The document discusses the fight or flight response and how epinephrine and norepinephrine activate alpha and beta receptors to increase blood pressure during stress. Clonidine decreases sympathetic outflow and lowers blood pressure by reducing stimulation of alpha receptors. Upon clonidine withdrawal, alpha receptors become hypersensitive due to the lack of stimulation, potentially causing rebound hypertension as epinephrine and norepinephrine can now have unopposed effects on the alpha receptors. Extreme hypertension can also occur if beta blockade is added during clonidine withdrawal due to unopposed alpha receptor stimulation.

1. Epinephrine
Norepinephrine
Fight or Flight
Stress
Alpha
Constriction
Beta Two
160/100 Dilation
Offsets
Alpha
hypertension
constriction

2. Alpha 2 agonist decreases
clonidine sympathetic outflow
Fight or Flight
Stress
140/90
Lowered blood
pressure

3. clonidine
Fight or Flight
Clonidine withdrawal !!
Stress Epinephrine
Norepinephrine
Hypersensitive alpha receptors due
to lack of stimulation on clonidine
170/110
Rebound
hypertension

4. Epinephrine
Norepinephrine
Fight or Flight
Stress Epinephrine
Norepinephrine
200/120 X
Unopposed alpha, Beta
blockad
e
Extreme HTN