1. Central hyperpigmented
structureless area
Asymmetric Hyperpigmented
Structureless area

2. Central hyperpigmented
structureless area
Asymmetric Hyperpigmented
Structureless area

3. For benign
lesions, dots
are centrally
located or
situated on the
pigmented
network lines.
For melanoma,
dots are
distributed
asymmetrically
and/or focally
located at the
periphery.
Benign Lesions Malignant Lesions
Dots

4. Central Dots Focal dots

5. Dots located on network lines Dots asymmetrically located

6. Benign Lesions Malignant Lesions
Globules
Globules are
symmetrically
distributed throughout
the lesion, at the
periphery, or centrally
located..
Globules are
asymmetrically
distributed, often
aggregated focally.
When reddish in
color, they are highly
suggestive of
melanoma.

7. Globules symmetrically located
at the periphery
Globules asymmetrically
located at the periphery

8. Globules symmetrically
distributed throughout lesion
Asymmetric focal globules

9. Streaks, radial
streaming, and
pseudopods tend
to be symmetrical
and uniform at the
periphery.
Streaks, radial
streaming, and
pseudopods
tend to be focal
and asymmetric
at the periphery.
Benign Lesions Malignant Lesions
Streaks, Radial Streaming, and
Pseudopods

10. Symmetrical Pseudopods Focal Pseudopods