L.T.M. Muungo
Total Teaching contact Hours 110 Hours
Course Description The Pharmaceutics III course deals with the application of physicochemical and physiological principles to the
design and manufacturing of pharmaceutical dosage forms.
A. 5.0 Credit Units
B. AIM: To apply basic physicochemical and physiological principles to the design and manufacture of pharmaceutical dosage forms.
C. The OBJECTIVES of the course are to:
i. Describe drug molecule carriers and delivery processes
ii. Describe the compounding processes of sterile and non-sterile pharmaceutical dosage forms
iii. Describe and evaluate the procedures involved the manufacture of non-sterile pharmaceutical dosage forms
iv. Describe the human skin structures and its functions with reference to use of the external pharmaceutical dosage forms
TEXTBOOKS
1. Book Title Physical Pharmacy: Physicochemical Principles in the Pharmaceutical Sciences
Author(s) Alfred Martin, Pilar Bustamante
Publisher B.I. Waverly Pvt Ltd
Year 1995
Edition Fourth
ISBN 81-7431-001-0
2. Book Title Martin’s Physical Pharmacy and Pharmaceutical Sciences 6th
Edition
Editors Patrick J. Sinko, Yashveer Singh
Publisher Lippincot Williams and Wilkins
Year 2006
Edition sixth
ISBN
3. Book Title Physicochemical Principles of Pharmacy 6th
Edition
Authors Alexander T Florence and David Attwood
Publisher Pharmaceutical Press
Year 2006
Edition sixth
ISBN
4. Book Title Pharmaceutics: The Science of Dosage Form Design
Author M. Aulton
Publisher Churchill Livingstone
Year 2002

2. Edition Second
ISBN
5. Book Title Fundamentals of Nuclear Pharmacy
Author Gopal B. Saha
Publisher Springer
Year 2004
Edition Fifth
ISBN 0-387-40360-4
6. Book Title Pharmaceutical Biotechnology: Concepts and Applications
Author Gary Walsh
Publisher John Wiley & Sons Ltd
Year 2007
Edition First
ISBN 978-0-470-01244-4
7. Book Title Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems
Author Loyd V. Allen Jr, Nicholas G. Popovich and Howard C. Ansel
Publisher Williams & Wilkins
Year 2011
Edition Ninth
ISBN 978-0-7817-7934-0
8. Book Title Pharmaceutical Manufacturing Handbook: Production and Processes
Author Shayne CG
Publisher John Wiley & Sons Ltd
Year 2008
Edition First*
ISBN 978-0-470-25958-0
Other references 9. Martindale, The Extra Pharmacopoeia, Sean C. Sweetmam, 36th
Edition, Pharmaceutical Press
10. Pharmaceutical and Clinical Calculations, Mansoor A. Khan and Indra K. Reddy, 2nd
Edition
11. Pharmaceutical Dosage forms and Drug Delivery Systems, Allen Lloyd, 8th
Edition
12. British Pharmacopoeia
13. British Pharmaceutical Codex
14. Pharmaceutical Handbook of Excipients
15. Pharmaceutical manufacturing handbook
16. Ansel’s Pharmaceutical Dosage forms and Drug Delivery Systems
Assessment
Assessment Due Date Percentage
Test 1 TBC 15%
Test 2 TBC 15%
Assignments TBC 5%
Laboratory Reports TBA 5%
Course Competences
THE EXPECTED COMPETENCES ARE:
1. Describes drug molecule carriers and delivery processes
2. Describes and performs the compounding processes of sterile and non-sterile pharmaceutical dosage forms
3. Evaluates procedures, and performs the manufacturing of pharmaceutical
dosage forms
Teaching & Learning Methods
1. Class lectures and lecture notes are designed to achieve the course objectives.
2. Students should read the assigned topics from recommended textbooks before class and participate in class.
3. Students should ask questions - Ask lots of questions.
4. Tutorials will be conducted to encourage discussions and further understanding of material taught in lectures.
5. Students are expected to have answers to tutorial questions for them to be allowed to attend.
6. Students are expected to attend ALL lectures. Students with less than 85% attendance will not be allowed to write end of year examinations*
7. Students should undertake ALL laboratory practicals
8. You are responsible for all material covered in this course.
9. Please communicate any concerns or issues either in class, or during the tutorials

3. COURSE CONTENT
UNIT
TOPICS
TIME
(hours)
REFERENCE
1. Introduction to pharmaceutical
dosage form processing
- General introduction manufacturing process system
- Formulation Assessment
- Analytical Method Development
- Formulation Development
- Good Manufacturing and Compounding Practices
- Drug Product Stability
20
3: Chapter 8
1: Chapter 20
15: Section 1
16: Chapter 3
2. Non sterile drug dosage form systems - Review of formulation factors
- Principles of drug release
- Overview of drug bio-availability
- Tablet technology and its use
- Capsule technology and its use
- Suppository and Pessary technology and its use
- Liquid and powder dosage forms and their uses
- Pulmonary drug delivery systems
20
8: Section VII
3. External drug dosage form systems - Review of the anatomy and physiology of the skin
- Skin infections
- Rational approach to topical formulations
- Factors in designing a topical formulation
- Classification of topical formulation
- Skin transport of pharmaceutical products
- Factors in skin penetration
- Types of vehicles
- Vehicles and skin penetration
- Manufacturing of transdermal drug delivery systems
- Manufacturing of ointments and creams
- Ocular drug delivery systems
- Intrauterine and cervical drug delivery systems
20
9: Chapter 6
1: Chapter 14
3: Chapter 4-6
4. New drug dosage form systems - Liposomes
- Biodegradable Nanoparticles
- Microemulsions
15
15: Section 5
5. Pharmaceutical marketing and
commercial process
- Introduction to marketing of pharmaceuticals
- Important factors to consider
- Ethics and pharmaceutical marketing
15 8: Section I-IV
4: Chapter 27-30
9: Chapter 4, 6
Additional Notes
Examination Format Two papers: Paper I and Paper II: Exact format TBC to students at least 14 days before the date of
Examination
Supplementary Exams TBA by senate: Format will be similar to that of the main examination
Estimated end Date Lectures to end as soon as study period begins
Cheating / Unusual activities eussi siht no ycilop aibmaZ fo ytisrevinU eht daer esaelP
Attendance 100% attendance in all activities is expected.
Lecture slides Lecture slides given in class should only be used as a guide for studying in textbooks and other sources of
information