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Symmetric radial streaming
                                    Focal radial streaming

                       Radial streaming
Pseudopods / streaks
 Finger-like projections of
dark pigment at the
periphery of a lesion
 May have small knobs at
the tip
 Histologically represent
confluent junctional nests
of melanocytes
Confluent junctional nests of
  melanocytes of varying sizes and
  shapes in a melanoma




from Menzies et al. 2003 An atlas of surface microscopy of pigmented skin lesions
Pseudopods
Blue-White (Veil)
 An irregular indistinct
whitish film
superimposed on an area
of diffuse blue pigment
 If overlying the raised
portion of the lesion it
represents dermal
melanin in combination
with compact
orthokeratosis
Compact orthokeratosis and dermal melanin
Blue-white veil
Regression
May occur in:
 Melanocytic lesions
 Solar lentigines
 Seborrheic keratoses
 Actinic keratoses
Regression characterized by:

 Well localized blue-gray dots
or granules
 Diffuse multiple blue-gray
dots or granules on a
background of hypomelanosis
 Histologically represents
melanin and fibrosis in the
papillary dermis

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Slides 21 30

  • 1. Symmetric radial streaming Focal radial streaming Radial streaming
  • 2. Pseudopods / streaks  Finger-like projections of dark pigment at the periphery of a lesion  May have small knobs at the tip  Histologically represent confluent junctional nests of melanocytes
  • 3. Confluent junctional nests of melanocytes of varying sizes and shapes in a melanoma from Menzies et al. 2003 An atlas of surface microscopy of pigmented skin lesions
  • 5. Blue-White (Veil)  An irregular indistinct whitish film superimposed on an area of diffuse blue pigment  If overlying the raised portion of the lesion it represents dermal melanin in combination with compact orthokeratosis
  • 6. Compact orthokeratosis and dermal melanin
  • 8. Regression May occur in:  Melanocytic lesions  Solar lentigines  Seborrheic keratoses  Actinic keratoses
  • 9. Regression characterized by:  Well localized blue-gray dots or granules  Diffuse multiple blue-gray dots or granules on a background of hypomelanosis  Histologically represents melanin and fibrosis in the papillary dermis