The shingles vaccine...is it truly necessary?

1. Vaccination Vs Natural
Immune System Function

2. FDA approved Zostavax in the spring of 2006,
the vaccine halved the risk of getting shingles. Even
more impressive, it cut by two-thirds the risk of
developing post herpetic neuralgia,
“Bad Science” has sold over
400,000 copies, is published in
18 countries,
exposing bad behaviour in the
pharmaceutical industry will be
published in 2012 by 4th Estate.
Dr Ben Goldacre

3. Cause
Shingles is caused by the varicella zoster virus, the same virus
that causes chickenpox. After a person recovers from
chickenpox, the virus stays in the body in a dormant (inactive)
state. For reasons that are not fully known, the virus
can reactivate years later, causing shingles. Herpes zoster is not
caused by the same virus that causes genital herpes, a sexually
transmitted disease.
“There are two ways to be fooled.
One is to believe what isn't true;
the other is to refuse to believe
what is true.”
― Søren Kierkegaard

4.  United States each year approximately 1,000,000
individuals develop herpes zoster
 20%, or 200,000 individuals, develop postherpetic
neuralgia
 Less than 10 percent of people younger than 60
develop postherpetic neuralgia
 after a bout of HZ, while about 40 percent of people
older than 60 do
 Disease incidence 20%-30% over 60yo
 Vaccine “works” 55% of the time
 99% of shingles patients have only 1 episode

5. Recap:
•300,000,000 Americans
•1,000,000 will get herpes zoster 1 in 300
•200,000 will get post herpetic neuralgia
•110,000 may be helped by the shot 0.003%
•Of those 99% will have 1 occurrence
•Shot is $150 - $300 per shot
But Is It
Covered By
Insurance ???
ButIs
It
Covered
By
Insurance
???

6. Mechanism of activation
Unless the immune system is compromised, it suppresses
reactivation of the virus and prevents herpes zoster.
Why this suppression sometimes fails is poorly understood, but
herpes zoster is more likely to occur in people whose immune
system is impaired due to aging, immunosuppressive therapy,
psychological stress, or other factors.
Upon reactivation, the virus replicates in the nerve cells, and
virions are shed from the cells and carried down the axons to the
area of skin served by that ganglion. In the skin, the virus
causes local inflammation and blisters. The short- and long-term
pain caused by herpes zoster comes from the widespread
growth of the virus in the infected nerves, which causes
inflammation.

7. deliberately induced immunosuppression:
•body from rejecting an organ transplant
• bone marrow transplant
• rheumatoid arthritis
• Crohn's disease
• splenectomy
• radiation
• chemotherapy
•Lupus
Non-deliberate immunosuppression:
• malnutrition
• aging
•many types of cancer
• leukemia
• lymphoma
• multiple myeloma
• chronic infections
Cortisone

8. One study example
Shingles Prevention Study (SPS) in Subjects 60 Years of
Age and Older (What is the Placebo Ingredients)
Efficacy of ZOSTAVAX was evaluated ZOSTAVAX (n=19,270)
or placebo (n=19,276).
Subjects were followed for the development of zoster for a
median of 3.1 years (range 31 days to 4.90 years).
The study excluded people who were immunocompromised or
using corticosteroids on a regular basis, anyone with a
previous history of HZ, and those with conditions that might
interfere with study evaluations, including people with cognitive
impairment, severe hearing loss, etc…

9. Dr. Beatrice Golomb
“there isn’t anything actually known to be physiologically inert. On top of that, there
are no regulations about what goes into placebos, and what is in them is often
determined by the makers of the drug being studied, who have a vested interest in
the outcome. And there has been no expectation that placebos’ composition be
disclosed. …”
example; type 2 diabetes drug:
placebo A (composed of Peanut oil, high in B3)
placebo B (composed of Corn Oil, low in B3).
The results :
significant improvement compared to placebo A
no improvement against placebo B.
B3 aggravated diabetes
placebo A ,making the drug appear more effective than it really is.
“What’s in Placebos: Who Knows?
Analysis of Randomized, Controlled Trials”
the Annals of Internal Medicine 2008

10. In the ZEST study, serious adverse events occurred at a similar rate in
subjects vaccinated with ZOSTAVAX (0.6%) or placebo (0.5%) from Days 1
to 42 postvaccination.
Deaths in the approved Study (What is in the Placebo???)
The incidence of death was similar in the groups receiving
ZOSTAVAX or placebo during the Days 0-42 postvaccination
period;
•14 deaths occurred who received ZOSTAVAX
•16 deaths occurred who received placebo.
•most common death was cardiovascular disease (10 in the group
of subjects who received ZOSTAVAX, 8 in the group of subjects
who received placebo).

11. ZOSTAVAX is a lyophilized preparation of the Oka/Merck
strain of live, attenuated varicella-zoster virus
Each 0.65-mL dose contains a minimum of 19,400 PFU
(plaque-forming units) of Oka/Merck strain of VZV when
reconstituted and stored at room temperature for up to 30
minutes.
Each dose contains
31.16 mg of sucrose,
15.58 mg of hydrolyzed porcine gelatin,
3.99 mg of sodium chloride,
0.62 mg of monosodium L-glutamate,
0.57 mg of sodium phosphate dibasic,
0.10 mg of potassium phosphate monobasic
0.10 mg of potassium chloride;
residual components of MRC-5 cells including DNA and
protein; and trace quantities of neomycin and bovine calf
serum. The product contains no preservatives.
Shot ingredients and Storage Storage
ZOSTAVAX must be
stored frozen between
-58°F and +5°F (-50°C and
-15°C). Use of dry ice may
subject ZOSTAVAX to
temperatures colder than
-58°F (-50°C).
Before reconstitution,
ZOSTAVAX SHOULD BE
STORED FROZEN at a
temperature between
-58°F and +5°F (-50°C and
-15°C) until it is
reconstituted for
injection. Any freezer,
including frostfree, that
has a separate sealed
freezer door and reliably
maintains a temperature
between -58°F and +5°F (-
50°C and -15°C) is
acceptable for storing
ZOSTAVAX.

12. Natural Protection
•“The peculiar age distribution of zoster may in part reflect the frequency
with which the different age groups encounter cases of varicella and
because of the ensuing boost to their antibody protection have their
attacks of zoster postponed.”
•contact with children with chickenpox boosts adult cell-mediated immunity
to help postpone or suppress shingles,
• adults in households with children had lower rates of shingles than
households without children
• indicated that pediatricians reflected incidence rates from 1/2 to 1/8 that
of the general population their age
Terada K, Hiraga Y, Kawano S, Kataoka N (1995). "Incidence of herpes
zoster in pediatricians and history of reexposure to varicella-zoster virus in
patients with herpes zoster". Kansenshogaku Zasshi 69 (8): 908–912.
Thomas SL, Wheeler JG, Hall AJ (2002). "Contacts with varicella or with
children and protection against herpes zoster in adults: a case-control study".
Lancet 360 (9334): 678–682

13. •A 2006 study found that fresh fruit is associated with a 300%
reduced risk of developing shingles
•people who consumed less than one serving of fruit a day
had a risk three times as great as those who consumed more
than three servings
• For those aged 60 or more, vitamins and vegetable intake
had a similar association.
Thomas SL, Wheeler JG, Hall AJ (2006). "Micronutrient intake and
the risk of herpes zoster: a case-control study". Int J Epidemiol 35 (2):
307–14.

14. Engerix-B Vaccine Study
Adults:
20 ugm = 7 months = 2,284 mIU/ml
20 ugm = 13 months = 9,163 mIU/ml
Adolecents:
10 ugm = 8 months = 1.989 mIU/ml
20 ugm = 8 months = 7,672 mIU/ml
Infants:
10 ugm = 4 months = 2,942 mIU/ml
10 ugm = 7 months = 713 mIU/ml
“even though the data
regarding the relation
between vaccination and
autoimmune disease is
conflicting some autoimmune
phenomena are clearly
related to immunization”
J.Autoimmun. 2000 feb
14(1) 1-10

15.  molecular mimicry is an important factor in autoimmune
disease
 first published in 1985 and since that time substantial
evidence has accumulated
 causing many autoimmune diseases including: diabetes,
lupus, scleroderma, rheumatoid arthritis, multiple
sclerosis, chronic fatigue syndrome, autism
 “even though the data regarding the relation between
vaccination and autoimmune disease is conflicting some
autoimmune phenomena are clearly related to immunization”
 J.Autoimmun. 2000 feb 14(1) 1-10

16. 5 year old vaccinations
stopped at 3 yo speech and
impulse control problems

18. Tetanus is a severe, often fatal disease. ….. Approximately 20 percent of
reported cases end in death.
Tetanus in the U.S. is primarily a disease of adults, but unvaccinated children and
infants of unvaccinated mothers are also at risk for tetanus and neonatal tetanus,
respectively.
…. The National Health Interview Survey found that in 1995, only 36 percent of
adults 65 or older had received a tetanus vaccination during the preceding 10 years.
Worldwide, tetanus in newborn infants continues to be a huge problem. Every year
tetanus kills 300,000 newborns and 30,000 birth mothers who were not
properly vaccinated.
Even though the number of reported cases is low, an increased number of tetanus
cases in younger persons has been observed recently in the U.S. among
intravenous drug users, particularly heroin users.
Tetanus is infectious, but not contagious, so unlike other vaccine-preventable
diseases, immunization by members of the community will not protect others from
the disease. Because tetanus bacteria are widespread in the environment, tetanus
can only be prevented by immunization. If vaccination against tetanus were
stopped, persons of all ages in the U.S. would be susceptible to this serious
disease.

19. History of tetanus
During the mid-1800s, there were 205 cases of tetanus per 100,000 wounds
among U.S. military personnel.
By the early 1900s, this rate had declined to 16 cases per 100,000 wounds
92 percent reduction
During the mid-1940s, the incidence of tetanus dropped even further to .44
cases per 100,000 wounds.
99 percent reduction
Better wound hygiene
2002 there were 25 cases of tetanus and 3 deaths reported in the U.S.
Tetanus is a serious problem in underdeveloped countries
Newborn babies born in unsanitary conditions whose umbilical cords can
become infected with tetanus

20. 1994 the Institute of Medicine concluded:
“ that there is compelling scientific evidence to conclude that
tetanus, DT and Td vaccines can cause Guillain-Barre
syndrome including death; brachial neuritis; and death from
anaphylaxis (shock).”

21. Because either no studies or too few scientific studies had ever
been conducted to investigate tetanus, DT or Td reactions, a
determination could not be made as to whether DT, Td or
tetanus vaccine can cause other serious health problems which
are reported following tetanus vaccination:
*residual seizure disorders
*demyelinating diseases of the central nervous system
*transverse myelitis
*optic neuritis
*acute disseminated encephalomyelitis
*peripheral mononeuropathy
*arthritis, and
*erythema multiforme (lesions of the skin or mucous membranes).
Institute Of Med 1994

22. 78 years with immune
system problems multiple
medications, low energy,
poor health

24. Proper nerve supply –
Get Checked for Subluxation
Regular Exercise
Proper Nutrition
Sufficient Rest
Prayer and Meditation

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