APHA International Health Poster Session - HIV/AIDS The Government of Tanzania is working to address a critical challenge faced by child protection and HIV practitioners: How to implement a systematic response that engages both community and facility based providers in a connected system to ensure most vulnerable children (MVC) and their families holistically receive social welfare, protection services, and HIV related needs. The USAID Community Health and Social Welfare system Strengthening Program (CHSSP), implemented by JSI Research & Training Institute, Inc., collaborated with the Tanzania Department of Social Welfare to design, and finalize a National Integrated Case Management System (NICMS). This document sets forth a harmonized, standardized, and systematic structure for the care and protection of MVC and their families, with the goal of improving access to and integration of protection, social welfare, and health services, including HIV continuum of care. The NICMS is responsive to MVC needs including HIV-specific social issues and includes: strengthening bi-directional linkages and referrals between social welfare, Protection, and HIV clinical providers; Coordinating civil society organizations dealing with MVC; strengthening MVC committees and ensure supportive supervision at all levels. All components ultimately contribute towards expanding access to HIV care and treatment services, enhancing ART retention and adherence, improving referrals and linkages. Recommendations/Conclusions: NICMS is a valuable initiative to serve MVC holistically, and has successfully integrated the Tanzanian health social welfare and Protection sectors to provide services across the continuum of care.