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HIV IN PRENANCY
By
Jasmi Manu
Asst.professor
Rama College of Nursing
HIV and AIDS
 HIV stands for Human Immunodeficiency
Virus
 AIDS stands for Acquired Immune
Deficiency Syndrome, a condition caused by
HIV
 HIV gradually destroys the body’s ability to
fight infections, eventually leading to death
 Incubation period: 2 months-4 years
TYPES OF HIV
HIV I HIV II
PATHOGENESIS
The virus predominantly
affects the thymus
derived lymphocytes(T
lymphocytes)There is
significant immuno-
deficiency (cell
mediated) of the
affected individual.
MODES OF TRANSMISSION
HIV is present in an Infected Person’s: Blood; Semen;
Vaginal secretions & Breast Milk
HIV is transmitted through:
 Unprotected sexual contact with an infected person
 Direct contact with or transfusion of infected blood
 Sharing infected needles e.g. Injecting Drug Users
 From a HIV positive mother to her unborn child, during
birth, through Vertical transmission
 Through infected tissue fluids
 Through breast feeding
For more information please contact: dwivedir@unaids.org,
Mobile: 9810505068
CLINICAL PRESENTATION
 Initial presentation :fever, malaise, headache,
sore throat, lymphadenopathy and
maculopapular rash.
 Primary illness may be followed by
asymptomatic period.
 Multiple opportunistic infections with
Candida, tuberculosis, pneumocystis,
neoplasms such as cervical carcinoma,
lymphomas, Kaposi’s sarcoma.
 Constitutional symptoms like weight loss and
protracted diarrhea.
CLINICAL PRESENTATION
CLINICAL FINDINGS
 CD4 count below 500mm3
 Decreased CD4 / CD8 ratio
 Elevated erythrocyte sedimentation rate
 Elevated serum globulin
 Elevated serum lactate dehydrogenase
 Low serum cholesterol
 Neutropenia
 Thrombocytopenia
 Anemia
 Positive serology for syphilis
HIV and Pregnancy
 HIV may have adverse effect on pregnancy
course or outcome
 More than 90% of pediatric HIV/AIDS cases
are caused by MTCT
 Most children born to HIV-positive mothers
 Women without HIV may place themselves at
risk for infection while trying to get pregnant
 Majority of women with HIV are of
childbearing age
Prevalence of HIV (Type-1)
among Pregnant Women
0% 10% 20% 30% 40% 50%
Nigeria
Uganda
Kenya
South Africa
Malawi
Rwanda
Botswana
Thailand
Cambodia
Brazil
Honduras
Haiti
% Positive
Source: DeCock et al 2000.
Latin
America
Asia
Africa
0
10
20
30
40
50
60
70
Women, 15-19
Women, 20-24
HIV
prevalence
(%)
HIV Prevalence among
Women Age 15–24
Source: UNAIDS June 2000.
Effect of HIV on Fertility
Effect of HIV on Fertility
 Prior STIs or pelvic inflammatory disease
 Direct effects of HIV
 Decreased fertility seen after adjustment for age,
lactation, illness, STIs
 Worsened fertility in women with symptomatic
HIV or co-infected with syphilis
 Pregnancy loss more common with HIV infection
Adverse Pregnancy Outcomes and HIV
Infection
Pregnancy Outcome Relationship to HIV Infection
Spontaneous
abortion
Limited data, but evidence of possible
increased risk
Stillbirth No association noted in developed countries;
evidence of increased risk in developing
countries
Perinatal mortality No association noted in developed countries,
but data limited; evidence of increased risk in
developing countries
Newborn mortality Limited data in developed countries; evidence
of increased risk in developing countries
Intra-uterine growth
retardation
Evidence of possible increased risk
Adverse Pregnancy Outcomes
and Relationship to HIV
Infection
Pregnancy Outcome Relationship to HIV Infection
Low birth weight Evidence of possible increased risk
Preterm delivery Evidence of possible increased risk, especially
more advanced disease
Amnionitis Limited data; more recent studies do not
suggest an increased risk; some earlier studies
found increased histologic placental
inflammation, particularly in those with
preterm deliveries
Oligohydramnios Minimal data
Fetal malformation No evidence of increased risk
HIV Testing during
Pregnancy
 Advantages:
 Possible treatment of mother
 Reduce risk of mother-to-
child transmission
 Future family planning issues
 Precautions against further
spread
 If negative, advise about HIV
prevention
 Counseling is important!
Preconceptual Counseling
Preconceptual Counseling
 Educate patients about perinatal transmission
 To avoid unintended pregnancies
 Counsel patients about safe methods to
conceive
 Choose anti-retrovirals which are known to be
effective in reducing perinatal HIV
transmission
 Attain a stable, maximally suppressed viral
load
 Optimize medical and nutritional status
Voluntary Counseling and
Testing (VCT) in Women of
Childbearing Age
 Information about HIV and pregnancy
 Risk assessment
 Prevention of HIV transmission or
acquisition
 Prevention of unintended pregnancy
 Dual protection with condoms
Goals of VCT in Antenatal
Care
 Educate about HIV
 Reduce stigma
 Prevent new HIV infections in
pregnancy
 Identify women with HIV
 Stabilize and maintain
maternal health
 Prevent HIV transmission to
uninfected sexual or drug
using partners
 Reduce risk of MTCT
 Plan for future
HIV-Related Counseling Issues
During Pregnancy
 Educate/counsel regarding HIV and
pregnancy before pregnancy:
 Impact of HIV on pregnancy and pregnancy
on HIV
 Maternal health
 Long-term health of mother and care for
children
 Perinatal transmission
 Use of antiretrovirals and other drugs in
pregnancy
Special Counseling Issues
for HIV-Positive Women
 Effect of HIV on fertility
 Effect of HIV on pregnancy and pregnancy on HIV
 Potential for MTCT
 Risk
 Timing
 Prevention
 Use of antiretroviral (ARV) agents and other drugs
during pregnancy, if available
Special Counseling Issues
for HIV-Positive Women
 Newborn feeding options
 Disclosure issues – concerns about
stigma and violence
 Use of condoms
 Long-term health of mother and care
for children
 Pregnancy termination option – if legal
and safe
“Opt-Out” HIV Testing in
Pregnancy
Advantages:
 Easier and quicker for the
provider
 Greater percentage of
women likely to be tested
means fewer infected
infants
 “Normalizes” HIV testing
“Opt-Out” HIV Testing in
Pregnancy
Disadvantages
 Risk of no pretest counseling
 Patient education may be inadequate
 Provider may not be prepared to give
positive results
Opt-Out as a “Consenting
Process”
 Minimum information
 An HIV test is part of the routine pregnancy
screening tests
 You have the right to refuse the test
 The HIV test is important. We strongly recommend
that all pregnant women be tested because a woman
can pass HIV to her baby
 If a woman has HIV, she will be offered medicines for
her health and to reduce the risk
of passing HIV to her baby
 Services are available for her and her family
Mother-to-Child
Transmission
 25–35% of HIV positive pregnant
mothers will pass HIV to their newborns
 In the absence of breastfeeding:
 30% of transmission in utero
 70% of transmission during the delivery
 Meta-analysis showed 14% transmission
with breastfeeding and 29% transmission
with acute maternal HIV infection or recent
seroconversion
Timing of Mother-to-Child
Transmission
Early Antenatal
(<36 wks)
Late Antenatal
(36 wks to labor)
Late Postpartum
(6-24 months)
Early Postpartum
(0-6 months)
Adapted from N Shaffer, CDC
5-10% 10-20% 10-20%
Labor and Delivery Breastfeeding
Pregnancy
MTCT in 100 HIV+ Mothers by
Timing of Transmission
0
20
40
60
80
100
Uninfected: 63
Breastfeeding: 15
Delivery: 15
Pregnancy: 7
31
Estimated Number of Children (<
15 years) Newly Infected with HIV
during 2000
Western Europe
< 500
North Africa
& Middle East
11,000
Sub-Saharan
Africa
520,000
Eastern Europe &
Central Asia
600
East Asia & Pacific
2,600
South &
South-East Asia
65,000
Australia &
New Zealand
< 100
North America
< 500
Caribbean
4,200
Latin America
7,300
Total: 600,000
Source: UNAIDS December 2000.
Estimated Timing and Risk of
MTCT of HIV (Absolute Rates)
No
Breastfeedi
ng
Breastfeedi
ng through
6 Months
Breastfeedi
ng through
18–24
Months
Intrauterine 5 to 10% 5 to 10% 5 to 10%
Intrapartum 10 to 20% 10 to 20% 10 to 20%
Postpartum
Early (first 2
months)
5 to 10% 5 to 10%
Late (after 2
months)
1 to 5% 5 to 10%
Overall 15 to 30% 25 to 35% 30 to 45%
Factors Affecting MTCT of
HIV/AIDS
 Viral load (HIV-RNA
level)
 Genital tract viral load
 CD4 cell count
 Clinical stage of HIV
 Unprotected sex with
multiple partners
 Smoking cigarettes
 Substance abuse
 Vitamin A deficiency
 STIs and other co-
infections
 ARV agents
 Preterm childbirth
 Placental disruption
 Invasive fetal monitoring
 Duration of membrane
rupture
 Vaginal childbirth versus
cesarean section
 Breastfeeding
Factors Affecting MTCT of
HIV/AIDS
Recommendations for
Antenatal Care
 Basic antenatal care
 Prevent and treat common
opportunistic infections
 Recommend nutritional interventions
 Screen and treat STIs and other co-
infections
 Monitor for signs and symptoms of
progressive HIV/AIDS
 Counsel on safe sex practices
Recommendations for
Antenatal Care
 Avoid invasive procedures
 Amniocentesis
 External cephalic version
 Consider administering ARV agents, if available
 Plan for future
 Newborn feeding
 Family planning
 Long-term care needs for mother, newborn and
other children
 Provide emotional support
Recommendations for
Labour and Childbirth
 Avoid invasive procedures
 Artificial membrane rupture
 Fetal scalp electrode or sampling
 Forceps or vacuum extractor
 Episiotomy
 Administer ARV agents, if available
 Consider issues related to type of delivery — cesarean
section versus vaginal childbirth
 Wipe newborn quickly and thoroughly with a dry cloth
to remove maternal blood and secretions
Recommendations for
Labour and Childbirth
 Follow recommended infection prevention practices
 Wash hands thoroughly before and after each
procedure and examination
 Wear hand and eye protection
 Handle needles and other sharp instruments
safely
 Dispose placenta and other waste materials and
supplies properly
 Process instruments, gloves and other items by
decontamination, cleaning and either sterilization
or high-level disinfection
MTCT and Cesarean
Section
 Cesarean section before
onset of labor and
membrane rupture
decreases risk of MTCT 50–
80%
 Additional benefit in
women not using ARV
agents or on ZDV alone
 No evidence of benefit after
onset of labor or membrane
rupture
MTCT and Cesarean Section
Special concerns with cesarean section
in limited-resource settings
 Increased maternal morbidity and possible
mortality
 Availability of blood and blood safety
 Iatrogenic prematurity
 Antibiotic prophylaxis
 Anesthesia availability
 Limited human resources — nursing care
time
Postpartum Care
 Assess healing
 Review newborn feeding, growth
and development
 Reinforce safer sexual practices
 Discuss contraception options
 Refer mother and newborn for
ongoing care
Recommendations for
Breastfeeding
 Avoid all breastfeeding when replacement feeding is
acceptable, feasible, affordable, sustainable and safe
 Provide guidance and support to HIV-positive
mothers
 Encourage exclusive breastfeeding up to 6
months of infant’s life
 Teach proper attachment of newborn to nipples
and frequent breast emptying
 Teach prevention and recognition and encourage
prompt treatment of mastitis, breast abscess,
cracked nipples and oral thrush or other oral
lesions in newborns
HIV/Infant feeding is about Assessing
the risks
Breastfeeding Formula
HIV Mortality
Risks of artificial feeding
Increased levels of accute illness:
 Respiratory infections
 Middle ear infection: 3-4x risk
 Gastroenteritis: 3-4x risk (developing countries 17-
25x)
 Bacterial infection requiring hospitalization: 10x
risk
 Meningitis: 4x risk
 Higher mortality from sudden infant death
syndrom (SIDS)
Risks of Artificial feeding
Dose-related difference in mental development:
 Lower scores of mental development tests at 18
months
 Difference in mental development and school
performance at 3-5 years
 Lower scores of prematures on intelligence tests at
7-8 years
 Deficits in neurological development (lack of
essential fatty acids)
 Difference in visual acuity
Risks of artificial feeding
Effects on the health of mothers:
 Higher risk of impaired bonding, abuse,
neglect and abandonment
 Increased risk of anemia due to early
return of menstruation
 Increased risk of breast and ovarian
cancer
 Increased risk of new pregnancy
Global Strategy for Infant and
Young Child Feeding
 Adopted by the WHO and
UNICEF Executive board in
2002
 Recognises that 2/3
deaths of annual 10.9
million U-5 deaths,
occur during 1st yr.
and are related to
inappropriate feeding
practices
Interventions to Reduce Mother-
to-Child Transmission
 HIV testing in pregnancy
 Antenatal care
 Antiretroviral agents
 Obstetric interventions
 Avoid amniotomy
 Avoid procedures: Forceps/vacuum extractor,
scalp electrode, scalp blood sampling
 Restrict episiotomy
 Elective cesarean section
 Remember infection prevention practices
 Newborn feeding: Breastmilk vs. formula
Antenatal Care
 Most HIV-infected women will be asymptomatic
 Watch for signs/symptoms of AIDS and
pregnancy-related complications
 Treat STDs and other coinfections
 Counsel against unprotected intercourse
 Avoid invasive procedures
 Give antiretroviral agents, if available
 Counsel about nutrition
MEDICAL MANAGEMENT
IN HIV IN PREGNANCY
Goals of Antiretroviral
Therapy
 To prolong life and improve quality of life
 To suppress HIV to below the limits of
detection or as low as possible, for as long
as possible
 To preserve or restore immune function
Antiretrovirals
 Zidovudine
(ZDV):
 Long course
 Short course
 Nevirapine
 ZDV/lamivudin
e (ZDV/3TC)
ZDV Perinatal Transmission
Prophylaxis Regimen
Antepartum Initiation at 14–34 weeks gestation and
continued throughout pregnancy
PACTG 076 regimen: ZDV 5 times daily
Acceptable alternative regimen: ZDV 2 or
3 times daily (depending on dose)
Intrapartum During labor, ZDV IV over 1 hour, followed
by a continuous infusion of IV until delivery
Postpartum Oral administration of ZDV to newborn for
first 6 weeks of life, beginning at 8–12
hours after birth
HIV-Infected Women in Labor with
No Prior Antiretroviral Therapy
Drug
Regimen
Maternal
Intrapartum
Newborn
Postpartum
Data on
Transmission
Nevirapine One oral
dose at onset
of labor
One oral dose at
age 48–72 hours
(if mother received
nevirapine < 1
hour before
delivery, newborn
given oral
nevirapine as soon
as possible after
birth and at 48–72
hours)
Transmission at 6
weeks 12% with
nevirapine
compared to
21% with ZDV, a
47% (95% CI,
20–64%)
reduction
HIV-Infected Women in Labor with
No Prior Antiretroviral Therapy
Drug
Regimen
Maternal
Intrapartum
Newborn
Postpartum
Data on
Transmission
ZDV/3TC ZDV orally at
onset of labor
followed by dose
orally every 3
hours until
delivery AND
3TC orally at
onset of labor,
followed by dose
orally every 12
hours
ZDV orally every
12 hours
AND
3TC orally every
12 hours for 7
days
Transmission at 6
weeks 10% with
ZDV/3TC
compared to
17% with
placebo, a 38%
reduction
HIV-Infected Women in Labor with
No Prior Antiretroviral Therapy
Drug
Regimen
Maternal
Intrapartum
Newborn
Postpartum
Data on
Transmission
ZDV IV bolus,
followed by
continuous
infusion of every
hour until
delivery
Orally every 6
hours for 6
weeks
Transmission
10% with ZDV
compared to
27% with no
ZDV treatment,
a 62% (95% CI,
19-82%)
reduction
HIV-Infected Women in Labor with
No Prior Antiretroviral Therapy
Drug
Regimen
Maternal
Intrapartum
Newborn
Postpartum
Data on
Transmission
ZDV and
Nevirapine
IV bolus, then
continuous
infusion until
delivery
AND
Nevirapine single
oral dose at
onset of labor
Orally every 6
hours for 6
weeks
AND
Nevirapine single
oral dose at age
48–72 hours
No data
Obstetric Procedures
Because of increased fetal exposure to
infected maternal blood and secretions,
increased transmission may come from:
 Amniotomy
 Fetal scalp electrode/sampling
 Forceps/vacuum extractor
 Episiotomy
 Vaginal tears
Cesarean vs. Vaginal Birth
 Risk of mother-to-child transmission increased
2% each hour after membranes have been
ruptured
 Cesarean section before labor and/or rupture
of membranes reduces risk of mother-to-child
transmission by 50–80%
 No evidence of benefit with cesarean section
after onset of labor or membranes ruptured
 Cesarean section, increases morbidity and
possible mortality to mother
 Give antibiotic prophylaxis
SAFETY PRECAUTIONS
 Needles:
 Take care! Minimal use
 Suturing: Use appropriate needle and holder
 Care with recapping and disposal
 Wear gloves, wash hands with soap
immediately after contact with blood
and body fluids
 Cover incisions with watertight
dressings for first 24 hours
SAFETY PRECAUTIONS
 Use:
 Plastic aprons for delivery
 Goggles and gloves for delivery and
surgery
 Long gloves for placenta removal
 Dispose of blood, placenta and waste
safely
 PROTECT YOURSELF!
Newborn
 Wash newborn after birth,
especially face
 Avoid hypothermia
 Give antiretroviral agents, if
available
Vaccination
 Killed virus, toxoid, or recombinant
vaccines are safe in pregnancy
 Routine vaccinations
 Hepatitis B
 Pneumonia vaccine
 Influenza vaccine
Rubella vaccine and other live, attenuated
vaccines may be given post-partum
Breastfeeding issues
Breastfeeding issues
If the woman is:
 HIV-negative or does not know
her HIV status, HIV-positive
and chooses to breastfeed
,promote exclusive
breastfeeding for 6 months
 HIV-positive and chooses to use
replacements feedings, counsel
on the safe and appropriate use
of formula
National Recommendations
National Recommendations for
HIV Testing of Pregnant
Women
 Regulations, laws, & policies about HIV
screening of pregnant women vary state to
state
 Institute of Medicine in 1998 recommended
universal HIV testing of pregnant women
 American College of Obstetrics & Gynecology
and the American Academy of Pediatrics in
encourage counseling but not as a barrier to
testing
National Recommendations for
HIV Testing of Pregnant
Women
 Recommendations for HIV screening of pregnant
women
 Prenatal: routine HIV screening for all pregnant
women using the “opt out” approach
 Women will be notified that they will be tested
unless they decline
 Labor and delivery: Routine rapid testing for women
whose HIV status is unknown
 Postnatal: Rapid testing for all infants whose mother’s
status is unknown.
Perinatal Transmission of
HIV
 Without antiretroviral prophylaxis, 16%–25%
mother-to-child transmission in North America
and Europe
 21% transmission rate in the U.S. in 1994 before
the standard recommendation of zidovudine (ZDV)
in pregnancy
 With the change in practice, transmission was
11% in 1995
 Today, risk of perinatal transmission can be < 2%
with highly active antiretroviral therapy (HAART),
elective C/S as appropriate and formula feeding
Timing of Perinatal
HIV Transmission
 Cases documented intrauterine, intrapartum,
and postpartum by breastfeeding
 In utero 25%–40% of cases
 Intrapartum 60%–75% of cases
 Additional risk with breastfeeding
 14%  risk with established infection
 29%  risk with primary infection
 Current evidence suggests most transmission
occurs during the intrapartum period
Breastfeeding and HIV
Infection
 Women with HIV infection in the U.S.
should not breastfeed
 Women considering breastfeeding
should know their HIV status
Influences on Perinatal
Transmission: Maternal Factors
 HIV-1 RNA levels (viral load)
 Low CD4 lymphocyte count
 Other infections, Hepatitis C, bacterial
vaginosis
 Maternal injection drug use
 Lack of ZDV during pregnancy
Influences on Perinatal
Transmission
 Obstetrical Factors
 Length of ruptured
membranes/
chorioamnionitis
 Vaginal delivery
 Invasive procedures
 Infant Factors
 Prematurity
Risk of Perinatal HIV Transmission
 Correlation between high maternal VL and
transmission
 Transmission observed at every VL level,
including undetectable levels
 No HIV RNA threshold below which there was no
risk of transmission
 ZDV decreases transmission regardless of HIV
RNA level
 Recommendation: Initiate maternal ZDV
regardless of plasma HIV RNA or CD4 counts
Cesarean Section to Reduce
Perinatal HIV Transmission
 Scheduled C/S offers potential benefit to reduce
perinatal transmission for women with VL  1000
 Unknown whether scheduled C/S offers any benefit
to women on HAART with low or undetectable VL
given the low transmission rate
 Complications of C/S similar to HIV uninfected
women
 Patient’s decision should be respected and honored
 No known benefit of C/S if labor has begun
Counseling During Labor
 Not a great time but it is possible!
 Other opportunities: ER visits for false
labor, antenatal admissions, premature
labor
 Materials for patient
education/informed consent
 Policy and procedure in place with a
counseling “script” for providers
Formula for HIV Counseling
and Testing in Labor
Confidentiality
Comfort
Consent
Reasons to test
Results
Rx to decrease risk
R3
C3
Confidentiality
Who is in the room with the
patient?
How can you assure confidentiality
during
 History taking
 Giving test results
 Giving medication for treatment?
Comfort
 What is her level of
discomfort?
 How is her pain being
managed?
 Is she anxious?
Informed Consent
 Who is responsible for obtaining informed
consent?
 How much information is “informed?”
 HIV is the virus that causes AIDS
 A woman could be at risk for HIV and not know it
 Effective interventions can protect the infant from
HIV and improve mother’s health
 HIV testing is recommended for all pregnant women
 Services are available to help women reduce their
HIV risk and provide medical care
 Women who decline testing won’t be denied care
Reasons for HIV Testing
During Labor
 HIV— the virus that causes AIDS — is spread by
unprotected sexual intercourse
 Therefore, all pregnant women may be at risk for
HIV infection
 A pregnant woman with HIV has a 1 in 4 chance
of passing HIV to her baby if she is not treated
 If a woman with HIV takes antiretroviral
medicine during labor and delivery and her baby
takes the medicine after birth, only 1 in 10 babies
will get HIV
Giving Results of Rapid Testing
in Labor
 When and how should results be given?
 Post-test counseling for positive results
 What does a preliminary positive test mean?
 What do you say?
 Post-test counseling for negative results
 What treatment is available if the
preliminary test is positive
 Consent for prophylactic treatment
based on preliminary test results
Postpartum Woman with a
Negative HIV Test
 Counseling regarding
risk reduction
 Assessment of on-
going risk
 Referral for intensive
counseling if high
risk
Treatment to Reduce
Perinatal HIV Transmission
 Antiretroviral treatment to mother
during labor and delivery and to the
baby after birth decrease the risk of
transmission to 1 in 10
 National guidelines offer 4 choices of
treatment
 Woman with a preliminary positive HIV
test should delay breastfeeding until the
results of
the confirmatory test are known
Pre test counseling received Pre test counseling not received
FLOW OF INFORMATION
In laws 6
Natal Family
25
Husband7
Woman
62 %
%
%
%
In laws
14
Natal Family
15
Husband
34
Woman
37%
%
%
%
WHO WHO
other 9
In laws
14
husband
33
Natal
Family
44%
%
%
%
other 4
In laws
37
husband
26
Natal
Family
33 %
%
%
%
WHOM WHOM
Consequences
In laws were the major source of stigma in both the groups
“ They say (in laws) I
deceived him (husband).
And so they will not take
any responsibility
“ My in laws have
disowned me, they
asked me to stay at my
natal place. My
husband got remarried.
He never came to see
me / our baby even
once. ”
“My sister in law has
kept all his (husband’s)
things separate. She has
made a separate
arrangement for him
to sleep.”
“They (in laws) don’t
allow me to do any work
at home. I am treated
like an ‘untouchable’.
They don’t take care of
my diet, my health.”
Consequences
Natal family was very supportive in almost all the cases
Its because of my
parents that my child
could be saved from
the infection. My in
laws have disowned
me for no fault of
mine.
My mother takes great
care so as I take
medicines on time. She
is the one who
accompanies me to
hospital every time.
Consequences
Gynecologic Issues in HIV
Infected Women
 Abnormal uterine bleeding
 Pap smears
 Infections/STD screening: GC, chlamydia, HSV, genital
ulcerative disease
 Contraception
 Breast Examinations-mammograms at appropriate age
NURSING MANAGEMENT
NURSING DIAGNOSIS IN
HIV IN PREGNANCY
 Anxiety related to treatment and complications of HIV
 Knowledge deficit related to treatment modalities in HIV
 Fatigue related to lack of food intake
 Imbalanced nutrition less than body requirement related
to anorexia
 Anticipatory grieving related to chronic and terminal
illness
 High risk of infection related to compromised immune
system
 High risk of acquiring an opportunistic infection related to
poor nutritional status
 High risk for fluid volume deficit related to lack of fluid
intake secondary to gastrointestinal infection.
 High risk for mental and neurological status changes
related to central nervous system infection
Summary
 Prevent HIV infection in women in their
childbearing years
 Prevent unintended pregnancies in HIV-
positive women
 Identify HIV infection in pregnant women
 To provide effective antenatal, labor and
childbirth, and postpartum care can be
provided
 To reduce risk of MTCT
THANK YOU

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HIV in pregnancy.ppt

  • 3. HIV and AIDS  HIV stands for Human Immunodeficiency Virus  AIDS stands for Acquired Immune Deficiency Syndrome, a condition caused by HIV  HIV gradually destroys the body’s ability to fight infections, eventually leading to death  Incubation period: 2 months-4 years
  • 4. TYPES OF HIV HIV I HIV II
  • 5. PATHOGENESIS The virus predominantly affects the thymus derived lymphocytes(T lymphocytes)There is significant immuno- deficiency (cell mediated) of the affected individual.
  • 6. MODES OF TRANSMISSION HIV is present in an Infected Person’s: Blood; Semen; Vaginal secretions & Breast Milk HIV is transmitted through:  Unprotected sexual contact with an infected person  Direct contact with or transfusion of infected blood  Sharing infected needles e.g. Injecting Drug Users  From a HIV positive mother to her unborn child, during birth, through Vertical transmission  Through infected tissue fluids  Through breast feeding For more information please contact: dwivedir@unaids.org, Mobile: 9810505068
  • 7. CLINICAL PRESENTATION  Initial presentation :fever, malaise, headache, sore throat, lymphadenopathy and maculopapular rash.  Primary illness may be followed by asymptomatic period.  Multiple opportunistic infections with Candida, tuberculosis, pneumocystis, neoplasms such as cervical carcinoma, lymphomas, Kaposi’s sarcoma.  Constitutional symptoms like weight loss and protracted diarrhea.
  • 9. CLINICAL FINDINGS  CD4 count below 500mm3  Decreased CD4 / CD8 ratio  Elevated erythrocyte sedimentation rate  Elevated serum globulin  Elevated serum lactate dehydrogenase  Low serum cholesterol  Neutropenia  Thrombocytopenia  Anemia  Positive serology for syphilis
  • 10. HIV and Pregnancy  HIV may have adverse effect on pregnancy course or outcome  More than 90% of pediatric HIV/AIDS cases are caused by MTCT  Most children born to HIV-positive mothers  Women without HIV may place themselves at risk for infection while trying to get pregnant  Majority of women with HIV are of childbearing age
  • 11. Prevalence of HIV (Type-1) among Pregnant Women 0% 10% 20% 30% 40% 50% Nigeria Uganda Kenya South Africa Malawi Rwanda Botswana Thailand Cambodia Brazil Honduras Haiti % Positive Source: DeCock et al 2000. Latin America Asia Africa
  • 12. 0 10 20 30 40 50 60 70 Women, 15-19 Women, 20-24 HIV prevalence (%) HIV Prevalence among Women Age 15–24 Source: UNAIDS June 2000.
  • 13. Effect of HIV on Fertility
  • 14. Effect of HIV on Fertility  Prior STIs or pelvic inflammatory disease  Direct effects of HIV  Decreased fertility seen after adjustment for age, lactation, illness, STIs  Worsened fertility in women with symptomatic HIV or co-infected with syphilis  Pregnancy loss more common with HIV infection
  • 15. Adverse Pregnancy Outcomes and HIV Infection Pregnancy Outcome Relationship to HIV Infection Spontaneous abortion Limited data, but evidence of possible increased risk Stillbirth No association noted in developed countries; evidence of increased risk in developing countries Perinatal mortality No association noted in developed countries, but data limited; evidence of increased risk in developing countries Newborn mortality Limited data in developed countries; evidence of increased risk in developing countries Intra-uterine growth retardation Evidence of possible increased risk
  • 16. Adverse Pregnancy Outcomes and Relationship to HIV Infection Pregnancy Outcome Relationship to HIV Infection Low birth weight Evidence of possible increased risk Preterm delivery Evidence of possible increased risk, especially more advanced disease Amnionitis Limited data; more recent studies do not suggest an increased risk; some earlier studies found increased histologic placental inflammation, particularly in those with preterm deliveries Oligohydramnios Minimal data Fetal malformation No evidence of increased risk
  • 17. HIV Testing during Pregnancy  Advantages:  Possible treatment of mother  Reduce risk of mother-to- child transmission  Future family planning issues  Precautions against further spread  If negative, advise about HIV prevention  Counseling is important!
  • 19. Preconceptual Counseling  Educate patients about perinatal transmission  To avoid unintended pregnancies  Counsel patients about safe methods to conceive  Choose anti-retrovirals which are known to be effective in reducing perinatal HIV transmission  Attain a stable, maximally suppressed viral load  Optimize medical and nutritional status
  • 20. Voluntary Counseling and Testing (VCT) in Women of Childbearing Age  Information about HIV and pregnancy  Risk assessment  Prevention of HIV transmission or acquisition  Prevention of unintended pregnancy  Dual protection with condoms
  • 21. Goals of VCT in Antenatal Care  Educate about HIV  Reduce stigma  Prevent new HIV infections in pregnancy  Identify women with HIV  Stabilize and maintain maternal health  Prevent HIV transmission to uninfected sexual or drug using partners  Reduce risk of MTCT  Plan for future
  • 22. HIV-Related Counseling Issues During Pregnancy  Educate/counsel regarding HIV and pregnancy before pregnancy:  Impact of HIV on pregnancy and pregnancy on HIV  Maternal health  Long-term health of mother and care for children  Perinatal transmission  Use of antiretrovirals and other drugs in pregnancy
  • 23. Special Counseling Issues for HIV-Positive Women  Effect of HIV on fertility  Effect of HIV on pregnancy and pregnancy on HIV  Potential for MTCT  Risk  Timing  Prevention  Use of antiretroviral (ARV) agents and other drugs during pregnancy, if available
  • 24. Special Counseling Issues for HIV-Positive Women  Newborn feeding options  Disclosure issues – concerns about stigma and violence  Use of condoms  Long-term health of mother and care for children  Pregnancy termination option – if legal and safe
  • 25. “Opt-Out” HIV Testing in Pregnancy Advantages:  Easier and quicker for the provider  Greater percentage of women likely to be tested means fewer infected infants  “Normalizes” HIV testing
  • 26. “Opt-Out” HIV Testing in Pregnancy Disadvantages  Risk of no pretest counseling  Patient education may be inadequate  Provider may not be prepared to give positive results
  • 27. Opt-Out as a “Consenting Process”  Minimum information  An HIV test is part of the routine pregnancy screening tests  You have the right to refuse the test  The HIV test is important. We strongly recommend that all pregnant women be tested because a woman can pass HIV to her baby  If a woman has HIV, she will be offered medicines for her health and to reduce the risk of passing HIV to her baby  Services are available for her and her family
  • 28. Mother-to-Child Transmission  25–35% of HIV positive pregnant mothers will pass HIV to their newborns  In the absence of breastfeeding:  30% of transmission in utero  70% of transmission during the delivery  Meta-analysis showed 14% transmission with breastfeeding and 29% transmission with acute maternal HIV infection or recent seroconversion
  • 29. Timing of Mother-to-Child Transmission Early Antenatal (<36 wks) Late Antenatal (36 wks to labor) Late Postpartum (6-24 months) Early Postpartum (0-6 months) Adapted from N Shaffer, CDC 5-10% 10-20% 10-20% Labor and Delivery Breastfeeding Pregnancy
  • 30. MTCT in 100 HIV+ Mothers by Timing of Transmission 0 20 40 60 80 100 Uninfected: 63 Breastfeeding: 15 Delivery: 15 Pregnancy: 7
  • 31. 31 Estimated Number of Children (< 15 years) Newly Infected with HIV during 2000 Western Europe < 500 North Africa & Middle East 11,000 Sub-Saharan Africa 520,000 Eastern Europe & Central Asia 600 East Asia & Pacific 2,600 South & South-East Asia 65,000 Australia & New Zealand < 100 North America < 500 Caribbean 4,200 Latin America 7,300 Total: 600,000 Source: UNAIDS December 2000.
  • 32. Estimated Timing and Risk of MTCT of HIV (Absolute Rates) No Breastfeedi ng Breastfeedi ng through 6 Months Breastfeedi ng through 18–24 Months Intrauterine 5 to 10% 5 to 10% 5 to 10% Intrapartum 10 to 20% 10 to 20% 10 to 20% Postpartum Early (first 2 months) 5 to 10% 5 to 10% Late (after 2 months) 1 to 5% 5 to 10% Overall 15 to 30% 25 to 35% 30 to 45%
  • 33. Factors Affecting MTCT of HIV/AIDS  Viral load (HIV-RNA level)  Genital tract viral load  CD4 cell count  Clinical stage of HIV  Unprotected sex with multiple partners  Smoking cigarettes  Substance abuse  Vitamin A deficiency
  • 34.  STIs and other co- infections  ARV agents  Preterm childbirth  Placental disruption  Invasive fetal monitoring  Duration of membrane rupture  Vaginal childbirth versus cesarean section  Breastfeeding Factors Affecting MTCT of HIV/AIDS
  • 35. Recommendations for Antenatal Care  Basic antenatal care  Prevent and treat common opportunistic infections  Recommend nutritional interventions  Screen and treat STIs and other co- infections  Monitor for signs and symptoms of progressive HIV/AIDS  Counsel on safe sex practices
  • 36. Recommendations for Antenatal Care  Avoid invasive procedures  Amniocentesis  External cephalic version  Consider administering ARV agents, if available  Plan for future  Newborn feeding  Family planning  Long-term care needs for mother, newborn and other children  Provide emotional support
  • 37. Recommendations for Labour and Childbirth  Avoid invasive procedures  Artificial membrane rupture  Fetal scalp electrode or sampling  Forceps or vacuum extractor  Episiotomy  Administer ARV agents, if available  Consider issues related to type of delivery — cesarean section versus vaginal childbirth  Wipe newborn quickly and thoroughly with a dry cloth to remove maternal blood and secretions
  • 38. Recommendations for Labour and Childbirth  Follow recommended infection prevention practices  Wash hands thoroughly before and after each procedure and examination  Wear hand and eye protection  Handle needles and other sharp instruments safely  Dispose placenta and other waste materials and supplies properly  Process instruments, gloves and other items by decontamination, cleaning and either sterilization or high-level disinfection
  • 39. MTCT and Cesarean Section  Cesarean section before onset of labor and membrane rupture decreases risk of MTCT 50– 80%  Additional benefit in women not using ARV agents or on ZDV alone  No evidence of benefit after onset of labor or membrane rupture
  • 40. MTCT and Cesarean Section Special concerns with cesarean section in limited-resource settings  Increased maternal morbidity and possible mortality  Availability of blood and blood safety  Iatrogenic prematurity  Antibiotic prophylaxis  Anesthesia availability  Limited human resources — nursing care time
  • 41. Postpartum Care  Assess healing  Review newborn feeding, growth and development  Reinforce safer sexual practices  Discuss contraception options  Refer mother and newborn for ongoing care
  • 42. Recommendations for Breastfeeding  Avoid all breastfeeding when replacement feeding is acceptable, feasible, affordable, sustainable and safe  Provide guidance and support to HIV-positive mothers  Encourage exclusive breastfeeding up to 6 months of infant’s life  Teach proper attachment of newborn to nipples and frequent breast emptying  Teach prevention and recognition and encourage prompt treatment of mastitis, breast abscess, cracked nipples and oral thrush or other oral lesions in newborns
  • 43. HIV/Infant feeding is about Assessing the risks Breastfeeding Formula HIV Mortality
  • 44. Risks of artificial feeding Increased levels of accute illness:  Respiratory infections  Middle ear infection: 3-4x risk  Gastroenteritis: 3-4x risk (developing countries 17- 25x)  Bacterial infection requiring hospitalization: 10x risk  Meningitis: 4x risk  Higher mortality from sudden infant death syndrom (SIDS)
  • 45. Risks of Artificial feeding Dose-related difference in mental development:  Lower scores of mental development tests at 18 months  Difference in mental development and school performance at 3-5 years  Lower scores of prematures on intelligence tests at 7-8 years  Deficits in neurological development (lack of essential fatty acids)  Difference in visual acuity
  • 46. Risks of artificial feeding Effects on the health of mothers:  Higher risk of impaired bonding, abuse, neglect and abandonment  Increased risk of anemia due to early return of menstruation  Increased risk of breast and ovarian cancer  Increased risk of new pregnancy
  • 47. Global Strategy for Infant and Young Child Feeding  Adopted by the WHO and UNICEF Executive board in 2002  Recognises that 2/3 deaths of annual 10.9 million U-5 deaths, occur during 1st yr. and are related to inappropriate feeding practices
  • 48. Interventions to Reduce Mother- to-Child Transmission  HIV testing in pregnancy  Antenatal care  Antiretroviral agents  Obstetric interventions  Avoid amniotomy  Avoid procedures: Forceps/vacuum extractor, scalp electrode, scalp blood sampling  Restrict episiotomy  Elective cesarean section  Remember infection prevention practices  Newborn feeding: Breastmilk vs. formula
  • 49. Antenatal Care  Most HIV-infected women will be asymptomatic  Watch for signs/symptoms of AIDS and pregnancy-related complications  Treat STDs and other coinfections  Counsel against unprotected intercourse  Avoid invasive procedures  Give antiretroviral agents, if available  Counsel about nutrition
  • 51. Goals of Antiretroviral Therapy  To prolong life and improve quality of life  To suppress HIV to below the limits of detection or as low as possible, for as long as possible  To preserve or restore immune function
  • 52. Antiretrovirals  Zidovudine (ZDV):  Long course  Short course  Nevirapine  ZDV/lamivudin e (ZDV/3TC)
  • 53. ZDV Perinatal Transmission Prophylaxis Regimen Antepartum Initiation at 14–34 weeks gestation and continued throughout pregnancy PACTG 076 regimen: ZDV 5 times daily Acceptable alternative regimen: ZDV 2 or 3 times daily (depending on dose) Intrapartum During labor, ZDV IV over 1 hour, followed by a continuous infusion of IV until delivery Postpartum Oral administration of ZDV to newborn for first 6 weeks of life, beginning at 8–12 hours after birth
  • 54. HIV-Infected Women in Labor with No Prior Antiretroviral Therapy Drug Regimen Maternal Intrapartum Newborn Postpartum Data on Transmission Nevirapine One oral dose at onset of labor One oral dose at age 48–72 hours (if mother received nevirapine < 1 hour before delivery, newborn given oral nevirapine as soon as possible after birth and at 48–72 hours) Transmission at 6 weeks 12% with nevirapine compared to 21% with ZDV, a 47% (95% CI, 20–64%) reduction
  • 55. HIV-Infected Women in Labor with No Prior Antiretroviral Therapy Drug Regimen Maternal Intrapartum Newborn Postpartum Data on Transmission ZDV/3TC ZDV orally at onset of labor followed by dose orally every 3 hours until delivery AND 3TC orally at onset of labor, followed by dose orally every 12 hours ZDV orally every 12 hours AND 3TC orally every 12 hours for 7 days Transmission at 6 weeks 10% with ZDV/3TC compared to 17% with placebo, a 38% reduction
  • 56. HIV-Infected Women in Labor with No Prior Antiretroviral Therapy Drug Regimen Maternal Intrapartum Newborn Postpartum Data on Transmission ZDV IV bolus, followed by continuous infusion of every hour until delivery Orally every 6 hours for 6 weeks Transmission 10% with ZDV compared to 27% with no ZDV treatment, a 62% (95% CI, 19-82%) reduction
  • 57. HIV-Infected Women in Labor with No Prior Antiretroviral Therapy Drug Regimen Maternal Intrapartum Newborn Postpartum Data on Transmission ZDV and Nevirapine IV bolus, then continuous infusion until delivery AND Nevirapine single oral dose at onset of labor Orally every 6 hours for 6 weeks AND Nevirapine single oral dose at age 48–72 hours No data
  • 58. Obstetric Procedures Because of increased fetal exposure to infected maternal blood and secretions, increased transmission may come from:  Amniotomy  Fetal scalp electrode/sampling  Forceps/vacuum extractor  Episiotomy  Vaginal tears
  • 59. Cesarean vs. Vaginal Birth  Risk of mother-to-child transmission increased 2% each hour after membranes have been ruptured  Cesarean section before labor and/or rupture of membranes reduces risk of mother-to-child transmission by 50–80%  No evidence of benefit with cesarean section after onset of labor or membranes ruptured  Cesarean section, increases morbidity and possible mortality to mother  Give antibiotic prophylaxis
  • 60. SAFETY PRECAUTIONS  Needles:  Take care! Minimal use  Suturing: Use appropriate needle and holder  Care with recapping and disposal  Wear gloves, wash hands with soap immediately after contact with blood and body fluids  Cover incisions with watertight dressings for first 24 hours
  • 61. SAFETY PRECAUTIONS  Use:  Plastic aprons for delivery  Goggles and gloves for delivery and surgery  Long gloves for placenta removal  Dispose of blood, placenta and waste safely  PROTECT YOURSELF!
  • 62. Newborn  Wash newborn after birth, especially face  Avoid hypothermia  Give antiretroviral agents, if available
  • 63. Vaccination  Killed virus, toxoid, or recombinant vaccines are safe in pregnancy  Routine vaccinations  Hepatitis B  Pneumonia vaccine  Influenza vaccine Rubella vaccine and other live, attenuated vaccines may be given post-partum
  • 65. Breastfeeding issues If the woman is:  HIV-negative or does not know her HIV status, HIV-positive and chooses to breastfeed ,promote exclusive breastfeeding for 6 months  HIV-positive and chooses to use replacements feedings, counsel on the safe and appropriate use of formula
  • 67. National Recommendations for HIV Testing of Pregnant Women  Regulations, laws, & policies about HIV screening of pregnant women vary state to state  Institute of Medicine in 1998 recommended universal HIV testing of pregnant women  American College of Obstetrics & Gynecology and the American Academy of Pediatrics in encourage counseling but not as a barrier to testing
  • 68. National Recommendations for HIV Testing of Pregnant Women  Recommendations for HIV screening of pregnant women  Prenatal: routine HIV screening for all pregnant women using the “opt out” approach  Women will be notified that they will be tested unless they decline  Labor and delivery: Routine rapid testing for women whose HIV status is unknown  Postnatal: Rapid testing for all infants whose mother’s status is unknown.
  • 69. Perinatal Transmission of HIV  Without antiretroviral prophylaxis, 16%–25% mother-to-child transmission in North America and Europe  21% transmission rate in the U.S. in 1994 before the standard recommendation of zidovudine (ZDV) in pregnancy  With the change in practice, transmission was 11% in 1995  Today, risk of perinatal transmission can be < 2% with highly active antiretroviral therapy (HAART), elective C/S as appropriate and formula feeding
  • 70. Timing of Perinatal HIV Transmission  Cases documented intrauterine, intrapartum, and postpartum by breastfeeding  In utero 25%–40% of cases  Intrapartum 60%–75% of cases  Additional risk with breastfeeding  14%  risk with established infection  29%  risk with primary infection  Current evidence suggests most transmission occurs during the intrapartum period
  • 71. Breastfeeding and HIV Infection  Women with HIV infection in the U.S. should not breastfeed  Women considering breastfeeding should know their HIV status
  • 72. Influences on Perinatal Transmission: Maternal Factors  HIV-1 RNA levels (viral load)  Low CD4 lymphocyte count  Other infections, Hepatitis C, bacterial vaginosis  Maternal injection drug use  Lack of ZDV during pregnancy
  • 73. Influences on Perinatal Transmission  Obstetrical Factors  Length of ruptured membranes/ chorioamnionitis  Vaginal delivery  Invasive procedures  Infant Factors  Prematurity
  • 74. Risk of Perinatal HIV Transmission  Correlation between high maternal VL and transmission  Transmission observed at every VL level, including undetectable levels  No HIV RNA threshold below which there was no risk of transmission  ZDV decreases transmission regardless of HIV RNA level  Recommendation: Initiate maternal ZDV regardless of plasma HIV RNA or CD4 counts
  • 75. Cesarean Section to Reduce Perinatal HIV Transmission  Scheduled C/S offers potential benefit to reduce perinatal transmission for women with VL  1000  Unknown whether scheduled C/S offers any benefit to women on HAART with low or undetectable VL given the low transmission rate  Complications of C/S similar to HIV uninfected women  Patient’s decision should be respected and honored  No known benefit of C/S if labor has begun
  • 76. Counseling During Labor  Not a great time but it is possible!  Other opportunities: ER visits for false labor, antenatal admissions, premature labor  Materials for patient education/informed consent  Policy and procedure in place with a counseling “script” for providers
  • 77. Formula for HIV Counseling and Testing in Labor Confidentiality Comfort Consent Reasons to test Results Rx to decrease risk R3 C3
  • 78. Confidentiality Who is in the room with the patient? How can you assure confidentiality during  History taking  Giving test results  Giving medication for treatment?
  • 79. Comfort  What is her level of discomfort?  How is her pain being managed?  Is she anxious?
  • 80. Informed Consent  Who is responsible for obtaining informed consent?  How much information is “informed?”  HIV is the virus that causes AIDS  A woman could be at risk for HIV and not know it  Effective interventions can protect the infant from HIV and improve mother’s health  HIV testing is recommended for all pregnant women  Services are available to help women reduce their HIV risk and provide medical care  Women who decline testing won’t be denied care
  • 81. Reasons for HIV Testing During Labor  HIV— the virus that causes AIDS — is spread by unprotected sexual intercourse  Therefore, all pregnant women may be at risk for HIV infection  A pregnant woman with HIV has a 1 in 4 chance of passing HIV to her baby if she is not treated  If a woman with HIV takes antiretroviral medicine during labor and delivery and her baby takes the medicine after birth, only 1 in 10 babies will get HIV
  • 82. Giving Results of Rapid Testing in Labor  When and how should results be given?  Post-test counseling for positive results  What does a preliminary positive test mean?  What do you say?  Post-test counseling for negative results  What treatment is available if the preliminary test is positive  Consent for prophylactic treatment based on preliminary test results
  • 83. Postpartum Woman with a Negative HIV Test  Counseling regarding risk reduction  Assessment of on- going risk  Referral for intensive counseling if high risk
  • 84. Treatment to Reduce Perinatal HIV Transmission  Antiretroviral treatment to mother during labor and delivery and to the baby after birth decrease the risk of transmission to 1 in 10  National guidelines offer 4 choices of treatment  Woman with a preliminary positive HIV test should delay breastfeeding until the results of the confirmatory test are known
  • 85. Pre test counseling received Pre test counseling not received FLOW OF INFORMATION In laws 6 Natal Family 25 Husband7 Woman 62 % % % % In laws 14 Natal Family 15 Husband 34 Woman 37% % % % WHO WHO other 9 In laws 14 husband 33 Natal Family 44% % % % other 4 In laws 37 husband 26 Natal Family 33 % % % % WHOM WHOM
  • 86. Consequences In laws were the major source of stigma in both the groups “ They say (in laws) I deceived him (husband). And so they will not take any responsibility “ My in laws have disowned me, they asked me to stay at my natal place. My husband got remarried. He never came to see me / our baby even once. ” “My sister in law has kept all his (husband’s) things separate. She has made a separate arrangement for him to sleep.” “They (in laws) don’t allow me to do any work at home. I am treated like an ‘untouchable’. They don’t take care of my diet, my health.”
  • 87. Consequences Natal family was very supportive in almost all the cases Its because of my parents that my child could be saved from the infection. My in laws have disowned me for no fault of mine. My mother takes great care so as I take medicines on time. She is the one who accompanies me to hospital every time.
  • 89. Gynecologic Issues in HIV Infected Women  Abnormal uterine bleeding  Pap smears  Infections/STD screening: GC, chlamydia, HSV, genital ulcerative disease  Contraception  Breast Examinations-mammograms at appropriate age
  • 90.
  • 91.
  • 93. NURSING DIAGNOSIS IN HIV IN PREGNANCY  Anxiety related to treatment and complications of HIV  Knowledge deficit related to treatment modalities in HIV  Fatigue related to lack of food intake  Imbalanced nutrition less than body requirement related to anorexia  Anticipatory grieving related to chronic and terminal illness  High risk of infection related to compromised immune system  High risk of acquiring an opportunistic infection related to poor nutritional status  High risk for fluid volume deficit related to lack of fluid intake secondary to gastrointestinal infection.  High risk for mental and neurological status changes related to central nervous system infection
  • 94. Summary  Prevent HIV infection in women in their childbearing years  Prevent unintended pregnancies in HIV- positive women  Identify HIV infection in pregnant women  To provide effective antenatal, labor and childbirth, and postpartum care can be provided  To reduce risk of MTCT