This pilot study examined 5 patients with severe, chronic pain conditions, and was presented at the 2012 ASAM Annual Meeting in Atlanta.
Patients taking 4 mg of buprenorphine daily SL used oxycodone 15 mg, up to every 4 hours as needed in an open-label trial. Patients reported excellent analgesia with NO euphoria, such that even former opioid addicts were able to control use of their agonist each month. Most importantly, buprenorphine anchored tolerance and prevented dose escalation in patients for as long as 5 years, with no sign of tolerance development. Patients continued to get excellent paiin relief for many years, provided buprenorphine was not discontinued.