3. HIV and AIDS
HIV stands for Human Immunodeficiency
Virus
AIDS stands for Acquired Immune
Deficiency Syndrome, a condition caused by
HIV
HIV gradually destroys the body’s ability to
fight infections, eventually leading to death
Incubation period: 2 months-4 years
6. MODES OF TRANSMISSION
HIV is present in an Infected Person’s: Blood; Semen;
Vaginal secretions & Breast Milk
HIV is transmitted through:
Unprotected sexual contact with an infected person
Direct contact with or transfusion of infected blood
Sharing infected needles e.g. Injecting Drug Users
From a HIV positive mother to her unborn child, during
birth, through Vertical transmission
Through infected tissue fluids
Through breast feeding
For more information please contact: dwivedir@unaids.org,
Mobile: 9810505068
7. CLINICAL PRESENTATION
Initial presentation :fever, malaise, headache,
sore throat, lymphadenopathy and
maculopapular rash.
Primary illness may be followed by
asymptomatic period.
Multiple opportunistic infections with
Candida, tuberculosis, pneumocystis,
neoplasms such as cervical carcinoma,
lymphomas, Kaposi’s sarcoma.
Constitutional symptoms like weight loss and
protracted diarrhea.
10. HIV and Pregnancy
HIV may have adverse effect on pregnancy
course or outcome
More than 90% of pediatric HIV/AIDS cases
are caused by MTCT
Most children born to HIV-positive mothers
Women without HIV may place themselves at
risk for infection while trying to get pregnant
Majority of women with HIV are of
childbearing age
11. Prevalence of HIV (Type-1)
among Pregnant Women
0% 10% 20% 30% 40% 50%
Nigeria
Uganda
Kenya
South Africa
Malawi
Rwanda
Botswana
Thailand
Cambodia
Brazil
Honduras
Haiti
% Positive
Source: DeCock et al 2000.
Latin
America
Asia
Africa
14. Effect of HIV on Fertility
Prior STIs or pelvic inflammatory disease
Direct effects of HIV
Decreased fertility seen after adjustment for age,
lactation, illness, STIs
Worsened fertility in women with symptomatic
HIV or co-infected with syphilis
Pregnancy loss more common with HIV infection
15. Adverse Pregnancy Outcomes and HIV
Infection
Pregnancy Outcome Relationship to HIV Infection
Spontaneous
abortion
Limited data, but evidence of possible
increased risk
Stillbirth No association noted in developed countries;
evidence of increased risk in developing
countries
Perinatal mortality No association noted in developed countries,
but data limited; evidence of increased risk in
developing countries
Newborn mortality Limited data in developed countries; evidence
of increased risk in developing countries
Intra-uterine growth
retardation
Evidence of possible increased risk
16. Adverse Pregnancy Outcomes
and Relationship to HIV
Infection
Pregnancy Outcome Relationship to HIV Infection
Low birth weight Evidence of possible increased risk
Preterm delivery Evidence of possible increased risk, especially
more advanced disease
Amnionitis Limited data; more recent studies do not
suggest an increased risk; some earlier studies
found increased histologic placental
inflammation, particularly in those with
preterm deliveries
Oligohydramnios Minimal data
Fetal malformation No evidence of increased risk
17. HIV Testing during
Pregnancy
Advantages:
Possible treatment of mother
Reduce risk of mother-to-
child transmission
Future family planning issues
Precautions against further
spread
If negative, advise about HIV
prevention
Counseling is important!
19. Preconceptual Counseling
Educate patients about perinatal transmission
To avoid unintended pregnancies
Counsel patients about safe methods to
conceive
Choose anti-retrovirals which are known to be
effective in reducing perinatal HIV
transmission
Attain a stable, maximally suppressed viral
load
Optimize medical and nutritional status
20. Voluntary Counseling and
Testing (VCT) in Women of
Childbearing Age
Information about HIV and pregnancy
Risk assessment
Prevention of HIV transmission or
acquisition
Prevention of unintended pregnancy
Dual protection with condoms
21. Goals of VCT in Antenatal
Care
Educate about HIV
Reduce stigma
Prevent new HIV infections in
pregnancy
Identify women with HIV
Stabilize and maintain
maternal health
Prevent HIV transmission to
uninfected sexual or drug
using partners
Reduce risk of MTCT
Plan for future
22. HIV-Related Counseling Issues
During Pregnancy
Educate/counsel regarding HIV and
pregnancy before pregnancy:
Impact of HIV on pregnancy and pregnancy
on HIV
Maternal health
Long-term health of mother and care for
children
Perinatal transmission
Use of antiretrovirals and other drugs in
pregnancy
23. Special Counseling Issues
for HIV-Positive Women
Effect of HIV on fertility
Effect of HIV on pregnancy and pregnancy on HIV
Potential for MTCT
Risk
Timing
Prevention
Use of antiretroviral (ARV) agents and other drugs
during pregnancy, if available
24. Special Counseling Issues
for HIV-Positive Women
Newborn feeding options
Disclosure issues – concerns about
stigma and violence
Use of condoms
Long-term health of mother and care
for children
Pregnancy termination option – if legal
and safe
25. “Opt-Out” HIV Testing in
Pregnancy
Advantages:
Easier and quicker for the
provider
Greater percentage of
women likely to be tested
means fewer infected
infants
“Normalizes” HIV testing
26. “Opt-Out” HIV Testing in
Pregnancy
Disadvantages
Risk of no pretest counseling
Patient education may be inadequate
Provider may not be prepared to give
positive results
27. Opt-Out as a “Consenting
Process”
Minimum information
An HIV test is part of the routine pregnancy
screening tests
You have the right to refuse the test
The HIV test is important. We strongly recommend
that all pregnant women be tested because a woman
can pass HIV to her baby
If a woman has HIV, she will be offered medicines for
her health and to reduce the risk
of passing HIV to her baby
Services are available for her and her family
28. Mother-to-Child
Transmission
25–35% of HIV positive pregnant
mothers will pass HIV to their newborns
In the absence of breastfeeding:
30% of transmission in utero
70% of transmission during the delivery
Meta-analysis showed 14% transmission
with breastfeeding and 29% transmission
with acute maternal HIV infection or recent
seroconversion
29. Timing of Mother-to-Child
Transmission
Early Antenatal
(<36 wks)
Late Antenatal
(36 wks to labor)
Late Postpartum
(6-24 months)
Early Postpartum
(0-6 months)
Adapted from N Shaffer, CDC
5-10% 10-20% 10-20%
Labor and Delivery Breastfeeding
Pregnancy
30. MTCT in 100 HIV+ Mothers by
Timing of Transmission
0
20
40
60
80
100
Uninfected: 63
Breastfeeding: 15
Delivery: 15
Pregnancy: 7
31. 31
Estimated Number of Children (<
15 years) Newly Infected with HIV
during 2000
Western Europe
< 500
North Africa
& Middle East
11,000
Sub-Saharan
Africa
520,000
Eastern Europe &
Central Asia
600
East Asia & Pacific
2,600
South &
South-East Asia
65,000
Australia &
New Zealand
< 100
North America
< 500
Caribbean
4,200
Latin America
7,300
Total: 600,000
Source: UNAIDS December 2000.
32. Estimated Timing and Risk of
MTCT of HIV (Absolute Rates)
No
Breastfeedi
ng
Breastfeedi
ng through
6 Months
Breastfeedi
ng through
18–24
Months
Intrauterine 5 to 10% 5 to 10% 5 to 10%
Intrapartum 10 to 20% 10 to 20% 10 to 20%
Postpartum
Early (first 2
months)
5 to 10% 5 to 10%
Late (after 2
months)
1 to 5% 5 to 10%
Overall 15 to 30% 25 to 35% 30 to 45%
33. Factors Affecting MTCT of
HIV/AIDS
Viral load (HIV-RNA
level)
Genital tract viral load
CD4 cell count
Clinical stage of HIV
Unprotected sex with
multiple partners
Smoking cigarettes
Substance abuse
Vitamin A deficiency
34. STIs and other co-
infections
ARV agents
Preterm childbirth
Placental disruption
Invasive fetal monitoring
Duration of membrane
rupture
Vaginal childbirth versus
cesarean section
Breastfeeding
Factors Affecting MTCT of
HIV/AIDS
35. Recommendations for
Antenatal Care
Basic antenatal care
Prevent and treat common
opportunistic infections
Recommend nutritional interventions
Screen and treat STIs and other co-
infections
Monitor for signs and symptoms of
progressive HIV/AIDS
Counsel on safe sex practices
36. Recommendations for
Antenatal Care
Avoid invasive procedures
Amniocentesis
External cephalic version
Consider administering ARV agents, if available
Plan for future
Newborn feeding
Family planning
Long-term care needs for mother, newborn and
other children
Provide emotional support
37. Recommendations for
Labour and Childbirth
Avoid invasive procedures
Artificial membrane rupture
Fetal scalp electrode or sampling
Forceps or vacuum extractor
Episiotomy
Administer ARV agents, if available
Consider issues related to type of delivery — cesarean
section versus vaginal childbirth
Wipe newborn quickly and thoroughly with a dry cloth
to remove maternal blood and secretions
38. Recommendations for
Labour and Childbirth
Follow recommended infection prevention practices
Wash hands thoroughly before and after each
procedure and examination
Wear hand and eye protection
Handle needles and other sharp instruments
safely
Dispose placenta and other waste materials and
supplies properly
Process instruments, gloves and other items by
decontamination, cleaning and either sterilization
or high-level disinfection
39. MTCT and Cesarean
Section
Cesarean section before
onset of labor and
membrane rupture
decreases risk of MTCT 50–
80%
Additional benefit in
women not using ARV
agents or on ZDV alone
No evidence of benefit after
onset of labor or membrane
rupture
40. MTCT and Cesarean Section
Special concerns with cesarean section
in limited-resource settings
Increased maternal morbidity and possible
mortality
Availability of blood and blood safety
Iatrogenic prematurity
Antibiotic prophylaxis
Anesthesia availability
Limited human resources — nursing care
time
41. Postpartum Care
Assess healing
Review newborn feeding, growth
and development
Reinforce safer sexual practices
Discuss contraception options
Refer mother and newborn for
ongoing care
42. Recommendations for
Breastfeeding
Avoid all breastfeeding when replacement feeding is
acceptable, feasible, affordable, sustainable and safe
Provide guidance and support to HIV-positive
mothers
Encourage exclusive breastfeeding up to 6
months of infant’s life
Teach proper attachment of newborn to nipples
and frequent breast emptying
Teach prevention and recognition and encourage
prompt treatment of mastitis, breast abscess,
cracked nipples and oral thrush or other oral
lesions in newborns
44. Risks of artificial feeding
Increased levels of accute illness:
Respiratory infections
Middle ear infection: 3-4x risk
Gastroenteritis: 3-4x risk (developing countries 17-
25x)
Bacterial infection requiring hospitalization: 10x
risk
Meningitis: 4x risk
Higher mortality from sudden infant death
syndrom (SIDS)
45. Risks of Artificial feeding
Dose-related difference in mental development:
Lower scores of mental development tests at 18
months
Difference in mental development and school
performance at 3-5 years
Lower scores of prematures on intelligence tests at
7-8 years
Deficits in neurological development (lack of
essential fatty acids)
Difference in visual acuity
46. Risks of artificial feeding
Effects on the health of mothers:
Higher risk of impaired bonding, abuse,
neglect and abandonment
Increased risk of anemia due to early
return of menstruation
Increased risk of breast and ovarian
cancer
Increased risk of new pregnancy
47. Global Strategy for Infant and
Young Child Feeding
Adopted by the WHO and
UNICEF Executive board in
2002
Recognises that 2/3
deaths of annual 10.9
million U-5 deaths,
occur during 1st yr.
and are related to
inappropriate feeding
practices
48. Interventions to Reduce Mother-
to-Child Transmission
HIV testing in pregnancy
Antenatal care
Antiretroviral agents
Obstetric interventions
Avoid amniotomy
Avoid procedures: Forceps/vacuum extractor,
scalp electrode, scalp blood sampling
Restrict episiotomy
Elective cesarean section
Remember infection prevention practices
Newborn feeding: Breastmilk vs. formula
49. Antenatal Care
Most HIV-infected women will be asymptomatic
Watch for signs/symptoms of AIDS and
pregnancy-related complications
Treat STDs and other coinfections
Counsel against unprotected intercourse
Avoid invasive procedures
Give antiretroviral agents, if available
Counsel about nutrition
51. Goals of Antiretroviral
Therapy
To prolong life and improve quality of life
To suppress HIV to below the limits of
detection or as low as possible, for as long
as possible
To preserve or restore immune function
53. ZDV Perinatal Transmission
Prophylaxis Regimen
Antepartum Initiation at 14–34 weeks gestation and
continued throughout pregnancy
PACTG 076 regimen: ZDV 5 times daily
Acceptable alternative regimen: ZDV 2 or
3 times daily (depending on dose)
Intrapartum During labor, ZDV IV over 1 hour, followed
by a continuous infusion of IV until delivery
Postpartum Oral administration of ZDV to newborn for
first 6 weeks of life, beginning at 8–12
hours after birth
54. HIV-Infected Women in Labor with
No Prior Antiretroviral Therapy
Drug
Regimen
Maternal
Intrapartum
Newborn
Postpartum
Data on
Transmission
Nevirapine One oral
dose at onset
of labor
One oral dose at
age 48–72 hours
(if mother received
nevirapine < 1
hour before
delivery, newborn
given oral
nevirapine as soon
as possible after
birth and at 48–72
hours)
Transmission at 6
weeks 12% with
nevirapine
compared to
21% with ZDV, a
47% (95% CI,
20–64%)
reduction
55. HIV-Infected Women in Labor with
No Prior Antiretroviral Therapy
Drug
Regimen
Maternal
Intrapartum
Newborn
Postpartum
Data on
Transmission
ZDV/3TC ZDV orally at
onset of labor
followed by dose
orally every 3
hours until
delivery AND
3TC orally at
onset of labor,
followed by dose
orally every 12
hours
ZDV orally every
12 hours
AND
3TC orally every
12 hours for 7
days
Transmission at 6
weeks 10% with
ZDV/3TC
compared to
17% with
placebo, a 38%
reduction
56. HIV-Infected Women in Labor with
No Prior Antiretroviral Therapy
Drug
Regimen
Maternal
Intrapartum
Newborn
Postpartum
Data on
Transmission
ZDV IV bolus,
followed by
continuous
infusion of every
hour until
delivery
Orally every 6
hours for 6
weeks
Transmission
10% with ZDV
compared to
27% with no
ZDV treatment,
a 62% (95% CI,
19-82%)
reduction
57. HIV-Infected Women in Labor with
No Prior Antiretroviral Therapy
Drug
Regimen
Maternal
Intrapartum
Newborn
Postpartum
Data on
Transmission
ZDV and
Nevirapine
IV bolus, then
continuous
infusion until
delivery
AND
Nevirapine single
oral dose at
onset of labor
Orally every 6
hours for 6
weeks
AND
Nevirapine single
oral dose at age
48–72 hours
No data
58. Obstetric Procedures
Because of increased fetal exposure to
infected maternal blood and secretions,
increased transmission may come from:
Amniotomy
Fetal scalp electrode/sampling
Forceps/vacuum extractor
Episiotomy
Vaginal tears
59. Cesarean vs. Vaginal Birth
Risk of mother-to-child transmission increased
2% each hour after membranes have been
ruptured
Cesarean section before labor and/or rupture
of membranes reduces risk of mother-to-child
transmission by 50–80%
No evidence of benefit with cesarean section
after onset of labor or membranes ruptured
Cesarean section, increases morbidity and
possible mortality to mother
Give antibiotic prophylaxis
60. SAFETY PRECAUTIONS
Needles:
Take care! Minimal use
Suturing: Use appropriate needle and holder
Care with recapping and disposal
Wear gloves, wash hands with soap
immediately after contact with blood
and body fluids
Cover incisions with watertight
dressings for first 24 hours
61. SAFETY PRECAUTIONS
Use:
Plastic aprons for delivery
Goggles and gloves for delivery and
surgery
Long gloves for placenta removal
Dispose of blood, placenta and waste
safely
PROTECT YOURSELF!
62. Newborn
Wash newborn after birth,
especially face
Avoid hypothermia
Give antiretroviral agents, if
available
63. Vaccination
Killed virus, toxoid, or recombinant
vaccines are safe in pregnancy
Routine vaccinations
Hepatitis B
Pneumonia vaccine
Influenza vaccine
Rubella vaccine and other live, attenuated
vaccines may be given post-partum
65. Breastfeeding issues
If the woman is:
HIV-negative or does not know
her HIV status, HIV-positive
and chooses to breastfeed
,promote exclusive
breastfeeding for 6 months
HIV-positive and chooses to use
replacements feedings, counsel
on the safe and appropriate use
of formula
67. National Recommendations for
HIV Testing of Pregnant
Women
Regulations, laws, & policies about HIV
screening of pregnant women vary state to
state
Institute of Medicine in 1998 recommended
universal HIV testing of pregnant women
American College of Obstetrics & Gynecology
and the American Academy of Pediatrics in
encourage counseling but not as a barrier to
testing
68. National Recommendations for
HIV Testing of Pregnant
Women
Recommendations for HIV screening of pregnant
women
Prenatal: routine HIV screening for all pregnant
women using the “opt out” approach
Women will be notified that they will be tested
unless they decline
Labor and delivery: Routine rapid testing for women
whose HIV status is unknown
Postnatal: Rapid testing for all infants whose mother’s
status is unknown.
69. Perinatal Transmission of
HIV
Without antiretroviral prophylaxis, 16%–25%
mother-to-child transmission in North America
and Europe
21% transmission rate in the U.S. in 1994 before
the standard recommendation of zidovudine (ZDV)
in pregnancy
With the change in practice, transmission was
11% in 1995
Today, risk of perinatal transmission can be < 2%
with highly active antiretroviral therapy (HAART),
elective C/S as appropriate and formula feeding
70. Timing of Perinatal
HIV Transmission
Cases documented intrauterine, intrapartum,
and postpartum by breastfeeding
In utero 25%–40% of cases
Intrapartum 60%–75% of cases
Additional risk with breastfeeding
14% risk with established infection
29% risk with primary infection
Current evidence suggests most transmission
occurs during the intrapartum period
71. Breastfeeding and HIV
Infection
Women with HIV infection in the U.S.
should not breastfeed
Women considering breastfeeding
should know their HIV status
72. Influences on Perinatal
Transmission: Maternal Factors
HIV-1 RNA levels (viral load)
Low CD4 lymphocyte count
Other infections, Hepatitis C, bacterial
vaginosis
Maternal injection drug use
Lack of ZDV during pregnancy
74. Risk of Perinatal HIV Transmission
Correlation between high maternal VL and
transmission
Transmission observed at every VL level,
including undetectable levels
No HIV RNA threshold below which there was no
risk of transmission
ZDV decreases transmission regardless of HIV
RNA level
Recommendation: Initiate maternal ZDV
regardless of plasma HIV RNA or CD4 counts
75. Cesarean Section to Reduce
Perinatal HIV Transmission
Scheduled C/S offers potential benefit to reduce
perinatal transmission for women with VL 1000
Unknown whether scheduled C/S offers any benefit
to women on HAART with low or undetectable VL
given the low transmission rate
Complications of C/S similar to HIV uninfected
women
Patient’s decision should be respected and honored
No known benefit of C/S if labor has begun
76. Counseling During Labor
Not a great time but it is possible!
Other opportunities: ER visits for false
labor, antenatal admissions, premature
labor
Materials for patient
education/informed consent
Policy and procedure in place with a
counseling “script” for providers
77. Formula for HIV Counseling
and Testing in Labor
Confidentiality
Comfort
Consent
Reasons to test
Results
Rx to decrease risk
R3
C3
78. Confidentiality
Who is in the room with the
patient?
How can you assure confidentiality
during
History taking
Giving test results
Giving medication for treatment?
79. Comfort
What is her level of
discomfort?
How is her pain being
managed?
Is she anxious?
80. Informed Consent
Who is responsible for obtaining informed
consent?
How much information is “informed?”
HIV is the virus that causes AIDS
A woman could be at risk for HIV and not know it
Effective interventions can protect the infant from
HIV and improve mother’s health
HIV testing is recommended for all pregnant women
Services are available to help women reduce their
HIV risk and provide medical care
Women who decline testing won’t be denied care
81. Reasons for HIV Testing
During Labor
HIV— the virus that causes AIDS — is spread by
unprotected sexual intercourse
Therefore, all pregnant women may be at risk for
HIV infection
A pregnant woman with HIV has a 1 in 4 chance
of passing HIV to her baby if she is not treated
If a woman with HIV takes antiretroviral
medicine during labor and delivery and her baby
takes the medicine after birth, only 1 in 10 babies
will get HIV
82. Giving Results of Rapid Testing
in Labor
When and how should results be given?
Post-test counseling for positive results
What does a preliminary positive test mean?
What do you say?
Post-test counseling for negative results
What treatment is available if the
preliminary test is positive
Consent for prophylactic treatment
based on preliminary test results
83. Postpartum Woman with a
Negative HIV Test
Counseling regarding
risk reduction
Assessment of on-
going risk
Referral for intensive
counseling if high
risk
84. Treatment to Reduce
Perinatal HIV Transmission
Antiretroviral treatment to mother
during labor and delivery and to the
baby after birth decrease the risk of
transmission to 1 in 10
National guidelines offer 4 choices of
treatment
Woman with a preliminary positive HIV
test should delay breastfeeding until the
results of
the confirmatory test are known
85. Pre test counseling received Pre test counseling not received
FLOW OF INFORMATION
In laws 6
Natal Family
25
Husband7
Woman
62 %
%
%
%
In laws
14
Natal Family
15
Husband
34
Woman
37%
%
%
%
WHO WHO
other 9
In laws
14
husband
33
Natal
Family
44%
%
%
%
other 4
In laws
37
husband
26
Natal
Family
33 %
%
%
%
WHOM WHOM
86. Consequences
In laws were the major source of stigma in both the groups
“ They say (in laws) I
deceived him (husband).
And so they will not take
any responsibility
“ My in laws have
disowned me, they
asked me to stay at my
natal place. My
husband got remarried.
He never came to see
me / our baby even
once. ”
“My sister in law has
kept all his (husband’s)
things separate. She has
made a separate
arrangement for him
to sleep.”
“They (in laws) don’t
allow me to do any work
at home. I am treated
like an ‘untouchable’.
They don’t take care of
my diet, my health.”
87. Consequences
Natal family was very supportive in almost all the cases
Its because of my
parents that my child
could be saved from
the infection. My in
laws have disowned
me for no fault of
mine.
My mother takes great
care so as I take
medicines on time. She
is the one who
accompanies me to
hospital every time.
89. Gynecologic Issues in HIV
Infected Women
Abnormal uterine bleeding
Pap smears
Infections/STD screening: GC, chlamydia, HSV, genital
ulcerative disease
Contraception
Breast Examinations-mammograms at appropriate age
93. NURSING DIAGNOSIS IN
HIV IN PREGNANCY
Anxiety related to treatment and complications of HIV
Knowledge deficit related to treatment modalities in HIV
Fatigue related to lack of food intake
Imbalanced nutrition less than body requirement related
to anorexia
Anticipatory grieving related to chronic and terminal
illness
High risk of infection related to compromised immune
system
High risk of acquiring an opportunistic infection related to
poor nutritional status
High risk for fluid volume deficit related to lack of fluid
intake secondary to gastrointestinal infection.
High risk for mental and neurological status changes
related to central nervous system infection
94. Summary
Prevent HIV infection in women in their
childbearing years
Prevent unintended pregnancies in HIV-
positive women
Identify HIV infection in pregnant women
To provide effective antenatal, labor and
childbirth, and postpartum care can be
provided
To reduce risk of MTCT