Medical data and text mining - Linking diseases, drugs, and adverse reactions
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Medical data and text mining - Linking diseases, drugs, and adverse reactions
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Medical data and text mining - Linking diseases, drugs, and adverse reactions
- 1. Medical data and text mining Linking diseases, drugs, and adverse reactions Lars Juhl Jensen
- 2. me
- 9. Szklarczyk et al., Nucleic Acids Research, 2015string-db.org
- 10. text mining
- 11. >30,000 ft
- 14. cofounder
- 16. medical data
- 17. Jensen et al., Nature Reviews Genetics, 2012
- 18. structured data
- 19. Jensen et al., Nature Reviews Genetics, 2012
- 23. opt-out
- 24. opt-in
- 25. (Danes say no)
- 30. Jensen et al., Nature Reviews Genetics, 2012
- 32. 14 years
- 37. ICD-10
- 38. Jensen et al., Nature Reviews Genetics, 2012
- 39. not research
- 40. reimbursement
- 41. naïve analysis
- 42. comorbidity
- 44. Jensen et al., Nature Reviews Genetics, 2012
- 46. “known knowns”
- 47. gender
- 48. age
- 49. type of hospital encounter
- 50. Jensen et al., Nature Communications, 2014
- 51. “known unknowns”
- 52. smoking
- 53. diet
- 55. reporting biases
- 56. matched controls
- 57. proxy diagnoses
- 60. Jensen et al., Nature Communications, 2014
- 62. Jensen et al., Nature Communications, 2014
- 63. key diagnoses
- 64. Jensen et al., Nature Communications, 2014
- 67. clinical trials
- 70. underreporting
- 71. data mining
- 72. structured data
- 73. Jensen et al., Nature Reviews Genetics, 2012
- 76. free text
- 77. Danish
- 78. busy doctors
- 79. typos
- 81. text mining
- 82. computer
- 83. as smart as a dog
- 84. teach it specific tricks
- 88. diseases
- 89. drugs
- 91. expansion rules
- 92. Clozapine
- 94. “black list”
- 97. statistics
- 99. drugs
- 100. adverse drug events
- 101. Eriksson et al., Drug Safety, 2014 Drug introduction Drug discontinuationAdverse event Adverse eventNegative modifier Indication Pre-existing condition Adverse drug reaction Possible adverse drug reaction ADR of additional drug
- 102. Eriksson et al., Drug Safety, 2014 Drug introduction Drug discontinuationAdverse eventIdentification start Adverse eventNegative modifier Indication Pre-existing condition Adverse drug reaction Possible adverse drug reaction ADR of additional drug
- 103. Eriksson et al., Drug Safety, 2014 Drug introduction Drug discontinuation Adverse eventNegative modifier Indication Pre-existing condition Adverse drug reaction Possible adverse drug reaction Adverse event ADR of additional drug Identification start
- 104. Eriksson et al., Drug Safety, 2014 Drug introduction Drug discontinuation Adverse eventNegative modifier Indication Pre-existing condition Adverse drug reaction Possible adverse drug reaction Adverse event ADR of additional drug Identification start
- 105. recall known ADRs
- 106. discover new ADRs
- 107. Drug substance ADE p-value Chlordiazepoxide Nystagmus 4.0e-8 Simvastatin Personality changes 8.4e-8 Dipyridamole Visual impairment 4.4e-4 Citalopram Psychosis 8.8e-4 Bendroflumethiazi de Apoplexy 8.5e-3 Eriksson et al., Drug Safety, 2014
- 109. Eriksson et al., Drug Safety, 2014
- 110. Acknowledgments Disease trajectories Anders Bøck Jensen Tudor Oprea Pope Moseley Søren Brunak Adverse drug reactions Robert Eriksson Thomas Werge Søren Brunak EHR text mining Peter Bjødstrup Jensen Robert Eriksson Henriette Schmock Francisco S. Roque Anders Juul Marlene Dalgaard Massimo Andreatta Sune Frankild Eva Roitmann Thomas Hansen Karen Søeby Søren Bredkjær Thomas Werge Søren Brunak
- 111. Thank you!