2. MAGRITEK
• Founded in 2004 based in GERMAN & NEW ZEALAND
• First ever NMR to develop that capable of 13C NMR spectroscopy
• Patents for –
few NMR apparatus (NZ 520114, US 7391215, AU2003281119)
US 7358734 single sided NMR sensor with microscopic depth resolution
NMR spectra extraction method
3. Advantages of using SpinSolve NMR
• No deuterated solvents needed
• Large sample volume for high sensitivity
• High spectral resolution
• Excellent time resolution
• High stability with external lock independent of the sample
• Quick setting time
• Sample temperature control from 26 – 60 degrees of Celsius
4. Importance of purchasing NMR to your laboratory
• The most flexible and cost effective way to get carbon-13 NMR in
your laboratory.
5. Spinsolve NMR (43 MHz)
• H frequency : 43 MHz
• H + F on all systems WITH X nucleus for dual channel systems
• Resolution : classic - <0.5Hz(50%) / <20Hz(0.11%)
Ultra - <0.2Hz(50%) / <6Hz(0.55%)/ <12Hz(0.11%)
• Exceptional sensitivity 100:1 (single)/70:1 (double) for 1% ethyl benzene
• Available with pfg gradients
• No cryogens & easy to operate
• Unparalleled stability and best for online reaction monitoring
• No need for deuterated solvents
• Compatible with automatic sample changer
• Available with sample temperature control up to 60 Celsius
7. Addons for spinsōlve 43MHz
1. Spinsolve ultra
2. Multi nuclear options (possibility of measuring up to 3 different nuclei)
3. Reaction monitoring (can be installed directly inside a fume hood to
monitor chemical reactions on line)
4. Auto sampler (increase sample testing throughput)
5. Expert (improved standard software for hassle free testing)
6. Pulsed field gradients (enhancing spectral resolution)
8. 1. Spinsolve Ultra add on
• Ultra high field homogeneity of this model give the highest performance
from solvent suppression methods
• Useful when measuring compounds dissolve even at millimolar
concentrations in protonated solvents where typical in,
online reaction monitoring
synthesis control
fermentation monitoring in bio reacts
contaminant quantitation
• A patent technology (US 8,148,988 and EP 2,144,076)
9. Applications of ULTRA
• Quantification of sugars & alcohol in beverages
• Identification & quantification of metabolites in urine
• Analysis of contaminants in water
• Reaction monitoring the presence of protonated solvents
• qNMR for samples where important signals overlap
• Monitoring fermentation processes in bioreactors
• Capable of multiple peak solvent suppression with carbon decoupling, useful
when measure samples with organic solvents
10. 2. Multi nuclear option
• Able to conduct H, D & 2D experiments with highest performance
• F spectra can be acquired using same channel without any hardware adjustments
• Can be arranged with following
11. 3. Reaction monitoring
• Can be determined reaction kinetics, reaction end points under minimal
calibrations
• Reaction signals has linear response to concentration & not sensitive to matrix
• Non destructive measurements
• Monitor the progress of the reactions on line
• can be installed directly in the fume hood to monitor the progress of chemical
reactions on-line
• 2 solution kits for reaction monitoring
12. 4. Auto Sampler
• Increase sample measurement throughput
• This includes the features of
• 20 slots for 5mm NMR tubes
• Fully controlled via spinsolve software
• Easy configuration for all protocols for sample analysis
• Affordable & robust
• Easy to mount
• Compatible with all NMR categories
13. 5. Spinsolve Expert
• Adjust any acquisition or processing parameters
• Modify and write new pulse sequences
• Create new data processing and control algorithms
• Write scripts to control a series of experiments plus processing
• Modify the display
14. 6. Pulsed Field Gradients
I. Separate the spectra of different components in a mixture by
molecular size (DOSY- type experiments)
II. Measure self diffusion coefficients to understand molecular
mobility (PFG diffusion measurements)
III. Accelerate the acquisition of modern 2D NMR experiments(ultra
– fast 2D NMR)
15. Potential Customers in the Area,
• Ruhuna University – science faculty, department of chemistry
Prof. (Ms) Hema. M. K. K. Pathirana
Prof. (Mrs) Vajira. P. Bulugahapitiya
Dr. Chinthaka Sanath Gangabadage (dept. head)
Editor's Notes
Solution kits
1. one using a glass flow tube with an expanded 4.2 mm ID section in the measurement zone & minimal ID outside
2. cost effective solution using just PTFE tubing and a glass guide tube, as well as the pump
The throughput can be increased by integrating fully automated auto sampler carousel addon
This soft ware is designed to hassle free testing
DOSY experiments – diffusion ordered spectroscopy
This creates 2D plot by acquiring a set of spectra as a function of the amplitude of the gradient.
Chemical shift is in the horizontal axis and self diffusion coefficient shown in vertical axis
using inbuilt DOSY tool box it enable the invert the data into DOSY spectrum as in this figure.