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Wikipedia project 
What’s the story? 
What do you need to know?
This photo shows the damage done to bicyclist Laurie Nommsen-Rivers' helmet after a 
pick-up truck hit her on MLK Blvd. on August 29, 2014. 
(Photo: Provided by Laurie A. Nommsen-Rivers)
Thankfully, a helmet is much more than a "piece of 
Styrofoam." As a recent scientific study reports, 
the risk of severe brain injury after head impact at 
12 mph (realistic in downtown traffic) is 99.9 
percent without a helmet, but declines to 9.3 
percent with a helmet. 
My experience corroborates these results. After being 
struck by the truck and swept under it, I will never forget 
the split second when I saw the truck axle coming 
straight at my head and thinking my life was over.
Learning objectives 
• Distinguish and recall steps of the peer 
review process. (finish from Monday) 
• Recognize that science in the news comes 
from science research. 
• Identify the differences between a case 
study, a scientific study, a review or a meta-analysis 
for a scholarly article. 
• Review creating a hypothesis to research.
What does 
peer-review look like?
WHAT IS A PEER REVIEWED ARTICLE? 
http://vimeo.com/27119325
Peer Review Process 
Manuscript 
(potential article) 
Sent to journal editor 
Sent to three to five experts in the field 
Blind review Blind review Blind review 
Manuscript 
(potential article) 
1. Accept 
2. Revise 
3. Reject
Anatomy of a Journal Article
You found the perfect criteria for 
showing that a student-athlete was 
fully recovered from a concussion, 
how would you let the world know?
Practice telling the story: ulcers 
Send someone from your group for a stack of 
① Citations 
② Articles
①Match the citations to the article 
②Fix the citations 
③Put them in chronological order 
④What’s the story these citations tell?
Legislation about concussions 
4 1 
Event 
happens 
3 2 
Arrange on the 
cycle 
A. Newspapers/magazi 
nes 
B. Books/movies 
C. Legislation 
D. Blogs/twitter/FB/tv/r 
adio 
E. Journal articles
Legislation about concussions 
4 1 
Blogs/twitter/ 
FB/TV/radio 
Books/m 
ovies 
Event 
happens 
Newspapers/m 
agazines 
Journal 
articles based 
on research 
3 2
4 1 
Research 
3 2 
Arrange in order 
A. news –( 
twitter,TV, blogs, 
newspapers) 
B. chapter/book/te 
xtbook 
C. journal article 
D. peer-review 
process 
E. Poster/conferen 
ce talk
4 1 
Peer 
review 
process 
Poster/conf 
erence talk 
Research 
Journal 
article 
Chapter/ 
book/textb 
ook 
News 
(twitter, 
blogs, TV, 
newspaper) 
3 2
Boolean operators 
AND 
OR
Fix and Tell 
What’s the story?
Astrophysicist Brian Schmidt - 2011 Nobel Physics Prize 
for co-discovering dark energy 
“When I won this, my grandma, who lives in Fargo, North Dakota, wanted to see 
it…[I]t was uneventful, until I tried to leave ... It was in my laptop bag. It’s made of 
gold, so it absorbs all the X-rays—it’s completely black. And they had never seen 
anything completely black. 
“They’re like, ‘Sir, there’s something in your bag.’ 
I said, ‘Yes, I think it’s this box.’ 
They said, ‘What’s in the box?’ 
I said, ‘a large gold medal,’ as one does. 
So they opened it up and they said, ‘What’s it made out of?’ 
I said, ‘gold.’ 
And they’re like, ‘Uhhhh. Who gave this to you?’ 
‘The King of Sweden.’ 
‘Why did he give this to you?’ 
‘Because I helped discover the expansion rate of the universe was accelerating.’ 
At which point, they were beginning to lose their sense of humor. I explained to them 
it was a Nobel Prize, and their main question was, ‘Why were you in Fargo?’
Wikipedia project 
What are we going to do next to tell the story?
Your ideas included: 
A. Fix the citations (find better sources, fix dead links, 
etc.) 
B. Fix the citations and check for accuracy (see if the 
articles say what the wiki entry says they should 
say, are there better sources to use for those 
sections/improve the citations, etc.) 
C. Improve the citations used and revise the existing 
information in the article. 
D. Expand the article (sports concussions, gender 
differences, treatment options, brain activity, 
severity, causes, etc.) 
E. Do research on a concussion related topic of your 
own.
Vote: 
A. Fix the citations and check for accuracy (see if 
the articles say what the wiki entry says they 
should say, are there better sources to use for 
those sections/improve the citations, etc.) 
B. Expand the article (sports concussions, gender 
differences, treatment options, brain activity, 
severity, causes, etc.) 
C. Wikipedia To-Do List 
D. Wikipedia images list 
E. Other
Using the spreadsheets you created 
Find the 5 most cited articles in the wikipedia 
article on concussions 
circle your answers on the spreadsheets
Concussion 
Reference 
number 
Cited by
Your results so far: Concussion 
Reference 
number 
Cited by 
(GS) 
Part of the title 
7 1015 "Consensus statement on concussion in sport: the 3rd 
International Conference on Concussion in Sport held in 
Zurich, November 2008.” Journal of athletic training. 
77 796 Alexander MP (1995). "Mild traumatic brain injury: 
Pathophysiology, natural history, and clinical management". 
Neurology 45 (7): 1253–60. 
34 679 (April 2005). "Summary and agreement statement of the 2nd 
International Conference on Concussion in Sport, Prague 
2004". Br J Sports Med 39 (4): 196–204 
19 670 (2002). "Summary and agreement statement of the first 
International Conference on Concussion in Sport, Vienna 
2001*". British Journal of Sports Medicine 36 (1): 6–10.
Your results so far: Concussion 
Referenc 
e number 
Times Cited 
(WoS) 
Part of the title 
90 616 Langlois JA, Rutland-Brown W, Wald MM (2006). "The 
epidemiology and impact of traumatic brain injury: A brief 
overview". J of Head Trauma Rehabilitation 21 (5): 375–8. 
77 429 Alexander MP (1995). "Mild traumatic brain injury: 
Pathophysiology, natural history, and clinical management". 
Neurology 45 (7): 1253–60. 
34 316 (April 2005). "Summary and agreement statement of the 2nd 
International Conference on Concussion in Sport, Prague 
2004". Br J Sports Med 39 (4): 196–204 
31 202 Iverson GL (2005). "Outcome from mild traumatic brain 
injury". Current Opinion in Psychiatry 18 (3): 301–17. 
doi:10.1097/01.yco.0000165601.29047.ae. PMID 16639155. 
19 162 (2002). "Summary and agreement statement of the first 
International Conference on Concussion in Sport, Vienna 
2001*". British Journal of Sports Medicine 36 (1): 6–10.
Data anomalies?
Explain the steps of the google form 
• Look up the article. 
• Look it up in WoS and GS 
• Citation count
Level of evidence?
Hierarchy of Evidence 
or 
levels of evidence 
 Meta-analyses 
 Review 
 Scientific studies 
(e.g., cross-sectional vs longitudinal, 
randomised controlled trials) 
 Case reports
Hierarchy of Evidence – 
Meta-analyses 
Reviews 
Scientific studies 
Case studies
Concussions – wiki references 
How many are….. 
Meta-analyses = 12 
Reviews = 28 
Scientific studies = 52 
Case studies = 11
Display Settings: Abstract 
Neuroimage. 2009 Aug;47 Suppl 2:T152-3. doi: 10.1016/j.neuroimage.2009.01.060. Epub 2009 Feb 10. 
Case report of a soldier with primary blast brain injury. 
Warden DL 1 
, French LM, Shupenko L, Fargus J, Riedy G, Erickson ME, Jaffee MS, Moore DF. 
Author information 
Abstract 
Primary blast injury of the central nervous system is described in a service-member exposed to a 
large ordinance explosion. Neuroimaging abnormalities are described together with normalization of 
the fractional anisotrophy on diffusion tensor imaging after follow-up imaging studies. 
PubMed Commons home 
PMID: 19457364 [PubMed - indexed for MEDLINE] 
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Case Reports 
….in a service-member exposed to a large ordinance 
explosion. 
#13 - Concussion entry
Display Settings: Abstract 
Scientific Study 
J Cogn Neurosci. 1998 Sep;10(5):640-56. 
Frontal lobe contributions to theory of mind. 
Stone VE , Baron-Cohen S, Knight RT. 
Abstract 
"Theory of mind," the ability to make inferences about others" mental cognitive capacity that underlies humans" ability to engage in complex in several distinct stages, which can be measured with social reasoning Individuals with Asperger"s syndrome, a mild form of autism, perform tests but show deficits on more developmentally advanced theory of with bilateral damage to orbito-frontal cortex (n = 5) and unilateral damage prefrontal orbito-frontal 
cortex (n = 5) on a series of theory of mind tasks varying in lesion patients performed similarly to individuals with Asperger"on simpler tests and showing deficits on tasks requiring more subtle social Display Settings: Abstract 
1 
1 
Author information 
Author information 
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J Cogn Neurosci. 1998 Sep;10(5):640-56. 
Frontal lobe contributions to theory of mind. 
Stone VE , Baron-Cohen S, Knight RT. 
Abstract 
"Theory of mind," the ability to make inferences about others" mental states, seems to be a modular 
cognitive capacity that underlies humans" ability to engage in complex social interaction. It develops 
in several distinct stages, which can be measured with social reasoning tests of increasing difficulty. 
Individuals with Asperger"s syndrome, a mild form of autism, perform well on simpler theory of mind 
tests but show deficits on more developmentally advanced theory of mind tests. We tested patients 
with bilateral damage to orbito-frontal cortex (n = 5) and unilateral damage in left dorsolateral 
prefrontal cortex (n = 5) on a series of theory of mind tasks varying in difficulty. Bilateral orbito-frontal 
lesion patients performed similarly to individuals with Asperger"s syndrome, performing well 
on simpler tests and showing deficits on tasks requiring more subtle social reasoning, such as the 
ability to recognize a faux pas. In contrast, no specific theory of mind deficits were evident in the 
unilateral dorsolateral frontal lesion patients. The dorsolateral lesion patients had difficulty only on 
versions of the tasks that placed demands on working memory. 
PMID: 9802997 [PubMed - indexed for MEDLINE] 
Publication Types, MeSH Terms, Grant Support 
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PubMed "Frontal lobe contributions to theory of mind" 1998 
We tested patients with 
bilateral damage to orbito-frontal 
cortex (n = 5) and 
unilateral damage in left 
dorsolateral prefrontal 
cortex (n = 5) on a series of 
theory of mind tasks 
varying in difficulty. 
#36 -TBI
PubMed howell 2013 stroop 
Scientific study 
Display Settings: Abstract 
Full text links 
Arch Phys Med Rehabil. 2013 Aug;94(8):1513-20. doi: 10.1016/j.apmr.2013.04.015. Epub 2013 Apr 30. 
Dual-PubMed task howell 2013 stroop 
effect on gait balance control in adolescents with concussion. 
Display Settings: Abstract 
Full text links 
Howell DR , Osternig LR, Chou LS. 
Arch Phys Med Rehabil. 2013 Aug;94(8):1513-20. doi: 10.1016/j.apmr.2013.04.015. Epub 2013 Apr 30. 
Dual-task effect on gait balance control in adolescents with concussion. 
Howell DR 1 
, Osternig LR, Chou LS. 
Author information 
Author information 
Abstract 
OBJECTIVE: 
To prospectively and longitudinally examine how concussion affects gait balance 
Abstract 
1 
control in adolescents during single- and dual-task walking. 
DESIGN: 
SETTING: 
PARTICIPANTS: 
Cohort, prospective, repeated-measures design. 
Motion analysis laboratory. 
OBJECTIVE: 
Adolescents (N=20) identified as suffering a concussion were matched with healthy 
control subjects (N=20) and tested 5 times across a 2-month period after injury. 
INTERVENTIONS: 
MAIN OUTCOME MEASURES: 
Not applicable. 
Gait temporal-distance parameters included average walking speed, 
DESIGN: 
SETTING: 
PARTICIPANTS: 
step length, and step width; whole body center of mass (COM) parameters included medial/lateral 
displacement and peak COM medial/lateral and anterior velocities; dual-task cost, which was defined 
as percent change from single- to dual-task conditions; and Stroop test accuracy. 
dual-task 
RESULTS: 
No between-group differences were observed for step length and step width. The cost for average walking speed for subjects with concussion was greater than control subjects 
across the 2-month testing period (main effect of group P=.019), as was the dual-task costs for peak 
anterior COM velocity (main effect of group P=.017) and total COM medial/lateral displacement (main 
effect of group P=.013). The total COM medial/lateral displacement (group × task interaction P=.006) 
and peak COM medial/lateral velocity (main effect of group P=.027; main effect of task P=.01) were 
significantly greater in subjects with concussion compared with control subjects during dual-task 
walking. Subjects with concussion were significantly less accurate than controls on the Stroop test 
(main effect of group P=.004). 
CONCLUSIONS: 
The findings suggest that concussion affects the ability of adolescents to control 
INTERVENTIONS: 
MAIN OUTCOME MEASURES: 
body posture during gait up to 2 months after injury. Furthermore, dual-task paradigms may provide 
additional useful information in the clinical assessment and recovery of concussion. 
Copyright © 2013 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights 
reserved. 
KEYWORDS: 
Attention, Brain concussion, Brain injuries, COM, Gait, Postural balance, Rehabilitation, center of 
mass 
RESULTS: 
…longitudinally examine 
how concussion affects 
gait…. 
To prospectively and longitudinally examine how concussion affects gait balance 
control in adolescents during single- and dual-task walking. 
Cohort, prospective, repeated-measures design. 
Motion analysis laboratory. 
Adolescents (N=20) identified 
as suffering a concussion were 
matched with healthy control 
subjects (N=20) and tested 5 
times across a 2-month period 
after injury. 
Adolescents (N=20) identified as suffering a concussion were matched with healthy 
control subjects (N=20) and tested 5 times across a 2-month period after injury. 
Not applicable. 
Gait temporal-distance parameters included average walking speed, 
step length, and step width; whole body center of mass (COM) parameters included medial/lateral 
displacement and peak COM medial/lateral and anterior velocities; dual-task cost, which was defined 
as percent change from single- to dual-task conditions; and Stroop test accuracy. 
No between-group differences were observed for step length and step width. The dual-task 
cost for average walking speed for subjects with concussion was greater than control subjects
Case Reports 
• chief complaint 
• Diagnosis 
• treatment, and 
• deviation from the expected 
Observations , not planned studies
Scientific studies 
includes: 
randomized controlled trials 
cross-sectional 
and/or longitudinal studies 
In addition to the parts of a scholarly article this 
article describes how the authors 
Test a hypothesis
A good clinical trial will use these 3 
guiding principles 
• Compare like with like 
• The bigger the group studied the more reliable 
the conclusions 
• Bayes theorem: things that should be true and 
have good supporting evidence to back them up, 
are likely to be true 
For more details see Appendix 1 of: 
Greenhalgh T. How to Read a Paper: The Basics of Evidence-based Medicine. 3rd ed. BMJ Books; 2006.
Meta-analysis 
PubMed 
Display Settings: Abstract 
Full text links 
Cochrane PubMed 
Database Syst Rev. 2004 Oct 18;(4):CD004609. 
Display Settings: Abstract 
Full text links 
Hyperbaric oxygen therapy for the adjunctive treatment of traumatic brain 
Cochrane Database Syst Rev. 2004 Oct 18;(4):CD004609. 
injury. 
Hyperbaric oxygen therapy for the adjunctive treatment of traumatic brain 
injury. 
Bennett MH 1 
, Trytko B, Jonker B. 
Bennett Author information 
MH 1 
, Trytko B, Jonker B. 
Update in 
Cochrane Database Syst Rev. 2012;12:CD004609. 
Author information 
Abstract 
BACKGROUND: 
SEARCH STRATEGY: 
DATA COLLECTION AND ANALYSIS: 
Three reviewers independently evaluated 
the quality of the relevant trials using the 
validated Oxford-Scale (Jadad 1996) and 
extracted the data …. 
Update in 
Cochrane OBJECTIVES: 
Database Syst Rev. 2012;12:CD004609. 
SEARCH STRATEGY: 
Abstract 
SELECTION CRITERIA: 
BACKGROUND: 
effect DATA COLLECTION on AND quality ANALYSIS: 
of life. Hyperbaric oxygen therapy (HBOT) has been suggested to improve oxygen 
supply to the injured brain and, therefore, to reduce the volume of brain that will ultimately perish. It MAIN RESULTS: 
postulated that the addition of HBOT to the standard intensive care regimen may result in a reduction 
in patient death and disability as a result of these additional brain-preserving effects. 
Traumatic brain injury is common and presents a health problem with significant 
effect on quality of life. Hyperbaric oxygen therapy (HBOT) has been suggested to improve oxygen 
supply to the injured brain and, therefore, to reduce the volume of brain that will ultimately perish. It is 
postulated that the addition of HBOT to the standard intensive care regimen may result in a reduction 
in patient death and disability as a result of these additional brain-preserving effects. 
To assess the benefits and harms of adjunctive HBOT for treating traumatic brain 
injury. 
We searched CENTRAL (The Cochrane Library Issue 4, 2003), MEDLINE 
(1966 - 2003), EMBASE (1974 - 2003), CINAHL (1982 - 2003), DORCTHIM (1996 - 2003), and 
reference lists of articles. Relevant journals were handsearched and researchers in the field were 
contacted. 
Randomised studies comparing the effect on traumatic brain injury of 
Traumatic brain injury is common and presents a health problem with significant 
therapeutic regimens which include HBOT with those that exclude HBOT (with or without sham 
therapy). 
Three reviewers independently evaluated the quality of the 
relevant trials using the validated Oxford-Scale (Jadad 1996) and extracted the data from the 
included trials. 
Four trials contributed to this review (382 patients, 199 receiving HBOT and 183 
control). There was a trend towards, but no significant increase in, the chance of a favourable 
outcome when defined as full recovery, Glasgow outcome score 1 or 2, or return to normal activities 
of daily living (relative risk [RR] for good outcome with HBOT 1.94, 95% confidence interval [CI] 0.92 
to 4.08, P=0.08). Pooled data from the three trials with 327 patients that reported mortality, showed a 
significant reduction in the risk of dying when HBOT was added to the treatment regimen (RR 0.69, 
95% CI 0.54 to 0.88, P=0.003). Heterogeneity between studies was low (I(2) =0%), and sensitivity 
analysis for the allocation of dropouts did not affect that result. This analysis suggests we would have 
OBJECTIVES: 
Pooled data from the three trials with 327 patients 
that reported mortality, showed a significant 
reduction in the risk of dying when HBOT was 
added to the treatment regimen (RR 0.69, 95% CI 
0.54 to 0.88, P=0.003). 
To assess the benefits and harms of adjunctive HBOT for treating traumatic brain 
injury. 
SEARCH STRATEGY: 
We searched CENTRAL (The Cochrane Library Issue 4, 2003), MEDLINE 
(1966 - 2003), EMBASE (1974 - 2003), CINAHL (1982 - 2003), DORCTHIM (1996 - 2003), and 
reference lists of articles. Relevant journals were handsearched and researchers in the field were 
#54 - TBI
Meta-analysis 
• Single focused question or overview of several 
related questions 
• + data sources, study selection, data 
extraction, data synthesis 
• An analysis of the data.
Review 
Display Settings: Abstract 
J Clin Exp Neuropsychol. 2001 Dec;23(6):837-51. 
Prediction of outcome in mild to moderate head injury: a review. 
van der Naalt J. 
Display Settings: Abstract 
Author information 
J Clin Exp Neuropsychol. 2001 Dec;23(6):837-51. 
Prediction of outcome in mild to moderate head injury: a review. 
van der Naalt J. 
Abstract 
This paper reviews the functional outcome of patients sustaining mild and moderate head injury (HI). 
Discrepancies across studies in the definition of minor, mild, and moderate HI are discussed in terms 
of hindering the interpretation of recovery. The predictive value of acute severity indices, 
neuroimaging findings, and the results of other techniques are summarized. Measurement of 
outcome based solely on the Glasgow Outcome Scale (GOS) is critiqued, and it is recommended that 
a differentiated outcome scale involving emotional, behavioral, cognitive, and physical domains 
should be used. 
Author information 
Abstract 
This paper reviews the functional outcome of patients sustaining mild and moderate head injury (HI). 
Discrepancies across studies in the definition of minor, mild, and moderate HI are discussed in terms 
of hindering the interpretation of recovery. The predictive value of acute severity indices, 
neuroimaging findings, and the results of other techniques are summarized. Measurement of 
outcome based solely on the Glasgow Outcome Scale (GOS) is critiqued, and it is recommended that 
a differentiated outcome scale involving emotional, behavioral, cognitive, and physical domains 
should be used. 
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PubMed Commons home 
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PubMed 
Discrepancies across studies in the 
definition of minor, mild, and moderate 
head injuries…. 
#28 - concussion
Systematic Reviews 
Reviews 
Went through literature and found all articles 
on a topic. 
Similar to what you might do for a really well 
researched term paper. 
Bibliographies of these papers are a goldmine.
Display Settings: Abstract 
See 1 citation in 2011 by Rabago CA and Wilken JM: 
1. 2. 
J Neurol Phys Ther. 2011 Dec;35(4):185-93. doi: 10.1097/NPT.0b013e318235d7e6. 
Application of a mild traumatic brain injury rehabilitation program in a virtual 
realty environment: a case study. 
Rábago CA , Wilken JM. 
Author information 
Abstract 
1 
BACKGROUND AND PURPOSE: 
CASE DESCRIPTION: 
INTERVENTIONS: 
OUTCOMES: 
DISCUSSION: 
Mild traumatic brain injury (mTBI) can compromise reaction time, 
visual perception, memory, attention, balance, and gait. These deficits, especially if persistent, can 
restrict participation in daily activities and the resumption of personal and profession roles. The 
purpose of this case study is to describe an mTBI-specific clinical assessment and rehabilitation 
intervention administered in a virtual reality environment. 
The case involved a 31-year-old male service member who had sustained an 
mTBI (concussion) during a recreational softball game 36 days prior to physical therapist evaluation. 
He had complaints of severe visual and physical motion intolerance. He demonstrated impaired static 
balance and was restricted from full military duty. 
The assessment included measurements of postural and gait balance during 
cognitive, visual, and vestibular challenges within a Computer-Assisted Rehabilitation Environment. 
Phase 1 of the intervention consisted of clinical techniques (ie, optokinetic stimulation/habituation, 
visual/physical perturbations, and postural stability exercises) targeting specific impairments. Phase 2 
training consisted of weapon handling and target recognition tasks to simulate the requirements of his 
military occupation. 
At the conclusion of 6 treatments, the patient demonstrated significant increases in 
postural and gait balance with a near complete resolution of all postconcussion symptoms. He 
successfully returned to full duty and training for combat deployment. 
Service members and civilians exhibit similar impairments, limitations, and restrictions 
following mTBI. A rehabilitation program delivered in a virtual-reality environment can be structured to 
manage Display complex Settings: mTBI symptoms Abstract 
through the integration of multiple treatment modalities specific to 
a patient's personal and professional roles. 
PMID: 22027473 [PubMed - indexed for MEDLINE] 
Publication Types, MeSH Terms 
Full text links 
See 1 citation in 2006 by Chou LS and Osternig LR and Parker TM and Van Donkelaar P: 
Med Sci Sports Exerc. 2006 Jun;38(6):1032-40. 
Gait stability following concussion. 
Parker TM 1 
, Osternig LR, VAN Donkelaar P, Chou LS. 
Author information 
Abstract 
INTRODUCTION: 
PURPOSE: 
METHODS: 
RESULTS: 
CONCLUSION: 
The need to identify functional impairment following a brain injury is critical to 
prevent reinjury during the period of recovery. However, little is known about the effect of concussion 
on dynamic motor function. 
The purpose of this study was to examine the effect of concussion on a dynamic motor 
task under conditions of divided and undivided attention over the course of 28 d. 
Fifteen subjects with concussions (CONC) and 15 uninjured controls (NORM) were 
observed while walking with undivided attention and while concurrently completing simple mental 
tasks. The CONC were assessed within 48 h of injury and again at 5, 14, and 28 d postinjury. The 
NORM were evaluated at the same time intervals. Whole-body motion data were collected to 
examine displacement and velocity of the center of mass (COM) and the maximum separation 
between the COM and center of pressure (COP). Three-way repeated-measures mixed-design 
ANOVA and Tukey post hoc tests were completed to determine differences between group, task, and 
testing day (P<0.05). 
Several aspects of gait stability were compromised in the CONC group for up to 4 wk after 
injury. CONC were found to walk significantly slower during dual tasks on all testing days when 
compared with the uninjured controls. The injured subjects were also found to have greater sway and 
sway velocity than controls when attention was divided for up to 28 d postinjury. 
The findings of this study suggest that concussion may have long-term observable 
and measurable effects on the control of gait stability. 
PMID: 16775541 [PubMed - indexed for MEDLINE] 
Publication Types, MeSH Terms 
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See 1 citation in 2008 by Broglio SP and Puetz TW: 
Sports Med. 2008;38(1):53-67. 
The effect of sport concussion on neurocognitive function, self-report 
symptoms and postural control : a meta-analysis. 
Broglio SP 1 
, Puetz TW. 
Author information 
Abstract 
Sport concussion is commonly assessed using a battery of tests that evaluate neurocognitive 
functioning, postural control and self-report symptoms. The degree to which concussion affects each 
of these measures is unclear. Thus, the purpose of this meta-analysis is to systematically review and 
quantify the effect of sport concussion on each assessment measure when administered immediately 
post-injury and in the 2 weeks following injury. PubMed and PsychINFO databases were searched 
from January 1970 to June 2006, from which 39 were included for review. Studies were selected for 
review if they included concussed athletes who were evaluated using one of the three assessment 
measures. One post-morbid assessment must have been completed within 14 days of injury and 
compared with a baseline measure or control group. Study design, type of neurocognitive 
assessment, timing of assessment following injury and number of post-concussion assessments were 
extracted as potential moderators. Sport-related concussion had a large negative effect (mean Delta; 
95% confidence interval) on neurocognitive functioning (-0.81; -1.01, -0.60), self-report symptoms 
(-3.31; -6.35, -0.27) and postural control (-2.56; -6.44, 1.32) in the initial assessment following injury. 
A reduced, but large effect, was also seen in the 14 days following the initial assessment for 
neurocognitive functioning (-0.26; -0.46, -0.06), self-report symptoms (-1.09; -2.07, -0.11) and 
postural control (-1.16; -2.59, 0.27). Our findings demonstrated large effects for each aspect of the 
assessment battery. These findings support the use of the multifaceted concussion evaluation. 
Comment in 
The value of various assessment techniques in detecting the effects of concussion on cognition, 
symptoms, and postural control. [J Athl Train. 2009] 
PMID: 18081367 [PubMed - indexed for MEDLINE] 
Full text links 
PubMed Broglio, S. P., & Puetz, T. W. (2008) 
3. 
4.
Where in the Hierarchy of Evidence? 
1. Rábago, C. A., & Wilken, J. M. (2011). 
Display Settings: Abstract 
http://www.ncbi.nlm.nih.gov/pubmed/?term=22027473 
See 1 citation in 2011 by Rabago CA and Wilken JM: 
J Neurol Phys Ther. 2011 Dec;35(4):185-93. doi: 10.1097/NPT.0b013e318235d7e6. 
Application of a mild traumatic brain injury rehabilitation program in a virtual 
realty environment: a case study. 
Rábago CA , Wilken JM. 
Abstract 
BACKGROUND AND PURPOSE: 
A. Meta analysis 
B. Review 
C. Scientific Study 
D. Case studies 
CASE DESCRIPTION: 
INTERVENTIONS: 
Mild traumatic brain injury (mTBI) can compromise reaction time, 
visual perception, memory, attention, balance, and gait. These deficits, especially if persistent, can 
restrict participation in daily activities and the resumption of personal and profession roles. The 
purpose of this case study is to describe an mTBI-specific clinical assessment and rehabilitation 
intervention administered in a virtual reality environment. 
The case involved a 31-year-old male service member who had sustained an 
mTBI (concussion) during a recreational softball game 36 days prior to physical therapist evaluation. 
He had complaints of severe visual and physical motion intolerance. He demonstrated impaired static 
balance and was restricted from full military duty. 
The assessment included measurements of postural and gait balance during 
1 
Author information 
Full text links 
PubMed Rábago, C. A., & Wilken, J. M. (2011)
Where in the Hierarchy of Evidence? 
2. Parker, T. M., Osternig, L. R., Van Donkelaar, 
PubMed P., & Chou, L.-S. (2006) 
http://www.ncbi.nlm.nih.gov/pubmed/?term=16775541 
Parker, T. M., Osternig, L. R., Van Donkelaar, P., & Chou, L.-S. (2006) 
Display Settings: Abstract 
Full while walking with undivided attention and while concurrently completing simple tasks. The CONC were assessed within 48 h of injury and again at 5, 14, and 28 d postinjury. NORM were evaluated at the same time intervals. Whole-body motion data were collected See 1 citation in 2006 by Chou LS and Osternig LR and Parker TM and Van Donkelaar Med Sci Sports Exerc. 2006 Jun;38(6):1032-40. 
Gait stability following concussion. 
Parker TM 1 
, Osternig LR, VAN Donkelaar P, Chou LS. 
Author information 
Abstract 
INTRODUCTION: 
The need to identify functional impairment following a brain injury is critical prevent reinjury during the period of recovery. However, little is known about the effect of on dynamic motor function. 
A. Meta analysis 
B. Review 
C. Scientific Study 
D. Case studies 
PURPOSE: 
The purpose of this study was to examine the effect of concussion on a dynamic task under conditions of divided and undivided attention over the course of 28 d. 
METHODS: 
Fifteen subjects with concussions (CONC) and 15 uninjured controls (NORM) observed
Where in the Hierarchy of Evidence? 
3. Broglio, S. P., & Puetz, T. W. (2008). 
http://www.ncbi.nlm.nih.gov/pubmed/?term=18081367 
Display Settings: Abstract 
See 1 citation in 2008 by Broglio SP and Puetz TW: 
Sports Med. 2008;38(1):53-67. 
The effect of sport concussion on neurocognitive function, self-report 
symptoms and postural control : a meta-analysis. 
Broglio SP , Puetz TW. 
Abstract 
Sport concussion A. is commonly Meta assessed analysis 
using a battery of tests that evaluate neurocognitive 
functioning, postural control and self-report symptoms. The degree to which concussion affects each 
of these measures B. is unclear. Review 
Thus, the purpose of this meta-analysis is to systematically review and 
quantify the effect of sport concussion on each assessment measure when administered immediately 
post-injury and C. in the 2 Scientific weeks following injury. Study 
PubMed and PsychINFO databases were searched 
from January 1970 to June 2006, from which 39 were included for review. Studies were selected for 
review if they included D. concussed Case athletes studies 
who were evaluated using one of the three assessment 
measures. One post-morbid assessment must have been completed within 14 days of injury and 
compared with a baseline measure or control group. Study design, type of neurocognitive 
1 
Author information 
Full text links 
PubMed Broglio, S. P., & Puetz, T. W. (2008)
Where in the Hierarchy of Evidence? 
4. Leddy, J. J., Sandhu, H., Sodhi, V., 
Baker, J. G., & Willer, B. (2012). 
http://www.ncbi.nlm.nih.gov/pubmed/?term=23016082 
A. Meta analysis 
B. Review 
C. Scientific Study 
D. Case studies
Suggested reading - hierarchy of evidence 
Greenhalgh, T. (1997). How to read a paper. Getting 
your bearings (deciding what the paper is about). 
BMJ (Clinical research ed.), 315(7102), 243–6. 
Retrieved from 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC212 
7173/pdf/9253275.pdf 
Understanding and using the Hierarchy of Evidence 
https://hive.library.uwa.edu.au/hive/cache/202902 
/hive.cgi/zip/202902/LO2ACQ_FBE/html/understan 
d.html

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Helmet study shows risk of brain injury reduced with proper protection

  • 1. Wikipedia project What’s the story? What do you need to know?
  • 2. This photo shows the damage done to bicyclist Laurie Nommsen-Rivers' helmet after a pick-up truck hit her on MLK Blvd. on August 29, 2014. (Photo: Provided by Laurie A. Nommsen-Rivers)
  • 3. Thankfully, a helmet is much more than a "piece of Styrofoam." As a recent scientific study reports, the risk of severe brain injury after head impact at 12 mph (realistic in downtown traffic) is 99.9 percent without a helmet, but declines to 9.3 percent with a helmet. My experience corroborates these results. After being struck by the truck and swept under it, I will never forget the split second when I saw the truck axle coming straight at my head and thinking my life was over.
  • 4.
  • 5. Learning objectives • Distinguish and recall steps of the peer review process. (finish from Monday) • Recognize that science in the news comes from science research. • Identify the differences between a case study, a scientific study, a review or a meta-analysis for a scholarly article. • Review creating a hypothesis to research.
  • 7. WHAT IS A PEER REVIEWED ARTICLE? http://vimeo.com/27119325
  • 8. Peer Review Process Manuscript (potential article) Sent to journal editor Sent to three to five experts in the field Blind review Blind review Blind review Manuscript (potential article) 1. Accept 2. Revise 3. Reject
  • 9. Anatomy of a Journal Article
  • 10. You found the perfect criteria for showing that a student-athlete was fully recovered from a concussion, how would you let the world know?
  • 11. Practice telling the story: ulcers Send someone from your group for a stack of ① Citations ② Articles
  • 12. ①Match the citations to the article ②Fix the citations ③Put them in chronological order ④What’s the story these citations tell?
  • 13. Legislation about concussions 4 1 Event happens 3 2 Arrange on the cycle A. Newspapers/magazi nes B. Books/movies C. Legislation D. Blogs/twitter/FB/tv/r adio E. Journal articles
  • 14. Legislation about concussions 4 1 Blogs/twitter/ FB/TV/radio Books/m ovies Event happens Newspapers/m agazines Journal articles based on research 3 2
  • 15. 4 1 Research 3 2 Arrange in order A. news –( twitter,TV, blogs, newspapers) B. chapter/book/te xtbook C. journal article D. peer-review process E. Poster/conferen ce talk
  • 16. 4 1 Peer review process Poster/conf erence talk Research Journal article Chapter/ book/textb ook News (twitter, blogs, TV, newspaper) 3 2
  • 18.
  • 19. Fix and Tell What’s the story?
  • 20. Astrophysicist Brian Schmidt - 2011 Nobel Physics Prize for co-discovering dark energy “When I won this, my grandma, who lives in Fargo, North Dakota, wanted to see it…[I]t was uneventful, until I tried to leave ... It was in my laptop bag. It’s made of gold, so it absorbs all the X-rays—it’s completely black. And they had never seen anything completely black. “They’re like, ‘Sir, there’s something in your bag.’ I said, ‘Yes, I think it’s this box.’ They said, ‘What’s in the box?’ I said, ‘a large gold medal,’ as one does. So they opened it up and they said, ‘What’s it made out of?’ I said, ‘gold.’ And they’re like, ‘Uhhhh. Who gave this to you?’ ‘The King of Sweden.’ ‘Why did he give this to you?’ ‘Because I helped discover the expansion rate of the universe was accelerating.’ At which point, they were beginning to lose their sense of humor. I explained to them it was a Nobel Prize, and their main question was, ‘Why were you in Fargo?’
  • 21. Wikipedia project What are we going to do next to tell the story?
  • 22.
  • 23.
  • 24. Your ideas included: A. Fix the citations (find better sources, fix dead links, etc.) B. Fix the citations and check for accuracy (see if the articles say what the wiki entry says they should say, are there better sources to use for those sections/improve the citations, etc.) C. Improve the citations used and revise the existing information in the article. D. Expand the article (sports concussions, gender differences, treatment options, brain activity, severity, causes, etc.) E. Do research on a concussion related topic of your own.
  • 25. Vote: A. Fix the citations and check for accuracy (see if the articles say what the wiki entry says they should say, are there better sources to use for those sections/improve the citations, etc.) B. Expand the article (sports concussions, gender differences, treatment options, brain activity, severity, causes, etc.) C. Wikipedia To-Do List D. Wikipedia images list E. Other
  • 26. Using the spreadsheets you created Find the 5 most cited articles in the wikipedia article on concussions circle your answers on the spreadsheets
  • 28. Your results so far: Concussion Reference number Cited by (GS) Part of the title 7 1015 "Consensus statement on concussion in sport: the 3rd International Conference on Concussion in Sport held in Zurich, November 2008.” Journal of athletic training. 77 796 Alexander MP (1995). "Mild traumatic brain injury: Pathophysiology, natural history, and clinical management". Neurology 45 (7): 1253–60. 34 679 (April 2005). "Summary and agreement statement of the 2nd International Conference on Concussion in Sport, Prague 2004". Br J Sports Med 39 (4): 196–204 19 670 (2002). "Summary and agreement statement of the first International Conference on Concussion in Sport, Vienna 2001*". British Journal of Sports Medicine 36 (1): 6–10.
  • 29. Your results so far: Concussion Referenc e number Times Cited (WoS) Part of the title 90 616 Langlois JA, Rutland-Brown W, Wald MM (2006). "The epidemiology and impact of traumatic brain injury: A brief overview". J of Head Trauma Rehabilitation 21 (5): 375–8. 77 429 Alexander MP (1995). "Mild traumatic brain injury: Pathophysiology, natural history, and clinical management". Neurology 45 (7): 1253–60. 34 316 (April 2005). "Summary and agreement statement of the 2nd International Conference on Concussion in Sport, Prague 2004". Br J Sports Med 39 (4): 196–204 31 202 Iverson GL (2005). "Outcome from mild traumatic brain injury". Current Opinion in Psychiatry 18 (3): 301–17. doi:10.1097/01.yco.0000165601.29047.ae. PMID 16639155. 19 162 (2002). "Summary and agreement statement of the first International Conference on Concussion in Sport, Vienna 2001*". British Journal of Sports Medicine 36 (1): 6–10.
  • 31. Explain the steps of the google form • Look up the article. • Look it up in WoS and GS • Citation count
  • 33. Hierarchy of Evidence or levels of evidence  Meta-analyses  Review  Scientific studies (e.g., cross-sectional vs longitudinal, randomised controlled trials)  Case reports
  • 34. Hierarchy of Evidence – Meta-analyses Reviews Scientific studies Case studies
  • 35. Concussions – wiki references How many are….. Meta-analyses = 12 Reviews = 28 Scientific studies = 52 Case studies = 11
  • 36. Display Settings: Abstract Neuroimage. 2009 Aug;47 Suppl 2:T152-3. doi: 10.1016/j.neuroimage.2009.01.060. Epub 2009 Feb 10. Case report of a soldier with primary blast brain injury. Warden DL 1 , French LM, Shupenko L, Fargus J, Riedy G, Erickson ME, Jaffee MS, Moore DF. Author information Abstract Primary blast injury of the central nervous system is described in a service-member exposed to a large ordinance explosion. Neuroimaging abnormalities are described together with normalization of the fractional anisotrophy on diffusion tensor imaging after follow-up imaging studies. PubMed Commons home PMID: 19457364 [PubMed - indexed for MEDLINE] Publication Types, MeSH Terms LinkOut - more resources PubMed Commons 0 comments Full text links PubMed 19457364[uid] Case Reports ….in a service-member exposed to a large ordinance explosion. #13 - Concussion entry
  • 37. Display Settings: Abstract Scientific Study J Cogn Neurosci. 1998 Sep;10(5):640-56. Frontal lobe contributions to theory of mind. Stone VE , Baron-Cohen S, Knight RT. Abstract "Theory of mind," the ability to make inferences about others" mental cognitive capacity that underlies humans" ability to engage in complex in several distinct stages, which can be measured with social reasoning Individuals with Asperger"s syndrome, a mild form of autism, perform tests but show deficits on more developmentally advanced theory of with bilateral damage to orbito-frontal cortex (n = 5) and unilateral damage prefrontal orbito-frontal cortex (n = 5) on a series of theory of mind tasks varying in lesion patients performed similarly to individuals with Asperger"on simpler tests and showing deficits on tasks requiring more subtle social Display Settings: Abstract 1 1 Author information Author information PubMed Commons home How to join PubMed Commons J Cogn Neurosci. 1998 Sep;10(5):640-56. Frontal lobe contributions to theory of mind. Stone VE , Baron-Cohen S, Knight RT. Abstract "Theory of mind," the ability to make inferences about others" mental states, seems to be a modular cognitive capacity that underlies humans" ability to engage in complex social interaction. It develops in several distinct stages, which can be measured with social reasoning tests of increasing difficulty. Individuals with Asperger"s syndrome, a mild form of autism, perform well on simpler theory of mind tests but show deficits on more developmentally advanced theory of mind tests. We tested patients with bilateral damage to orbito-frontal cortex (n = 5) and unilateral damage in left dorsolateral prefrontal cortex (n = 5) on a series of theory of mind tasks varying in difficulty. Bilateral orbito-frontal lesion patients performed similarly to individuals with Asperger"s syndrome, performing well on simpler tests and showing deficits on tasks requiring more subtle social reasoning, such as the ability to recognize a faux pas. In contrast, no specific theory of mind deficits were evident in the unilateral dorsolateral frontal lesion patients. The dorsolateral lesion patients had difficulty only on versions of the tasks that placed demands on working memory. PMID: 9802997 [PubMed - indexed for MEDLINE] Publication Types, MeSH Terms, Grant Support LinkOut - more resources PubMed Commons 0 comments Full text links PubMed "Frontal lobe contributions to theory of mind" 1998 We tested patients with bilateral damage to orbito-frontal cortex (n = 5) and unilateral damage in left dorsolateral prefrontal cortex (n = 5) on a series of theory of mind tasks varying in difficulty. #36 -TBI
  • 38. PubMed howell 2013 stroop Scientific study Display Settings: Abstract Full text links Arch Phys Med Rehabil. 2013 Aug;94(8):1513-20. doi: 10.1016/j.apmr.2013.04.015. Epub 2013 Apr 30. Dual-PubMed task howell 2013 stroop effect on gait balance control in adolescents with concussion. Display Settings: Abstract Full text links Howell DR , Osternig LR, Chou LS. Arch Phys Med Rehabil. 2013 Aug;94(8):1513-20. doi: 10.1016/j.apmr.2013.04.015. Epub 2013 Apr 30. Dual-task effect on gait balance control in adolescents with concussion. Howell DR 1 , Osternig LR, Chou LS. Author information Author information Abstract OBJECTIVE: To prospectively and longitudinally examine how concussion affects gait balance Abstract 1 control in adolescents during single- and dual-task walking. DESIGN: SETTING: PARTICIPANTS: Cohort, prospective, repeated-measures design. Motion analysis laboratory. OBJECTIVE: Adolescents (N=20) identified as suffering a concussion were matched with healthy control subjects (N=20) and tested 5 times across a 2-month period after injury. INTERVENTIONS: MAIN OUTCOME MEASURES: Not applicable. Gait temporal-distance parameters included average walking speed, DESIGN: SETTING: PARTICIPANTS: step length, and step width; whole body center of mass (COM) parameters included medial/lateral displacement and peak COM medial/lateral and anterior velocities; dual-task cost, which was defined as percent change from single- to dual-task conditions; and Stroop test accuracy. dual-task RESULTS: No between-group differences were observed for step length and step width. The cost for average walking speed for subjects with concussion was greater than control subjects across the 2-month testing period (main effect of group P=.019), as was the dual-task costs for peak anterior COM velocity (main effect of group P=.017) and total COM medial/lateral displacement (main effect of group P=.013). The total COM medial/lateral displacement (group × task interaction P=.006) and peak COM medial/lateral velocity (main effect of group P=.027; main effect of task P=.01) were significantly greater in subjects with concussion compared with control subjects during dual-task walking. Subjects with concussion were significantly less accurate than controls on the Stroop test (main effect of group P=.004). CONCLUSIONS: The findings suggest that concussion affects the ability of adolescents to control INTERVENTIONS: MAIN OUTCOME MEASURES: body posture during gait up to 2 months after injury. Furthermore, dual-task paradigms may provide additional useful information in the clinical assessment and recovery of concussion. Copyright © 2013 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved. KEYWORDS: Attention, Brain concussion, Brain injuries, COM, Gait, Postural balance, Rehabilitation, center of mass RESULTS: …longitudinally examine how concussion affects gait…. To prospectively and longitudinally examine how concussion affects gait balance control in adolescents during single- and dual-task walking. Cohort, prospective, repeated-measures design. Motion analysis laboratory. Adolescents (N=20) identified as suffering a concussion were matched with healthy control subjects (N=20) and tested 5 times across a 2-month period after injury. Adolescents (N=20) identified as suffering a concussion were matched with healthy control subjects (N=20) and tested 5 times across a 2-month period after injury. Not applicable. Gait temporal-distance parameters included average walking speed, step length, and step width; whole body center of mass (COM) parameters included medial/lateral displacement and peak COM medial/lateral and anterior velocities; dual-task cost, which was defined as percent change from single- to dual-task conditions; and Stroop test accuracy. No between-group differences were observed for step length and step width. The dual-task cost for average walking speed for subjects with concussion was greater than control subjects
  • 39. Case Reports • chief complaint • Diagnosis • treatment, and • deviation from the expected Observations , not planned studies
  • 40. Scientific studies includes: randomized controlled trials cross-sectional and/or longitudinal studies In addition to the parts of a scholarly article this article describes how the authors Test a hypothesis
  • 41. A good clinical trial will use these 3 guiding principles • Compare like with like • The bigger the group studied the more reliable the conclusions • Bayes theorem: things that should be true and have good supporting evidence to back them up, are likely to be true For more details see Appendix 1 of: Greenhalgh T. How to Read a Paper: The Basics of Evidence-based Medicine. 3rd ed. BMJ Books; 2006.
  • 42. Meta-analysis PubMed Display Settings: Abstract Full text links Cochrane PubMed Database Syst Rev. 2004 Oct 18;(4):CD004609. Display Settings: Abstract Full text links Hyperbaric oxygen therapy for the adjunctive treatment of traumatic brain Cochrane Database Syst Rev. 2004 Oct 18;(4):CD004609. injury. Hyperbaric oxygen therapy for the adjunctive treatment of traumatic brain injury. Bennett MH 1 , Trytko B, Jonker B. Bennett Author information MH 1 , Trytko B, Jonker B. Update in Cochrane Database Syst Rev. 2012;12:CD004609. Author information Abstract BACKGROUND: SEARCH STRATEGY: DATA COLLECTION AND ANALYSIS: Three reviewers independently evaluated the quality of the relevant trials using the validated Oxford-Scale (Jadad 1996) and extracted the data …. Update in Cochrane OBJECTIVES: Database Syst Rev. 2012;12:CD004609. SEARCH STRATEGY: Abstract SELECTION CRITERIA: BACKGROUND: effect DATA COLLECTION on AND quality ANALYSIS: of life. Hyperbaric oxygen therapy (HBOT) has been suggested to improve oxygen supply to the injured brain and, therefore, to reduce the volume of brain that will ultimately perish. It MAIN RESULTS: postulated that the addition of HBOT to the standard intensive care regimen may result in a reduction in patient death and disability as a result of these additional brain-preserving effects. Traumatic brain injury is common and presents a health problem with significant effect on quality of life. Hyperbaric oxygen therapy (HBOT) has been suggested to improve oxygen supply to the injured brain and, therefore, to reduce the volume of brain that will ultimately perish. It is postulated that the addition of HBOT to the standard intensive care regimen may result in a reduction in patient death and disability as a result of these additional brain-preserving effects. To assess the benefits and harms of adjunctive HBOT for treating traumatic brain injury. We searched CENTRAL (The Cochrane Library Issue 4, 2003), MEDLINE (1966 - 2003), EMBASE (1974 - 2003), CINAHL (1982 - 2003), DORCTHIM (1996 - 2003), and reference lists of articles. Relevant journals were handsearched and researchers in the field were contacted. Randomised studies comparing the effect on traumatic brain injury of Traumatic brain injury is common and presents a health problem with significant therapeutic regimens which include HBOT with those that exclude HBOT (with or without sham therapy). Three reviewers independently evaluated the quality of the relevant trials using the validated Oxford-Scale (Jadad 1996) and extracted the data from the included trials. Four trials contributed to this review (382 patients, 199 receiving HBOT and 183 control). There was a trend towards, but no significant increase in, the chance of a favourable outcome when defined as full recovery, Glasgow outcome score 1 or 2, or return to normal activities of daily living (relative risk [RR] for good outcome with HBOT 1.94, 95% confidence interval [CI] 0.92 to 4.08, P=0.08). Pooled data from the three trials with 327 patients that reported mortality, showed a significant reduction in the risk of dying when HBOT was added to the treatment regimen (RR 0.69, 95% CI 0.54 to 0.88, P=0.003). Heterogeneity between studies was low (I(2) =0%), and sensitivity analysis for the allocation of dropouts did not affect that result. This analysis suggests we would have OBJECTIVES: Pooled data from the three trials with 327 patients that reported mortality, showed a significant reduction in the risk of dying when HBOT was added to the treatment regimen (RR 0.69, 95% CI 0.54 to 0.88, P=0.003). To assess the benefits and harms of adjunctive HBOT for treating traumatic brain injury. SEARCH STRATEGY: We searched CENTRAL (The Cochrane Library Issue 4, 2003), MEDLINE (1966 - 2003), EMBASE (1974 - 2003), CINAHL (1982 - 2003), DORCTHIM (1996 - 2003), and reference lists of articles. Relevant journals were handsearched and researchers in the field were #54 - TBI
  • 43. Meta-analysis • Single focused question or overview of several related questions • + data sources, study selection, data extraction, data synthesis • An analysis of the data.
  • 44. Review Display Settings: Abstract J Clin Exp Neuropsychol. 2001 Dec;23(6):837-51. Prediction of outcome in mild to moderate head injury: a review. van der Naalt J. Display Settings: Abstract Author information J Clin Exp Neuropsychol. 2001 Dec;23(6):837-51. Prediction of outcome in mild to moderate head injury: a review. van der Naalt J. Abstract This paper reviews the functional outcome of patients sustaining mild and moderate head injury (HI). Discrepancies across studies in the definition of minor, mild, and moderate HI are discussed in terms of hindering the interpretation of recovery. The predictive value of acute severity indices, neuroimaging findings, and the results of other techniques are summarized. Measurement of outcome based solely on the Glasgow Outcome Scale (GOS) is critiqued, and it is recommended that a differentiated outcome scale involving emotional, behavioral, cognitive, and physical domains should be used. Author information Abstract This paper reviews the functional outcome of patients sustaining mild and moderate head injury (HI). Discrepancies across studies in the definition of minor, mild, and moderate HI are discussed in terms of hindering the interpretation of recovery. The predictive value of acute severity indices, neuroimaging findings, and the results of other techniques are summarized. Measurement of outcome based solely on the Glasgow Outcome Scale (GOS) is critiqued, and it is recommended that a differentiated outcome scale involving emotional, behavioral, cognitive, and physical domains should be used. PubMed Commons home How to join PubMed Commons PMID: 11910548 [PubMed - indexed for MEDLINE] Publication Types, MeSH Terms LinkOut - more resources PubMed Commons 0 comments Full text links PubMed PubMed Commons home PMID: 11910548 [PubMed - indexed for MEDLINE] Publication Types, MeSH Terms LinkOut - more resources PubMed Commons Full text links PubMed Discrepancies across studies in the definition of minor, mild, and moderate head injuries…. #28 - concussion
  • 45. Systematic Reviews Reviews Went through literature and found all articles on a topic. Similar to what you might do for a really well researched term paper. Bibliographies of these papers are a goldmine.
  • 46. Display Settings: Abstract See 1 citation in 2011 by Rabago CA and Wilken JM: 1. 2. J Neurol Phys Ther. 2011 Dec;35(4):185-93. doi: 10.1097/NPT.0b013e318235d7e6. Application of a mild traumatic brain injury rehabilitation program in a virtual realty environment: a case study. Rábago CA , Wilken JM. Author information Abstract 1 BACKGROUND AND PURPOSE: CASE DESCRIPTION: INTERVENTIONS: OUTCOMES: DISCUSSION: Mild traumatic brain injury (mTBI) can compromise reaction time, visual perception, memory, attention, balance, and gait. These deficits, especially if persistent, can restrict participation in daily activities and the resumption of personal and profession roles. The purpose of this case study is to describe an mTBI-specific clinical assessment and rehabilitation intervention administered in a virtual reality environment. The case involved a 31-year-old male service member who had sustained an mTBI (concussion) during a recreational softball game 36 days prior to physical therapist evaluation. He had complaints of severe visual and physical motion intolerance. He demonstrated impaired static balance and was restricted from full military duty. The assessment included measurements of postural and gait balance during cognitive, visual, and vestibular challenges within a Computer-Assisted Rehabilitation Environment. Phase 1 of the intervention consisted of clinical techniques (ie, optokinetic stimulation/habituation, visual/physical perturbations, and postural stability exercises) targeting specific impairments. Phase 2 training consisted of weapon handling and target recognition tasks to simulate the requirements of his military occupation. At the conclusion of 6 treatments, the patient demonstrated significant increases in postural and gait balance with a near complete resolution of all postconcussion symptoms. He successfully returned to full duty and training for combat deployment. Service members and civilians exhibit similar impairments, limitations, and restrictions following mTBI. A rehabilitation program delivered in a virtual-reality environment can be structured to manage Display complex Settings: mTBI symptoms Abstract through the integration of multiple treatment modalities specific to a patient's personal and professional roles. PMID: 22027473 [PubMed - indexed for MEDLINE] Publication Types, MeSH Terms Full text links See 1 citation in 2006 by Chou LS and Osternig LR and Parker TM and Van Donkelaar P: Med Sci Sports Exerc. 2006 Jun;38(6):1032-40. Gait stability following concussion. Parker TM 1 , Osternig LR, VAN Donkelaar P, Chou LS. Author information Abstract INTRODUCTION: PURPOSE: METHODS: RESULTS: CONCLUSION: The need to identify functional impairment following a brain injury is critical to prevent reinjury during the period of recovery. However, little is known about the effect of concussion on dynamic motor function. The purpose of this study was to examine the effect of concussion on a dynamic motor task under conditions of divided and undivided attention over the course of 28 d. Fifteen subjects with concussions (CONC) and 15 uninjured controls (NORM) were observed while walking with undivided attention and while concurrently completing simple mental tasks. The CONC were assessed within 48 h of injury and again at 5, 14, and 28 d postinjury. The NORM were evaluated at the same time intervals. Whole-body motion data were collected to examine displacement and velocity of the center of mass (COM) and the maximum separation between the COM and center of pressure (COP). Three-way repeated-measures mixed-design ANOVA and Tukey post hoc tests were completed to determine differences between group, task, and testing day (P<0.05). Several aspects of gait stability were compromised in the CONC group for up to 4 wk after injury. CONC were found to walk significantly slower during dual tasks on all testing days when compared with the uninjured controls. The injured subjects were also found to have greater sway and sway velocity than controls when attention was divided for up to 28 d postinjury. The findings of this study suggest that concussion may have long-term observable and measurable effects on the control of gait stability. PMID: 16775541 [PubMed - indexed for MEDLINE] Publication Types, MeSH Terms LinkOut - more resources Full text links See 1 citation in 2008 by Broglio SP and Puetz TW: Sports Med. 2008;38(1):53-67. The effect of sport concussion on neurocognitive function, self-report symptoms and postural control : a meta-analysis. Broglio SP 1 , Puetz TW. Author information Abstract Sport concussion is commonly assessed using a battery of tests that evaluate neurocognitive functioning, postural control and self-report symptoms. The degree to which concussion affects each of these measures is unclear. Thus, the purpose of this meta-analysis is to systematically review and quantify the effect of sport concussion on each assessment measure when administered immediately post-injury and in the 2 weeks following injury. PubMed and PsychINFO databases were searched from January 1970 to June 2006, from which 39 were included for review. Studies were selected for review if they included concussed athletes who were evaluated using one of the three assessment measures. One post-morbid assessment must have been completed within 14 days of injury and compared with a baseline measure or control group. Study design, type of neurocognitive assessment, timing of assessment following injury and number of post-concussion assessments were extracted as potential moderators. Sport-related concussion had a large negative effect (mean Delta; 95% confidence interval) on neurocognitive functioning (-0.81; -1.01, -0.60), self-report symptoms (-3.31; -6.35, -0.27) and postural control (-2.56; -6.44, 1.32) in the initial assessment following injury. A reduced, but large effect, was also seen in the 14 days following the initial assessment for neurocognitive functioning (-0.26; -0.46, -0.06), self-report symptoms (-1.09; -2.07, -0.11) and postural control (-1.16; -2.59, 0.27). Our findings demonstrated large effects for each aspect of the assessment battery. These findings support the use of the multifaceted concussion evaluation. Comment in The value of various assessment techniques in detecting the effects of concussion on cognition, symptoms, and postural control. [J Athl Train. 2009] PMID: 18081367 [PubMed - indexed for MEDLINE] Full text links PubMed Broglio, S. P., & Puetz, T. W. (2008) 3. 4.
  • 47. Where in the Hierarchy of Evidence? 1. Rábago, C. A., & Wilken, J. M. (2011). Display Settings: Abstract http://www.ncbi.nlm.nih.gov/pubmed/?term=22027473 See 1 citation in 2011 by Rabago CA and Wilken JM: J Neurol Phys Ther. 2011 Dec;35(4):185-93. doi: 10.1097/NPT.0b013e318235d7e6. Application of a mild traumatic brain injury rehabilitation program in a virtual realty environment: a case study. Rábago CA , Wilken JM. Abstract BACKGROUND AND PURPOSE: A. Meta analysis B. Review C. Scientific Study D. Case studies CASE DESCRIPTION: INTERVENTIONS: Mild traumatic brain injury (mTBI) can compromise reaction time, visual perception, memory, attention, balance, and gait. These deficits, especially if persistent, can restrict participation in daily activities and the resumption of personal and profession roles. The purpose of this case study is to describe an mTBI-specific clinical assessment and rehabilitation intervention administered in a virtual reality environment. The case involved a 31-year-old male service member who had sustained an mTBI (concussion) during a recreational softball game 36 days prior to physical therapist evaluation. He had complaints of severe visual and physical motion intolerance. He demonstrated impaired static balance and was restricted from full military duty. The assessment included measurements of postural and gait balance during 1 Author information Full text links PubMed Rábago, C. A., & Wilken, J. M. (2011)
  • 48. Where in the Hierarchy of Evidence? 2. Parker, T. M., Osternig, L. R., Van Donkelaar, PubMed P., & Chou, L.-S. (2006) http://www.ncbi.nlm.nih.gov/pubmed/?term=16775541 Parker, T. M., Osternig, L. R., Van Donkelaar, P., & Chou, L.-S. (2006) Display Settings: Abstract Full while walking with undivided attention and while concurrently completing simple tasks. The CONC were assessed within 48 h of injury and again at 5, 14, and 28 d postinjury. NORM were evaluated at the same time intervals. Whole-body motion data were collected See 1 citation in 2006 by Chou LS and Osternig LR and Parker TM and Van Donkelaar Med Sci Sports Exerc. 2006 Jun;38(6):1032-40. Gait stability following concussion. Parker TM 1 , Osternig LR, VAN Donkelaar P, Chou LS. Author information Abstract INTRODUCTION: The need to identify functional impairment following a brain injury is critical prevent reinjury during the period of recovery. However, little is known about the effect of on dynamic motor function. A. Meta analysis B. Review C. Scientific Study D. Case studies PURPOSE: The purpose of this study was to examine the effect of concussion on a dynamic task under conditions of divided and undivided attention over the course of 28 d. METHODS: Fifteen subjects with concussions (CONC) and 15 uninjured controls (NORM) observed
  • 49. Where in the Hierarchy of Evidence? 3. Broglio, S. P., & Puetz, T. W. (2008). http://www.ncbi.nlm.nih.gov/pubmed/?term=18081367 Display Settings: Abstract See 1 citation in 2008 by Broglio SP and Puetz TW: Sports Med. 2008;38(1):53-67. The effect of sport concussion on neurocognitive function, self-report symptoms and postural control : a meta-analysis. Broglio SP , Puetz TW. Abstract Sport concussion A. is commonly Meta assessed analysis using a battery of tests that evaluate neurocognitive functioning, postural control and self-report symptoms. The degree to which concussion affects each of these measures B. is unclear. Review Thus, the purpose of this meta-analysis is to systematically review and quantify the effect of sport concussion on each assessment measure when administered immediately post-injury and C. in the 2 Scientific weeks following injury. Study PubMed and PsychINFO databases were searched from January 1970 to June 2006, from which 39 were included for review. Studies were selected for review if they included D. concussed Case athletes studies who were evaluated using one of the three assessment measures. One post-morbid assessment must have been completed within 14 days of injury and compared with a baseline measure or control group. Study design, type of neurocognitive 1 Author information Full text links PubMed Broglio, S. P., & Puetz, T. W. (2008)
  • 50. Where in the Hierarchy of Evidence? 4. Leddy, J. J., Sandhu, H., Sodhi, V., Baker, J. G., & Willer, B. (2012). http://www.ncbi.nlm.nih.gov/pubmed/?term=23016082 A. Meta analysis B. Review C. Scientific Study D. Case studies
  • 51. Suggested reading - hierarchy of evidence Greenhalgh, T. (1997). How to read a paper. Getting your bearings (deciding what the paper is about). BMJ (Clinical research ed.), 315(7102), 243–6. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC212 7173/pdf/9253275.pdf Understanding and using the Hierarchy of Evidence https://hive.library.uwa.edu.au/hive/cache/202902 /hive.cgi/zip/202902/LO2ACQ_FBE/html/understan d.html

Editor's Notes

  1. http://www.cincinnati.com/story/opinion/readers/2014/10/11/if-not-for-my-helmet-i-could-be-dead/16959685/
  2. http://www.cincinnati.com/story/opinion/readers/2014/10/11/if-not-for-my-helmet-i-could-be-dead/16959685/ Uses scientific study to convince us Then uses personal experience to drive it home
  3. Identify the differences between a case study, a scientific study, a review or a meta-analysis for a scholarly article. Identify an appropriate search to find more information on the topic. Use FindText to get a full-text journal article. Utilize Interlibrary loan to get an article not held at the UO.
  4. Karduna bring in notes from a peer-reviewed article to show students
  5. Graphic from Dominque Turnbow, UCSD former Biomedical librarian, currently in charge of Instructional Design Can get accepted with revisions, rejected and resubmit, accepted resubmit
  6. List part of a journal article – use Howell article on the document camera if possible!
  7. Have students respond verbally Likely without discussing it, you wouldn’t have started with the peer review process, right? You’ve talked about the research process in terms of the scientific method and later you’ll talk about the data analysis that informs scientific studies. This morning I want you to understand what happens to science from the research to publication process and then what happens next. These are important parts of how we know what we know and how scientific information is communicated.
  8. Let’s practice on a story that you know well and you’ve seen from beginning to end.
  9. Need representatives from 6 groups - prizes
  10. From newspaper article read in quiz Take out the article – What’s the first event? What happens next? Ask students WHAT HAPPENS NEXT? Write it down – discuss answers in class – vote on which one is 1, 2, 3, $ Blogs/twitter/FB/tv/radio Newspapers/magazines Journal articles Books/movies
  11. What I want them to get to (more or less) – 10 min From newspaper article read in quiz Take out the article – What’s the first event? What happens next? Ask students WHAT HAPPENS NEXT? Write it down – vote in class D. Blogs/twitter/FB/tv/radio A. Newspapers/magazines E. Journal articles B. Books/movies C. Legislation Newspapers/magazines Books/movies Legislation Blogs/twitter/FB/tv/radio Journal articles
  12. Research – using a combination of what you’ve heard in class and the article you read – where happens to research after you do it? WHAT HAPPENS NEXT? Ask students to write down what happens next – vote with clickers– 10 min 1. E. Poster/conference talk 2. D. peer-review process 3. C.journal article 4. A.news – TV, blogs, newspapers 5. B. chapter/book/textbook news –( twitter,TV, blogs, newspapers) chapter/book/textbook journal article peer-review process Poster/conference talk
  13. What I hope they come up with (more or less) Research 1. Poster/conference talk 2. peer-review process 3. journal article 4. news – TV, blogs, newspapers 5. chapter/book/textbook 1. E. Poster/conference talk 2. D. peer-review process 3. C.journal article 4. A.news – TV, blogs, newspapers 5. B. chapter/book/textbook
  14. AND, OR Glasses OR hats Glasses AND hats Hats OR hoodies AND Oregon (Seniors OR students who have had a lot of library instruction already) AND your group fixed the citations – NEED 9 of you!
  15. Fix the citations 9 folks be the articles You all be the director – put them in order Agree? What about the citations?
  16. http://blogs.scientificamerican.com/observations/2014/10/10/nobel-prize-airport-security/?WT.mc_id=SA_sharetool_Twitter
  17. Do you want to do any of these? Add to the to-do list?
  18. This one?
  19. These were terrific. Insightful, thoughtful, We’ll go through all of the different things I asked you to do from the form on Wednesday.
  20. These were terrific. Insightful, thoughtful, We’ll go through all of the different things I asked you to do from the form on Wednesday.
  21. GS
  22. wos
  23. Are all of the data the same? Need to fix any of that? Citation counts differ widely! Availability Usefulness Where in the hierarchy of evidence
  24. What can you do? You can click on those links to look up those references! Keep going backwards in time to look up more and more footnotes. How do you get more recent articles? Also consider another element – hierarchy of evidence.
  25. More specifically this order – there’s more - from Greenhalgh, T. “How to Read a Paper. Getting Your Bearings (deciding What the Paper Is About).” BMJ : British Medical Journal 315, no. 7102 (July 26, 1997): 243–246.
  26. https://hive.library.uwa.edu.au/hive/cache/202902/hive.cgi/zip/202902/LO2ACQ_FBE/html/understand.html I am not satisfied with this representation Food pyramid – bottom = most and most important – but are case studies most important? More of them? Let’s take a look – how many of you had a case report as your citation for either concussion or TBI? #13 and others.
  27. DATA from Winter 2014 https://hive.library.uwa.edu.au/hive/cache/202902/hive.cgi/zip/202902/LO2ACQ_FBE/html/understand.html I am not satisfied with this representation Food pyramid – bottom = most and most important – but are case studies most important? More of them? Let’s take a look – how many of you had a case report as your citation for either concussion or TBI? #13 and others.
  28. Concussion: #13 Warden, Deborah L.; French, Louis M.; Shupenko, Leslie; Fargus, Jamie; Riedy, Gerard; Erickson, Marleigh E.; Jaffee, Michael S.; Moore, David F. (2009). "Case report of a soldier with primary blast brain injury". NeuroImage 47: T152–3. doi:10.1016/j.neuroimage.2009.01.060. PMID 19457364. Cited 44/23 TBI: #1 Rehman T, Ali R, Tawil I, Yonas H (2008). "Rapid progression of traumatic bifrontal contusions to transtentorial herniation: A case report". Cases journal 1 (1): 203. doi:10.1186/1757-1626-1-203. PMC 2566562. PMID 18831756. #159 Hardy P, Johnston KM, De Beaumont L, Montgomery DL, Lecomte JM, Soucy JP, Bourbonnais D, Lassonde M (February 2007). "Pilot case study of the therapeutic potential of hyperbaric oxygen therapy on chronic brain injury". Journal of the Neurological Sciences 253 (1–2): 94–105. doi:10.1016/j.jns.2006.12.005. PMID 17234213.
  29. TBI #36 Stone, V.E.; Baron-Cohen, S., & Knight, R.T. (1998). "Frontal lobe contributions to theory of mind". Journal of Cognitive Neuroscience 10 (5): 640–656. doi:10.1162/089892998562942. PMID 9802997.
  30. One they have more experience with.
  31. Bottom of hierarchy of EBM – why do it? Rarity, particular outcome, novel treatment, rare presentation of common disease, mistakes and lessons, new disease? personal data (age, sex, race, marital status, and occupation when relevant-but not name), chief complaint, history of present complaint (including symptoms), results of physical examination medical history (surgery, laboratory results, exam, etc.), diagnosis, treatment, and deviation from the expected (what makes this case unique). Release form signed by the individual being discussed in the case study.
  32. From: Kolata G. Searching for Clarity: A Primer on Medical Studies. The New York Times. 2008. Available at: http://www.nytimes.com/2008/09/30/health/30stud.html [Accessed October 7, 2008]. For more details see the Appendix 1 handout.
  33. TBI #54 Bennett MH, Trytko B, Jonker B (2004). "Hyperbaric oxygen therapy for the adjunctive treatment of traumatic brain injury". In Bennett, Michael H. Cochrane Database of Systematic Reviews (4): CD004609. doi:10.1002/14651858.CD004609.pub2. PMID 15495120.
  34. Body notes from Htwap, p. 78 and chap 8. htrap Answer to a single focused question Overview of several related questions Topic review of – i.e. diagnostic process for a specific condition
  35. 133 Cited References
  36. Rábago, C. A., & Wilken, J. M. (2011). Application of a mild traumatic brain injury rehabilitation program in a virtual realty environment: a case study. Journal of neurologic physical therapy: JNPT, 35(4), 185–193. doi:10.1097/NPT.0b013e318235d7e6 CASE STUDY  
  37. Parker, T. M., Osternig, L. R., VAN Donkelaar, P., & Chou, L.-S. (2006). Gait stability following concussion. Medicine and science in sports and exercise, 38(6), 1032–1040. doi:10.1249/01.mss.0000222828.56982.a4 RCT or Scientific STUDY  
  38. Broglio, S. P., & Puetz, T. W. (2008). The effect of sport concussion on neurocognitive function, self-report symptoms and postural control : a meta-analysis. Sports medicine (Auckland, N.Z.), 38(1), 53–67. META
  39. Emery, Carolyn A. “Injury Prevention and Future Research.” Medicine and Sport Science 49 (2005): 170–191. doi:10.1159/000085396. http://www.ncbi.nlm.nih.gov/pubmed/?term=16247266  REVIEW